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Scnn1a sodium channel, nonvoltage-gated 1 alpha [ Mus musculus (house mouse) ]

Gene ID: 20276, updated on 23-Jun-2021

Summary

Official Symbol
Scnn1aprovided by MGI
Official Full Name
sodium channel, nonvoltage-gated 1 alphaprovided by MGI
Primary source
MGI:MGI:101782
See related
Ensembl:ENSMUSG00000030340
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Sc; mEN; ENaC; SCNEA; Scnn1; mENaC
Expression
Biased expression in lung adult (RPKM 90.9), colon adult (RPKM 43.3) and 8 other tissues See more
Orthologs
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Genomic context

See Scnn1a in Genome Data Viewer
Location:
6 F3; 6 59.32 cM
Exon count:
15
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (125290978..125321906)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (125314271..125344943)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 6 NC_000072.5 (125271358..125294961)

Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 4930417O13 gene Neighboring gene tubulin, alpha 3A Neighboring gene lymphotoxin B receptor Neighboring gene tumor necrosis factor receptor superfamily, member 1a Neighboring gene pleckstrin homology domain containing, family G (with RhoGef domain) member 6 Neighboring gene predicted gene, 52918

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables WW domain binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables WW domain binding ISO
Inferred from Sequence Orthology
more info
 
enables actin binding ISO
Inferred from Sequence Orthology
more info
 
enables ligand-gated sodium channel activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables ligand-gated sodium channel activity IDA
Inferred from Direct Assay
more info
PubMed 
enables ligand-gated sodium channel activity IGI
Inferred from Genetic Interaction
more info
PubMed 
contributes_to ligand-gated sodium channel activity ISO
Inferred from Sequence Orthology
more info
 
enables ligand-gated sodium channel activity ISO
Inferred from Sequence Orthology
more info
 
contributes_to sodium channel activity IDA
Inferred from Direct Assay
more info
PubMed 
contributes_to sodium ion transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
PubMed 
Component Evidence Code Pubs
located_in acrosomal vesicle ISO
Inferred from Sequence Orthology
more info
 
located_in apical plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in cell projection IEA
Inferred from Electronic Annotation
more info
 
located_in ciliary membrane ISO
Inferred from Sequence Orthology
more info
 
located_in cilium IEA
Inferred from Electronic Annotation
more info
 
located_in cortical actin cytoskeleton ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasmic vesicle IEA
Inferred from Electronic Annotation
more info
 
located_in cytosol IDA
Inferred from Direct Assay
more info
PubMed 
located_in external side of plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in extracellular exosome ISO
Inferred from Sequence Orthology
more info
 
located_in integral component of membrane IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in integral component of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in integral component of plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in motile cilium ISO
Inferred from Sequence Orthology
more info
 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane IMP
Inferred from Mutant Phenotype
more info
PubMed 
part_of plasma membrane protein complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of sodium channel complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of sodium channel complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of sodium channel complex IGI
Inferred from Genetic Interaction
more info
PubMed 
part_of sodium channel complex ISO
Inferred from Sequence Orthology
more info
 
located_in sperm principal piece ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
amiloride-sensitive sodium channel subunit alpha
Names
ENaC alpha
alpha-ENaC
alpha-NaCH
amiloride-sensitive epithelial sodium channel
epithelial Na(+) channel subunit alpha
epithelial sodium channel alpha subunit
nonvoltage-gated sodium channel 1 subunit alpha
sodium channel, nonvoltage-gated, type I, alpha polypeptide

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_011324.2NP_035454.2  amiloride-sensitive sodium channel subunit alpha

    See identical proteins and their annotated locations for NP_035454.2

    Status: VALIDATED

    Source sequence(s)
    AC140324, AF112185, AK140389
    Consensus CDS
    CCDS39641.2
    UniProtKB/Swiss-Prot
    Q61180
    UniProtKB/TrEMBL
    Q3USG4
    Related
    ENSMUSP00000080164.8, ENSMUST00000081440.14
    Conserved Domains (2) summary
    TIGR00859
    Location:80677
    ENaC; sodium channel transporter
    TIGR00867
    Location:88600
    deg-1; degenerin

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000072.7 Reference GRCm39 C57BL/6J

    Range
    125290978..125321906
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030255276.2XP_030111136.1  amiloride-sensitive sodium channel subunit alpha isoform X2

    Conserved Domains (1) summary
    cl02990
    Location:1349
    ASC; Amiloride-sensitive sodium channel
  2. XM_017321471.3XP_017176960.1  amiloride-sensitive sodium channel subunit alpha isoform X1

    Conserved Domains (1) summary
    TIGR00859
    Location:25539
    ENaC; sodium channel transporter
  3. XM_036165971.1XP_036021864.1  amiloride-sensitive sodium channel subunit alpha isoform X2

    Conserved Domains (1) summary
    cl02990
    Location:1349
    ASC; Amiloride-sensitive sodium channel
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