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Scp2 sterol carrier protein 2, liver [ Mus musculus (house mouse) ]

Gene ID: 20280, updated on 25-Jan-2022

Summary

Official Symbol
Scp2provided by MGI
Official Full Name
sterol carrier protein 2, liverprovided by MGI
Primary source
MGI:MGI:98254
See related
Ensembl:ENSMUSG00000028603 AllianceGenome:MGI:98254
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
SCPX; SCP-2; SCP-X; C76618; C79031; NSL-TP; ns-LTP; AA409774; AA409893
Summary
Predicted to enable several functions, including C-acyltransferase activity; cholesterol binding activity; and lipid transfer activity. Involved in regulation of phospholipid biosynthetic process. Acts upstream of or within peroxisome organization. Located in endoplasmic reticulum; mitochondrion; and peroxisome. Is expressed in several structures, including central nervous system; hair follicle; intestine; liver; and retina layer. Orthologous to human SCP2 (sterol carrier protein 2). [provided by Alliance of Genome Resources, Nov 2021]
Expression
Broad expression in liver adult (RPKM 155.8), liver E18 (RPKM 130.2) and 24 other tissues See more
Orthologs
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Genomic context

See Scp2 in Genome Data Viewer
Location:
4 C7; 4 50.2 cM
Exon count:
17
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (107901027..108002168, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (108043830..108144971, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 4 NC_000070.5 (107716444..107791104, complement)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene podocan Neighboring gene predicted gene, 23354 Neighboring gene microRNA 6397 Neighboring gene predicted gene, 54248 Neighboring gene enoyl Coenzyme A hydratase domain containing 2

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables acetyl-CoA C-acyltransferase activity ISO
Inferred from Sequence Orthology
more info
 
enables acetyl-CoA C-myristoyltransferase activity ISO
Inferred from Sequence Orthology
more info
 
enables acyltransferase activity IEA
Inferred from Electronic Annotation
more info
 
enables acyltransferase activity, transferring groups other than amino-acyl groups IEA
Inferred from Electronic Annotation
more info
 
enables cholesterol binding ISO
Inferred from Sequence Orthology
more info
 
enables cholesterol transfer activity ISO
Inferred from Sequence Orthology
more info
 
enables fatty-acyl-CoA binding ISO
Inferred from Sequence Orthology
more info
 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables lipid binding IEA
Inferred from Electronic Annotation
more info
 
enables long-chain fatty acyl-CoA binding ISO
Inferred from Sequence Orthology
more info
 
enables oleic acid binding ISO
Inferred from Sequence Orthology
more info
 
enables phosphatidylcholine transfer activity ISO
Inferred from Sequence Orthology
more info
 
enables phosphatidylethanolamine transfer activity ISO
Inferred from Sequence Orthology
more info
 
enables phosphatidylinositol transfer activity ISO
Inferred from Sequence Orthology
more info
 
enables propanoyl-CoA C-acyltransferase activity IEA
Inferred from Electronic Annotation
more info
 
enables propionyl-CoA C2-trimethyltridecanoyltransferase activity ISO
Inferred from Sequence Orthology
more info
 
enables propionyl-CoA C2-trimethyltridecanoyltransferase activity TAS
Traceable Author Statement
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein-containing complex binding ISO
Inferred from Sequence Orthology
more info
 
enables signaling receptor binding ISO
Inferred from Sequence Orthology
more info
 
enables sterol binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within acyl-CoA metabolic process TAS
Traceable Author Statement
more info
PubMed 
involved_in aging ISO
Inferred from Sequence Orthology
more info
 
involved_in bile acid metabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in fatty acid beta-oxidation ISO
Inferred from Sequence Orthology
more info
 
involved_in inositol trisphosphate biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
involved_in intracellular cholesterol transport ISO
Inferred from Sequence Orthology
more info
 
involved_in lipid hydroperoxide transport ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within lipid metabolic process IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within lipid transport IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within peroxisome organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in phospholipid transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in phospholipid transport ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cholesterol biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cholesterol import ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of intracellular cholesterol transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of intracellular cholesterol transport ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of steroid biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of steroid metabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in progesterone biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
involved_in protein localization to plasma membrane ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of phospholipid biosynthetic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in steroid biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in steroid biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in endoplasmic reticulum IDA
Inferred from Direct Assay
more info
PubMed 
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
 
located_in extrinsic component of membrane ISO
Inferred from Sequence Orthology
more info
 
located_in extrinsic component of mitochondrial outer membrane ISO
Inferred from Sequence Orthology
more info
 
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
 
located_in membrane ISO
Inferred from Sequence Orthology
more info
 
located_in mitochondrion HDA PubMed 
located_in mitochondrion IDA
Inferred from Direct Assay
more info
PubMed 
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 
located_in peroxisomal matrix ISO
Inferred from Sequence Orthology
more info
 
located_in peroxisomal matrix TAS
Traceable Author Statement
more info
 
located_in peroxisome IDA
Inferred from Direct Assay
more info
PubMed 
located_in peroxisome ISO
Inferred from Sequence Orthology
more info
 
located_in peroxisome TAS
Traceable Author Statement
more info
PubMed 
part_of protein-containing complex ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
sterol carrier protein 2; non-specific lipid-transfer protein
Names
SCP-2/3-oxoacyl-CoA thiolase
SCP-2/thiolase
SCP-chi
acetyl-CoA C-myristoyltransferase
nonspecific lipid transfer protein
propanoyl-CoA C-acyltransferase
sterol carrier protein X
straight-chain acyl-CoA oxidase
NP_035457.1
XP_011238779.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_011327.4NP_035457.1  sterol carrier protein 2

    See identical proteins and their annotated locations for NP_035457.1

    Status: VALIDATED

    Source sequence(s)
    AK004860, BB774576, CJ238474, DN176201, M91458
    Consensus CDS
    CCDS18446.1
    UniProtKB/Swiss-Prot
    P32020
    Related
    ENSMUSP00000030340.9, ENSMUST00000030340.15
    Conserved Domains (3) summary
    PRK08256
    Location:12404
    PRK08256; lipid-transfer protein; Provisional
    cd00826
    Location:17403
    nondecarbox_cond_enzymes; nondecarboxylating condensing enzymes; In general, thiolases catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. There are 2 ...
    pfam02036
    Location:452538
    SCP2; SCP-2 sterol transfer family

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    107901027..108002168 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011240477.2XP_011238779.1  non-specific lipid-transfer protein isoform X1

    See identical proteins and their annotated locations for XP_011238779.1

    Conserved Domains (2) summary
    PRK08256
    Location:8388
    PRK08256; lipid-transfer protein; Provisional
    pfam02036
    Location:436522
    SCP2; SCP-2 sterol transfer family
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