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Zc3h7b zinc finger CCCH type containing 7B [ Mus musculus (house mouse) ]

Gene ID: 20286, updated on 5-Mar-2024

Summary

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Official Symbol
Zc3h7bprovided by MGI
Official Full Name
zinc finger CCCH type containing 7Bprovided by MGI
Primary source
MGI:MGI:1328310
See related
Ensembl:ENSMUSG00000022390 AllianceGenome:MGI:1328310
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Gm627; Scrg3; Zc2h7b; mKIAA1031
Summary
Predicted to enable miRNA binding activity. Predicted to be involved in production of miRNAs involved in gene silencing by miRNA. Orthologous to human ZC3H7B (zinc finger CCCH-type containing 7B). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in CNS E14 (RPKM 16.5), whole brain E14.5 (RPKM 16.2) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
15 E1; 15 38.23 cM
Exon count:
24
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (81629299..81680470)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (81745098..81796269)

Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene L3MBTL2 polycomb repressive complex 1 subunit Neighboring gene STARR-seq mESC enhancer starr_39263 Neighboring gene chondroadherin-like Neighboring gene RAN GTPase activating protein 1 Neighboring gene STARR-positive B cell enhancer ABC_E1915 Neighboring gene STARR-seq mESC enhancer starr_39269 Neighboring gene STARR-positive B cell enhancer ABC_E944 Neighboring gene predicted gene, 17597 Neighboring gene thyrotroph embryonic factor

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Gene expression in scrapie. Cloning of a new scrapie-responsive gene and the identification of increased levels of seven other mRNA transcripts. Dandoy-Dron F, et al. J Biol Chem, 1998 Mar 27. PMID 9516475
  2. Stage-specific changes in gene expression in acutely isolated mouse CNS progenitor cells. Abramova N, et al. Dev Biol, 2005 Jul 15. PMID 15890332
  3. Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. Okazaki N, et al. DNA Res, 2003 Aug 31. PMID 14621295
  4. Matrix-screening reveals a vast potential for direct protein-protein interactions among RNA binding proteins. Lang B, et al. Nucleic Acids Res, 2021 Jul 9. PMID 34133714, Free PMC Article
  5. Database resources of the National Center for Biotechnology Information. Wheeler DL, et al. Nucleic Acids Res, 2001 Jan 1. PMID 11125038, Free PMC Article

See all (22) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables miRNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables miRNA binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in miRNA processing IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in miRNA processing ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_positive_effect post-transcriptional regulation of gene expression ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
  

General protein information

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Preferred Names
zinc finger CCCH domain-containing protein 7B
Names
scrapie responsive gene 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001081016.2 → NP_001074485.1  zinc finger CCCH domain-containing protein 7B

    See identical proteins and their annotated locations for NP_001074485.1

    Status: VALIDATED

    Source sequence(s)
    AC158970
    Consensus CDS
    CCDS37150.1
    UniProtKB/TrEMBL
    F8VPP8
    Related
    ENSMUSP00000105181.2, ENSMUST00000109554.3
    Conserved Domains (5) summary
    TIGR00990
    Location:18 → 162
    3a0801s09; mitochondrial precursor proteins import receptor (72 kDa mitochondrial outermembrane protein) (mitochondrial import receptor for the ADP/ATP carrier) (translocase of outermembrane tom70)
    sd00020
    Location:845 → 867
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00006
    Location:39 → 64
    TPR; TPR repeat [structural motif]
    pfam00642
    Location:891 → 913
    zf-CCCH; Zinc finger C-x8-C-x5-C-x3-H type (and similar)
    pfam12171
    Location:845 → 868
    zf-C2H2_jaz; Zinc-finger double-stranded RNA-binding

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000081.7 Reference GRCm39 C57BL/6J

    Range
    81629299..81680470
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017316520.2 → XP_017172009.1  zinc finger CCCH domain-containing protein 7B isoform X2

    UniProtKB/TrEMBL
    F8VPP8
    Conserved Domains (5) summary
    TIGR00990
    Location:18 → 162
    3a0801s09; mitochondrial precursor proteins import receptor (72 kDa mitochondrial outermembrane protein) (mitochondrial import receptor for the ADP/ATP carrier) (translocase of outermembrane tom70)
    sd00020
    Location:845 → 867
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00006
    Location:39 → 64
    TPR; TPR repeat [structural motif]
    pfam00642
    Location:891 → 913
    zf-CCCH; Zinc finger C-x8-C-x5-C-x3-H type (and similar)
    pfam12171
    Location:845 → 868
    zf-C2H2_jaz; Zinc-finger double-stranded RNA-binding
Nucleotide Protein Strain
Heading Accession and Version

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