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Msr1 macrophage scavenger receptor 1 [ Mus musculus (house mouse) ]

Gene ID: 20288, updated on 26-Oct-2021

Summary

Official Symbol
Msr1provided by MGI
Official Full Name
macrophage scavenger receptor 1provided by MGI
Primary source
MGI:MGI:98257
See related
Ensembl:ENSMUSG00000025044
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
MSR; Scvr; MRS-A; MSR-A; SR-AI; SR-AII; Scara1
Expression
Broad expression in liver E18 (RPKM 1.9), liver E14 (RPKM 1.1) and 18 other tissues See more
Orthologs
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Genomic context

See Msr1 in Genome Data Viewer
Location:
8 A4; 8 23.89 cM
Exon count:
13
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (39996284..40095790, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (39543232..39642750, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 8 NC_000074.5 (40667054..40728032, complement)

Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene predicted gene 6213 Neighboring gene voltage-dependent anion channel 3 pseudogene Neighboring gene copine VIII pseudogene Neighboring gene H/ACA ribonucleoprotein complex subunit 3 pseudogene Neighboring gene predicted gene, 36741

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables amyloid-beta binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables amyloid-beta binding IGI
Inferred from Genetic Interaction
more info
PubMed 
enables cargo receptor activity IGI
Inferred from Genetic Interaction
more info
PubMed 
enables low-density lipoprotein particle binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables low-density lipoprotein particle binding IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables scavenger receptor activity IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
part_of collagen trimer IEA
Inferred from Electronic Annotation
more info
 
located_in cytoplasmic vesicle ISO
Inferred from Sequence Orthology
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
is_active_in external side of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
part_of low-density lipoprotein particle IEA
Inferred from Electronic Annotation
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in plasma membrane IMP
Inferred from Mutant Phenotype
more info
PubMed 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in plasma membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
macrophage scavenger receptor types I and II
Names
SR-A
macrophage acetylated LDL receptor I and II
scavenger receptor type A

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001113326.1NP_001106797.1  macrophage scavenger receptor types I and II isoform b

    See identical proteins and their annotated locations for NP_001106797.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) includes alternate exons in the 5' coding region, compared to variant 1. The resulting protein (isoform b) has a distinct C-terminus and is longer than isoform a.
    Source sequence(s)
    AF203781, AK150518
    Consensus CDS
    CCDS52542.1
    UniProtKB/Swiss-Prot
    P30204
    UniProtKB/TrEMBL
    Q8CED7
    Related
    ENSMUSP00000026021.7, ENSMUST00000026021.14
    Conserved Domains (4) summary
    pfam01391
    Location:277338
    Collagen; Collagen triple helix repeat (20 copies)
    smart00202
    Location:357457
    SR; Scavenger receptor Cys-rich
    pfam00530
    Location:362457
    SRCR; Scavenger receptor cysteine-rich domain
    pfam03523
    Location:125173
    Macscav_rec; Macrophage scavenger receptor
  2. NM_031195.2NP_112472.2  macrophage scavenger receptor types I and II isoform a

    See identical proteins and their annotated locations for NP_112472.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript but encodes the shorter isoform (a).
    Source sequence(s)
    AC111028, AK151855, AK155589
    Consensus CDS
    CCDS52543.1
    UniProtKB/TrEMBL
    Q8CED7
    Related
    ENSMUSP00000132535.2, ENSMUST00000170091.3
    Conserved Domains (3) summary
    pfam01391
    Location:277338
    Collagen; Collagen triple helix repeat (20 copies)
    COG0840
    Location:118275
    Tar; Methyl-accepting chemotaxis protein [Cell motility, Signal transduction mechanisms]
    pfam03523
    Location:125173
    Macscav_rec; Macrophage scavenger receptor

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000074.7 Reference GRCm39 C57BL/6J

    Range
    39996284..40095790 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006509311.4XP_006509374.1  macrophage scavenger receptor types I and II isoform X1

    Conserved Domains (4) summary
    pfam01391
    Location:306367
    Collagen; Collagen triple helix repeat (20 copies)
    smart00202
    Location:386443
    SR; Scavenger receptor Cys-rich
    COG0840
    Location:147304
    Tar; Methyl-accepting chemotaxis protein [Cell motility, Signal transduction mechanisms]
    pfam03523
    Location:154202
    Macscav_rec; Macrophage scavenger receptor
  2. XM_006509312.4XP_006509375.1  macrophage scavenger receptor types I and II isoform X2

    Conserved Domains (4) summary
    pfam01391
    Location:273334
    Collagen; Collagen triple helix repeat (20 copies)
    smart00202
    Location:353453
    SR; Scavenger receptor Cys-rich
    COG0840
    Location:114271
    Tar; Methyl-accepting chemotaxis protein [Cell motility, Signal transduction mechanisms]
    pfam03523
    Location:121169
    Macscav_rec; Macrophage scavenger receptor
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