Msr1 macrophage scavenger receptor 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Msr1provided by MGI
Official Full Name: macrophage scavenger receptor 1provided by MGI
Primary source: MGI:MGI:98257
See related: Ensembl:ENSMUSG00000025044 AllianceGenome:MGI:98257
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: MSR; SR-A; Scvr; MRS-A; MSR-A; SR-AI; SR-AII; Scara1
Summary: Enables amyloid-beta binding activity; cargo receptor activity; and low-density lipoprotein particle binding activity. Involved in several processes, including endocytosis; positive regulation of cholesterol storage; and positive regulation of macrophage derived foam cell differentiation. Acts upstream of or within lipoprotein transport. Located in plasma membrane. Is expressed in several structures, including alimentary system; limb; neural tube; reproductive system; and yolk sac. Human ortholog(s) of this gene implicated in Barrett's esophagus; arteriosclerosis; and prostate cancer. Orthologous to human MSR1 (macrophage scavenger receptor 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Broad expression in liver E18 (RPKM 1.9), liver E14 (RPKM 1.1) and 18 other tissues See more
Orthologs: human all
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Genomic context

Location:: 8 A4; 8 23.89 cM

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	8	NC_000074.7 (39996284..40095790, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	8	NC_000074.6 (39543232..39642750, complement)

Chromosome 8 - NC_000074.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Macrophage scavenger receptor A1 antagonizes abdominal aortic aneurysm via upregulating IRG1.
Title: Macrophage scavenger receptor A1 antagonizes abdominal aortic aneurysm via upregulating IRG1.
MSR1 is not required for obesity-associated inflammation and insulin resistance in mice.
Title: MSR1 is not required for obesity-associated inflammation and insulin resistance in mice.
Role of macrophage scavenger receptor MSR1 in the progression of non-alcoholic steatohepatitis.
Title: Role of macrophage scavenger receptor MSR1 in the progression of non-alcoholic steatohepatitis.
SRA Suppresses Antiviral Innate Immune Response in Macrophages by Limiting TBK1 K63 Ubiquitination via Deubiquitinase USP15.
Title: SRA Suppresses Antiviral Innate Immune Response in Macrophages by Limiting TBK1 K63 Ubiquitination via Deubiquitinase USP15.
Blocking Msr1 by berberine alkaloids inhibits caspase-11-dependent coagulation in bacterial sepsis.
Title: Blocking Msr1 by berberine alkaloids inhibits caspase-11-dependent coagulation in bacterial sepsis.
The CD36 and SR-A/CD204 scavenger receptors fine-tune Staphylococcus aureus-stimulated cytokine production in mouse macrophages.
Title: The CD36 and SR-A/CD204 scavenger receptors fine-tune Staphylococcus aureus-stimulated cytokine production in mouse macrophages.
The role of macrophage scavenger receptor 1 (Msr1) in prion pathogenesis.
Title: The role of macrophage scavenger receptor 1 (Msr1) in prion pathogenesis.
Critical contribution of macrophage scavenger receptor 1 to the uptake of nanostructured DNA by immune cells.
Title: Critical contribution of macrophage scavenger receptor 1 to the uptake of nanostructured DNA by immune cells.
Scavenger receptor A1 participates in uptake of Leptospira interrogans serovar Autumnalis strain 56606v and inflammation in mouse macrophages.
Title: Scavenger receptor A1 participates in uptake of Leptospira interrogans serovar Autumnalis strain 56606v and inflammation in mouse macrophages.
Glycoursodeoxycholic Acid Ameliorates Atherosclerosis and Alters Gut Microbiota in Apolipoprotein E-Deficient Mice.
Title: Glycoursodeoxycholic Acid Ameliorates Atherosclerosis and Alters Gut Microbiota in Apolipoprotein E-Deficient Mice.

Submit: New GeneRIF Correction See all GeneRIFs (126)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (2) 1 citation
Endonuclease-mediated (5)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

L04275 (e-PCR)
- UniSTS:159755

Msr1 (e-PCR), detects polymorphism
- UniSTS:181874

Msr1 (e-PCR), detects polymorphism
- UniSTS:144375

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables amyloid-beta binding	IBA Inferred from Biological aspect of Ancestor more info
enables amyloid-beta binding	IGI Inferred from Genetic Interaction more info	PubMed
enables cargo receptor activity	IGI Inferred from Genetic Interaction more info	PubMed
enables low-density lipoprotein particle binding	IBA Inferred from Biological aspect of Ancestor more info
enables low-density lipoprotein particle binding	IMP Inferred from Mutant Phenotype more info	PubMed
enables scavenger receptor activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in amyloid-beta clearance	IBA Inferred from Biological aspect of Ancestor more info
involved_in amyloid-beta clearance	IGI Inferred from Genetic Interaction more info	PubMed
involved_in amyloid-beta clearance	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cholesterol transport	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within endocytosis	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within establishment of localization in cell	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within lipoprotein transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of gene expression	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in phagocytosis, engulfment	IGI Inferred from Genetic Interaction more info	PubMed
involved_in plasma lipoprotein particle clearance	IBA Inferred from Biological aspect of Ancestor more info
involved_in plasma lipoprotein particle clearance	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of cholesterol storage	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of cholesterol storage	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of macrophage derived foam cell differentiation	IGI Inferred from Genetic Interaction more info	PubMed
involved_in receptor-mediated endocytosis	IGI Inferred from Genetic Interaction more info	PubMed

Component	Evidence Code	Pubs
part_of collagen trimer	IEA Inferred from Electronic Annotation more info
part_of low-density lipoprotein particle	IEA Inferred from Electronic Annotation more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	IMP Inferred from Mutant Phenotype more info	PubMed
located_in plasma membrane	TAS Traceable Author Statement more info

General protein information

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Preferred Names: macrophage scavenger receptor types I and II

Names: macrophage acetylated LDL receptor I and II; scavenger receptor type A

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001113326.2 → NP_001106797.2 macrophage scavenger receptor types I and II isoform b

Status: VALIDATED

Source sequence(s)

AC111028

Consensus CDS

CCDS52542.1

Related

ENSMUSP00000026021.7, ENSMUST00000026021.14
NM_031195.3 → NP_112472.3 macrophage scavenger receptor types I and II isoform a

Status: VALIDATED

Source sequence(s)

AC111028

Consensus CDS

CCDS52543.1

Related

ENSMUSP00000132535.2, ENSMUST00000170091.3

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000074.7 Reference GRCm39 C57BL/6J

Range

39996284..40095790 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006509311.4 → XP_006509374.1 macrophage scavenger receptor types I and II isoform X1

UniProtKB/Swiss-Prot

E9QNQ5, P30204, Q923G0, Q9QZ56

Conserved Domains (4) summary

pfam01391
Location:306 → 367

Collagen; Collagen triple helix repeat (20 copies)

smart00202
Location:386 → 443

SR; Scavenger receptor Cys-rich

COG0840
Location:147 → 304

Tar; Methyl-accepting chemotaxis protein [Cell motility, Signal transduction mechanisms]

pfam03523
Location:154 → 202

Macscav_rec; Macrophage scavenger receptor
XM_006509312.4 → XP_006509375.1 macrophage scavenger receptor types I and II isoform X2

UniProtKB/Swiss-Prot

E9QNQ5, P30204, Q923G0, Q9QZ56

Conserved Domains (4) summary

pfam01391
Location:273 → 334

Collagen; Collagen triple helix repeat (20 copies)

smart00202
Location:353 → 453

SR; Scavenger receptor Cys-rich

COG0840
Location:114 → 271

Tar; Methyl-accepting chemotaxis protein [Cell motility, Signal transduction mechanisms]

pfam03523
Location:121 → 169

Macscav_rec; Macrophage scavenger receptor