Ccl1 C-C motif chemokine ligand 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Ccl1provided by MGI
Official Full Name: C-C motif chemokine ligand 1provided by MGI
Primary source: MGI:MGI:98258
See related: Ensembl:ENSMUSG00000020702 AllianceGenome:MGI:98258
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: P500; Tca3; I-309; Scya1; Tca-3
Summary: Enables cytokine activity. Acts upstream of or within chemotaxis. Predicted to be located in extracellular region. Predicted to be active in extracellular space. Is expressed in heart; late tubule; and testis. Human ortholog(s) of this gene implicated in chronic obstructive pulmonary disease; multiple sclerosis; pulmonary tuberculosis; and tuberculosis. Orthologous to human CCL1 (C-C motif chemokine ligand 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Low expression observed in reference dataset See more
Orthologs: human all
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Genomic context

Location:: 11 C; 11 49.99 cM

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	11	NC_000077.7 (82067492..82070638, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	11	NC_000077.6 (82176666..82179812, complement)

Chromosome 11 - NC_000077.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The chemokine CCL1 facilitates pulmonary fibrosis by promoting macrophage migration and M2 polarization.
Title: The chemokine CCL1 facilitates pulmonary fibrosis by promoting macrophage migration and M2 polarization.
CCR8 Signaling via CCL1 Regulates Responses of Intestinal IFN-gamma Producing Innate Lymphoid CelIs and Protects From Experimental Colitis.
Title: CCR8 Signaling via CCL1 Regulates Responses of Intestinal IFN-γ Producing Innate Lymphoid CelIs and Protects From Experimental Colitis.
Disruption of the CCL1-CCR8 axis promotes atherosclerosis.
Title: Disruption of the CCL1-CCR8 axis inhibits vascular Treg recruitment and function and promotes atherosclerosis in mice.
These results indicate that high mortality rates of mice irradiated with 7-10 Gy of gamma rays are reducible by depleting CCL1 in combination with the intestinal lineage cell transplantation.
Title: Survival of Mice with Gastrointestinal Acute Radiation Syndrome through Control of Bacterial Translocation.
Findings provide evidence that CCL1 possibly contributes to 5-fluorouracil/paclitaxel chemoresistance in CT26 colorectal cell line via TGF-beta and nuclear factor-kappa B signaling pathways.
Title: Participation of CCL1 in Snail-Positive Fibroblasts in Colorectal Cancer Contribute to 5-Fluorouracil/Paclitaxel Chemoresistance.
Sca-1(+) progenitor cells found to exhibit increased migration was associated with elevated levels of chemokines, CCL2 (chemokine (C-C motif) ligand 2) and CXCL1 (chemokine (C-X-C motif) ligand 1), and their corresponding receptors.
Title: Vascular Stem/Progenitor Cell Migration Induced by Smooth Muscle Cell-Derived Chemokine (C-C Motif) Ligand 2 and Chemokine (C-X-C motif) Ligand 1 Contributes to Neointima Formation.
Study reports showing that I. ricinus saliva can increase the production of three chemokines, CCL1, CCL2 and CXCL2. This upregulation reflects Th2 polarization of the host immunity due to the effect of tick saliva and in the case of CCL2 probably facilitates tick engorgement in the late, rapid feeding phase.
Title: Tick saliva increases production of three chemokines including monocyte chemoattractant protein-1, a histamine-releasing cytokine.
Our data indicate that estradiol is important in regulating the effects of keratinocyte growth factor on mouse uterine epithelial cell secretion of CCL20 and CXCL1.
Title: Estradiol regulation of constitutive and keratinocyte growth factor-induced CCL20 and CXCL1 secretion by mouse uterine epithelial cells.
CCL-1 is one of the key molecules in pathogenesis in neuropathic pain.
Title: CCL-1 in the spinal cord contributes to neuropathic pain induced by nerve injury.
These data identify a novel function for CCL1-CCR8 in metastasis and lymph node LECs as a critical checkpoint for the entry of metastases into the lymph nodes.
Title: Tumor cell entry into the lymph node is controlled by CCL1 chemokine expressed by lymph node lymphatic sinuses.

Submit: New GeneRIF Correction See all GeneRIFs (24)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (1) 1 citation
Endonuclease-mediated (4) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

M23501 (e-PCR)
- UniSTS:124940

NoName (e-PCR)
- UniSTS:494157

BF534335 (e-PCR), detects polymorphism
- UniSTS:259409

Ccl1 (e-PCR), detects polymorphism
- UniSTS:259411

D11Pas42 (e-PCR), detects polymorphism
- UniSTS:259438

NoName (e-PCR)
- UniSTS:484986

Scya1 (e-PCR), detects polymorphism
- UniSTS:144377

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables CCR chemokine receptor binding	IBA Inferred from Biological aspect of Ancestor more info
enables chemokine activity	IBA Inferred from Biological aspect of Ancestor more info
enables chemokine activity	ISO Inferred from Sequence Orthology more info
enables cytokine activity	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in antimicrobial humoral immune response mediated by antimicrobial peptide	IBA Inferred from Biological aspect of Ancestor more info
involved_in antimicrobial humoral immune response mediated by antimicrobial peptide	ISO Inferred from Sequence Orthology more info
involved_in cellular response to interleukin-17	IDA Inferred from Direct Assay more info	PubMed
involved_in chemokine-mediated signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within chemotaxis	IDA Inferred from Direct Assay more info	PubMed
involved_in eosinophil chemotaxis	IBA Inferred from Biological aspect of Ancestor more info
involved_in immune response	IEA Inferred from Electronic Annotation more info
involved_in inflammatory response	IBA Inferred from Biological aspect of Ancestor more info
involved_in killing of cells of another organism	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of GTPase activity	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of cell migration	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of cytosolic calcium ion concentration	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of inflammatory response	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of interleukin-17 production	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of monocyte chemotaxis	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in extracellular region	IEA Inferred from Electronic Annotation more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: C-C motif chemokine 1

Names: CCR8 ligand; SIS-epsilon; T-cell activation protein 3; chemokine (C-C motif) ligand 1; small-inducible cytokine A1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.