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Cxcl2 chemokine (C-X-C motif) ligand 2 [ Mus musculus (house mouse) ]

Gene ID: 20310, updated on 5-Jan-2022

Summary

Official Symbol
Cxcl2provided by MGI
Official Full Name
chemokine (C-X-C motif) ligand 2provided by MGI
Primary source
MGI:MGI:1340094
See related
Ensembl:ENSMUSG00000058427
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
GROb; Gro2; Mip2; Scyb; MIP-2; Scyb2; MIP-2a; Mgsa-b; CINC-2a
Summary
Predicted to enable CXCR chemokine receptor binding activity and chemokine activity. Involved in response to molecule of bacterial origin. Located in extracellular space. Is expressed in several structures, including alimentary system; embryo mesenchyme; floor plate; respiratory system; and skin. Orthologous to several human genes including CXCL3 (C-X-C motif chemokine ligand 3). [provided by Alliance of Genome Resources, Nov 2021]
Expression
Broad expression in thymus adult (RPKM 1.4), small intestine adult (RPKM 1.0) and 15 other tissues See more
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Genomic context

See Cxcl2 in Genome Data Viewer
Location:
5 E1; 5 44.78 cM
Exon count:
4
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (91051758..91053797)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (90903899..90905938)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 5 NC_000071.5 (91332925..91334964)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene chemokine (C-X-C motif) ligand 15 Neighboring gene chemokine (C-X-C motif) ligand 1 Neighboring gene methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2-like Neighboring gene predicted gene, 52819 Neighboring gene epithelial mitogen

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables CXCR chemokine receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables chemokine activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables chemokine activity ISO
Inferred from Sequence Orthology
more info
 
enables cytokine activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in antimicrobial humoral immune response mediated by antimicrobial peptide IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in antimicrobial humoral immune response mediated by antimicrobial peptide ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to lipopolysaccharide IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in chemokine-mediated signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within chemotaxis IEA
Inferred from Electronic Annotation
more info
 
involved_in chemotaxis IEA
Inferred from Electronic Annotation
more info
 
involved_in defense response IEA
Inferred from Electronic Annotation
more info
 
involved_in immune response IEA
Inferred from Electronic Annotation
more info
 
involved_in inflammatory response IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in killing of cells of another organism ISO
Inferred from Sequence Orthology
more info
 
involved_in leukocyte chemotaxis ISO
Inferred from Sequence Orthology
more info
 
involved_in neuron death ISO
Inferred from Sequence Orthology
more info
 
involved_in neutrophil chemotaxis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in neutrophil chemotaxis ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cytosolic calcium ion concentration ISO
Inferred from Sequence Orthology
more info
 
involved_in response to molecule of bacterial origin IDA
Inferred from Direct Assay
more info
PubMed 
involved_in response to molecule of bacterial origin ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
 
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in extracellular space IDA
Inferred from Direct Assay
more info
PubMed 
located_in extracellular space ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
C-X-C motif chemokine 2
Names
macrophage inflammatory protein 2
small inducible cytokine subfamily, member 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_009140.2NP_033166.1  C-X-C motif chemokine 2 precursor

    See identical proteins and their annotated locations for NP_033166.1

    Status: PROVISIONAL

    Source sequence(s)
    AC157938
    Consensus CDS
    CCDS39144.1
    UniProtKB/Swiss-Prot
    P10889
    UniProtKB/TrEMBL
    Q3U1J5
    Related
    ENSMUSP00000074885.7, ENSMUST00000075433.8
    Conserved Domains (1) summary
    cd00273
    Location:3395
    Chemokine_CXC; Chemokine_CXC: 1 of 4 subgroup designations based on the arrangement of the two N-terminal cysteine residues; includes a number of secreted growth factors and interferons involved in mitogenic, chemotactic, and inflammatory activity; many members ...

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    91051758..91053797
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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