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EPB41L1 erythrocyte membrane protein band 4.1 like 1 [ Homo sapiens (human) ]

Gene ID: 2036, updated on 7-Apr-2024

Summary

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Official Symbol
EPB41L1provided by HGNC
Official Full Name
erythrocyte membrane protein band 4.1 like 1provided by HGNC
Primary source
HGNC:HGNC:3378
See related
Ensembl:ENSG00000088367 MIM:602879; AllianceGenome:HGNC:3378
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
4.1N; MRD11
Summary
Erythrocyte membrane protein band 4.1 (EPB41) is a multifunctional protein that mediates interactions between the erythrocyte cytoskeleton and the overlying plasma membrane. The encoded protein binds and stabilizes D2 and D3 dopamine receptors at the neuronal plasma membrane. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2015]
Expression
Broad expression in brain (RPKM 24.1), adrenal (RPKM 21.5) and 21 other tissues See more
Orthologs
mouse all
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Genomic context

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Location:
20q11.23
Exon count:
27
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 20 NC_000020.11 (36091414..36232799)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 20 NC_060944.1 (37812399..37953498)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 20 NC_000020.10 (34679336..34820721)

Chromosome 20 - NC_000020.11Genomic Context describing neighboring genes Neighboring gene MED14-independent group 3 enhancer GRCh37_chr20:34637879-34639078 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17803 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12866 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:34679298-34680250 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12867 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:34681205-34682156 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:34683285-34683786 Neighboring gene non-coding RNA activated by DNA damage Neighboring gene NANOG hESC enhancer GRCh37_chr20:34685650-34686158 Neighboring gene high mobility group box 3 pseudogene 2 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:34700699-34701198 Neighboring gene uncharacterized LOC124904977 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:34716909-34717410 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17804 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12869 Neighboring gene uncharacterized LOC124904893 Neighboring gene EPB41L1 antisense RNA 1 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12870 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:34761581-34762283 Neighboring gene uncharacterized LOC124904892 Neighboring gene Sharpr-MPRA regulatory region 2694 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17805 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr20:34799860-34801059 Neighboring gene uncharacterized LOC105372602 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr20:34858840-34860039 Neighboring gene AAR2 splicing factor Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:34959277-34959938 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:34959939-34960600 Neighboring gene OCT4-NANOG-H3K4me1 hESC enhancer GRCh37_chr20:34960601-34961262 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:34961263-34961922 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:34961923-34962584 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:34964801-34965786 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:34966822-34967482 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:34968805-34969464 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:34969762-34970692 Neighboring gene DLG associated protein 4 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:34978479-34978979 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:34980118-34980829 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:34996041-34996689 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:35060233-35060734 Neighboring gene ReSE screen-validated silencer GRCh37_chr20:35069878-35070075 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:35082739-35083539 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:35089423-35090213 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:35090214-35091004 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:35092411-35093337 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:35093338-35094263 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17807 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:35100944-35101844 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:35125835-35126334 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17808 Neighboring gene DLGAP4 antisense RNA 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Protein 4.1N is required for the formation of the lateral membrane domain in human bronchial epithelial cells. Wang Y, et al. Biochim Biophys Acta Biomembr, 2018 May. PMID 29428502, Free PMC Article
  2. 4.1N suppresses hypoxia-induced epithelial-mesenchymal transition in epithelial ovarian cancer cells. Zhang L, et al. Mol Med Rep, 2016 Jan. PMID 26648170
  3. Defective expression of Protein 4.1N is correlated to tumor progression, aggressive behaviors and chemotherapy resistance in epithelial ovarian cancer. Xi C, et al. Gynecol Oncol, 2013 Dec. PMID 23994105
  4. The linoleic acid derivative DCP-LA increases membrane surface localization of the α7 ACh receptor in a protein 4.1N-dependent manner. Kanno T, et al. Biochem J, 2013 Mar 1. PMID 23256752
  5. Protein 4.1, a component of the erythrocyte membrane skeleton and its related homologue proteins forming the protein 4.1/FERM superfamily. Diakowski W, et al. Folia Histochem Cytobiol, 2006. PMID 17219717

See all (77) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. 4.1N, betaII spectrin and ankyrin G are structural components of the lateral membrane skeleton and this skeleton plays an essential role in the assembly of a fully functional lateral membrane.
    Title: Protein 4.1N is required for the formation of the lateral membrane domain in human bronchial epithelial cells.
  2. Data show that overexpression of 4.1N protein decreased expression of flotillin-1, decreased activation of beta-catenin/Wnt pathway in non-small-cell lung cancer (NSCLC) cells.
    Title: 4.1N is involved in a flotillin-1/β-catenin/Wnt pathway and suppresses cell proliferation and migration in non-small cell lung cancer cell lines.
  3. Data suggest that repression of JNK-c-Jun signaling through pancreatic polypeptide receptor 1 (PP1) is one of the key anti-tumor mechanisms of neuronal membrane cytoskeletal protein 4.1 (4.1N).
    Title: Protein 4.1N acts as a potential tumor suppressor linking PP1 to JNK-c-Jun pathway regulation in NSCLC.
  4. the data of the current study identified 4.1N as an inhibitor of hypoxiainduced tumor progression in epithelial ovarian cancer cells.
    Title: 4.1N suppresses hypoxia-induced epithelial-mesenchymal transition in epithelial ovarian cancer cells.
  5. Kainate receptor GluK2a post-translational modifications differentially regulate association with 4.1N to control activity-dependent receptor endocytosis
    Title: Kainate receptor post-translational modifications differentially regulate association with 4.1N to control activity-dependent receptor endocytosis.
  6. This protein has been found differentially expressed in thalami from patients with schizophrenia.
    Title: Proteome analysis of the thalamus and cerebrospinal fluid reveals glycolysis dysfunction and potential biomarkers candidates for schizophrenia.
  7. Observational study of gene-disease association. (HuGE Navigator)
    Title: Association study of 182 candidate genes in anorexia nervosa.
  8. Using shotgun mass spectrometry, we found this protein differentially expressed in the dorsolateral prefrontal cortex from patients with schizophrenia.
    Title: Prefrontal cortex shotgun proteome analysis reveals altered calcium homeostasis and immune system imbalance in schizophrenia.
  9. protein 4.1N/dopamine receptor interaction is required for localization or stability of dopamine receptors at the neuronal plasma membrane.
    Title: D2 and D3 dopamine receptor cell surface localization mediated by interaction with protein 4.1N.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Associated conditions

Description Tests
Intellectual disability, autosomal dominant 11
MedGen: C3280285 OMIM: 614257 GeneReviews: Not available
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EBI GWAS Catalog

Description
Genome-wide meta-analysis identifies 11 new loci for anthropometric traits and provides insights into genetic architecture.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • KIAA0338, MGC11072, DKFZp686H17242

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables actin binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables structural molecule activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in actomyosin structure organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cortical actin cytoskeleton organization IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cytoskeleton IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol TAS
Traceable Author Statement
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
  
located_in plasma membrane TAS
Traceable Author Statement
more info
  

General protein information

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Preferred Names
band 4.1-like protein 1
Names
neuron-type nonerythroid protein 4.1
neuronal protein 4.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_031853.3 RefSeqGene

    Range
    68237..146296
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001258329.1 → NP_001245258.1  band 4.1-like protein 1 isoform c

    See identical proteins and their annotated locations for NP_001245258.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and uses an alternate in-frame splice junction at the 5' end of an exon compared to variant 1. The resulting isoform (c) has the same N- and C-termini but is 1 aa shorter compared to isoform a.
    Source sequence(s)
    AK299817, AL121895, BC040259
    Consensus CDS
    CCDS58771.1
    UniProtKB/TrEMBL
    A0A0C4DH22, B3KUB6
    Related
    ENSP00000363057.4, ENST00000373946.7
    Conserved Domains (7) summary
    smart00295
    Location:99 → 288
    B41; Band 4.1 homologues
    cd13184
    Location:283 → 376
    FERM_C_4_1_family; FERM domain C-lobe of Protein 4.1 family
    pfam00373
    Location:183 → 288
    FERM_M; FERM central domain
    pfam04382
    Location:493 → 524
    SAB; SAB domain
    pfam05902
    Location:790 → 867
    4_1_CTD; 4.1 protein C-terminal domain (CTD)
    pfam08736
    Location:385 → 425
    FA; FERM adjacent (FA)
    pfam09379
    Location:101 → 164
    FERM_N; FERM N-terminal domain

  2. NM_001258330.1 → NP_001245259.1  band 4.1-like protein 1 isoform d

    See identical proteins and their annotated locations for NP_001245259.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR and coding sequence and lacks two alternate in-frame exons compared to variant 1. The resulting isoform (d) has a shorter and distinct N-terminus and lacks two alternate internal segments compared to isoform a.
    Source sequence(s)
    AK126875, AK299817, AL121895
    Consensus CDS
    CCDS58770.1
    UniProtKB/TrEMBL
    B3KUB6
    Related
    ENSP00000487049.2, ENST00000628415.2
    Conserved Domains (5) summary
    smart00295
    Location:68 → 257
    B41; Band 4.1 homologues
    cd13184
    Location:252 → 345
    FERM_C_4_1_family; FERM domain C-lobe of Protein 4.1 family
    pfam04382
    Location:451 → 481
    SAB; SAB domain
    pfam05902
    Location:595 → 688
    4_1_CTD; 4.1 protein C-terminal domain (CTD)
    pfam08736
    Location:354 → 395
    FA; FERM adjacent (FA)

  3. NM_001258331.2 → NP_001245260.1  band 4.1-like protein 1 isoform b

    See identical proteins and their annotated locations for NP_001245260.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR and coding sequence and lacks two alternate in-frame exons compared to variant 1. The resulting isoform (b) is shorter at the N-terminus and lacks two alternate internal segments compared to isoform a. Variants 2 and 5 both encode the same isoform (b).
    Source sequence(s)
    AL035420, AL121895, BC013885
    Consensus CDS
    CCDS13272.1
    UniProtKB/TrEMBL
    B3KUB6
    Related
    ENSP00000202028.5, ENST00000202028.9
    Conserved Domains (6) summary
    smart00295
    Location:37 → 226
    B41; Band 4.1 homologues
    cd13184
    Location:221 → 314
    FERM_C_4_1_family; FERM domain C-lobe of Protein 4.1 family
    pfam04382
    Location:420 → 450
    SAB; SAB domain
    pfam05902
    Location:673 → 766
    4_1_CTD; 4.1 protein C-terminal domain (CTD)
    pfam08736
    Location:323 → 364
    FA; FERM adjacent (FA)
    cl26247
    Location:334 → 525
    DNA_pol3_delta2; DNA polymerase III, delta subunit

  4. NM_001424373.1 → NP_001411302.1  band 4.1-like protein 1 isoform e

    Status: REVIEWED

    Source sequence(s)
    AL121895

  5. NM_001424374.1 → NP_001411303.1  band 4.1-like protein 1 isoform f

    Status: REVIEWED

    Source sequence(s)
    AL121895

  6. NM_001424375.1 → NP_001411304.1  band 4.1-like protein 1 isoform g

    Status: REVIEWED

    Source sequence(s)
    AL121895

  7. NM_001424376.1 → NP_001411305.1  band 4.1-like protein 1 isoform h

    Status: REVIEWED

    Source sequence(s)
    AL121895

  8. NM_001424377.1 → NP_001411306.1  band 4.1-like protein 1 isoform i

    Status: REVIEWED

    Source sequence(s)
    AL121895

  9. NM_001424378.1 → NP_001411307.1  band 4.1-like protein 1 isoform j

    Status: REVIEWED

    Source sequence(s)
    AL121895

  10. NM_001424379.1 → NP_001411308.1  band 4.1-like protein 1 isoform k

    Status: REVIEWED

    Source sequence(s)
    AL121895

  11. NM_001424380.1 → NP_001411309.1  band 4.1-like protein 1 isoform l

    Status: REVIEWED

    Source sequence(s)
    AL121895

  12. NM_001424381.1 → NP_001411310.1  band 4.1-like protein 1 isoform m

    Status: REVIEWED

    Source sequence(s)
    AL121895

  13. NM_001424382.1 → NP_001411311.1  band 4.1-like protein 1 isoform n

    Status: REVIEWED

    Source sequence(s)
    AL121895

  14. NM_001424383.1 → NP_001411312.1  band 4.1-like protein 1 isoform o

    Status: REVIEWED

    Source sequence(s)
    AL121895

  15. NM_001424384.1 → NP_001411313.1  band 4.1-like protein 1 isoform p

    Status: REVIEWED

    Source sequence(s)
    AL121895

  16. NM_001424385.1 → NP_001411314.1  band 4.1-like protein 1 isoform q

    Status: REVIEWED

    Source sequence(s)
    AL121895

  17. NM_001424386.1 → NP_001411315.1  band 4.1-like protein 1 isoform r

    Status: REVIEWED

    Source sequence(s)
    AL121895

  18. NM_001424387.1 → NP_001411316.1  band 4.1-like protein 1 isoform s

    Status: REVIEWED

    Source sequence(s)
    AL121895

  19. NM_001424388.1 → NP_001411317.1  band 4.1-like protein 1 isoform t

    Status: REVIEWED

    Source sequence(s)
    AL121895

  20. NM_001424389.1 → NP_001411318.1  band 4.1-like protein 1 isoform u

    Status: REVIEWED

    Source sequence(s)
    AL121895

  21. NM_001424390.1 → NP_001411319.1  band 4.1-like protein 1 isoform v

    Status: REVIEWED

    Source sequence(s)
    AL121895

  22. NM_001424391.1 → NP_001411320.1  band 4.1-like protein 1 isoform w

    Status: REVIEWED

    Source sequence(s)
    AL121895

  23. NM_001424392.1 → NP_001411321.1  band 4.1-like protein 1 isoform x

    Status: REVIEWED

    Source sequence(s)
    AL121895

  24. NM_001424393.1 → NP_001411322.1  band 4.1-like protein 1 isoform y

    Status: REVIEWED

    Source sequence(s)
    AL121895

  25. NM_001424394.1 → NP_001411323.1  band 4.1-like protein 1 isoform z

    Status: REVIEWED

    Source sequence(s)
    AL121895

  26. NM_001424395.1 → NP_001411324.1  band 4.1-like protein 1 isoform aa

    Status: REVIEWED

    Source sequence(s)
    AL121895

  27. NM_001424396.1 → NP_001411325.1  band 4.1-like protein 1 isoform bb

    Status: REVIEWED

    Source sequence(s)
    AL121895

  28. NM_001424397.1 → NP_001411326.1  band 4.1-like protein 1 isoform cc

    Status: REVIEWED

    Source sequence(s)
    AL121895

  29. NM_001424398.1 → NP_001411327.1  band 4.1-like protein 1 isoform dd

    Status: REVIEWED

    Source sequence(s)
    AL121895

  30. NM_001424399.1 → NP_001411328.1  band 4.1-like protein 1 isoform ee

    Status: REVIEWED

    Source sequence(s)
    AL121895

  31. NM_001424400.1 → NP_001411329.1  band 4.1-like protein 1 isoform ff

    Status: REVIEWED

    Source sequence(s)
    AL121895

  32. NM_001424401.1 → NP_001411330.1  band 4.1-like protein 1 isoform gg

    Status: REVIEWED

    Source sequence(s)
    AL121895

  33. NM_001424402.1 → NP_001411331.1  band 4.1-like protein 1 isoform hh

    Status: REVIEWED

    Source sequence(s)
    AL121895

  34. NM_001424403.1 → NP_001411332.1  band 4.1-like protein 1 isoform g

    Status: REVIEWED

    Source sequence(s)
    AL035420, AL121895

  35. NM_001424404.1 → NP_001411333.1  band 4.1-like protein 1 isoform j

    Status: REVIEWED

    Source sequence(s)
    AL035420, AL121895

  36. NM_001424405.1 → NP_001411334.1  band 4.1-like protein 1 isoform l

    Status: REVIEWED

    Source sequence(s)
    AL035420, AL121895

  37. NM_001424406.1 → NP_001411335.1  band 4.1-like protein 1 isoform ii

    Status: REVIEWED

    Source sequence(s)
    AL035420, AL121895

  38. NM_001424407.1 → NP_001411336.1  band 4.1-like protein 1 isoform z

    Status: REVIEWED

    Source sequence(s)
    AL035420, AL121895
    Related
    ENSP00000363061.2, ENST00000373950.6

  39. NM_012156.2 → NP_036288.2  band 4.1-like protein 1 isoform a

    See identical proteins and their annotated locations for NP_036288.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (a).
    Source sequence(s)
    AB002336, AL121895, DB503878
    Consensus CDS
    CCDS13271.1
    UniProtKB/Swiss-Prot
    O15046, Q4VXM6, Q4VXM7, Q4VXM8, Q4VXN4, Q6ZT61, Q8IUU7, Q96CV5, Q96L65, Q9H4G0
    UniProtKB/TrEMBL
    B3KUB6
    Related
    ENSP00000337168.2, ENST00000338074.7
    Conserved Domains (7) summary
    smart00295
    Location:99 → 288
    B41; Band 4.1 homologues
    cd13184
    Location:283 → 376
    FERM_C_4_1_family; FERM domain C-lobe of Protein 4.1 family
    pfam00373
    Location:183 → 288
    FERM_M; FERM central domain
    pfam04382
    Location:493 → 524
    SAB; SAB domain
    pfam05902
    Location:791 → 868
    4_1_CTD; 4.1 protein C-terminal domain (CTD)
    pfam08736
    Location:385 → 425
    FA; FERM adjacent (FA)
    pfam09379
    Location:101 → 164
    FERM_N; FERM N-terminal domain

  40. NM_177996.2 → NP_818932.1  band 4.1-like protein 1 isoform b

    See identical proteins and their annotated locations for NP_818932.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) has a different 5' UTR and multiple coding region differences compared to variant 1. The resulting isoform (b) has a shorter N-terminus and lacks two in-frame segments compared to isoform a. Variants 2 and 5 both encode the same isoform (b).
    Source sequence(s)
    AK299817, AL121895, BC013885
    Consensus CDS
    CCDS13272.1
    UniProtKB/TrEMBL
    B3KUB6
    Related
    ENSP00000399214.1, ENST00000441639.5
    Conserved Domains (6) summary
    smart00295
    Location:37 → 226
    B41; Band 4.1 homologues
    cd13184
    Location:221 → 314
    FERM_C_4_1_family; FERM domain C-lobe of Protein 4.1 family
    pfam04382
    Location:420 → 450
    SAB; SAB domain
    pfam05902
    Location:673 → 766
    4_1_CTD; 4.1 protein C-terminal domain (CTD)
    pfam08736
    Location:323 → 364
    FA; FERM adjacent (FA)
    cl26247
    Location:334 → 525
    DNA_pol3_delta2; DNA polymerase III, delta subunit

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000020.11 Reference GRCh38.p14 Primary Assembly

    Range
    36091414..36232799
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047439972.1 → XP_047295928.1  band 4.1-like protein 1 isoform X10

  2. XM_047439975.1 → XP_047295931.1  band 4.1-like protein 1 isoform X11

  3. XM_047439985.1 → XP_047295941.1  band 4.1-like protein 1 isoform X18

  4. XM_047439983.1 → XP_047295939.1  band 4.1-like protein 1 isoform X16

  5. XM_047439966.1 → XP_047295922.1  band 4.1-like protein 1 isoform X1

    UniProtKB/TrEMBL
    A0A0C4DH22
    Related
    ENSP00000363052.1, ENST00000373941.5

  6. XM_047439976.1 → XP_047295932.1  band 4.1-like protein 1 isoform X12

  7. XM_047439973.1 → XP_047295929.1  band 4.1-like protein 1 isoform X10

  8. XM_047439974.1 → XP_047295930.1  band 4.1-like protein 1 isoform X11

  9. XM_047439984.1 → XP_047295940.1  band 4.1-like protein 1 isoform X18

  10. XM_047439988.1 → XP_047295944.1  band 4.1-like protein 1 isoform X21

  11. XM_047439989.1 → XP_047295945.1  band 4.1-like protein 1 isoform X22

  12. XM_047440009.1 → XP_047295965.1  band 4.1-like protein 1 isoform X39

  13. XM_011528685.1 → XP_011526987.1  band 4.1-like protein 1 isoform X17

    See identical proteins and their annotated locations for XP_011526987.1

    UniProtKB/TrEMBL
    B3KUB6
    Conserved Domains (5) summary
    smart00295
    Location:99 → 288
    B41; Band 4.1 homologues
    cd13184
    Location:283 → 376
    FERM_C_4_1_family; FERM domain C-lobe of Protein 4.1 family
    pfam04382
    Location:494 → 524
    SAB; SAB domain
    pfam05902
    Location:654 → 731
    4_1_CTD; 4.1 protein C-terminal domain (CTD)
    pfam08736
    Location:385 → 426
    FA; FERM adjacent (FA)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060944.1 Alternate T2T-CHM13v2.0

    Range
    37812399..37953498
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054323152.1 → XP_054179127.1  band 4.1-like protein 1 isoform X10

  2. XM_054323155.1 → XP_054179130.1  band 4.1-like protein 1 isoform X11

  3. XM_054323167.1 → XP_054179142.1  band 4.1-like protein 1 isoform X18

  4. XM_054323161.1 → XP_054179136.1  band 4.1-like protein 1 isoform X15

  5. XM_054323164.1 → XP_054179139.1  band 4.1-like protein 1 isoform X16

  6. XM_054323143.1 → XP_054179118.1  band 4.1-like protein 1 isoform X1

    UniProtKB/TrEMBL
    A0A0C4DH22

  7. XM_054323156.1 → XP_054179131.1  band 4.1-like protein 1 isoform X12

  8. XM_054323153.1 → XP_054179128.1  band 4.1-like protein 1 isoform X10

  9. XM_054323154.1 → XP_054179129.1  band 4.1-like protein 1 isoform X11

  10. XM_054323166.1 → XP_054179141.1  band 4.1-like protein 1 isoform X18

  11. XM_054323170.1 → XP_054179145.1  band 4.1-like protein 1 isoform X21

  12. XM_054323171.1 → XP_054179146.1  band 4.1-like protein 1 isoform X22

  13. XM_054323190.1 → XP_054179165.1  band 4.1-like protein 1 isoform X39

  14. XM_054323165.1 → XP_054179140.1  band 4.1-like protein 1 isoform X17

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9H4G0.2 GenPept UniProtKB/Swiss-Prot:Q9H4G0

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