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Sgk1 serum/glucocorticoid regulated kinase 1 [ Mus musculus (house mouse) ]

Gene ID: 20393, updated on 16-Oct-2021

Summary

Official Symbol
Sgk1provided by MGI
Official Full Name
serum/glucocorticoid regulated kinase 1provided by MGI
Primary source
MGI:MGI:1340062
See related
Ensembl:ENSMUSG00000019970
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Sgk
Summary
This gene encodes a serine/threonine protein kinase that plays an important role in cellular stress response. This kinase activates certain potassium, sodium, and chloride channels, suggesting an involvement in the regulation of processes such as cell survival, neuronal excitability, and renal sodium excretion. This enzyme is activated by protein phosphorylation and degraded via the ubiquitination and proteasome pathway. Multiple transcript variants encoding different isoforms have been found for this gene. A pseudogene of this gene was identified on chromosome 12. [provided by RefSeq, Sep 2009]
Expression
Ubiquitous expression in colon adult (RPKM 16.7), large intestine adult (RPKM 16.3) and 28 other tissues See more
Orthologs
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Genomic context

See Sgk1 in Genome Data Viewer
Location:
10; 10 A3
Exon count:
19
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (21758083..21875802)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (21882184..21999903)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 10 NC_000076.5 (21601990..21719709)

Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene pluripotency associated transcript 6 Neighboring gene predicted gene, 46215 Neighboring gene predicted gene, 23839 Neighboring gene pyrophosphatase (inorganic) 1 pseudogene Neighboring gene uncharacterized LOC118567833 Neighboring gene predicted gene 7672

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables 3-phosphoinositide-dependent protein kinase binding ISO
Inferred from Sequence Orthology
more info
 
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
enables potassium channel regulator activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables protein serine kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables protein serine/threonine kinase activity ISO
Inferred from Sequence Orthology
more info
 
enables protein serine/threonine/tyrosine kinase activity ISO
Inferred from Sequence Orthology
more info
PubMed 
enables tau protein binding ISO
Inferred from Sequence Orthology
more info
 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within apoptotic process IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within cellular response to DNA damage stimulus IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within cellular response to aldosterone IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within cellular response to insulin stimulus ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular sodium ion homeostasis ISO
Inferred from Sequence Orthology
more info
 
involved_in glucocorticoid mediated signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in intracellular signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in long-term memory ISO
Inferred from Sequence Orthology
more info
 
involved_in microtubule depolymerization ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of microtubule polymerization ISO
Inferred from Sequence Orthology
more info
 
involved_in neuron projection morphogenesis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in neuron projection morphogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in peptidyl-serine phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in peptidyl-serine phosphorylation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within phosphorylation IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of cell growth ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of dendrite morphogenesis ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of sodium ion transport ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within protein phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of cell cycle ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within regulation of protein localization ISO
Inferred from Sequence Orthology
more info
 
involved_in visual learning ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in cytosol TAS
Traceable Author Statement
more info
 
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
 
located_in neuron projection ISO
Inferred from Sequence Orthology
more info
 
located_in nuclear speck ISO
Inferred from Sequence Orthology
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 
located_in perinuclear region of cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
serine/threonine-protein kinase Sgk1
Names
serum and glucocorticoid-dependent protein kinase
NP_001155317.2
NP_001155319.1
NP_001155320.1
NP_001155321.1
NP_001155322.1
NP_035491.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001161845.2NP_001155317.2  serine/threonine-protein kinase Sgk1 isoform a

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a).
    Source sequence(s)
    BC070401, BY493368
    Consensus CDS
    CCDS48515.1
    UniProtKB/Swiss-Prot
    Q9WVC6
    Related
    ENSMUSP00000114074.2, ENSMUST00000120509.8
    Conserved Domains (2) summary
    smart00220
    Location:191448
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd05602
    Location:183521
    STKc_SGK1; Catalytic domain of the Protein Serine/Threonine Kinase, Serum- and Glucocorticoid-induced Kinase 1
  2. NM_001161847.2NP_001155319.1  serine/threonine-protein kinase Sgk1 isoform b

    See identical proteins and their annotated locations for NP_001155319.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and 5' coding sequence compared to variant 1. The resulting isoform (b) is shorter at the N-terminus compared to isoform a. Both variants 2 and 3 encode the same isoform (b).
    Source sequence(s)
    AC153555, AK159131, BY493368, CN709375
    Consensus CDS
    CCDS48518.1
    UniProtKB/Swiss-Prot
    Q9WVC6
    UniProtKB/TrEMBL
    E9Q8C1
    Related
    ENSMUSP00000128873.2, ENSMUST00000164659.8
    Conserved Domains (2) summary
    smart00220
    Location:71328
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd05602
    Location:63401
    STKc_SGK1; Catalytic domain of the Protein Serine/Threonine Kinase, Serum- and Glucocorticoid-induced Kinase 1
  3. NM_001161848.2NP_001155320.1  serine/threonine-protein kinase Sgk1 isoform b

    See identical proteins and their annotated locations for NP_001155320.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and 5' coding sequence compared to variant 1. The resulting isoform (b) is shorter at the N-terminus compared to isoform a. Both variants 2 and 3 encode the same isoform (b).
    Source sequence(s)
    AK159131, BY493368, BY736002
    Consensus CDS
    CCDS48518.1
    UniProtKB/Swiss-Prot
    Q9WVC6
    UniProtKB/TrEMBL
    E9Q8C1
    Conserved Domains (2) summary
    smart00220
    Location:71328
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd05602
    Location:63401
    STKc_SGK1; Catalytic domain of the Protein Serine/Threonine Kinase, Serum- and Glucocorticoid-induced Kinase 1
  4. NM_001161849.2NP_001155321.1  serine/threonine-protein kinase Sgk1 isoform c

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR and 5' coding sequence compared to variant 1. The resulting isoform (c) has a shorter and distinct N-terminus compared to isoform a.
    Source sequence(s)
    AK159131, BY493368, BY786122
    Consensus CDS
    CCDS48516.1
    UniProtKB/Swiss-Prot
    Q9WVC6
    UniProtKB/TrEMBL
    E9Q1B0
    Related
    ENSMUSP00000097614.4, ENSMUST00000100036.10
    Conserved Domains (1) summary
    cd05602
    Location:76414
    STKc_SGK1; Catalytic domain of the Protein Serine/Threonine Kinase, Serum- and Glucocorticoid-induced Kinase 1
  5. NM_001161850.2NP_001155322.1  serine/threonine-protein kinase Sgk1 isoform d

    See identical proteins and their annotated locations for NP_001155322.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR and 5' coding sequence compared to variant 1. The resulting isoform (d) has a shorter and distinct N-terminus compared to isoform a.
    Source sequence(s)
    AK132234, BY493368, CK626189
    Consensus CDS
    CCDS48517.1
    UniProtKB/Swiss-Prot
    Q9WVC6
    Related
    ENSMUSP00000090343.5, ENSMUST00000092673.11
    Conserved Domains (1) summary
    cd05602
    Location:104442
    STKc_SGK1; Catalytic domain of the Protein Serine/Threonine Kinase, Serum- and Glucocorticoid-induced Kinase 1
  6. NM_011361.3NP_035491.1  serine/threonine-protein kinase Sgk1 isoform e

    See identical proteins and their annotated locations for NP_035491.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6) differs in the 5' UTR and 5' coding sequence compared to variant 1. The resulting isoform (e) has a shorter and distinct N-terminus compared to isoform a.
    Source sequence(s)
    AC153555, AK159131, BY493368
    Consensus CDS
    CCDS23726.1
    UniProtKB/Swiss-Prot
    Q9WVC6
    Related
    ENSMUSP00000020145.6, ENSMUST00000020145.12
    Conserved Domains (1) summary
    cd05602
    Location:90428
    STKc_SGK1; Catalytic domain of the Protein Serine/Threonine Kinase, Serum- and Glucocorticoid-induced Kinase 1

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000076.7 Reference GRCm39 C57BL/6J

    Range
    21758083..21875802
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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