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St3gal3 ST3 beta-galactoside alpha-2,3-sialyltransferase 3 [ Mus musculus (house mouse) ]

Gene ID: 20441, updated on 21-Apr-2024

Summary

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Official Symbol
St3gal3provided by MGI
Official Full Name
ST3 beta-galactoside alpha-2,3-sialyltransferase 3provided by MGI
Primary source
MGI:MGI:1316659
See related
Ensembl:ENSMUSG00000028538 AllianceGenome:MGI:1316659
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
ST3N; Siat3; Siat6; ST3GalIII
Summary
Enables beta-galactoside (CMP) alpha-2,3-sialyltransferase activity. Involved in ganglioside biosynthetic process via lactosylceramide. Acts upstream of or within protein glycosylation. Predicted to be located in Golgi apparatus and membrane. Predicted to be integral component of membrane. Is expressed in several structures, including alimentary system; central nervous system; cranium; eye; and hemolymphoid system gland. Human ortholog(s) of this gene implicated in autosomal recessive non-syndromic intellectual disability and developmental and epileptic encephalopathy 15. Orthologous to human ST3GAL3 (ST3 beta-galactoside alpha-2,3-sialyltransferase 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in colon adult (RPKM 43.9), adrenal adult (RPKM 31.6) and 25 other tissues See more
Orthologs
human all
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Genomic context

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Location:
4 D1- D2.1; 4 53.84 cM
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (117789349..117992169, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (117932152..118134972, complement)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E10251 Neighboring gene importin 13 Neighboring gene artemin Neighboring gene RIKEN cDNA 9530034E10 gene Neighboring gene predicted gene, 54253 Neighboring gene STARR-seq mESC enhancer starr_11191 Neighboring gene STARR-seq mESC enhancer starr_11192 Neighboring gene STARR-positive B cell enhancer ABC_E6201 Neighboring gene lysine (K)-specific demethylase 4A Neighboring gene predicted gene, 23382 Neighboring gene predicted gene, 54252

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Haploinsufficiency of the Attention-Deficit/Hyperactivity Disorder Risk Gene St3gal3 in Mice Causes Alterations in Cognition and Expression of Genes Involved in Myelination and Sialylation. Rivero O, et al. Front Genet, 2021. PMID 34650588, Free PMC Article
  2. Mice deficient in the St3gal3 gene product α2,3 sialyltransferase (ST3Gal-III) exhibit enhanced allergic eosinophilic airway inflammation. Kiwamoto T, et al. J Allergy Clin Immunol, 2014 Jan. PMID 23830412, Free PMC Article
  3. Developmental patterns of GalBeta1,3(4)GlcNAc alpha2,3-sialyltransferase (ST3Gal III) expression in the mouse: in situ hybridization using DIG-labeled RNA probes. Ji MY, et al. Arch Pharm Res, 1999 Jun. PMID 10403125
  4. Sialylation regulates brain structure and function. Yoo SW, et al. FASEB J, 2015 Jul. PMID 25846372, Free PMC Article
  5. Control of post-translational modifications in antithrombin during murine post-natal development by miR-200a. Teruel R, et al. J Biomed Sci, 2013 May 16. PMID 23678987, Free PMC Article

See all (31) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Sialyltransferase Mutations Alter the Expression of Calcium-Binding Interneurons in Mice Neocortex, Hippocampus and Striatum.
    Title: Sialyltransferase Mutations Alter the Expression of Calcium-Binding Interneurons in Mice Neocortex, Hippocampus and Striatum.
  2. St3gal2/3 double-null mice displayed dysmyelination marked by a reduction in major myelin proteins, fewer myelinated axons, a decrease in myelin thickness, possibly by dysregulation of ganglioside-mediated oligodendroglial precursor cell proliferation.
    Title: Sialylation regulates brain structure and function.
  3. knock-out mice have enhanced allergic eosinophilic airway inflammation
    Title: Mice deficient in the St3gal3 gene product α2,3 sialyltransferase (ST3Gal-III) exhibit enhanced allergic eosinophilic airway inflammation.
  4. mRNA levels of St3gal3 potentially involved in antithrombin sialylation, were 85% lower in neonates in comparison with adults.
    Title: Control of post-translational modifications in antithrombin during murine post-natal development by miR-200a.
  5. these studies demonstrate that ST3Gal-III plays an important role in Siglec-F ligand formation and eosinophil apoptosis with resultant effects on eosinophilic inflammation in the lung.
    Title: Sialyltransferase ST3Gal-III regulates Siglec-F ligand formation and eosinophilic lung inflammation in mice.
  6. was not found to play a role in regulating synthesis of selectin ligands nor in vitro rolling of marrow-derived neutrophils on E- or P-selectins presented by Chinese hamster ovary cells
    Title: Sialyltransferase specificity in selectin ligand formation.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Targeted (1)  1 citation
  • Endonuclease-mediated (1) 

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables N-acetyllactosaminide alpha-2,3-sialyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables beta-galactoside (CMP) alpha-2,3-sialyltransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables glycosyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables sialyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in ganglioside biosynthetic process via lactosylceramide IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein glycosylation IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within protein glycosylation IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in Golgi apparatus IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
CMP-N-acetylneuraminate-beta-1,4-galactoside alpha-2,3-sialyltransferase
Names
N-acetyllactosaminide alpha-2,3-sialyltransferase
alpha 2,3-ST 3
beta-galactoside alpha-2,3-sialyltransferase 3
gal beta-1,3(4) GlcNAc alpha-2,3 sialyltransferase
sialyltransferase 3
sialyltransferase 6 (N-acetyllacosaminide alpha 2,3-sialyltransferase)
NP_001155246.1
NP_001272449.1
NP_001272450.1
NP_033202.3
XP_006502953.1
XP_006502954.1
XP_006502955.1
XP_006502956.1
XP_006502957.1
XP_006502958.1
XP_006502959.1
XP_006502960.1
XP_006502961.1
XP_006502962.1
XP_030109232.1
XP_030109233.1
XP_030109234.1
XP_030109235.1
XP_036019823.1
XP_036019824.1
XP_036019825.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001161774.2 → NP_001155246.1  CMP-N-acetylneuraminate-beta-1,4-galactoside alpha-2,3-sialyltransferase isoform a

    See identical proteins and their annotated locations for NP_001155246.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 3 all encode isoform a.
    Source sequence(s)
    AK013016, BB868500, BF472945, CX240214
    Consensus CDS
    CCDS18544.1
    UniProtKB/Swiss-Prot
    P97325, Q922X5
    UniProtKB/TrEMBL
    Q3UWD5, Q9DBB6
    Related
    ENSMUSP00000102018.2, ENSMUST00000106410.8
    Conserved Domains (1) summary
    pfam00777
    Location:106 → 370
    Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)

  2. NM_001285520.1 → NP_001272449.1  CMP-N-acetylneuraminate-beta-1,4-galactoside alpha-2,3-sialyltransferase isoform a

    See identical proteins and their annotated locations for NP_001272449.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 3 all encode isoform a.
    Source sequence(s)
    AK005053, AK136442, BB868500, BF472945
    Consensus CDS
    CCDS18544.1
    UniProtKB/Swiss-Prot
    P97325, Q922X5
    UniProtKB/TrEMBL
    Q3UWD5, Q9DBB6
    Conserved Domains (1) summary
    pfam00777
    Location:106 → 370
    Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)

  3. NM_001285521.1 → NP_001272450.1  CMP-N-acetylneuraminate-beta-1,4-galactoside alpha-2,3-sialyltransferase isoform b

    See identical proteins and their annotated locations for NP_001272450.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR and lacks an alternate in-frame exon in the 5' coding region, compared to variant 1. The encoded isoform (b) is shorter than isoform a.
    Source sequence(s)
    AK013016, BB868500, BF472945
    Consensus CDS
    CCDS71458.1
    UniProtKB/TrEMBL
    Q3UWD5, Q9CZ48, Q9DBB6
    Related
    ENSMUSP00000095525.2, ENSMUST00000097912.8
    Conserved Domains (1) summary
    pfam00777
    Location:90 → 354
    Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)

  4. NM_009176.5 → NP_033202.3  CMP-N-acetylneuraminate-beta-1,4-galactoside alpha-2,3-sialyltransferase isoform a

    See identical proteins and their annotated locations for NP_033202.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (a). Variants 1, 2 and 3 all encode isoform a.
    Source sequence(s)
    AK005053, AK136442, AL611952, BB868500, BF472945
    Consensus CDS
    CCDS18544.1
    UniProtKB/Swiss-Prot
    P97325, Q922X5
    UniProtKB/TrEMBL
    Q3UWD5, Q9DBB6
    Related
    ENSMUSP00000030263.3, ENSMUST00000030263.9
    Conserved Domains (1) summary
    pfam00777
    Location:106 → 370
    Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    117789349..117992169 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006502898.4 → XP_006502961.1  CMP-N-acetylneuraminate-beta-1,4-galactoside alpha-2,3-sialyltransferase isoform X7

    See identical proteins and their annotated locations for XP_006502961.1

    UniProtKB/TrEMBL
    Q3UWD5, Q9CZ48, Q9DBB6
    Conserved Domains (1) summary
    pfam00777
    Location:90 → 354
    Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)

  2. XM_006502895.1 → XP_006502958.1  CMP-N-acetylneuraminate-beta-1,4-galactoside alpha-2,3-sialyltransferase isoform X3

    See identical proteins and their annotated locations for XP_006502958.1

    UniProtKB/TrEMBL
    Q3UWD5, Q9DBB6
    Conserved Domains (1) summary
    pfam00777
    Location:106 → 398
    Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)

  3. XM_036163930.1 → XP_036019823.1  CMP-N-acetylneuraminate-beta-1,4-galactoside alpha-2,3-sialyltransferase isoform X4

    UniProtKB/TrEMBL
    Q3UWD5, Q9DBB6
    Conserved Domains (1) summary
    pfam00777
    Location:128 → 392
    Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)

  4. XM_036163931.1 → XP_036019824.1  CMP-N-acetylneuraminate-beta-1,4-galactoside alpha-2,3-sialyltransferase isoform X7

    UniProtKB/TrEMBL
    Q3UWD5, Q9CZ48, Q9DBB6
    Conserved Domains (1) summary
    pfam00777
    Location:90 → 354
    Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)

  5. XM_030253375.1 → XP_030109235.1  CMP-N-acetylneuraminate-beta-1,4-galactoside alpha-2,3-sialyltransferase isoform X6

    UniProtKB/TrEMBL
    Q3UWD5, Q9DBB6
    Conserved Domains (1) summary
    pfam00777
    Location:112 → 376
    Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)

  6. XM_030253374.2 → XP_030109234.1  CMP-N-acetylneuraminate-beta-1,4-galactoside alpha-2,3-sialyltransferase isoform X5

    UniProtKB/TrEMBL
    Q3UWD5, Q9DBB6
    Conserved Domains (1) summary
    pfam00777
    Location:90 → 382
    Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)

  7. XM_006502892.3 → XP_006502955.1  CMP-N-acetylneuraminate-beta-1,4-galactoside alpha-2,3-sialyltransferase isoform X1

    See identical proteins and their annotated locations for XP_006502955.1

    UniProtKB/TrEMBL
    Q3UWD5, Q9DBB6
    Conserved Domains (1) summary
    pfam00777
    Location:128 → 420
    Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)

  8. XM_006502894.2 → XP_006502957.1  CMP-N-acetylneuraminate-beta-1,4-galactoside alpha-2,3-sialyltransferase isoform X3

    See identical proteins and their annotated locations for XP_006502957.1

    UniProtKB/TrEMBL
    Q3UWD5, Q9DBB6
    Conserved Domains (1) summary
    pfam00777
    Location:106 → 398
    Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)

  9. XM_030253373.1 → XP_030109233.1  CMP-N-acetylneuraminate-beta-1,4-galactoside alpha-2,3-sialyltransferase isoform X5

    UniProtKB/TrEMBL
    Q3UWD5, Q9DBB6
    Conserved Domains (1) summary
    pfam00777
    Location:90 → 382
    Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)

  10. XM_030253372.1 → XP_030109232.1  CMP-N-acetylneuraminate-beta-1,4-galactoside alpha-2,3-sialyltransferase isoform X3

    UniProtKB/TrEMBL
    Q3UWD5, Q9DBB6
    Conserved Domains (1) summary
    pfam00777
    Location:106 → 398
    Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)

  11. XM_006502891.3 → XP_006502954.1  CMP-N-acetylneuraminate-beta-1,4-galactoside alpha-2,3-sialyltransferase isoform X1

    See identical proteins and their annotated locations for XP_006502954.1

    UniProtKB/TrEMBL
    Q3UWD5, Q9DBB6
    Conserved Domains (1) summary
    pfam00777
    Location:128 → 420
    Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)

  12. XM_006502897.3 → XP_006502960.1  CMP-N-acetylneuraminate-beta-1,4-galactoside alpha-2,3-sialyltransferase isoform X5

    UniProtKB/TrEMBL
    Q3UWD5, Q9DBB6
    Conserved Domains (1) summary
    pfam00777
    Location:90 → 382
    Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)

  13. XM_006502893.3 → XP_006502956.1  CMP-N-acetylneuraminate-beta-1,4-galactoside alpha-2,3-sialyltransferase isoform X2

    UniProtKB/TrEMBL
    Q3UWD5, Q9DBB6
    Conserved Domains (1) summary
    pfam00777
    Location:112 → 404
    Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)

  14. XM_006502896.3 → XP_006502959.1  CMP-N-acetylneuraminate-beta-1,4-galactoside alpha-2,3-sialyltransferase isoform X4

    UniProtKB/TrEMBL
    Q3UWD5, Q9DBB6
    Conserved Domains (1) summary
    pfam00777
    Location:128 → 392
    Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)

  15. XM_006502890.3 → XP_006502953.1  CMP-N-acetylneuraminate-beta-1,4-galactoside alpha-2,3-sialyltransferase isoform X1

    See identical proteins and their annotated locations for XP_006502953.1

    UniProtKB/TrEMBL
    Q3UWD5, Q9DBB6
    Conserved Domains (1) summary
    pfam00777
    Location:128 → 420
    Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)

  16. XM_036163932.1 → XP_036019825.1  CMP-N-acetylneuraminate-beta-1,4-galactoside alpha-2,3-sialyltransferase isoform X9

    Conserved Domains (1) summary
    pfam00777
    Location:128 → 276
    Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)

  17. XM_006502899.3 → XP_006502962.1  CMP-N-acetylneuraminate-beta-1,4-galactoside alpha-2,3-sialyltransferase isoform X8

    Conserved Domains (1) summary
    pfam00777
    Location:128 → 271
    Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)

RNA

  1. XR_004941855.1 RNA Sequence

  2. XR_376302.4 RNA Sequence

  3. XR_376301.3 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P97325.2 GenPept UniProtKB/Swiss-Prot:P97325

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