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St8sia1 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 1 [ Mus musculus (house mouse) ]

Gene ID: 20449, updated on 23-Jun-2021

Summary

Official Symbol
St8sia1provided by MGI
Official Full Name
ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 1provided by MGI
Primary source
MGI:MGI:106011
See related
Ensembl:ENSMUSG00000030283
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Si; GD3; GD3S; Sia-T; Siat8; Siat8a; 9330109E03Rik
Expression
Biased expression in thymus adult (RPKM 5.6), kidney adult (RPKM 5.0) and 10 other tissues See more
Orthologs
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Genomic context

See St8sia1 in Genome Data Viewer
Location:
6 G3; 6 74.78 cM
Exon count:
10
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (142767267..142935247, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (142821541..142989528, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 6 NC_000072.5 (142770061..142912972, complement)

Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 53249 Neighboring gene cytidine monophospho-N-acetylneuraminic acid synthetase Neighboring gene predicted gene, 46981 Neighboring gene sulfotransferase family 6B, member 2 Neighboring gene predicted gene 7457 Neighboring gene predicted gene 7468 Neighboring gene C2 calcium-dependent domain containing 5 Neighboring gene predicted gene, 31108 Neighboring gene predicted gene, 38921

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity ISO
Inferred from Sequence Orthology
more info
 
enables glycosyltransferase activity IEA
Inferred from Electronic Annotation
more info
 
enables sialyltransferase activity ISO
Inferred from Sequence Orthology
more info
 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in N-glycan processing IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within cellular response to heat IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within lipid metabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in oligosaccharide metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within positive regulation of cell population proliferation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in protein glycosylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in protein glycosylation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within sphingolipid metabolic process IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in Golgi apparatus IEA
Inferred from Electronic Annotation
more info
 
located_in integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase
Names
GD3 synthase
SIAT8-A
ST8Sia I
ST8SiaI
alpha-2, 8-sialyltransferase
alpha-2,8-sialyltransferase 8A
ganglioside GD3 synthase
ganglioside GT3 synthase
sialyltransferase 8 A
sialyltransferase 8A
sialyltransferase St8Sia I
sialytransferase St8Sia I
NP_035504.2
XP_006506991.1
XP_006506992.1
XP_006506993.1
XP_011239876.1
XP_011239877.1
XP_011239878.1
XP_017176961.1
XP_030111143.1
XP_036021874.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_011374.2NP_035504.2  alpha-N-acetylneuraminide alpha-2,8-sialyltransferase

    See identical proteins and their annotated locations for NP_035504.2

    Status: VALIDATED

    Source sequence(s)
    AC122483, BC024821
    Consensus CDS
    CCDS20689.1
    UniProtKB/Swiss-Prot
    Q64687
    Related
    ENSMUSP00000032421.4, ENSMUST00000032421.4
    Conserved Domains (1) summary
    pfam00777
    Location:91343
    Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000072.7 Reference GRCm39 C57BL/6J

    Range
    142767267..142935247 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011241575.3XP_011239877.1  alpha-N-acetylneuraminide alpha-2,8-sialyltransferase isoform X2

    See identical proteins and their annotated locations for XP_011239877.1

    UniProtKB/TrEMBL
    Q3V3B1
    Conserved Domains (1) summary
    pfam00777
    Location:11263
    Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)
  2. XM_006506929.4XP_006506992.1  alpha-N-acetylneuraminide alpha-2,8-sialyltransferase isoform X2

    See identical proteins and their annotated locations for XP_006506992.1

    UniProtKB/TrEMBL
    Q3V3B1
    Conserved Domains (1) summary
    pfam00777
    Location:11263
    Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)
  3. XM_006506930.5XP_006506993.1  alpha-N-acetylneuraminide alpha-2,8-sialyltransferase isoform X2

    See identical proteins and their annotated locations for XP_006506993.1

    UniProtKB/TrEMBL
    Q3V3B1
    Conserved Domains (1) summary
    pfam00777
    Location:11263
    Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)
  4. XM_017321472.3XP_017176961.1  alpha-N-acetylneuraminide alpha-2,8-sialyltransferase isoform X4

    Conserved Domains (1) summary
    pfam00777
    Location:20200
    Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)
  5. XM_030255283.1XP_030111143.1  alpha-N-acetylneuraminide alpha-2,8-sialyltransferase isoform X4

    Conserved Domains (1) summary
    pfam00777
    Location:20200
    Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)
  6. XM_006506928.4XP_006506991.1  alpha-N-acetylneuraminide alpha-2,8-sialyltransferase isoform X2

    See identical proteins and their annotated locations for XP_006506991.1

    UniProtKB/TrEMBL
    Q3V3B1
    Conserved Domains (1) summary
    pfam00777
    Location:11263
    Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)
  7. XM_011241574.2XP_011239876.1  alpha-N-acetylneuraminide alpha-2,8-sialyltransferase isoform X1

    Conserved Domains (1) summary
    pfam00777
    Location:20272
    Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)
  8. XM_011241576.4XP_011239878.1  alpha-N-acetylneuraminide alpha-2,8-sialyltransferase isoform X3

    Conserved Domains (1) summary
    pfam00777
    Location:91198
    Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)
  9. XM_036165981.1XP_036021874.1  alpha-N-acetylneuraminide alpha-2,8-sialyltransferase isoform X5

    Conserved Domains (1) summary
    pfam00777
    Location:91194
    Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)
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