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St8sia2 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 2 [ Mus musculus (house mouse) ]

Gene ID: 20450, updated on 13-Jun-2021

Summary

Official Symbol
St8sia2provided by MGI
Official Full Name
ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 2provided by MGI
Primary source
MGI:MGI:106020
See related
Ensembl:ENSMUSG00000025789
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
ST; STX; Sia; Siat8b; AI323367; ST8SiaII
Expression
Biased expression in whole brain E14.5 (RPKM 29.1), CNS E14 (RPKM 24.1) and 5 other tissues See more
Orthologs
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Genomic context

See St8sia2 in Genome Data Viewer
Location:
7; 7 D1
Exon count:
6
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (73588867..73663475, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (73939119..74013727, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 7 NC_000073.5 (81084005..81158568, complement)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene microRNA 7234 Neighboring gene predicted gene, 21269 Neighboring gene SCAN domain containing 3 pseudogene Neighboring gene alpha-enolase pseudogene Neighboring gene solute carrier organic anion transporter family, member 3a1

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity ISO
Inferred from Sequence Orthology
more info
 
enables glycosyltransferase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables sialyltransferase activity ISO
Inferred from Sequence Orthology
more info
 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in N-glycan processing IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in N-glycan processing ISO
Inferred from Sequence Orthology
more info
 
involved_in ganglioside biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within neuron projection extension ISO
Inferred from Sequence Orthology
more info
 
involved_in oligosaccharide metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in oligosaccharide metabolic process ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of neuron death ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of synapse assembly ISO
Inferred from Sequence Orthology
more info
 
involved_in protein glycosylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in protein glycosylation ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in Golgi apparatus IEA
Inferred from Electronic Annotation
more info
 
located_in early endosome IDA
Inferred from Direct Assay
more info
PubMed 
located_in integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in perinuclear region of cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in recycling endosome IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
alpha-2,8-sialyltransferase 8B
Names
SIAT8-B
polysialic acid synthase
sialyltransferase 8 (alpha-2, 8-sialyltransferase) B
sialyltransferase 8B
sialyltransferase St8Sia II
sialyltransferase X
sialytransferase St8Sia II

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_009181.2NP_033207.2  alpha-2,8-sialyltransferase 8B precursor

    See identical proteins and their annotated locations for NP_033207.2

    Status: VALIDATED

    Source sequence(s)
    BB649753, BC096546, CF747845
    Consensus CDS
    CCDS21365.1
    UniProtKB/Swiss-Prot
    O35696
    Related
    ENSMUSP00000026896.5, ENSMUST00000026896.10
    Conserved Domains (1) summary
    pfam00777
    Location:109368
    Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    73588867..73663475 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006540731.2XP_006540794.1  alpha-2,8-sialyltransferase 8B isoform X1

    Conserved Domains (1) summary
    pfam00777
    Location:88347
    Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)
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