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Slc17a1 solute carrier family 17 (sodium phosphate), member 1 [ Mus musculus (house mouse) ]

Gene ID: 20504, updated on 11-Apr-2024

Summary

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Official Symbol
Slc17a1provided by MGI
Official Full Name
solute carrier family 17 (sodium phosphate), member 1provided by MGI
Primary source
MGI:MGI:103209
See related
Ensembl:ENSMUSG00000021335 AllianceGenome:MGI:103209
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Npt1; Napi1; NAPI-1
Summary
Predicted to enable sialic acid transmembrane transporter activity. Predicted to be involved in sialic acid transport; urate metabolic process; and urate transport. Predicted to act upstream of or within sodium ion transport. Predicted to be located in apical plasma membrane. Predicted to be active in lysosome. Predicted to be integral component of plasma membrane. Is expressed in cortical renal tubule and lower jaw molar. Orthologous to human SLC17A1 (solute carrier family 17 member 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Restricted expression toward kidney adult (RPKM 67.9) See more
Orthologs
human all
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Genomic context

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Location:
13 A3.1; 13 9.97 cM
Exon count:
16
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (24051607..24079713)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (23867624..23895730)

Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene solute carrier family 17 (sodium phosphate), member 2 Neighboring gene solute carrier family 17 (sodium phosphate), member 3 Neighboring gene solute carrier family 17 (sodium phosphate), member 4 Neighboring gene U1 small nuclear ribonucleoprotein 1C, pseudogene 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Vesicular glutamate transporter 1 immunoreactivity in motor endplates of striated esophageal but not skeletal muscles in the mouse. Kraus T, et al. Neurosci Lett, 2004 Apr 22. PMID 15082177
  2. Assignment of renal specific Na(+)-phosphate cotransporter gene Slc17a1 to mouse chromosome bands 13A3-->A4 by in situ hybridization. Zhang XX, et al. Cytogenet Cell Genet, 1997. PMID 9186516
  3. Type 1 sodium-dependent phosphate transporter (SLC17A1 Protein) is a Cl(-)-dependent urate exporter. Iharada M, et al. J Biol Chem, 2010 Aug 20. PMID 20566650, Free PMC Article
  4. Vesicular glutamate transporters VGLUT1 and VGLUT2 define two subsets of unipolar brush cells in organotypic cultures of mouse vestibulocerebellum. Nunzi MG, et al. Neuroscience, 2003. PMID 14614902
  5. Subtype switching of vesicular glutamate transporters at parallel fibre-Purkinje cell synapses in developing mouse cerebellum. Miyazaki T, et al. Eur J Neurosci, 2003 Jun. PMID 12823463

See all (32) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. results strongly suggested that NPT1 is a Cl(-)-dependent polyspecific anion exporter involved in urate excretion under physiological conditions
    Title: Type 1 sodium-dependent phosphate transporter (SLC17A1 Protein) is a Cl(-)-dependent urate exporter.
  2. Subtype switching of vesicular glutamate transporters at parallel fibre-Purkinje cell synapses in developing mouse cerebellum.
    Title: Subtype switching of vesicular glutamate transporters at parallel fibre-Purkinje cell synapses in developing mouse cerebellum.
  3. The finding of VGLUT1 immunoreactivity in motor endplates of striated esophageal but not skeletal muscles may reflect differences in functional properties and the embryonic origin between skeletal and esophageal striated muscle fibers.
    Title: Vesicular glutamate transporter 1 immunoreactivity in motor endplates of striated esophageal but not skeletal muscles in the mouse.
  4. Mossy terminals are immunoreactive for VGLUT1 and mGluR1alpha dendritic brushes are immunopositive for VGLUT1 in organotypic cultures of mouse vestibulocerebellum.
    Title: Vesicular glutamate transporters VGLUT1 and VGLUT2 define two subsets of unipolar brush cells in organotypic cultures of mouse vestibulocerebellum.
  5. Data show that hepatocyte nuclear factor 1 alpha (HNF1alpha) directly transactivates the Npt1 promoter and that the HSS3 region contributes to this activation.
    Title: Hepatocyte nuclear factor 1 alpha controls renal expression of the Npt1-Npt4 anionic transporter locus.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables symporter activity IEA
Inferred from Electronic Annotation
more info
  
enables transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in monoatomic anion transport IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within monoatomic ion transport IEA
Inferred from Electronic Annotation
more info
  
involved_in phosphate ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within sodium ion transport IEA
Inferred from Electronic Annotation
more info
  
involved_in sodium-dependent phosphate transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in sodium-dependent phosphate transport ISO
Inferred from Sequence Orthology
more info
  
involved_in transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
involved_in urate metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in urate transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in urate transport ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in apical plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in apical plasma membrane ISO
Inferred from Sequence Orthology
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
sodium-dependent phosphate transport protein 1
Names
Na(+)/PI cotransporter 1
renal Na(+)-dependent phosphate cotransporter 1
renal sodium-phosphate transport protein 1
sodium-dependent phosphate/anion cotransporter
sodium/phosphate type I cotransporter
solute carrier family 17 (sodium/hydrogen exchanger), member 1
solute carrier family 17 vesicular glutamate transporter), member 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001170638.1 → NP_001164109.1  sodium-dependent phosphate transport protein 1

    See identical proteins and their annotated locations for NP_001164109.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    AA986929, AI663290, AK132800, AK164712, AW261800, CJ065843
    Consensus CDS
    CCDS26372.1
    UniProtKB/Swiss-Prot
    A9Z1Z4, Q61983, Q91YA1
    UniProtKB/TrEMBL
    Q91WV5
    Related
    ENSMUSP00000106043.2, ENSMUST00000110413.8
    Conserved Domains (2) summary
    cd06174
    Location:71 → 449
    MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
    TIGR00894
    Location:1 → 464
    2A0114euk; Na(+)-dependent inorganic phosphate cotransporter

  2. NM_009198.3 → NP_033224.3  sodium-dependent phosphate transport protein 1

    See identical proteins and their annotated locations for NP_033224.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the protein. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    AA986929, AI116499, AI663290, AK132800, AK164712, AW261800, CJ065843
    Consensus CDS
    CCDS26372.1
    UniProtKB/Swiss-Prot
    A9Z1Z4, Q61983, Q91YA1
    UniProtKB/TrEMBL
    Q91WV5
    Related
    ENSMUSP00000006785.8, ENSMUST00000006785.8
    Conserved Domains (2) summary
    cd06174
    Location:71 → 449
    MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
    TIGR00894
    Location:1 → 464
    2A0114euk; Na(+)-dependent inorganic phosphate cotransporter

RNA

  1. NR_121611.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) contains an alternate 5' terminal exon and lacks an alternate internal exon, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AI663290, AK132800, AK164712, AL590388, AL606464

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000079.7 Reference GRCm39 C57BL/6J

    Range
    24051607..24079713
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006516616.4 → XP_006516679.1  sodium-dependent phosphate transport protein 1 isoform X1

    UniProtKB/TrEMBL
    Q91WV5
    Conserved Domains (1) summary
    TIGR00894
    Location:34 → 497
    2A0114euk; Na(+)-dependent inorganic phosphate cotransporter

  2. XM_006516617.2 → XP_006516680.1  sodium-dependent phosphate transport protein 1 isoform X2

    UniProtKB/TrEMBL
    Q91WV5
    Conserved Domains (1) summary
    TIGR00894
    Location:1 → 376
    2A0114euk; Na(+)-dependent inorganic phosphate cotransporter
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q61983.2 GenPept UniProtKB/Swiss-Prot:Q61983

Gene LinkOut

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