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Slc2a1 solute carrier family 2 (facilitated glucose transporter), member 1 [ Mus musculus (house mouse) ]

Gene ID: 20525, updated on 14-Jun-2022

Summary

Official Symbol
Slc2a1provided by MGI
Official Full Name
solute carrier family 2 (facilitated glucose transporter), member 1provided by MGI
Primary source
MGI:MGI:95755
See related
Ensembl:ENSMUSG00000028645 AllianceGenome:MGI:95755
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Glut1; Glut-1; M100200; Rgsc200
Summary
Enables D-glucose transmembrane transporter activity and dehydroascorbic acid transmembrane transporter activity. Involved in dehydroascorbic acid transport and glucose transmembrane transport. Acts upstream of or within cellular response to glucose starvation. Located in several cellular components, including basolateral plasma membrane; female pronucleus; and photoreceptor inner segment. Is expressed in several structures, including alimentary system; central nervous system; early conceptus; genitourinary system; and sensory organ. Human ortholog(s) of this gene implicated in brain disease (multiple); carbohydrate metabolic disorder; myelomeningocele; obesity; and type 2 diabetes mellitus. Orthologous to human SLC2A1 (solute carrier family 2 member 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in liver E14.5 (RPKM 161.1), placenta adult (RPKM 140.1) and 25 other tissues See more
Orthologs
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Genomic context

See Slc2a1 in Genome Data Viewer
Location:
4 D2.1; 4
Exon count:
11
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (118965942..118994527)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (119108745..119137330)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 4 NC_000070.5 (118781350..118809935)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 35510 Neighboring gene predicted gene, 52706 Neighboring gene predicted gene 12867 Neighboring gene zinc finger protein 691 Neighboring gene erythroblast membrane-associated protein

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Targeted (3)  1 citation
  • Chemically induced (ENU) (1) 
  • Endonuclease-mediated (1)  1 citation

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables D-glucose transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables D-glucose transmembrane transporter activity IDA
Inferred from Direct Assay
more info
PubMed 
enables D-glucose transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
 
enables dehydroascorbic acid transmembrane transporter activity IDA
Inferred from Direct Assay
more info
PubMed 
enables dehydroascorbic acid transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
 
enables glucose transmembrane transporter activity IDA
Inferred from Direct Assay
more info
PubMed 
enables glucose transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
 
enables hexose transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables kinase binding ISO
Inferred from Sequence Orthology
more info
 
enables long-chain fatty acid transporter activity ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein self-association ISO
Inferred from Sequence Orthology
more info
 
enables transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
 
enables xenobiotic transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within carbohydrate transport IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within cellular response to glucose starvation IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within central nervous system development ISO
Inferred from Sequence Orthology
more info
 
involved_in dehydroascorbic acid transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in dehydroascorbic acid transport IDA
Inferred from Direct Assay
more info
PubMed 
involved_in dehydroascorbic acid transport ISO
Inferred from Sequence Orthology
more info
 
involved_in glucose import IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in glucose import across plasma membrane ISO
Inferred from Sequence Orthology
more info
 
involved_in glucose transmembrane transport IDA
Inferred from Direct Assay
more info
PubMed 
involved_in glucose transmembrane transport ISO
Inferred from Sequence Orthology
more info
 
involved_in long-chain fatty acid import across plasma membrane ISO
Inferred from Sequence Orthology
more info
 
involved_in monosaccharide transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in protein-containing complex assembly ISO
Inferred from Sequence Orthology
more info
 
involved_in response to insulin IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within transport across blood-brain barrier ISO
Inferred from Sequence Orthology
more info
 
involved_in xenobiotic transport ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
is_active_in Golgi membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in Z disc ISO
Inferred from Sequence Orthology
more info
 
is_active_in apical plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in apical plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in apical plasma membrane ISO
Inferred from Sequence Orthology
more info
 
is_active_in basolateral plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in basolateral plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in basolateral plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in caveola ISO
Inferred from Sequence Orthology
more info
 
located_in cell-cell junction ISO
Inferred from Sequence Orthology
more info
 
located_in cortical actin cytoskeleton ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in cytosol IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in female germ cell nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in female pronucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
is_active_in integral component of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in integral component of plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in intercalated disc ISO
Inferred from Sequence Orthology
more info
 
located_in intracellular anatomical structure IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in membrane ISO
Inferred from Sequence Orthology
more info
 
located_in membrane raft IDA
Inferred from Direct Assay
more info
PubMed 
located_in midbody ISO
Inferred from Sequence Orthology
more info
 
located_in photoreceptor inner segment IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in presynapse IDA
Inferred from Direct Assay
more info
PubMed 
colocalizes_with sarcolemma ISO
Inferred from Sequence Orthology
more info
 
located_in sarcolemma ISO
Inferred from Sequence Orthology
more info
 
located_in synapse IDA
Inferred from Direct Assay
more info
PubMed 
located_in vesicle IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
solute carrier family 2, facilitated glucose transporter member 1
Names
GT1
glucose transporter type 1, erythrocyte/brain
solute carrier family 2, member 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_011400.3NP_035530.2  solute carrier family 2, facilitated glucose transporter member 1

    See identical proteins and their annotated locations for NP_035530.2

    Status: VALIDATED

    Source sequence(s)
    BC055340, BY233228
    Consensus CDS
    CCDS18569.1
    UniProtKB/Swiss-Prot
    P17809
    Related
    ENSMUSP00000030398.4, ENSMUST00000030398.10
    Conserved Domains (2) summary
    cd06174
    Location:62450
    MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
    pfam00083
    Location:19467
    Sugar_tr; Sugar (and other) transporter

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    118965942..118994527
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006502908.2XP_006502971.1  solute carrier family 2, facilitated glucose transporter member 1 isoform X1

    Conserved Domains (1) summary
    cd17431
    Location:10454
    MFS_GLUT_Class1; Class 1 Glucose transporters (GLUTs) of the Major Facilitator Superfamily