Smr3a submaxillary gland androgen regulated protein 3A [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Smr3aprovided by MGI
Official Full Name: submaxillary gland androgen regulated protein 3Aprovided by MGI
Primary source: MGI:MGI:102763
See related: Ensembl:ENSMUSG00000029280 AllianceGenome:MGI:102763
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: MSG1; MSG3; Smr1; Smr3
Summary: Predicted to enable endopeptidase inhibitor activity. Predicted to be involved in regulation of sensory perception of pain. Predicted to be located in extracellular region. Orthologous to human SMR3A (submaxillary gland androgen regulated protein 3A). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Low expression observed in reference dataset See more
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Genomic context

Location:: 5 E1; 5 43.56 cM

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	5	NC_000071.7 (88139414..88156393)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	5	NC_000071.6 (87991555..88008534)

Chromosome 5 - NC_000071.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

In corporal smooth muscle cells from a sickle-cell-disese mouse, there was Smr3a up-regulation at a life stage prior to priapism, so the changes in gene expression are unlikely due to priapism, but rather due to the hypoxic conditions in SCD.
Title: Opiorphin is a master regulator of the hypoxic response in corporal smooth muscle cells.

Submit: New GeneRIF Correction

General gene information

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Markers

RH125016 (e-PCR)
- UniSTS:161838

AA589601 (e-PCR)
- UniSTS:207823

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables endopeptidase inhibitor activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in regulation of sensory perception of pain	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in extracellular region	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: submaxillary gland androgen-regulated protein 3A

Names: salivary protein MSG1; submaxillary gland androgen regulated protein 3; submaxillary gland androgen-regulated protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_011422.4 → NP_035552.1 submaxillary gland androgen-regulated protein 3A precursor

See identical proteins and their annotated locations for NP_035552.1

Status: VALIDATED

Source sequence(s)

AC154123

Consensus CDS

CCDS19398.1

UniProtKB/Swiss-Prot

B7ZP11, Q61900

Related

ENSMUSP00000031211.5, ENSMUST00000031211.6

Conserved Domains (1) summary

pfam15621
Location:1 → 30

PROL5-SMR; Proline-rich submaxillary gland androgen-regulated family

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000071.7 Reference GRCm39 C57BL/6J

Range

88139414..88156393

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_017320753.2 → XP_017176242.1 submaxillary gland androgen-regulated protein 3A isoform X1

UniProtKB/Swiss-Prot

B7ZP11, Q61900

Conserved Domains (1) summary

pfam15621
Location:1 → 30

PROL5-SMR; Proline-rich submaxillary gland androgen-regulated family

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

NM_011423.2: Suppressed sequence

Description

NM_011423.2: This RefSeq was permanently suppressed because currently there is not sufficient data to support this transcript.