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Sort1 sortilin 1 [ Mus musculus (house mouse) ]

Gene ID: 20661, updated on 11-Jul-2021

Summary

Official Symbol
Sort1provided by MGI
Official Full Name
sortilin 1provided by MGI
Primary source
MGI:MGI:1338015
See related
Ensembl:ENSMUSG00000068747
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
s; Nt; Ntr3; Ntsr3; AI852375; 2900053A11Rik
Expression
Broad expression in genital fat pad adult (RPKM 112.8), lung adult (RPKM 52.3) and 22 other tissues See more
Orthologs
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Genomic context

See Sort1 in Genome Data Viewer
Location:
3; 3 F3
Exon count:
22
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (108191272..108268835)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (108283974..108361519)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 3 NC_000069.5 (108087050..108164429)

Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene SIVA1, apoptosis-inducing factor pseudogene Neighboring gene proteasome subunit alpha 5 Neighboring gene predicted gene, 19343 Neighboring gene myosin binding protein H-like Neighboring gene predicted gene 12522 Neighboring gene proline/serine-rich coiled-coil 1

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables enzyme binding ISO
Inferred from Sequence Orthology
more info
 
enables nerve growth factor binding ISO
Inferred from Sequence Orthology
more info
 
enables nerve growth factor receptor activity ISO
Inferred from Sequence Orthology
more info
 
enables neurotensin receptor activity, non-G protein-coupled ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables retromer complex binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in G protein-coupled receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in Golgi to endosome transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in Golgi to endosome transport ISO
Inferred from Sequence Orthology
more info
 
involved_in Golgi to lysosome transport ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within cell differentiation IEA
Inferred from Electronic Annotation
more info
 
involved_in endocytosis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within endocytosis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in endocytosis ISO
Inferred from Sequence Orthology
more info
 
involved_in endosome to lysosome transport ISO
Inferred from Sequence Orthology
more info
 
involved_in endosome transport via multivesicular body sorting pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in extrinsic apoptotic signaling pathway via death domain receptors ISO
Inferred from Sequence Orthology
more info
 
involved_in glucose import IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in glucose import ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within multicellular organism development IEA
Inferred from Electronic Annotation
more info
 
involved_in myotube differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in myotube differentiation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within negative regulation of fat cell differentiation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of lipoprotein lipase activity ISO
Inferred from Sequence Orthology
more info
 
involved_in neuropeptide signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in neurotrophin TRK receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within ossification IEA
Inferred from Electronic Annotation
more info
 
involved_in plasma membrane to endosome transport ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of epithelial cell apoptotic process ISO
Inferred from Sequence Orthology
more info
 
involved_in post-Golgi vesicle-mediated transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within protein targeting to lysosome IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of gene expression ISO
Inferred from Sequence Orthology
more info
 
involved_in response to insulin IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in response to insulin ISO
Inferred from Sequence Orthology
more info
 
involved_in vesicle organization IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in vesicle organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in vesicle organization ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
is_active_in Golgi apparatus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in Golgi apparatus ISO
Inferred from Sequence Orthology
more info
 
located_in cell surface ISO
Inferred from Sequence Orthology
more info
 
located_in clathrin-coated pit ISO
Inferred from Sequence Orthology
more info
 
located_in clathrin-coated vesicle ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasmic vesicle ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasmic vesicle membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in dendrite ISO
Inferred from Sequence Orthology
more info
 
located_in early endosome ISO
Inferred from Sequence Orthology
more info
 
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
 
located_in endosome IEA
Inferred from Electronic Annotation
more info
 
located_in endosome membrane ISO
Inferred from Sequence Orthology
more info
 
is_active_in integral component of membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in integral component of membrane ISO
Inferred from Sequence Orthology
more info
 
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
 
located_in lysosome ISO
Inferred from Sequence Orthology
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in neuronal cell body ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 
located_in perinuclear region of cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in trans-Golgi network transport vesicle IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
sortilin
Names
mNTR3
neurotensin receptor 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001271599.1NP_001258528.1  sortilin isoform 1 precursor

    See identical proteins and their annotated locations for NP_001258528.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AK147442, AL671899, BP762146, CJ177243
    Consensus CDS
    CCDS80003.1
    UniProtKB/Swiss-Prot
    Q6PHU5
    Related
    ENSMUSP00000123564.3, ENSMUST00000135636.6
    Conserved Domains (2) summary
    smart00602
    Location:131739
    VPS10; VPS10 domain
    pfam15901
    Location:572739
    Sortilin_C; Sortilin, neurotensin receptor 3, C-terminal
  2. NM_019972.3NP_064356.2  sortilin isoform 2 precursor

    See identical proteins and their annotated locations for NP_064356.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1.
    Source sequence(s)
    BC056343, BP762146, CJ177243
    Consensus CDS
    CCDS17756.1
    UniProtKB/Swiss-Prot
    Q6PHU5
    Related
    ENSMUSP00000099692.5, ENSMUST00000102632.7
    Conserved Domains (2) summary
    smart00602
    Location:131739
    VPS10; VPS10 domain
    pfam15901
    Location:572739
    Sortilin_C; Sortilin, neurotensin receptor 3, C-terminal

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000069.7 Reference GRCm39 C57BL/6J

    Range
    108191272..108268835
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006501223.5XP_006501286.3  sortilin isoform X1

  2. XM_006501224.5XP_006501287.3  sortilin isoform X2

    Conserved Domains (1) summary
    smart00602
    Location:188795
    VPS10; VPS10 domain
  3. XM_030252513.2XP_030108373.1  sortilin isoform X3

    Conserved Domains (1) summary
    smart00602
    Location:22570
    VPS10; VPS10 domain
  4. XM_030252515.2XP_030108375.1  sortilin isoform X4

    Conserved Domains (1) summary
    smart00602
    Location:22569
    VPS10; VPS10 domain
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