Klhl25 kelch-like 25 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Klhl25provided by MGI
Official Full Name: kelch-like 25provided by MGI
Primary source: MGI:MGI:2668031
See related: Ensembl:ENSMUSG00000055652 AllianceGenome:MGI:2668031
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Enc-1; 2810402K13Rik
Summary: Predicted to be involved in protein ubiquitination; regulation of translational initiation; and ubiquitin-dependent protein catabolic process. Predicted to act upstream of or within regulation of translation. Predicted to be part of Cul3-RING ubiquitin ligase complex. Predicted to be active in cytoplasm. Is expressed in central nervous system; nervous system; peripheral nervous system; and retina. Orthologous to human KLHL25 (kelch like family member 25). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in testis adult (RPKM 15.7), ovary adult (RPKM 15.4) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 7 D1; 7 43.81 cM

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	7	NC_000073.7 (75498086..75523881)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	7	NC_000073.6 (75848338..75874133)

Chromosome 7 - NC_000073.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Chemically induced (ENU) (1)

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables molecular_function	ND No biological Data available more info
enables ubiquitin-like ligase-substrate adaptor activity	IDA Inferred from Direct Assay more info	PubMed
enables ubiquitin-like ligase-substrate adaptor activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in negative regulation of fatty acid biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of fatty acid oxidation	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of fatty acid oxidation	ISO Inferred from Sequence Orthology more info
involved_in protein ubiquitination	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of translation	IEA Inferred from Electronic Annotation more info
involved_in regulation of translational initiation	ISO Inferred from Sequence Orthology more info
involved_in ubiquitin-dependent protein catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in ubiquitin-dependent protein catabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in ubiquitin-dependent protein catabolic process	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
part_of Cul3-RING ubiquitin ligase complex	IBA Inferred from Biological aspect of Ancestor more info
part_of Cul3-RING ubiquitin ligase complex	IDA Inferred from Direct Assay more info	PubMed
part_of Cul3-RING ubiquitin ligase complex	ISO Inferred from Sequence Orthology more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: kelch-like protein 25

Names: ENC-2; ectoderm-neural cortex protein 2; ectoderm-neural cortex-1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001122780.1 → NP_001116252.1 kelch-like protein 25

See identical proteins and their annotated locations for NP_001116252.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Variants 1-3 encode the same the protein.

Source sequence(s)

AK143086, BY241272

Consensus CDS

CCDS21369.1

UniProtKB/Swiss-Prot

Q8R2P1

Related

ENSMUSP00000133175.3, ENSMUST00000171155.4

Conserved Domains (3) summary

PHA03098
Location:39 → 566

PHA03098; kelch-like protein; Provisional

sd00038
Location:330 → 374

Kelch; KELCH repeat [structural motif]

cd18254
Location:24 → 151

BTB_POZ_KLHL25; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 25 (KLHL25)
NM_029652.1 → NP_083928.1 kelch-like protein 25

See identical proteins and their annotated locations for NP_083928.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longest transcript. Variants 1-3 encode the same the protein.

Source sequence(s)

AK143086, BY042513, BY241272

Consensus CDS

CCDS21369.1

UniProtKB/Swiss-Prot

Q8R2P1

Related

ENSMUSP00000089707.6, ENSMUST00000092073.11

Conserved Domains (3) summary

PHA03098
Location:39 → 566

PHA03098; kelch-like protein; Provisional

sd00038
Location:330 → 374

Kelch; KELCH repeat [structural motif]

cd18254
Location:24 → 151

BTB_POZ_KLHL25; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 25 (KLHL25)
NM_182782.2 → NP_877583.1 kelch-like protein 25

See identical proteins and their annotated locations for NP_877583.1

Status: VALIDATED

Description

Transcript Variant: This variant (3) differs in the 3' UTR, compared to variant 1. Variants 1-3 encode the same the protein.

Source sequence(s)

AK143086, BP767188, BY042513, BY241272

Consensus CDS

CCDS21369.1

UniProtKB/Swiss-Prot

Q8R2P1

Related

ENSMUSP00000146102.2, ENSMUST00000206019.2

Conserved Domains (3) summary

PHA03098
Location:39 → 566

PHA03098; kelch-like protein; Provisional

sd00038
Location:330 → 374

Kelch; KELCH repeat [structural motif]

cd18254
Location:24 → 151

BTB_POZ_KLHL25; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 25 (KLHL25)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000073.7 Reference GRCm39 C57BL/6J

Range

75498086..75523881

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_011250832.3 → XP_011249134.1 kelch-like protein 25 isoform X1

See identical proteins and their annotated locations for XP_011249134.1

UniProtKB/Swiss-Prot

Q8R2P1

Conserved Domains (3) summary

PHA03098
Location:39 → 566

PHA03098; kelch-like protein; Provisional

sd00038
Location:330 → 374

Kelch; KELCH repeat [structural motif]

cd18254
Location:24 → 151

BTB_POZ_KLHL25; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 25 (KLHL25)