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Alg11 asparagine-linked glycosylation 11 (alpha-1,2-mannosyltransferase) [ Mus musculus (house mouse) ]

Gene ID: 207958, updated on 23-Jun-2021

Summary

Official Symbol
Alg11provided by MGI
Official Full Name
asparagine-linked glycosylation 11 (alpha-1,2-mannosyltransferase)provided by MGI
Primary source
MGI:MGI:2142632
See related
Ensembl:ENSMUSG00000063362
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
AI849156; AW492253; Mmat-4(5); B230397C21
Expression
Ubiquitous expression in placenta adult (RPKM 5.0), bladder adult (RPKM 4.1) and 28 other tissues See more
Orthologs
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Genomic context

See Alg11 in Genome Data Viewer
Location:
8; 8 A2
Exon count:
4
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (22550731..22561643)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (22060721..22071627)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 8 NC_000074.5 (23171192..23178761)

Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene coiled-coil domain containing 70 Neighboring gene ATPase, Cu++ transporting, beta polypeptide Neighboring gene NIMA (never in mitosis gene a)-related expressed kinase 5 Neighboring gene small nucleolar RNA U13 Neighboring gene NIMA (never in mitosis gene a)-related expressed kinase 3

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Targeted (2) 

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables GDP-Man:Man3GlcNAc2-PP-Dol alpha-1,2-mannosyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables glycosyltransferase activity IEA
Inferred from Electronic Annotation
more info
 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in oligosaccharide-lipid intermediate biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in protein N-linked glycosylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
 
is_active_in endoplasmic reticulum membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
GDP-Man:Man(3)GlcNAc(2)-PP-Dol alpha-1,2-mannosyltransferase
Names
asparagine-linked glycosylation 11 homolog (yeast, alpha-1,2-mannosyltransferase)
asparagine-linked glycosylation protein 11 homolog
defective mannosyltransferase IV(V)
glycolipid 2-alpha-mannosyltransferase
mannosyltransferase IV(V)
NP_001230090.1
NP_898965.1
XP_006509108.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001243161.1NP_001230090.1  GDP-Man:Man(3)GlcNAc(2)-PP-Dol alpha-1,2-mannosyltransferase isoform 1

    See identical proteins and their annotated locations for NP_001230090.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    AK157746, BC061469
    Consensus CDS
    CCDS57613.1
    UniProtKB/Swiss-Prot
    Q3TZM9
    UniProtKB/TrEMBL
    A0A077K846
    Related
    ENSMUSP00000072382.7, ENSMUST00000072572.13
    Conserved Domains (2) summary
    cd03806
    Location:64480
    GT1_ALG11_like; This family is most closely related to the GT1 family of glycosyltransferases. ALG11 in yeast is involved in adding the final 1,2-linked Man to the Man5GlcNAc2-PP-Dol synthesized on the cytosolic face of the ER. The deletion analysis of ALG11 was shown ...
    PLN02949
    Location:64492
    PLN02949; transferase, transferring glycosyl groups
  2. NM_183142.4NP_898965.1  GDP-Man:Man(3)GlcNAc(2)-PP-Dol alpha-1,2-mannosyltransferase isoform 2

    See identical proteins and their annotated locations for NP_898965.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site in the coding region, compared to variant 1. It encodes isoform 2, which is shorter than isoform 1.
    Source sequence(s)
    AK046475, AK157746, BC061469
    Consensus CDS
    CCDS40292.1
    UniProtKB/Swiss-Prot
    Q3TZM9
    Related
    ENSMUSP00000106365.3, ENSMUST00000110737.3
    Conserved Domains (2) summary
    cd03806
    Location:64438
    GT1_ALG11_like; This family is most closely related to the GT1 family of glycosyltransferases. ALG11 in yeast is involved in adding the final 1,2-linked Man to the Man5GlcNAc2-PP-Dol synthesized on the cytosolic face of the ER. The deletion analysis of ALG11 was shown ...
    PLN02949
    Location:64450
    PLN02949; transferase, transferring glycosyl groups

RNA

  1. NR_040650.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) uses an alternate splice site that introduces a premature stop codon, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AK157746, BC061469

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000074.7 Reference GRCm39 C57BL/6J

    Range
    22550731..22561643
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006509045.3XP_006509108.1  GDP-Man:Man(3)GlcNAc(2)-PP-Dol alpha-1,2-mannosyltransferase isoform X1

    Conserved Domains (1) summary
    cd03806
    Location:39455
    GT4_ALG11-like; alpha-1,2-mannosyltransferase ALG11 and similar proteins
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