Sult1e1 sulfotransferase family 1E, member 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Sult1e1provided by MGI
Official Full Name: sulfotransferase family 1E, member 1provided by MGI
Primary source: MGI:MGI:98431
See related: Ensembl:ENSMUSG00000029272 AllianceGenome:MGI:98431
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: EST; Ste; ST1E1
Summary: Enables steroid sulfotransferase activity. Involved in estrogen metabolic process. Acts upstream of or within female pregnancy. Located in cytoplasm. Is expressed in liver; nervous system; nose; and reproductive system. Human ortholog(s) of this gene implicated in breast cancer and endometrial cancer. Orthologous to human SULT1E1 (sulfotransferase family 1E member 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in bladder adult (RPKM 2.1), genital fat pad adult (RPKM 1.8) and 2 other tissues See more
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Genomic context

Location:: 5 E1; 5 43.56 cM

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	5	NC_000071.7 (87723827..87739470, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	5	NC_000071.6 (87575968..87591611, complement)

Chromosome 5 - NC_000071.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Hepatocyte estrogen sulfotransferase inhibition protects female mice from concanavalin A-induced T cell-mediated hepatitis independent of estrogens.
Title: Hepatocyte estrogen sulfotransferase inhibition protects female mice from concanavalin A-induced T cell-mediated hepatitis independent of estrogens.
Estrogen Sulfotransferase is Highly Expressed in Vascular Endothelial Cells Overlying Atherosclerotic Plaques.
Title: Estrogen Sulfotransferase is Highly Expressed in Vascular Endothelial Cells Overlying Atherosclerotic Plaques.
Inhibition of Estrogen Sulfotransferase (SULT1E1/EST) Ameliorates Ischemic Acute Kidney Injury in Mice.
Title: Inhibition of Estrogen Sulfotransferase (SULT1E1/EST) Ameliorates Ischemic Acute Kidney Injury in Mice.
Nuclear receptor CAR-ERalpha signaling regulates the estrogen sulfotransferase gene in the liver.
Title: Nuclear receptor CAR-ERα signaling regulates the estrogen sulfotransferase gene in the liver.
These results revealed a sex- and tissue-specific role of EST in hemorrhagic shock (HS)-induced acute lung injury (ALI). Pharmacological inhibition of EST may represent an effective approach to manage HS-induced ALI.
Title: Hepatic Estrogen Sulfotransferase Distantly Sensitizes Mice to Hemorrhagic Shock-Induced Acute Lung Injury.
Increased expression of SULT1E1 is associated with obstructive cholestasis.
Title: Cholestasis-induced bile acid elevates estrogen level via farnesoid X receptor-mediated suppression of the estrogen sulfotransferase SULT1E1.
A crucial adipose- and male-specific role of Est in maintaining the whole-body energy homeostasis.
Title: Sex- and Tissue-Specific Role of Estrogen Sulfotransferase in Energy Homeostasis and Insulin Sensitivity.
Gene profiling identifies sulfotransferase family 1E (Sult1e1), which encodes a sulfotransferase E1 responsible for inactivation of estrogen, as a gene upregulated in non-alcoholic steatohepatitis in both genders and most conspicuously in male IkbkbDeltahep mice having worst non-alcoholic steatohepatitis and lowest plasma estradiol levels.
Title: Gender difference in NASH susceptibility: Roles of hepatocyte Ikkβ and Sult1e1.
The role of estrogen sulfotransferase, a conjugating enzyme that sulfonates and deactivates estrogens, in sepsis response is reported.
Title: Oestrogen sulfotransferase ablation sensitizes mice to sepsis.
Liver ischemia and reperfusion (I/R) induced the expression of EST and comprised estrogen activity in an Nrf2-dependent manner. EST ablation gender-specifically affected I/R sensitivity.
Title: Estrogen Sulfotransferase Is an Oxidative Stress-responsive Gene That Gender-specifically Affects Liver Ischemia/Reperfusion Injury.

Submit: New GeneRIF Correction See all GeneRIFs (21)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (1) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D14Arb6 (e-PCR), detects polymorphism
- UniSTS:226600

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables aryl sulfotransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables estrone sulfotransferase activity	ISO Inferred from Sequence Orthology more info
enables flavonol 3-sulfotransferase activity	ISO Inferred from Sequence Orthology more info
enables lipid binding	IEA Inferred from Electronic Annotation more info
enables steroid binding	IEA Inferred from Electronic Annotation more info
enables steroid sulfotransferase activity	IDA Inferred from Direct Assay more info	PubMed
enables steroid sulfotransferase activity	ISO Inferred from Sequence Orthology more info
enables sulfotransferase activity	ISO Inferred from Sequence Orthology more info	PubMed
enables transferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in 3'-phosphoadenosine 5'-phosphosulfate metabolic process	ISO Inferred from Sequence Orthology more info
involved_in estrogen catabolic process	ISO Inferred from Sequence Orthology more info
involved_in estrogen metabolic process	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within estrogen metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in estrogen metabolic process	ISO Inferred from Sequence Orthology more info
involved_in ethanol catabolic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within female pregnancy	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within lipid metabolic process	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of fat cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in sulfation	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within sulfation	ISO Inferred from Sequence Orthology more info	PubMed
involved_in sulfation	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in nuclear membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: sulfotransferase 1E1

Names: sulfotransferase, estrogen preferring

NP_075624.2

EC 2.8.2.4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.