U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Stim1 stromal interaction molecule 1 [ Mus musculus (house mouse) ]

Gene ID: 20866, updated on 26-Sep-2022

Summary

Official Symbol
Stim1provided by MGI
Official Full Name
stromal interaction molecule 1provided by MGI
Primary source
MGI:MGI:107476
See related
Ensembl:ENSMUSG00000030987 AllianceGenome:MGI:107476
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
SIM
Summary
Enables identical protein binding activity. Acts upstream of or within myotube differentiation and store-operated calcium entry. Located in endoplasmic reticulum. Part of protein-containing complex. Is expressed in several structures, including alimentary system; central nervous system; gonad; hemolymphoid system gland; and musculature. Human ortholog(s) of this gene implicated in Stormorken syndrome; immunodeficiency 10; and tubular aggregate myopathy 1. Orthologous to human STIM1 (stromal interaction molecule 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in colon adult (RPKM 37.3), testis adult (RPKM 30.1) and 28 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See Stim1 in Genome Data Viewer
Location:
7 E2- E3; 7 54.71 cM
Exon count:
16
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (101909279..102086525)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (102261514..102437319)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene nucleoporin 98 Neighboring gene post-GPI attachment to proteins 2 Neighboring gene ras homolog family member G Neighboring gene methyltransferase like 6 pseudogene Neighboring gene ribonucleotide reductase M1 Neighboring gene olfactory receptor family 55 subfamily B member 3

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables calcium channel regulator activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables calcium channel regulator activity IDA
Inferred from Direct Assay
more info
PubMed 
enables calcium channel regulator activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables calcium channel regulator activity ISO
Inferred from Sequence Orthology
more info
PubMed 
enables calcium ion binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables calcium ion binding ISO
Inferred from Sequence Orthology
more info
 
enables channel activator activity IDA
Inferred from Direct Assay
more info
PubMed 
enables channel activator activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables channel activator activity ISO
Inferred from Sequence Orthology
more info
PubMed 
enables identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables ion channel regulator activity involved in G protein-coupled receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
enables ion channel regulator activity involved in G protein-coupled receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables ion channel regulator activity involved in G protein-coupled receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables microtubule plus-end binding ISO
Inferred from Sequence Orthology
more info
 
enables protease binding ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables store-operated calcium channel activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in activation of store-operated calcium channel activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in activation of store-operated calcium channel activity ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within calcium ion transport IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within cation transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cellular calcium ion homeostasis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in detection of calcium ion ISO
Inferred from Sequence Orthology
more info
 
involved_in enamel mineralization ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within establishment of localization in cell IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in ion channel modulating, G protein-coupled receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
involved_in ion channel modulating, G protein-coupled receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within ion transport IEA
Inferred from Electronic Annotation
more info
 
involved_in ligand-gated ion channel signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
involved_in ligand-gated ion channel signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within myotube differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in phospholipase C-activating G protein-coupled acetylcholine receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
involved_in phospholipase C-activating G protein-coupled receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of adenylate cyclase activity ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of angiogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of insulin secretion IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of insulin secretion IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of calcium ion transport ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of store-operated calcium entry ISO
Inferred from Sequence Orthology
more info
 
involved_in store-operated calcium entry IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within store-operated calcium entry IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within store-operated calcium entry IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in store-operated calcium entry ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in cortical endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
 
is_active_in endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in endoplasmic reticulum IDA
Inferred from Direct Assay
more info
PubMed 
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
 
located_in growth cone ISO
Inferred from Sequence Orthology
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in microtubule IEA
Inferred from Electronic Annotation
more info
 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
is_active_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in plasma membrane ISO
Inferred from Sequence Orthology
more info
PubMed 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in plasma membrane raft ISO
Inferred from Sequence Orthology
more info
 
part_of protein-containing complex IPI
Inferred from Physical Interaction
more info
PubMed 
located_in sarcoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
 
located_in sarcoplasmic reticulum membrane ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
stromal interaction molecule 1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001374058.1NP_001360987.1  stromal interaction molecule 1 isoform 2 precursor

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2), also known as Stim1A (PMID:34942054), contains an alternate in-frame exon in the 3' coding region, compared to variant 1. The resulting protein (isoform 2, Stim1a, alpha) has a longer C-terminus relative to isoform 1.
    Source sequence(s)
    AC102535, AC139579
    Conserved Domains (3) summary
    cd09573
    Location:128201
    SAM_STIM1; SAM domain of STIM1 subfamily proteins
    COG1196
    Location:237434
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    pfam16533
    Location:344441
    SOAR; STIM1 Orai1-activating region
  2. NM_001374060.1NP_001360989.1  stromal interaction molecule 1 isoform 3 precursor

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3), also known as Stim1b (PMID:33730587), contains an alternate exon, relative to variant 1. The resulting protein (isoform 3, Stim1b) has a shorter and distinct C-terminus relative to isoform 1.
    Source sequence(s)
    AC102535, AC139579
    Consensus CDS
    CCDS90292.1
    UniProtKB/TrEMBL
    A0A1B0GR78, A0A6P7RDL7
    Related
    ENSMUSP00000147410.2, ENSMUST00000211457.2
    Conserved Domains (3) summary
    cd09573
    Location:128201
    SAM_STIM1; SAM domain of STIM1 subfamily proteins
    COG1196
    Location:237434
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    pfam16533
    Location:344441
    SOAR; STIM1 Orai1-activating region
  3. NM_001400557.1NP_001387486.1  stromal interaction molecule 1 isoform 4 precursor

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4), also known as Stim1L uses an alternate in frame splice site compared to variant 1. The encoded protein is longer than isoform (1).
    Source sequence(s)
    AC102535, AC139579
    UniProtKB/TrEMBL
    A0A1B0GRA5
  4. NM_009287.5NP_033313.2  stromal interaction molecule 1 isoform 1 precursor

    See identical proteins and their annotated locations for NP_033313.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes isoform 1
    Source sequence(s)
    AC102535, AC139579
    Consensus CDS
    CCDS21530.1
    UniProtKB/Swiss-Prot
    P70302, Q8K1E1
    Related
    ENSMUSP00000033289.5, ENSMUST00000033289.6
    Conserved Domains (3) summary
    cd09573
    Location:128201
    SAM_STIM1; SAM domain of STIM1 subfamily proteins
    COG1196
    Location:237434
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    pfam16533
    Location:344441
    SOAR; STIM1 Orai1-activating region

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    101909279..102086525
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036152856.1XP_036008749.1  stromal interaction molecule 1 isoform X2

    Conserved Domains (3) summary
    cd09573
    Location:54127
    SAM_STIM1; SAM domain of STIM1 subfamily proteins
    COG1196
    Location:163360
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    pfam16533
    Location:270367
    SOAR; STIM1 Orai1-activating region
  2. XM_036152855.1XP_036008748.1  stromal interaction molecule 1 isoform X2

    Conserved Domains (3) summary
    cd09573
    Location:54127
    SAM_STIM1; SAM domain of STIM1 subfamily proteins
    COG1196
    Location:163360
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    pfam16533
    Location:270367
    SOAR; STIM1 Orai1-activating region
  3. XM_006507536.4XP_006507599.1  stromal interaction molecule 1 isoform X3

    Conserved Domains (3) summary
    cd09573
    Location:128201
    SAM_STIM1; SAM domain of STIM1 subfamily proteins
    COG1196
    Location:237434
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    pfam16533
    Location:344441
    SOAR; STIM1 Orai1-activating region
  4. XM_006507533.4XP_006507596.1  stromal interaction molecule 1 isoform X1

    UniProtKB/TrEMBL
    A0A1B0GRA5
    Related
    ENSMUSP00000147443.2, ENSMUST00000209255.2
    Conserved Domains (3) summary
    cd09573
    Location:128201
    SAM_STIM1; SAM domain of STIM1 subfamily proteins
    COG1196
    Location:237434
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    pfam16533
    Location:344441
    SOAR; STIM1 Orai1-activating region