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Hmgcs1 3-hydroxy-3-methylglutaryl-Coenzyme A synthase 1 [ Mus musculus (house mouse) ]

Gene ID: 208715, updated on 25-Jan-2022

Summary

Official Symbol
Hmgcs1provided by MGI
Official Full Name
3-hydroxy-3-methylglutaryl-Coenzyme A synthase 1provided by MGI
Primary source
MGI:MGI:107592
See related
Ensembl:ENSMUSG00000093930 AllianceGenome:MGI:107592
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
B130032C06Rik
Summary
Predicted to enable several functions, including hydroxymethylglutaryl-CoA synthase activity; organic acid binding activity; and protein homodimerization activity. Predicted to be involved in several processes, including acetyl-CoA metabolic process; cellular response to low-density lipoprotein particle stimulus; and farnesyl diphosphate biosynthetic process, mevalonate pathway. Predicted to act upstream of or within cholesterol biosynthetic process. Predicted to be located in cytoplasm. Predicted to be active in cytosol. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; integumental system; and sensory organ. Orthologous to human HMGCS1 (3-hydroxy-3-methylglutaryl-CoA synthase 1). [provided by Alliance of Genome Resources, Nov 2021]
Expression
Broad expression in CNS E18 (RPKM 127.4), CNS E14 (RPKM 70.2) and 22 other tissues See more
Orthologs
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Genomic context

See Hmgcs1 in Genome Data Viewer
Location:
13 D2.3; 13
Exon count:
12
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (120151887..120169796)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (119690351..119708260)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 13 NT_110857.1 (114710..132325, complement)

Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 53794 Neighboring gene RIKEN cDNA 1700074H08 gene Neighboring gene NIM1 serine/threonine protein kinase Neighboring gene predicted gene, 52026 Neighboring gene predicted gene, 41077 Neighboring gene zinc finger protein 131

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Endonuclease-mediated (1) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC36662, MGC98430

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables acyltransferase activity IEA
Inferred from Electronic Annotation
more info
 
enables hydroxymethylglutaryl-CoA synthase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables hydroxymethylglutaryl-CoA synthase activity ISO
Inferred from Sequence Orthology
more info
 
enables isomerase activity ISO
Inferred from Sequence Orthology
more info
 
enables organic acid binding ISO
Inferred from Sequence Orthology
more info
 
enables protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
 
enables small molecule binding ISO
Inferred from Sequence Orthology
more info
 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
hydroxymethylglutaryl-CoA synthase, cytoplasmic
Names
3-hydroxy-3-methylglutaryl coenzyme A synthase
HMG-CoA synthase
NP_001278368.1
NP_666054.2
XP_006517641.1
XP_036013850.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001291439.1NP_001278368.1  hydroxymethylglutaryl-CoA synthase, cytoplasmic

    See identical proteins and their annotated locations for NP_001278368.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 both encode the same protein.
    Source sequence(s)
    AK031297, AK044835, CJ071929
    Consensus CDS
    CCDS56901.1
    UniProtKB/Swiss-Prot
    Q8JZK9
    Related
    ENSMUSP00000136944.2, ENSMUST00000179869.3
    Conserved Domains (1) summary
    TIGR01833
    Location:13469
    HMG-CoA-S_euk; 3-hydroxy-3-methylglutaryl-CoA-synthase, eukaryotic clade
  2. NM_145942.5NP_666054.2  hydroxymethylglutaryl-CoA synthase, cytoplasmic

    See identical proteins and their annotated locations for NP_666054.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 both encode the same protein.
    Source sequence(s)
    AK031297, AK044835, CJ071929
    Consensus CDS
    CCDS56901.1
    UniProtKB/Swiss-Prot
    Q8JZK9
    Related
    ENSMUSP00000153064.2, ENSMUST00000224188.2
    Conserved Domains (1) summary
    TIGR01833
    Location:13469
    HMG-CoA-S_euk; 3-hydroxy-3-methylglutaryl-CoA-synthase, eukaryotic clade

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000079.7 Reference GRCm39 C57BL/6J

    Range
    120151887..120169796
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006517578.3XP_006517641.1  hydroxymethylglutaryl-CoA synthase, cytoplasmic isoform X2

    See identical proteins and their annotated locations for XP_006517641.1

    UniProtKB/Swiss-Prot
    Q8JZK9
    Conserved Domains (1) summary
    TIGR01833
    Location:13469
    HMG-CoA-S_euk; 3-hydroxy-3-methylglutaryl-CoA-synthase, eukaryotic clade
  2. XM_036157957.1XP_036013850.1  hydroxymethylglutaryl-CoA synthase, cytoplasmic isoform X1

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