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Sult1a1 sulfotransferase family 1A, phenol-preferring, member 1 [ Mus musculus (house mouse) ]

Gene ID: 20887, updated on 21-Apr-2024

Summary

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Official Symbol
Sult1a1provided by MGI
Official Full Name
sulfotransferase family 1A, phenol-preferring, member 1provided by MGI
Primary source
MGI:MGI:102896
See related
Ensembl:ENSMUSG00000030711 AllianceGenome:MGI:102896
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
PST; Stp; Stp1; ST1A1; ST1A4; mSTp1
Summary
Enables nucleotide binding activity and sulfotransferase activity. Acts upstream of or within sulfation. Predicted to be located in cytosol. Predicted to be active in cytoplasm. Is expressed in adrenal gland; central nervous system; gland; meninges; and nervous system. Human ortholog(s) of this gene implicated in several diseases, including breast cancer; gastrointestinal system cancer (multiple); lung cancer (multiple); reproductive organ cancer (multiple); and urinary bladder cancer. Orthologous to several human genes including SULT1A1 (sulfotransferase family 1A member 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in liver adult (RPKM 40.1), liver E18 (RPKM 24.9) and 18 other tissues See more
Orthologs
human all
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Genomic context

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Location:
7 F3; 7 69.25 cM
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (126272042..126289615, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (126672865..126690443, complement)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 39087 Neighboring gene nuclear protein transcription regulator 1 Neighboring gene SAGA complex associated factor 29 Neighboring gene STARR-seq mESC enhancer starr_20153 Neighboring gene STARR-positive B cell enhancer ABC_E6601 Neighboring gene sulfotransferase family 1A, phenol-preferring, member 1 pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E3751 Neighboring gene STARR-positive B cell enhancer ABC_E2252 Neighboring gene SLX1 structure-specific endonuclease subunit homolog B (S. cerevisiae) Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:133845996-133846179 Neighboring gene STARR-positive B cell enhancer ABC_E10475 Neighboring gene bolA family member 2 Neighboring gene coronin, actin binding protein 1A

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Decreased phenol sulfotransferase activities associated with hyperserotonemia in autism spectrum disorders. Pagan C, et al. Transl Psychiatry, 2021 Jan 7. PMID 33414449, Free PMC Article
  2. Formation of hepatic DNA adducts by methyleugenol in mouse models: drastic decrease by Sult1a1 knockout and strong increase by transgenic human SULT1A1/2. Herrmann K, et al. Carcinogenesis, 2014 Apr. PMID 24318996
  3. Steroid sulfotransferases. Luu-The V, et al. J Endocrinol, 1996 Sep. PMID 8943792
  4. Molecular cloning of cDNA encoding the phenol/aryl form of sulfotransferase (mSTp1) from mouse liver. Kong AN, et al. Biochim Biophys Acta, 1993 Jan 23. PMID 8424956
  5. The effect of knockout of sulfotransferases 1a1 and 1d1 and of transgenic human sulfotransferases 1A1/1A2 on the formation of DNA adducts from furfuryl alcohol in mouse models. Sachse B, et al. Carcinogenesis, 2014 Oct. PMID 25053625

See all (41) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Suggest SULT1A1/1A2 play a central role in furfuryl alcohol bioactivation and the formation of hemoglobin adducts.
    Title: Hemoglobin adducts of furfuryl alcohol in genetically modified mouse models: Role of endogenous sulfotransferases 1a1 and 1d1 and transgenic human sulfotransferases 1A1/1A2.
  2. SULT1A1 is responsible for bioactivation of food genotoxicants 5-hydroxymethylfurfural and furfuryl alcohol.
    Title: Bioactivation of food genotoxicants 5-hydroxymethylfurfural and furfuryl alcohol by sulfotransferases from human, mouse and rat: a comparative study.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1)  1 citation
  • Endonuclease-mediated (3) 

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables 3'-phosphoadenosine 5'-phosphosulfate binding ISO
Inferred from Sequence Orthology
more info
  
enables amine sulfotransferase activity ISO
Inferred from Sequence Orthology
more info
  
enables aryl sulfotransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables aryl sulfotransferase activity ISO
Inferred from Sequence Orthology
more info
  
enables flavonol 3-sulfotransferase activity ISO
Inferred from Sequence Orthology
more info
  
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables nucleotide binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables steroid sulfotransferase activity ISO
Inferred from Sequence Orthology
more info
  
enables sulfate binding ISO
Inferred from Sequence Orthology
more info
  
enables sulfotransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables sulfotransferase activity ISO
Inferred from Sequence Orthology
more info
 PubMed 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
enables tyrosine-ester sulfotransferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in 4-nitrophenol metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in catecholamine metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in estrogen metabolic process ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within lipid metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in response to glucocorticoid ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within steroid metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in sulfation IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within sulfation IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within sulfation ISO
Inferred from Sequence Orthology
more info
 PubMed 
involved_in sulfation ISO
Inferred from Sequence Orthology
more info
  
involved_in xenobiotic metabolic process ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
sulfotransferase 1A1
Names
aryl sulfotransferase
arylsulfotransferase ST1A4
phenol sulfotransferase
phenol/aryl sulfotransferase
sulfokinase
sulfotransferase, phenol preferring 1
NP_001390060.1
NP_598431.2
XP_006507601.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001403131.1 → NP_001390060.1  sulfotransferase 1A1 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC124505

  2. NM_133670.3 → NP_598431.2  sulfotransferase 1A1 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC124505
    Consensus CDS
    CCDS40128.2
    UniProtKB/TrEMBL
    E9QNL5, Q9R1S5
    Related
    ENSMUSP00000101981.3, ENSMUST00000106373.9
    Conserved Domains (1) summary
    pfam00685
    Location:41 → 291
    Sulfotransfer_1; Sulfotransferase domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    126272042..126289615 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006507538.5 → XP_006507601.1  sulfotransferase 1A1 isoform X1

    See identical proteins and their annotated locations for XP_006507601.1

    UniProtKB/TrEMBL
    E9QNL5, Q9R1S5
    Conserved Domains (1) summary
    pfam00685
    Location:41 → 291
    Sulfotransfer_1; Sulfotransferase domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P52840.1 GenPept UniProtKB/Swiss-Prot:P52840

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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