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Ccnb3 cyclin B3 [ Mus musculus (house mouse) ]

Gene ID: 209091, updated on 11-Apr-2024

Summary

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Official Symbol
Ccnb3provided by MGI
Official Full Name
cyclin B3provided by MGI
Primary source
MGI:MGI:2183443
See related
Ensembl:ENSMUSG00000051592 AllianceGenome:MGI:2183443
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
Predicted to enable cyclin-dependent protein serine/threonine kinase regulator activity. Predicted to be involved in mitotic cell cycle phase transition and regulation of cyclin-dependent protein serine/threonine kinase activity. Predicted to act upstream of or within cell division and meiotic cell cycle. Predicted to be located in nuclear speck. Predicted to be part of cyclin-dependent protein kinase holoenzyme complex. Predicted to be active in centrosome; cytoplasm; and nucleus. Is expressed in ovary and seminiferous tubule. Orthologous to human CCNB3 (cyclin B3). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Low expression observed in reference dataset See more
Orthologs
human all
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Genomic context

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Location:
X A1.1; X 3.13 cM
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) X NC_000086.8 (6845890..6907894, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) X NC_000086.7 (6979652..7041635, complement)

Chromosome X - NC_000086.8Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 5430428K19 gene Neighboring gene shroom family member 4 Neighboring gene STARR-seq mESC enhancer starr_46656 Neighboring gene STARR-seq mESC enhancer starr_46657 Neighboring gene STARR-seq mESC enhancer starr_46658 Neighboring gene diacylglycerol kinase kappa Neighboring gene STARR-seq mESC enhancer starr_46659 Neighboring gene STARR-seq mESC enhancer starr_46660 Neighboring gene A kinase anchor protein 4 Neighboring gene ribosomal protein L23a pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Cyclin B3 implements timely vertebrate oocyte arrest for fertilization. Bouftas N, et al. Dev Cell, 2022 Oct 10. PMID 36182686
  2. Recurrent pregnancy loss in mice lacking the X-linked Ccnb3 gene†. Chotiner JY, et al. Biol Reprod, 2022 Mar 19. PMID 34850816, Free PMC Article
  3. Degradation of Ccnb3 is essential for maintenance of MII arrest in oocyte. Meng TG, et al. Biochem Biophys Res Commun, 2020 Jan 1. PMID 31640856
  4. Cyclin B3 is dispensable for mouse spermatogenesis. Karasu ME, et al. Chromosoma, 2019 Sep. PMID 31446450, Free PMC Article
  5. Cyclin B3 is required for metaphase to anaphase transition in oocyte meiosis I. Li Y, et al. J Cell Biol, 2019 May 6. PMID 30770433, Free PMC Article

See all (20) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Recurrent pregnancy loss in mice lacking the X-linked Ccnb3 genedagger.
    Title: Recurrent pregnancy loss in mice lacking the X-linked Ccnb3 gene†.
  2. Our findings underscore the requirement for CCNB3 in female meiosis and suggest that ZGA-specific functions of CCNB3 observed in invertebrate species are not likely conserved in mammals. The Ccnb3-deficient mouse model is similar to a human infertility condition - recurrent pregnancy loss (RPL).
    Title: Recurrent pregnancy loss in mice lacking the X-linked Ccnb3 gene†.
  3. The results indicate that Ccnb3 plays a critical regulatory role in MII arrest and exit in mouse oocytes.
    Title: Degradation of Ccnb3 is essential for maintenance of MII arrest in oocyte.
  4. we found that males lacking cyclin B3 are fertile and show no detectable defects in spermatogenesis based on histological analysis of seminiferous tubules.
    Title: Cyclin B3 is dispensable for mouse spermatogenesis.
  5. Cyclin B3 is an M-phase cyclin which promotes anaphase I onset in oocyte meiosis.
    Title: Cyclin B3 promotes anaphase I onset in oocyte meiosis.
  6. Depletion of cyclin B3 inhibits metaphase-anaphase transition as indicated by a well-sustained MI spindle and cyclin B1 expression in meiotic oocytes.
    Title: Cyclin B3 controls anaphase onset independent of spindle assembly checkpoint in meiotic oocytes.
  7. cloning of a partial cDNA and localized mRNA to leptotene and zygotene spermatocytes
    Title: Characterization and expression of mammalian cyclin b3, a prepachytene meiotic cyclin.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables cyclin-dependent protein serine/threonine kinase regulator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within cell cycle IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within cell division IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within meiotic cell cycle IEA
Inferred from Electronic Annotation
more info
  
involved_in mitotic cell cycle phase transition IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of cyclin-dependent protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in centrosome IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of cyclin-dependent protein kinase holoenzyme complex IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nuclear speck ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
G2/mitotic-specific cyclin-B3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_183015.4 → NP_898836.2  G2/mitotic-specific cyclin-B3

    See identical proteins and their annotated locations for NP_898836.2

    Status: VALIDATED

    Source sequence(s)
    AL671962
    Consensus CDS
    CCDS29961.1
    UniProtKB/Swiss-Prot
    Q810T2, Q810T3, Q8VDC8
    UniProtKB/TrEMBL
    A2AEP2
    Related
    ENSMUSP00000111418.2, ENSMUST00000115752.8
    Conserved Domains (2) summary
    COG5024
    Location:1054 → 1372
    COG5024; Cyclin [Cell division and chromosome partitioning]
    pfam00134
    Location:1138 → 1263
    Cyclin_N; Cyclin, N-terminal domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000086.8 Reference GRCm39 C57BL/6J

    Range
    6845890..6907894 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017318448.1 → XP_017173937.1  G2/mitotic-specific cyclin-B3 isoform X1

    UniProtKB/Swiss-Prot
    Q810T2, Q810T3, Q8VDC8
    UniProtKB/TrEMBL
    A2AEP2
    Related
    ENSMUSP00000052272.8, ENSMUST00000056725.8
    Conserved Domains (2) summary
    COG5024
    Location:1054 → 1372
    COG5024; Cyclin [Cell division and chromosome partitioning]
    pfam00134
    Location:1138 → 1263
    Cyclin_N; Cyclin, N-terminal domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q810T2.2 GenPept UniProtKB/Swiss-Prot:Q810T2

Gene LinkOut

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