U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Suclg2 succinate-Coenzyme A ligase, GDP-forming, beta subunit [ Mus musculus (house mouse) ]

Gene ID: 20917, updated on 5-Mar-2024

Summary

Go to the top of the page Help
Official Symbol
Suclg2provided by MGI
Official Full Name
succinate-Coenzyme A ligase, GDP-forming, beta subunitprovided by MGI
Primary source
MGI:MGI:1306824
See related
Ensembl:ENSMUSG00000061838 AllianceGenome:MGI:1306824
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
G-SCS; GTPSCS; D6Wsu120e; SCS-betaG
Summary
Predicted to enable succinate-CoA ligase (GDP-forming) activity and succinate-semialdehyde dehydrogenase (NAD+) activity. Predicted to be involved in succinyl-CoA metabolic process and tricarboxylic acid cycle. Located in mitochondrion. Is expressed in several structures, including alimentary system; genitourinary system; nervous system; respiratory system; and sensory organ. Orthologous to human SUCLG2 (succinate-CoA ligase GDP-forming subunit beta). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in kidney adult (RPKM 29.5), liver adult (RPKM 17.1) and 27 other tissues See more
Orthologs
human all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Location:
6 D2; 6 44.63 cM
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (95449992..95695799, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (95473009..95718858, complement)

Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_16742 Neighboring gene cDNA sequence AY512915 Neighboring gene STARR-seq mESC enhancer starr_16743 Neighboring gene STARR-seq mESC enhancer starr_16744 Neighboring gene predicted gene, 53325 Neighboring gene STARR-seq mESC enhancer starr_16745 Neighboring gene STARR-seq mESC enhancer starr_16746 Neighboring gene STARR-seq mESC enhancer starr_16747 Neighboring gene STARR-positive B cell enhancer ABC_E10396 Neighboring gene STARR-seq mESC enhancer starr_16748 Neighboring gene STARR-seq mESC enhancer starr_16749 Neighboring gene STARR-positive B cell enhancer ABC_E4846 Neighboring gene STARR-positive B cell enhancer ABC_E11325 Neighboring gene STARR-positive B cell enhancer ABC_E4847 Neighboring gene STARR-seq mESC enhancer starr_16750 Neighboring gene predicted gene, 32009 Neighboring gene STARR-seq mESC enhancer starr_16751 Neighboring gene STARR-seq mESC enhancer starr_16752 Neighboring gene predicted gene, 38864

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Two transgenic mouse models for β-subunit components of succinate-CoA ligase yielding pleiotropic metabolic alterations. Kacso G, et al. Biochem J, 2016 Oct 15. PMID 27496549, Free PMC Article
  2. SUCLG2 identified as both a determinator of CSF Aβ1-42 levels and an attenuator of cognitive decline in Alzheimer's disease. Ramirez A, et al. Hum Mol Genet, 2014 Dec 15. PMID 25027320, Free PMC Article
  3. Genetic evidence for the expression of ATP- and GTP-specific succinyl-CoA synthetases in multicellular eucaryotes. Johnson JD, et al. J Biol Chem, 1998 Oct 16. PMID 9765291
  4. Loss of the selective autophagy receptor p62 impairs murine myeloid leukemia progression and mitophagy. Nguyen TD, et al. Blood, 2019 Jan 10. PMID 30498063
  5. Yin Yang 1 Orchestrates a Metabolic Program Required for Both Neural Crest Development and Melanoma Formation. Varum S, et al. Cell Stem Cell, 2019 Apr 4. PMID 30951662

See all (44) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

Go to the top of the page Help

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (2) 
  • Targeted (1) 
  • Endonuclease-mediated (3) 

Pathways from PubChem

Go to the top of the page

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Homology

Clone Names

  • MGC91183

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables GDP binding ISO
Inferred from Sequence Orthology
more info
  
enables GTP binding IEA
Inferred from Electronic Annotation
more info
  
enables catalytic activity IEA
Inferred from Electronic Annotation
more info
  
enables ligase activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables protein-containing complex binding ISO
Inferred from Sequence Orthology
more info
  
NOT enables succinate-CoA ligase (ADP-forming) activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables succinate-CoA ligase (GDP-forming) activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables succinate-CoA ligase (GDP-forming) activity ISO
Inferred from Sequence Orthology
more info
  
enables succinate-semialdehyde dehydrogenase (NAD+) activity ISA
Inferred from Sequence Alignment
more info
 PubMed 
Process Evidence Code Pubs
involved_in succinate metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in succinyl-CoA metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in succinyl-CoA metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in tricarboxylic acid cycle IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in tricarboxylic acid cycle ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in mitochondrion HDA PubMed 
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  
part_of protein-containing complex ISO
Inferred from Sequence Orthology
more info
  
part_of succinate-CoA ligase complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of succinate-CoA ligase complex (GDP-forming) IGI
Inferred from Genetic Interaction
more info
 PubMed 
part_of succinate-CoA ligase complex (GDP-forming) ISO
Inferred from Sequence Orthology
more info
  

General protein information

Go to the top of the page Help
Preferred Names
succinate--CoA ligase [GDP-forming] subunit beta, mitochondrial
Names
GTP-specific succinyl-CoA synthetase beta subunit
succinyl-CoA ligase [GDP-forming] subunit beta, mitochondrial
succinyl-CoA synthetase beta-G chain
NP_001313487.1
NP_001397340.1
NP_035637.2

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001326558.2 → NP_001313487.1  succinate--CoA ligase [GDP-forming] subunit beta, mitochondrial isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (2) has a shorter N-terminus compared to isoform 1.
    Source sequence(s)
    AC121612, AC125225, AC135018
    Consensus CDS
    CCDS85100.1
    UniProtKB/TrEMBL
    C6EQH3
    Related
    ENSMUSP00000078774.7, ENSMUST00000079847.8
    Conserved Domains (3) summary
    PRK00696
    Location:2 → 372
    sucC; succinyl-CoA synthetase subunit beta; Provisional
    pfam00549
    Location:258 → 372
    Ligase_CoA; CoA-ligase
    pfam08442
    Location:1 → 199
    ATP-grasp_2; ATP-grasp domain

  2. NM_001410411.1 → NP_001397340.1  succinate--CoA ligase [GDP-forming] subunit beta, mitochondrial isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC121612, AC125225, AC135018

  3. NM_011507.4 → NP_035637.2  succinate--CoA ligase [GDP-forming] subunit beta, mitochondrial isoform 1 precursor

    See identical proteins and their annotated locations for NP_035637.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AC121612, AC125225, AC135018
    Consensus CDS
    CCDS20381.1
    UniProtKB/Swiss-Prot
    Q3T9B8, Q3TJQ5, Q3TK63, Q66JT3, Q7TMY3, Q80VV1, Q8K2K9, Q9Z2I8
    UniProtKB/TrEMBL
    C6EQH3
    Related
    ENSMUSP00000144827.2, ENSMUST00000204224.3
    Conserved Domains (3) summary
    PRK00696
    Location:40 → 421
    sucC; succinyl-CoA synthetase subunit beta; Provisional
    pfam00549
    Location:307 → 421
    Ligase_CoA; CoA-ligase
    pfam08442
    Location:40 → 248
    ATP-grasp_2; ATP-grasp domain

RNA

  1. NR_177067.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC121612, AC125225, AC135018

  2. NR_177068.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC121612, AC125225, AC135018

  3. NR_177069.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC121612, AC125225, AC135018

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000072.7 Reference GRCm39 C57BL/6J

    Range
    95449992..95695799 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9Z2I8.3 GenPept UniProtKB/Swiss-Prot:Q9Z2I8

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous