U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Syn1 synapsin I [ Mus musculus (house mouse) ]

Gene ID: 20964, updated on 26-Sep-2022

Summary

Official Symbol
Syn1provided by MGI
Official Full Name
synapsin Iprovided by MGI
Primary source
MGI:MGI:98460
See related
Ensembl:ENSMUSG00000037217 AllianceGenome:MGI:98460
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Syn-1; Syn1-S
Summary
Enables identical protein binding activity and protein kinase binding activity. Involved in regulation of synaptic vesicle cycle and synaptic vesicle clustering. Acts upstream of or within neurotransmitter secretion. Located in several cellular components, including Schaffer collateral - CA1 synapse; synaptic vesicle membrane; and synaptonemal complex. Is expressed in diaphragm; intercostal muscle; molar; nervous system; and sensory organ. Used to study autism spectrum disorder. Human ortholog(s) of this gene implicated in X-linked epilepsy with variable learning disabilities and behavior disorders and non-syndromic X-linked intellectual disability 50. Orthologous to human SYN1 (synapsin I). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in frontal lobe adult (RPKM 77.1), cortex adult (RPKM 74.4) and 11 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See Syn1 in Genome Data Viewer
Location:
X A1.3; X 16.37 cM
Exon count:
13
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) X NC_000086.8 (20726750..20787157, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) X NC_000086.7 (20860511..20920918, complement)

Chromosome X - NC_000086.8Genomic Context describing neighboring genes Neighboring gene predicted gene, 26065 Neighboring gene Araf proto-oncogene, serine/threonine kinase Neighboring gene ribonuclease UK114 pseudogene Neighboring gene microRNA 5617 Neighboring gene tissue inhibitor of metalloproteinase 1 Neighboring gene complement factor properdin Neighboring gene ELK1, member of ETS oncogene family

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables calcium-dependent protein binding ISO
Inferred from Sequence Orthology
more info
 
enables identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein kinase binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
is_active_in Schaffer collateral - CA1 synapse IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in Schaffer collateral - CA1 synapse IMP
Inferred from Mutant Phenotype
more info
PubMed 
is_active_in axon IDA
Inferred from Direct Assay
more info
PubMed 
located_in axon IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in cell body IDA
Inferred from Direct Assay
more info
PubMed 
located_in clathrin-sculpted glutamate transport vesicle membrane TAS
Traceable Author Statement
more info
 
located_in cytoskeleton ISO
Inferred from Sequence Orthology
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
is_active_in dendrite IDA
Inferred from Direct Assay
more info
PubMed 
located_in dendrite ISO
Inferred from Sequence Orthology
more info
 
is_active_in extrinsic component of synaptic vesicle membrane ISO
Inferred from Sequence Orthology
more info
 
located_in intracellular organelle ISO
Inferred from Sequence Orthology
more info
 
located_in myelin sheath HDA PubMed 
located_in postsynaptic density IDA
Inferred from Direct Assay
more info
PubMed 
located_in presynapse IDA
Inferred from Direct Assay
more info
PubMed 
located_in presynapse ISO
Inferred from Sequence Orthology
more info
 
located_in presynaptic active zone IDA
Inferred from Direct Assay
more info
PubMed 
located_in presynaptic active zone ISO
Inferred from Sequence Orthology
more info
PubMed 
located_in synapse IDA
Inferred from Direct Assay
more info
PubMed 
located_in synapse ISO
Inferred from Sequence Orthology
more info
PubMed 
located_in synaptic vesicle ISO
Inferred from Sequence Orthology
more info
 
is_active_in synaptic vesicle membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in synaptic vesicle membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in synaptonemal complex IDA
Inferred from Direct Assay
more info
PubMed 

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001110780.1NP_001104250.1  synapsin-1 isoform b

    See identical proteins and their annotated locations for NP_001104250.1

    Status: VALIDATED

    Source sequence(s)
    AF085809, BB646141, BC022954
    Consensus CDS
    CCDS53018.1
    UniProtKB/Swiss-Prot
    O88935
    Related
    ENSMUSP00000111002.2, ENSMUST00000115345.8
    Conserved Domains (3) summary
    pfam02078
    Location:115212
    Synapsin; Synapsin, N-terminal domain
    pfam10581
    Location:127
    Synapsin_N; Synapsin N-terminal
    cl17255
    Location:214416
    ATP-grasp_4; ATP-grasp domain
  2. NM_013680.4NP_038708.3  synapsin-1 isoform a

    See identical proteins and their annotated locations for NP_038708.3

    Status: VALIDATED

    Source sequence(s)
    BB646141, BC022954, BI730087
    Consensus CDS
    CCDS53017.1
    UniProtKB/Swiss-Prot
    O88935, Q8QZT8
    Related
    ENSMUSP00000080568.7, ENSMUST00000081893.7
    Conserved Domains (3) summary
    pfam02078
    Location:115212
    Synapsin; Synapsin, N-terminal domain
    pfam10581
    Location:127
    Synapsin_N; Synapsin N-terminal
    cl17255
    Location:214416
    ATP-grasp_4; ATP-grasp domain

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000086.8 Reference GRCm39 C57BL/6J

    Range
    20726750..20787157 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)