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Ttc28 tetratricopeptide repeat domain 28 [ Mus musculus (house mouse) ]

Gene ID: 209683, updated on 21-Apr-2024

Summary

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Official Symbol
Ttc28provided by MGI
Official Full Name
tetratricopeptide repeat domain 28provided by MGI
Primary source
MGI:MGI:2140873
See related
Ensembl:ENSMUSG00000033209 AllianceGenome:MGI:2140873
Gene type
protein coding
RefSeq status
INFERRED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
TPRBK; 6030435N04; 2310015L07Rik
Summary
Predicted to enable kinase binding activity. Predicted to act upstream of or within regulation of mitotic cell cycle. Predicted to be located in microtubule cytoskeleton and midbody. Is expressed in several structures, including central nervous system; heart; and retina. Orthologous to human TTC28 (tetratricopeptide repeat domain 28). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in whole brain E14.5 (RPKM 8.8), CNS E14 (RPKM 8.2) and 24 other tissues See more
Orthologs
human all
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Genomic context

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Location:
5 F; 5 53.74 cM
Exon count:
25
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (111027652..111437646)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (110879785..111289780)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene ES cell cis-regulatory motif 10b Neighboring gene CapStarr-seq enhancer MGSCv37_chr5:111268841-111269029 Neighboring gene STARR-seq mESC enhancer starr_13970 Neighboring gene HscB iron-sulfur cluster co-chaperone Neighboring gene checkpoint kinase 2 Neighboring gene STARR-seq mESC enhancer starr_13974 Neighboring gene microRNA 701 Neighboring gene STARR-seq mESC enhancer starr_13978 Neighboring gene CapStarr-seq enhancer MGSCv37_chr5:111589073-111589226 Neighboring gene STARR-positive B cell enhancer mm9_chr5:111607344-111607645 Neighboring gene predicted gene, 35628 Neighboring gene phosphatidylinositol transfer protein, beta Neighboring gene predicted gene, 36027 Neighboring gene meningioma 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. A novel big protein TPRBK possessing 25 units of TPR motif is essential for the progress of mitosis and cytokinesis. Izumiyama T, et al. Gene, 2012 Dec 15. PMID 23036704
  2. Novel protein interactions with endoglin and activin receptor-like kinase 1: potential role in vascular networks. Xu G, et al. Mol Cell Proteomics, 2014 Feb. PMID 24319055, Free PMC Article
  3. Cell-Type-Specific Gene Expression in Developing Mouse Neocortex: Intermediate Progenitors Implicated in Axon Development. Bedogni F, et al. Front Mol Neurosci, 2021. PMID 34321999, Free PMC Article
  4. The ATG5 interactome links clathrin-mediated vesicular trafficking with the autophagosome assembly machinery. Baines K, et al. Autophagy Rep, 2022. PMID 35449600, Free PMC Article
  5. Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. Okazaki N, et al. DNA Res, 2003 Feb 28. PMID 12693553

See all (22) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (3) 
  • Endonuclease-mediated (2) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC7623

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables kinase binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within cell cycle IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within cell division IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within regulation of mitotic cell cycle ISO
Inferred from Sequence Orthology
more info
 PubMed 
involved_in regulation of mitotic cell cycle ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in centrosome ISO
Inferred from Sequence Orthology
more info
 PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
located_in midbody ISO
Inferred from Sequence Orthology
more info
 PubMed 
located_in mitotic spindle ISO
Inferred from Sequence Orthology
more info
 PubMed 
located_in mitotic spindle midzone ISO
Inferred from Sequence Orthology
more info
 PubMed 
located_in mitotic spindle pole ISO
Inferred from Sequence Orthology
more info
 PubMed 

General protein information

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Preferred Names
tetratricopeptide repeat protein 28
Names
TPR repeat protein 28
NP_001254551.1
XP_006534908.1
XP_006534909.1
XP_030110193.1
XP_030110194.1
XP_030110195.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001267622.1 → NP_001254551.1  tetratricopeptide repeat protein 28

    See identical proteins and their annotated locations for NP_001254551.1

    Status: INFERRED

    Source sequence(s)
    AC121934, AC122226, AC124425, AC155173, AW492543, BC046779
    Consensus CDS
    CCDS59682.1
    UniProtKB/Swiss-Prot
    J3QM46, J3QQ36, Q6P9J6, Q80TL5, Q80XJ3, Q8BV10, Q8C0F2
    UniProtKB/TrEMBL
    A0A0A0MQN9
    Related
    ENSMUSP00000137609.2, ENSMUST00000156290.9
    Conserved Domains (7) summary
    smart00028
    Location:388 → 420
    TPR; Tetratricopeptide repeats
    COG0457
    Location:688 → 989
    TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
    sd00006
    Location:85 → 115
    TPR; TPR repeat [structural motif]
    pfam12770
    Location:1384 → 1707
    CHAT; CHAT domain
    pfam13176
    Location:953 → 988
    TPR_7; Tetratricopeptide repeat
    pfam13414
    Location:88 → 151
    TPR_11; TPR repeat
    pfam13424
    Location:309 → 380
    TPR_12; Tetratricopeptide repeat

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    111027652..111437646
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006534845.5 → XP_006534908.1  tetratricopeptide repeat protein 28 isoform X1

    UniProtKB/TrEMBL
    A0A0A0MQN9
    Conserved Domains (5) summary
    PHA03377
    Location:1950 → 2334
    PHA03377; EBNA-3C; Provisional
    TIGR02917
    Location:27 → 838
    PEP_TPR_lipo; putative PEP-CTERM system TPR-repeat lipoprotein
    sd00006
    Location:495 → 523
    TPR; TPR repeat [structural motif]
    pfam12770
    Location:1291 → 1614
    CHAT; CHAT domain
    pfam17874
    Location:733 → 1053
    TPR_MalT; MalT-like TPR region

  2. XM_030254333.2 → XP_030110193.1  tetratricopeptide repeat protein 28 isoform X3

    Conserved Domains (5) summary
    PHA03377
    Location:1884 → 2268
    PHA03377; EBNA-3C; Provisional
    COG0457
    Location:278 → 552
    TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
    sd00006
    Location:429 → 457
    TPR; TPR repeat [structural motif]
    pfam13424
    Location:834 → 904
    TPR_12; Tetratricopeptide repeat
    pfam12770
    Location:1225 → 1548
    CHAT; CHAT domain

  3. XM_030254334.2 → XP_030110194.1  tetratricopeptide repeat protein 28 isoform X3

    Conserved Domains (5) summary
    PHA03377
    Location:1884 → 2268
    PHA03377; EBNA-3C; Provisional
    COG0457
    Location:278 → 552
    TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
    sd00006
    Location:429 → 457
    TPR; TPR repeat [structural motif]
    pfam13424
    Location:834 → 904
    TPR_12; Tetratricopeptide repeat
    pfam12770
    Location:1225 → 1548
    CHAT; CHAT domain

  4. XM_030254335.2 → XP_030110195.1  tetratricopeptide repeat protein 28 isoform X3

    Conserved Domains (5) summary
    PHA03377
    Location:1884 → 2268
    PHA03377; EBNA-3C; Provisional
    COG0457
    Location:278 → 552
    TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
    sd00006
    Location:429 → 457
    TPR; TPR repeat [structural motif]
    pfam13424
    Location:834 → 904
    TPR_12; Tetratricopeptide repeat
    pfam12770
    Location:1225 → 1548
    CHAT; CHAT domain

  5. XM_006534846.5 → XP_006534909.1  tetratricopeptide repeat protein 28 isoform X2

    UniProtKB/TrEMBL
    A0A0A0MQN9
    Conserved Domains (5) summary
    PHA03377
    Location:1931 → 2315
    PHA03377; EBNA-3C; Provisional
    TIGR02917
    Location:9 → 819
    PEP_TPR_lipo; putative PEP-CTERM system TPR-repeat lipoprotein
    sd00006
    Location:476 → 504
    TPR; TPR repeat [structural motif]
    pfam12770
    Location:1272 → 1595
    CHAT; CHAT domain
    pfam17874
    Location:714 → 1034
    TPR_MalT; MalT-like TPR region

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_024477.3: Suppressed sequence

    Description
    NM_024477.3: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q80XJ3.3 GenPept UniProtKB/Swiss-Prot:Q80XJ3

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