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Lpp LIM domain containing preferred translocation partner in lipoma [ Mus musculus (house mouse) ]

Gene ID: 210126, updated on 5-Mar-2024

Summary

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Official Symbol
Lppprovided by MGI
Official Full Name
LIM domain containing preferred translocation partner in lipomaprovided by MGI
Primary source
MGI:MGI:2441849
See related
Ensembl:ENSMUSG00000033306 AllianceGenome:MGI:2441849
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
D630048H16; 9430020K16Rik; B130055L10Rik
Summary
Predicted to enable metal ion binding activity. Predicted to be involved in cell-cell adhesion. Predicted to act upstream of or within cell adhesion. Predicted to be located in cytosol. Predicted to be active in focal adhesion and stress fiber. Is expressed in several structures, including alimentary system; brain; genitourinary system; immune system; and musculoskeletal system. Human ortholog(s) of this gene implicated in acute myeloid leukemia. Orthologous to human LPP (LIM domain containing preferred translocation partner in lipoma). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in bladder adult (RPKM 60.6), subcutaneous fat pad adult (RPKM 8.5) and 10 other tissues See more
Orthologs
human all
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Genomic context

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See Lpp in Genome Data Viewer
Location:
16 B1; 16 16.17 cM
Exon count:
19
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 16 NC_000082.7 (24212100..24811328)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (24393350..24992578)

Chromosome 16 - NC_000082.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_40457 Neighboring gene predicted gene, 41434 Neighboring gene CapStarr-seq enhancer MGSCv37_chr16:24428914-24429115 Neighboring gene BMP2 inducible kinase pseudogene Neighboring gene predicted gene, 24440 Neighboring gene LIM domain containing preferred translocation partner in lipoma, opposite strand Neighboring gene STARR-positive B cell enhancer ABC_E7434 Neighboring gene STARR-seq mESC enhancer starr_40461 Neighboring gene STARR-seq mESC enhancer starr_40463 Neighboring gene mortality factor 4 like 1, pseudogene 1 Neighboring gene STARR-positive B cell enhancer ABC_E2458 Neighboring gene STARR-seq mESC enhancer starr_40465 Neighboring gene microRNA 28a Neighboring gene predicted gene, 22672 Neighboring gene predicted gene, 52245 Neighboring gene STARR-seq mESC enhancer starr_40468 Neighboring gene STARR-seq mESC enhancer starr_40471 Neighboring gene RIKEN cDNA A230028O05 gene Neighboring gene CapStarr-seq enhancer MGSCv37_chr16:25055618-25055819 Neighboring gene STARR-seq mESC enhancer starr_40472 Neighboring gene predicted gene, 52256

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Targeted disruption of the mouse Lipoma Preferred Partner gene. Vervenne HB, et al. Biochem Biophys Res Commun, 2009 Feb 6. PMID 19111675
  2. Truncated and chimeric HMGI-C genes induce neoplastic transformation of NIH3T3 murine fibroblasts. Fedele M, et al. Oncogene, 1998 Jul 30. PMID 9696033
  3. The SHCA adapter protein cooperates with lipoma-preferred partner in the regulation of adhesion dynamics and invadopodia formation. Kiepas A, et al. J Biol Chem, 2020 Jul 31. PMID 32299913, Free PMC Article
  4. Cancer-associated fibroblasts regulate endothelial adhesion protein LPP to promote ovarian cancer chemoresistance. Leung CS, et al. J Clin Invest, 2018 Feb 1. PMID 29251630, Free PMC Article
  5. The focal adhesion and nuclear targeting capacity of the LIM-containing lipoma-preferred partner (LPP) protein. Petit MM, et al. J Biol Chem, 2003 Jan 24. PMID 12441356

See all (44) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The SHCA adapter protein cooperates with lipoma-preferred partner in the regulation of adhesion dynamics and invadopodia formation.
    Title: The SHCA adapter protein cooperates with lipoma-preferred partner in the regulation of adhesion dynamics and invadopodia formation.
  2. cancer-associated fibroblasts regulate endothelial LPP via a calcium-dependent signaling pathway involving microfibrillar-associated protein 5 (MFAP5), focal adhesion kinase (FAK), ERK, and LPP
    Title: Cancer-associated fibroblasts regulate endothelial adhesion protein LPP to promote ovarian cancer chemoresistance.
  3. Inactivation of Rho kinase (ROK) with ROK inhibitors significantly inhibited LPP mRNA expression in TGF-beta1-treated SMPCs.
    Title: TGF-β1-induced LPP expression dependant on Rho kinase during differentiation and migration of bone marrow-derived smooth muscle progenitor cells.
  4. interaction between LPP and alpha-actinin, an actin cross-linking protein, is necessary for TGFbeta-induced migration and invasion of ErbB2-expressing breast cancer cells.
    Title: A complex containing LPP and α-actinin mediates TGFβ-induced migration and invasion of ErbB2-expressing breast cancer cells.
  5. Mice with a targeted disruption of the Lpp gene were generated, and the importance of Lpp for embryonic development and adult functions was analysed.
    Title: Targeted disruption of the mouse Lipoma Preferred Partner gene.
  6. expression of LPP in smooth muscle is mediated by an alternative promoter that is regulated by SRF/myocardin.
    Title: Smooth muscle expression of lipoma preferred partner is mediated by an alternative intronic promoter that is regulated by serum response factor/myocardin.
  7. LPP contains specific domains that enable its focal adhesion and nuclear targeting capacity [LIM-containing lipoma-preferred partner [LPP]
    Title: The focal adhesion and nuclear targeting capacity of the LIM-containing lipoma-preferred partner (LPP) protein.
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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (3)  1 citation
  • Endonuclease-mediated (1) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within cell adhesion IEA
Inferred from Electronic Annotation
more info
  
involved_in cell-cell adhesion IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in anchoring junction IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
is_active_in focal adhesion IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in focal adhesion ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
is_active_in stress fiber IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
lipoma-preferred partner homolog
Names
lipoma preferred partner

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001145952.1 → NP_001139424.1  lipoma-preferred partner homolog isoform 1

    See identical proteins and their annotated locations for NP_001139424.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same isoform (1).
    Source sequence(s)
    AC135567, AK040643, AK050035, AK054550, AK085890, BF018106
    Consensus CDS
    CCDS28083.1
    UniProtKB/Swiss-Prot
    Q5U407, Q8BFW7, Q8BHI1, Q8BKI0, Q8BKN2, Q8BLF4, Q8BLG3, Q8C101
    Related
    ENSMUSP00000078005.3, ENSMUST00000078988.10
    Conserved Domains (4) summary
    cd09350
    Location:417 → 470
    LIM1_TRIP6; The first LIM domain of Thyroid receptor-interacting protein 6 (TRIP6)
    PRK14086
    Location:192 → 388
    dnaA; chromosomal replication initiator protein DnaA
    PRK14971
    Location:139 → 240
    PRK14971; DNA polymerase III subunit gamma/tau
    cl02475
    Location:537 → 602
    LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers

  2. NM_001145954.1 → NP_001139426.1  lipoma-preferred partner homolog isoform 2

    See identical proteins and their annotated locations for NP_001139426.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at an alternate start codon, compared to variant 1. This results in a shorter isoform (2) with a distinct N-terminus compared to isoform 1.
    Source sequence(s)
    AC135567, AK029567, AK040643, AK050035, AK085890, BF018106
    Consensus CDS
    CCDS49807.1
    UniProtKB/Swiss-Prot
    Q8BFW7
    Related
    ENSMUSP00000110969.3, ENSMUST00000115314.4
    Conserved Domains (3) summary
    cd09350
    Location:292 → 345
    LIM1_TRIP6; The first LIM domain of Thyroid receptor-interacting protein 6 (TRIP6)
    cl02475
    Location:412 → 477
    LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers
    cl08186
    Location:42 → 160
    DUF3251; Protein of unknown function (DUF3251)

  3. NM_178665.5 → NP_848780.3  lipoma-preferred partner homolog isoform 1

    See identical proteins and their annotated locations for NP_848780.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the predominant transcript. Variants 1 and 2 encode the same isoform (1).
    Source sequence(s)
    AC135567, AK040643, AK050035, AK085890, BF018106, CJ166632
    Consensus CDS
    CCDS28083.1
    UniProtKB/Swiss-Prot
    Q5U407, Q8BFW7, Q8BHI1, Q8BKI0, Q8BKN2, Q8BLF4, Q8BLG3, Q8C101
    Related
    ENSMUSP00000036304.7, ENSMUST00000038053.14
    Conserved Domains (4) summary
    cd09350
    Location:417 → 470
    LIM1_TRIP6; The first LIM domain of Thyroid receptor-interacting protein 6 (TRIP6)
    PRK14086
    Location:192 → 388
    dnaA; chromosomal replication initiator protein DnaA
    PRK14971
    Location:139 → 240
    PRK14971; DNA polymerase III subunit gamma/tau
    cl02475
    Location:537 → 602
    LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000082.7 Reference GRCm39 C57BL/6J

    Range
    24212100..24811328
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017316922.3 → XP_017172411.1  lipoma-preferred partner homolog isoform X2

    Conserved Domains (4) summary
    cd09350
    Location:416 → 469
    LIM1_TRIP6; The first LIM domain of Thyroid receptor-interacting protein 6 (TRIP6)
    PRK14086
    Location:191 → 387
    dnaA; chromosomal replication initiator protein DnaA
    PRK14971
    Location:138 → 239
    PRK14971; DNA polymerase III subunit gamma/tau
    cl02475
    Location:536 → 601
    LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers

  2. XM_030249029.1 → XP_030104889.1  lipoma-preferred partner homolog isoform X1

    UniProtKB/Swiss-Prot
    Q5U407, Q8BFW7, Q8BHI1, Q8BKI0, Q8BKN2, Q8BLF4, Q8BLG3, Q8C101
    Conserved Domains (4) summary
    cd09350
    Location:417 → 470
    LIM1_TRIP6; The first LIM domain of Thyroid receptor-interacting protein 6 (TRIP6)
    PRK14086
    Location:192 → 388
    dnaA; chromosomal replication initiator protein DnaA
    PRK14971
    Location:139 → 240
    PRK14971; DNA polymerase III subunit gamma/tau
    cl02475
    Location:537 → 602
    LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers

  3. XM_030249032.1 → XP_030104892.1  lipoma-preferred partner homolog isoform X2

    Conserved Domains (4) summary
    cd09350
    Location:416 → 469
    LIM1_TRIP6; The first LIM domain of Thyroid receptor-interacting protein 6 (TRIP6)
    PRK14086
    Location:191 → 387
    dnaA; chromosomal replication initiator protein DnaA
    PRK14971
    Location:138 → 239
    PRK14971; DNA polymerase III subunit gamma/tau
    cl02475
    Location:536 → 601
    LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers

  4. XM_006521957.5 → XP_006522020.1  lipoma-preferred partner homolog isoform X1

    See identical proteins and their annotated locations for XP_006522020.1

    UniProtKB/Swiss-Prot
    Q5U407, Q8BFW7, Q8BHI1, Q8BKI0, Q8BKN2, Q8BLF4, Q8BLG3, Q8C101
    Conserved Domains (4) summary
    cd09350
    Location:417 → 470
    LIM1_TRIP6; The first LIM domain of Thyroid receptor-interacting protein 6 (TRIP6)
    PRK14086
    Location:192 → 388
    dnaA; chromosomal replication initiator protein DnaA
    PRK14971
    Location:139 → 240
    PRK14971; DNA polymerase III subunit gamma/tau
    cl02475
    Location:537 → 602
    LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers

  5. XM_030249028.2 → XP_030104888.1  lipoma-preferred partner homolog isoform X1

    UniProtKB/Swiss-Prot
    Q5U407, Q8BFW7, Q8BHI1, Q8BKI0, Q8BKN2, Q8BLF4, Q8BLG3, Q8C101
    Conserved Domains (4) summary
    cd09350
    Location:417 → 470
    LIM1_TRIP6; The first LIM domain of Thyroid receptor-interacting protein 6 (TRIP6)
    PRK14086
    Location:192 → 388
    dnaA; chromosomal replication initiator protein DnaA
    PRK14971
    Location:139 → 240
    PRK14971; DNA polymerase III subunit gamma/tau
    cl02475
    Location:537 → 602
    LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers

  6. XM_030249031.1 → XP_030104891.1  lipoma-preferred partner homolog isoform X1

    UniProtKB/Swiss-Prot
    Q5U407, Q8BFW7, Q8BHI1, Q8BKI0, Q8BKN2, Q8BLF4, Q8BLG3, Q8C101
    Conserved Domains (4) summary
    cd09350
    Location:417 → 470
    LIM1_TRIP6; The first LIM domain of Thyroid receptor-interacting protein 6 (TRIP6)
    PRK14086
    Location:192 → 388
    dnaA; chromosomal replication initiator protein DnaA
    PRK14971
    Location:139 → 240
    PRK14971; DNA polymerase III subunit gamma/tau
    cl02475
    Location:537 → 602
    LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers

  7. XM_030249030.2 → XP_030104890.1  lipoma-preferred partner homolog isoform X1

    UniProtKB/Swiss-Prot
    Q5U407, Q8BFW7, Q8BHI1, Q8BKI0, Q8BKN2, Q8BLF4, Q8BLG3, Q8C101
    Conserved Domains (4) summary
    cd09350
    Location:417 → 470
    LIM1_TRIP6; The first LIM domain of Thyroid receptor-interacting protein 6 (TRIP6)
    PRK14086
    Location:192 → 388
    dnaA; chromosomal replication initiator protein DnaA
    PRK14971
    Location:139 → 240
    PRK14971; DNA polymerase III subunit gamma/tau
    cl02475
    Location:537 → 602
    LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8BFW7.1 GenPept UniProtKB/Swiss-Prot:Q8BFW7

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