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Mtmr9 myotubularin related protein 9 [ Mus musculus (house mouse) ]

Gene ID: 210376, updated on 5-Mar-2024

Summary

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Official Symbol
Mtmr9provided by MGI
Official Full Name
myotubularin related protein 9provided by MGI
Primary source
MGI:MGI:2442842
See related
Ensembl:ENSMUSG00000035078 AllianceGenome:MGI:2442842
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
MTMR8; mMTMH3; LIP-STYX; 9430075G12Rik
Summary
Enables enzyme regulator activity. Predicted to be involved in several processes, including phosphatidylinositol dephosphorylation; protein stabilization; and regulation of dephosphorylation. Predicted to act upstream of or within endocytosis. Predicted to be located in cytosol. Predicted to be part of protein-containing complex. Predicted to be active in cytoplasm and membrane. Is expressed in cranial ganglion; dorsal root ganglion; and trigeminal nerve. Orthologous to human MTMR9 (myotubularin related protein 9). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in CNS E18 (RPKM 15.6), whole brain E14.5 (RPKM 14.8) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
14 D1; 14 33.32 cM
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (63757100..63781402, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (63519651..63544027, complement)

Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_36924 Neighboring gene family with sequence similarity 167, member A Neighboring gene STARR-seq mESC enhancer starr_36926 Neighboring gene predicted gene 17232 Neighboring gene L-threonine dehydrogenase Neighboring gene STARR-positive B cell enhancer ABC_E8564 Neighboring gene VISTA enhancer mm1542 Neighboring gene predicted gene 15918 Neighboring gene STARR-seq mESC enhancer starr_36930 Neighboring gene X-linked Kx blood group related 6 Neighboring gene STARR-seq mESC enhancer starr_36931 Neighboring gene predicted gene, 38524

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. The role of myotubularin-related phosphatases in the control of autophagy and programmed cell death. Zou J, et al. Adv Biol Regul, 2012 Jan. PMID 22056831, Free PMC Article
  2. Lipid phosphatases identified by screening a mouse phosphatase shRNA library regulate T-cell differentiation and protein kinase B AKT signaling. Guo L, et al. Proc Natl Acad Sci U S A, 2013 May 14. PMID 23630283, Free PMC Article
  3. Regulation of leptin by agouti. Claycombe KJ, et al. Physiol Genomics, 2000 Apr 27. PMID 11015588
  4. Sequential breakdown of 3-phosphorylated phosphoinositides is essential for the completion of macropinocytosis. Maekawa M, et al. Proc Natl Acad Sci U S A, 2014 Mar 18. PMID 24591580, Free PMC Article
  5. Characterization of myotubularin-related protein 7 and its binding partner, myotubularin-related protein 9. Mochizuki Y, et al. Proc Natl Acad Sci U S A, 2003 Aug 19. PMID 12890864, Free PMC Article

See all (19) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. MTMR7 forms a complex with MTMR9 and dephosphorylates phosphatidylinositol 3-phosphate and Ins(1,3)P2 in neuronal cells.
    Title: Characterization of myotubularin-related protein 7 and its binding partner, myotubularin-related protein 9.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC54783

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables enzyme regulator activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein phosphatase binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein phosphatase binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within endocytosis IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of autophagy IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of autophagy ISO
Inferred from Sequence Orthology
more info
  
involved_in phosphatidylinositol dephosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of phosphatase activity ISO
Inferred from Sequence Orthology
more info
  
involved_in protein stabilization ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of phosphatidylinositol dephosphorylation ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cell projection IEA
Inferred from Electronic Annotation
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol TAS
Traceable Author Statement
more info
  
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
part_of protein-containing complex ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
myotubularin-related protein 9
Names
inactive phosphatidylinositol 3-phosphatase 9

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_177594.1 → NP_808262.1  myotubularin-related protein 9

    See identical proteins and their annotated locations for NP_808262.1

    Status: PROVISIONAL

    Source sequence(s)
    BC046275
    Consensus CDS
    CCDS27203.1
    UniProtKB/Swiss-Prot
    A6H6P1, Q80XL4, Q9Z2D0
    UniProtKB/TrEMBL
    Q3U896
    Related
    ENSMUSP00000059894.6, ENSMUST00000058679.7
    Conserved Domains (2) summary
    cd13211
    Location:1 → 97
    PH-GRAM_MTMR9; Myotubularian (MTM) related 9 protein (MTMR9) Pleckstrin Homology-Glucosyltransferases, Rab-like GTPase activators and Myotubularins (PH-GRAM) domain
    pfam06602
    Location:108 → 444
    Myotub-related; Myotubularin-like phosphatase domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000080.7 Reference GRCm39 C57BL/6J

    Range
    63757100..63781402 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030247706.2 → XP_030103566.1  myotubularin-related protein 9 isoform X1

    UniProtKB/TrEMBL
    Q3U896
    Conserved Domains (1) summary
    pfam06602
    Location:23 → 360
    Myotub-related; Myotubularin-like phosphatase domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9Z2D0.2 GenPept UniProtKB/Swiss-Prot:Q9Z2D0

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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