U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

ESRRG estrogen related receptor gamma [ Homo sapiens (human) ]

Gene ID: 2104, updated on 11-Apr-2024

Summary

Go to the top of the page Help
Official Symbol
ESRRGprovided by HGNC
Official Full Name
estrogen related receptor gammaprovided by HGNC
Primary source
HGNC:HGNC:3474
See related
Ensembl:ENSG00000196482 MIM:602969; AllianceGenome:HGNC:3474
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ERR3; ERRg; NR3B3; ERRgamma; ERR-gamma
Summary
This gene encodes a member of the estrogen receptor-related receptor (ESRR) family, which belongs to the nuclear hormone receptor superfamily. All members of the ESRR family share an almost identical DNA binding domain, which is composed of two C4-type zinc finger motifs. The ESRR members are orphan nuclear receptors; they bind to the estrogen response element and steroidogenic factor 1 response element, and activate genes controlled by both response elements in the absence of any ligands. The ESRR family is closely related to the estrogen receptor (ER) family. They share target genes, co-regulators and promoters, and by targeting the same set of genes, the ESRRs seem to interfere with the ER-mediated estrogen response in various ways. It has been reported that the family member encoded by this gene functions as a transcriptional activator of DNA cytosine-5-methyltransferases 1 (Dnmt1) expression by direct binding to its response elements in the DNMT1 promoters, modulates cell proliferation and estrogen signaling in breast cancer, and negatively regulates bone morphogenetic protein 2-induced osteoblast differentiation and bone formation. Multiple alternatively spliced transcript variants have been identified, which mainly differ at the 5' end and some of which encode protein isoforms differing in the N-terminal region. [provided by RefSeq, Aug 2011]
Expression
Biased expression in kidney (RPKM 4.4), stomach (RPKM 3.1) and 12 other tissues See more
Orthologs
mouse all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Location:
1q41
Exon count:
29
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (216503246..217137702, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (215743580..216378774, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (216676588..217311044, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene usherin Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr1:216419825-216420431 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_4209 Neighboring gene USH2A antisense RNA 1 Neighboring gene mitochondrial ribosomal protein S18B pseudogene 1 Neighboring gene ReSE screen-validated silencer GRCh37_chr1:216566486-216566587 Neighboring gene uncharacterized LOC107985596 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:216659268-216659830 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr1:216771579-216772306 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr1:216773848-216774416 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1817 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2536 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_4286 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_4347 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_4384 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr1:216913568-216914135 Neighboring gene uncharacterized LOC124904512 Neighboring gene ReSE screen-validated silencer GRCh37_chr1:217086328-217086517 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_4410 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:217168113-217168612 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_4481 Neighboring gene Sharpr-MPRA regulatory region 1545 Neighboring gene MPRA-validated peak697 silencer Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:217307024-217307790 Neighboring gene Sharpr-MPRA regulatory region 11696 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:217309339-217310050 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:217310051-217310761 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:217311473-217312183 Neighboring gene uncharacterized LOC107985461 Neighboring gene uncharacterized LOC105372920

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Nuclear receptor estrogen-related receptor gamma suppresses colorectal cancer aggressiveness by regulating Wnt/β-catenin signaling. Guo X, et al. Carcinogenesis, 2022 Oct 22. PMID 35728800
  2. Sex-specific effects of bisphenol A on the signaling pathway of ESRRG in the human placenta†. Zou Z, et al. Biol Reprod, 2022 Jun 13. PMID 35220427, Free PMC Article
  3. ESRRG promoter hypermethylation as a diagnostic and prognostic biomarker in laryngeal squamous cell carcinoma. Shen Z, et al. J Clin Lab Anal, 2019 Jul. PMID 31002184, Free PMC Article
  4. Estrogen-related receptor gamma functions as a tumor suppressor in gastric cancer. Kang MH, et al. Nat Commun, 2018 May 15. PMID 29765046, Free PMC Article
  5. Influence of estrogen-related receptor γ (ESRRG) rs1890552 A > G polymorphism on changes in fasting glucose and arterial stiffness. Kim M, et al. Sci Rep, 2017 Aug 29. PMID 28852080, Free PMC Article

See all (127) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. ERRgamma-inducible FGF23 promotes alcoholic liver injury through enhancing CYP2E1 mediated hepatic oxidative stress.
    Title: ERRγ-inducible FGF23 promotes alcoholic liver injury through enhancing CYP2E1 mediated hepatic oxidative stress.
  2. Estrogen receptor-related receptor gamma uppresses hypoxia-induced angiogenesis by regulating VEGFA in endometrial cancer.
    Title: Estrogen receptor-related receptor γ uppresses hypoxia-induced angiogenesis by regulating VEGFA in endometrial cancer.
  3. Role of Estrogen-Related Receptor gamma and PGC-1alpha/SIRT3 Pathway in Early Brain Injury After Subarachnoid Hemorrhage.
    Title: Role of Estrogen-Related Receptor γ and PGC-1α/SIRT3 Pathway in Early Brain Injury After Subarachnoid Hemorrhage.
  4. Nuclear receptor estrogen-related receptor gamma suppresses colorectal cancer aggressiveness by regulating Wnt/beta-catenin signaling.
    Title: Nuclear receptor estrogen-related receptor gamma suppresses colorectal cancer aggressiveness by regulating Wnt/β-catenin signaling.
  5. Sex-specific effects of bisphenol A on the signaling pathway of ESRRG in the human placentadagger.
    Title: Sex-specific effects of bisphenol A on the signaling pathway of ESRRG in the human placenta†.
  6. The nuclear receptor ERR cooperates with the cardiogenic factor GATA4 to orchestrate cardiomyocyte maturation.
    Title: The nuclear receptor ERR cooperates with the cardiogenic factor GATA4 to orchestrate cardiomyocyte maturation.
  7. Lupus susceptibility gene Esrrg modulates regulatory T cells through mitochondrial metabolism.
    Title: Lupus susceptibility gene Esrrg modulates regulatory T cells through mitochondrial metabolism.
  8. Estrogen-related receptor-gamma influences Helicobacter pylori infection by regulating TFF1 in gastric cancer.
    Title: Estrogen-related receptor-gamma influences Helicobacter pylori infection by regulating TFF1 in gastric cancer.
  9. Expression of estrogen-related receptors in ovarian cancer and impact on survival.
    Title: Expression of estrogen-related receptors in ovarian cancer and impact on survival.
  10. Orphan Nuclear Receptor ERRgamma Is a Transcriptional Regulator of CB1 Receptor-Mediated TFR2 Gene Expression in Hepatocytes.
    Title: Orphan Nuclear Receptor ERRγ Is a Transcriptional Regulator of CB1 Receptor-Mediated TFR2 Gene Expression in Hepatocytes.
Submit: New GeneRIF Correction See all GeneRIFs (76)

Phenotypes

Go to the top of the page Help

Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
A meta-analysis of two genome-wide association studies to identify novel loci for maximum number of alcoholic drinks.
EBI GWAS Catalog
Common genetic variation and antidepressant efficacy in major depressive disorder: a meta-analysis of three genome-wide pharmacogenetic studies.
EBI GWAS Catalog
Gene-alcohol interactions identify several novel blood pressure loci including a promising locus near SLC16A9.
EBI GWAS Catalog
Genome-wide association identifies ATOH7 as a major gene determining human optic disc size.
EBI GWAS Catalog
Genome-wide association scan for survival on dialysis in African-Americans with type 2 diabetes.
EBI GWAS Catalog
Genome-wide association study of chemotherapeutic agent-induced severe neutropenia/leucopenia for patients in Biobank Japan.
EBI GWAS Catalog
Hypertrophy-associated polymorphisms ascertained in a founder cohort applied to heart failure risk and mortality.
EBI GWAS Catalog

Variation

Go to the top of the page Help

See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Homology

Clone Names

  • FLJ16023, KIAA0832, DKFZp781L1617

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables AF-2 domain binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables DNA-binding transcription activator activity, RNA polymerase II-specific IEA
Inferred from Electronic Annotation
more info
  
enables DNA-binding transcription factor activity, RNA polymerase II-specific ISA
Inferred from Sequence Alignment
more info
  
enables estrogen response element binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables nuclear receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables nuclear steroid receptor activity IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables sequence-specific double-stranded DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables steroid binding IEA
Inferred from Electronic Annotation
more info
  
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in intracellular steroid hormone receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of cold-induced thermogenesis ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
involved_in positive regulation of transcription by RNA polymerase II ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in regulation of DNA-templated transcription IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in retinoic acid receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of chromatin IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of chromatin ISA
Inferred from Sequence Alignment
more info
  
located_in nucleoplasm TAS
Traceable Author Statement
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

Go to the top of the page Help
Preferred Names
estrogen-related receptor gamma
Names
ERR gamma-2
estrogen receptor-related protein 3
nuclear receptor subfamily 3 group B member 3

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_029784.1 RefSeqGene

    Range
    419327..639505
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001134285.3 → NP_001127757.1  estrogen-related receptor gamma isoform 2

    See identical proteins and their annotated locations for NP_001127757.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) lacks the 5' exon but has three alternate 5' exons and uses a downstream AUG start codon, compared to variant 1. The resulting isoform (2) is shorter at the N-terminus, compared to isoform 1. Variants 2-4, 9-15, and 17-21 encode the same isoform.
    Source sequence(s)
    AB020639, BU752915, BX647076
    Consensus CDS
    CCDS1517.1
    UniProtKB/TrEMBL
    C0SQ93, F1D8R6
    Related
    ENSP00000355907.2, ENST00000366940.6
    Conserved Domains (2) summary
    cd06946
    Location:214 → 433
    NR_LBD_ERR; The ligand binding domain of estrogen receptor-related nuclear receptors
    cd07170
    Location:99 → 195
    NR_DBD_ERR; DNA-binding domain of estrogen related receptors (ERR) is composed of two C4-type zinc fingers

  2. NM_001243505.2 → NP_001230434.1  estrogen-related receptor gamma isoform 3

    See identical proteins and their annotated locations for NP_001230434.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6) lacks three exons from the 5' end but has alternate three 5' exons and uses a downstream AUG start codon, compared to variant 1. The resulting isoform (3) is shorter at the N-terminus, compared to isoform 1.
    Source sequence(s)
    AB020639, BM723962, BU752915
    UniProtKB/Swiss-Prot
    P62508
    Conserved Domains (1) summary
    cd06946
    Location:1 → 205
    NR_LBD_ERR; The ligand binding domain of estrogen receptor-related nuclear receptors

  3. NM_001243506.2 → NP_001230435.1  estrogen-related receptor gamma isoform 4

    See identical proteins and their annotated locations for NP_001230435.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (7) lacks two exons from the 5' end but has two alternate 5' exons and uses a downstream AUG start codon, compared to variant 1. The resulting isoform (4) is shorter at the N-terminus, compared to isoform 1.
    Source sequence(s)
    AB020639, AK298851, BP349857, BU752915
    UniProtKB/TrEMBL
    B7Z5E9
    Conserved Domains (2) summary
    cd06946
    Location:52 → 271
    NR_LBD_ERR; The ligand binding domain of estrogen receptor-related nuclear receptors
    cl02596
    Location:1 → 33
    NR_DBD_like; DNA-binding domain of nuclear receptors is composed of two C4-type zinc fingers

  4. NM_001243507.2 → NP_001230436.1  estrogen-related receptor gamma isoform 5

    See identical proteins and their annotated locations for NP_001230436.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (8) lacks a 5' exon and an internal in-frame exon but has three alternate 5' exons and uses a downstream AUG start codon, compared to variant 1. The resulting isoform (5, also known as ERRgamma3) is shorter at the N-terminus and lacks an internal segment corresponding to the second zinc finger motif of the DNA binding domain (PMID:16460929), compared to isoform 1.
    Source sequence(s)
    AB020639, AB362218, AC096634, AK131193, BU752915, DB220304
    Consensus CDS
    CCDS58060.1
    UniProtKB/TrEMBL
    C0SQ93
    Related
    ENSP00000418629.1, ENST00000463665.5
    Conserved Domains (2) summary
    cd06946
    Location:175 → 394
    NR_LBD_ERR; The ligand binding domain of estrogen receptor-related nuclear receptors
    cl02596
    Location:99 → 156
    NR_DBD_like; DNA-binding domain of nuclear receptors is composed of two C4-type zinc fingers

  5. NM_001243509.2 → NP_001230438.1  estrogen-related receptor gamma isoform 2

    See identical proteins and their annotated locations for NP_001230438.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (9) lacks the 5' exon but has three alternate 5' exons and uses a downstream AUG start codon, compared to variant 1. The resulting isoform (2) is shorter at the N-terminus, compared to isoform 1. Variants 2-4, 9-15, and 17-21 encode the same isoform.
    Source sequence(s)
    AB020639, AB362218, AC096634, BU752915, DB220304
    Consensus CDS
    CCDS1517.1
    UniProtKB/TrEMBL
    C0SQ93, F1D8R6
    Related
    ENSP00000417374.1, ENST00000493748.5
    Conserved Domains (2) summary
    cd06946
    Location:214 → 433
    NR_LBD_ERR; The ligand binding domain of estrogen receptor-related nuclear receptors
    cd07170
    Location:99 → 195
    NR_DBD_ERR; DNA-binding domain of estrogen related receptors (ERR) is composed of two C4-type zinc fingers

  6. NM_001243510.3 → NP_001230439.1  estrogen-related receptor gamma isoform 2

    See identical proteins and their annotated locations for NP_001230439.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (10) uses an alternate exon structure in the 5' UTR and 5' coding region, compared to variant 1. This results in a distinct 5' UTR and use of a downstream in-frame start codon. The encoded isoform (2) has a shorter N-terminus compared to isoform 1. Variants 2-4, 9-15, and 17-21 encode the same isoform.
    Source sequence(s)
    AB020639, AY388457, BU752915, BX647076, DA293919
    Consensus CDS
    CCDS1517.1
    UniProtKB/TrEMBL
    C0SQ93, F1D8R6
    Related
    ENSP00000419594.1, ENST00000493603.5
    Conserved Domains (2) summary
    cd06946
    Location:214 → 433
    NR_LBD_ERR; The ligand binding domain of estrogen receptor-related nuclear receptors
    cd07170
    Location:99 → 195
    NR_DBD_ERR; DNA-binding domain of estrogen related receptors (ERR) is composed of two C4-type zinc fingers

  7. NM_001243511.3 → NP_001230440.1  estrogen-related receptor gamma isoform 2

    See identical proteins and their annotated locations for NP_001230440.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (11) uses an alternate exon structure in the 5' UTR and 5' coding region, compared to variant 1. This results in a distinct 5' UTR and use of a downstream in-frame start codon. The encoded isoform (2) has a shorter N-terminus compared to isoform 1. Variants 2-4, 9-15, and 17-21 encode the same isoform.
    Source sequence(s)
    AB020639, AY388460, BU752915, BX647076, DA293919
    Consensus CDS
    CCDS1517.1
    UniProtKB/TrEMBL
    C0SQ93, F1D8R6
    Conserved Domains (2) summary
    cd06946
    Location:214 → 433
    NR_LBD_ERR; The ligand binding domain of estrogen receptor-related nuclear receptors
    cd07170
    Location:99 → 195
    NR_DBD_ERR; DNA-binding domain of estrogen related receptors (ERR) is composed of two C4-type zinc fingers

  8. NM_001243512.1 → NP_001230441.1  estrogen-related receptor gamma isoform 2

    See identical proteins and their annotated locations for NP_001230441.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (12) lacks the 5' exon but has more than three alternate 5' exons and uses a downstream AUG start codon, compared to variant 1. The resulting isoform (2) is shorter at the N-terminus, compared to isoform 1. Variants 2-4, 9-15, and 17-21 encode the same isoform.
    Source sequence(s)
    AB020639, AB362218, AK131193, AY388458, BU752915
    Consensus CDS
    CCDS1517.1
    UniProtKB/TrEMBL
    C0SQ93, F1D8R6
    Related
    ENSP00000419155.1, ENST00000487276.5
    Conserved Domains (2) summary
    cd06946
    Location:214 → 433
    NR_LBD_ERR; The ligand binding domain of estrogen receptor-related nuclear receptors
    cd07170
    Location:99 → 195
    NR_DBD_ERR; DNA-binding domain of estrogen related receptors (ERR) is composed of two C4-type zinc fingers

  9. NM_001243513.1 → NP_001230442.1  estrogen-related receptor gamma isoform 2

    See identical proteins and their annotated locations for NP_001230442.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (13) lacks the 5' exon but has more than two alternate 5' exons and uses a downstream AUG start codon, compared to variant 1. The resulting isoform (2) is shorter at the N-terminus, compared to isoform 1. Variants 2-4, 9-15, and 17-21 encode the same isoform.
    Source sequence(s)
    AB020639, AB362218, AY388459, BU752915
    Consensus CDS
    CCDS1517.1
    UniProtKB/TrEMBL
    C0SQ93, F1D8R6
    Related
    ENSP00000355905.2, ENST00000366938.6
    Conserved Domains (2) summary
    cd06946
    Location:214 → 433
    NR_LBD_ERR; The ligand binding domain of estrogen receptor-related nuclear receptors
    cd07170
    Location:99 → 195
    NR_DBD_ERR; DNA-binding domain of estrogen related receptors (ERR) is composed of two C4-type zinc fingers

  10. NM_001243514.2 → NP_001230443.1  estrogen-related receptor gamma isoform 2

    See identical proteins and their annotated locations for NP_001230443.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (14) lacks the 5' exon but has an alternate 5' exon and uses a downstream AUG start codon, compared to variant 1. The resulting isoform (2) is shorter at the N-terminus, compared to isoform 1. Variants 2-4, 9-15, and 17-21 encode the same isoform.
    Source sequence(s)
    AB020639, AC096635, AY388461, BU752915
    Consensus CDS
    CCDS1517.1
    UniProtKB/TrEMBL
    C0SQ93, F1D8R6
    Related
    ENSP00000353108.3, ENST00000360012.7
    Conserved Domains (2) summary
    cd06946
    Location:214 → 433
    NR_LBD_ERR; The ligand binding domain of estrogen receptor-related nuclear receptors
    cd07170
    Location:99 → 195
    NR_DBD_ERR; DNA-binding domain of estrogen related receptors (ERR) is composed of two C4-type zinc fingers

  11. NM_001243515.2 → NP_001230444.1  estrogen-related receptor gamma isoform 2

    See identical proteins and their annotated locations for NP_001230444.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (15) has two additional exons in the 5' region and uses a downstream AUG start codon, compared to variant 1. The resulting isoform (2) is shorter at the N-terminus, compared to isoform 1. Variants 2-4, 9-15, and 17-21 encode the same isoform.
    Source sequence(s)
    AB020639, AK290945, BU752915, DA720944, DA722064
    Consensus CDS
    CCDS1517.1
    UniProtKB/TrEMBL
    C0SQ93, F1D8R6
    Conserved Domains (2) summary
    cd06946
    Location:214 → 433
    NR_LBD_ERR; The ligand binding domain of estrogen receptor-related nuclear receptors
    cd07170
    Location:99 → 195
    NR_DBD_ERR; DNA-binding domain of estrogen related receptors (ERR) is composed of two C4-type zinc fingers

  12. NM_001243518.2 → NP_001230447.1  estrogen-related receptor gamma isoform 6

    See identical proteins and their annotated locations for NP_001230447.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (16) has an additional exon in the 5' region, which includes an AUG start codon, and an additional segment in the middle region, compared to variant 1. The resulting isoform (6) has a longer and distinct N-terminus and an additional internal segment, compared to isoform 1.
    Source sequence(s)
    AB020639, BC064700, BU752915
    Consensus CDS
    CCDS58061.1
    UniProtKB/TrEMBL
    C0SQ93
    Related
    ENSP00000355904.1, ENST00000366937.5
    Conserved Domains (2) summary
    cd06946
    Location:249 → 468
    NR_LBD_ERR; The ligand binding domain of estrogen receptor-related nuclear receptors
    cd07170
    Location:127 → 223
    NR_DBD_ERR; DNA-binding domain of estrogen related receptors (ERR) is composed of two C4-type zinc fingers

  13. NM_001243519.2 → NP_001230448.1  estrogen-related receptor gamma isoform 2

    See identical proteins and their annotated locations for NP_001230448.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (17) has an additional segment in the 5' region and uses a downstream AUG start codon, compared to variant 1. The resulting isoform (2) is shorter at the N-terminus, compared to isoform 1. Variants 2-4, 9-15, and 17-21 encode the same isoform.
    Source sequence(s)
    AB020639, BC008218, BU752915, DA720944
    Consensus CDS
    CCDS1517.1
    UniProtKB/TrEMBL
    C0SQ93, F1D8R6
    Related
    ENSP00000375761.4, ENST00000391890.7
    Conserved Domains (2) summary
    cd06946
    Location:214 → 433
    NR_LBD_ERR; The ligand binding domain of estrogen receptor-related nuclear receptors
    cd07170
    Location:99 → 195
    NR_DBD_ERR; DNA-binding domain of estrogen related receptors (ERR) is composed of two C4-type zinc fingers

  14. NM_001350122.2 → NP_001337051.1  estrogen-related receptor gamma isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (18) lacks the 5' exon but has four alternate 5' exons and uses a downstream AUG start codon, compared to variant 1. The resulting isoform (2) is shorter at the N-terminus, compared to isoform 1. Variants 2-4, 9-15, and 17-21 encode the same isoform.
    Source sequence(s)
    AB020639, AC096634, AL603752, BU752915, CA397450, DA215341, DA293919, DB220304
    Consensus CDS
    CCDS1517.1
    UniProtKB/TrEMBL
    C0SQ93, F1D8R6
    Conserved Domains (2) summary
    cd06946
    Location:214 → 433
    NR_LBD_ERR; The ligand binding domain of estrogen receptor-related nuclear receptors
    cd07170
    Location:99 → 195
    NR_DBD_ERR; DNA-binding domain of estrogen related receptors (ERR) is composed of two C4-type zinc fingers

  15. NM_001350123.2 → NP_001337052.1  estrogen-related receptor gamma isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (19) lacks the 5' exon but has three alternate 5' exons and uses a downstream AUG start codon, compared to variant 1. The resulting isoform (2) is shorter at the N-terminus, compared to isoform 1. Variants 2-4, 9-15, and 17-21 encode the same isoform.
    Source sequence(s)
    AB020639, BU752915, CA397450, DB220304
    Consensus CDS
    CCDS1517.1
    UniProtKB/TrEMBL
    C0SQ93, F1D8R6
    Conserved Domains (2) summary
    cd06946
    Location:214 → 433
    NR_LBD_ERR; The ligand binding domain of estrogen receptor-related nuclear receptors
    cd07170
    Location:99 → 195
    NR_DBD_ERR; DNA-binding domain of estrogen related receptors (ERR) is composed of two C4-type zinc fingers

  16. NM_001350124.2 → NP_001337053.1  estrogen-related receptor gamma isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (20) lacks the 5' exon but has four alternate 5' exons and uses a downstream AUG start codon, compared to variant 1. The resulting isoform (2) is shorter at the N-terminus, compared to isoform 1. Variants 2-4, 9-15, and 17-21 encode the same isoform.
    Source sequence(s)
    AB020639, AL603752, BU752915, BX647076, CA397450, DA215341
    Consensus CDS
    CCDS1517.1
    UniProtKB/TrEMBL
    C0SQ93, F1D8R6
    Conserved Domains (2) summary
    cd06946
    Location:214 → 433
    NR_LBD_ERR; The ligand binding domain of estrogen receptor-related nuclear receptors
    cd07170
    Location:99 → 195
    NR_DBD_ERR; DNA-binding domain of estrogen related receptors (ERR) is composed of two C4-type zinc fingers

  17. NM_001350125.2 → NP_001337054.1  estrogen-related receptor gamma isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (21) lacks the 5' exon but has three alternate 5' exons and uses a downstream AUG start codon, compared to variant 1. The resulting isoform (2) is shorter at the N-terminus, compared to isoform 1. Variants 2-4, 9-15, and 17-21 encode the same isoform.
    Source sequence(s)
    AB020639, BU752915, CA397450, DA096417, DB220304
    Consensus CDS
    CCDS1517.1
    UniProtKB/TrEMBL
    C0SQ93, F1D8R6
    Conserved Domains (2) summary
    cd06946
    Location:214 → 433
    NR_LBD_ERR; The ligand binding domain of estrogen receptor-related nuclear receptors
    cd07170
    Location:99 → 195
    NR_DBD_ERR; DNA-binding domain of estrogen related receptors (ERR) is composed of two C4-type zinc fingers

  18. NM_001438.4 → NP_001429.2  estrogen-related receptor gamma isoform 1

    See identical proteins and their annotated locations for NP_001429.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes isoform 1.
    Source sequence(s)
    AB020639, BU752915
    Consensus CDS
    CCDS41468.1
    UniProtKB/Swiss-Prot
    A8K4I0, A8K6I2, B3KY84, E9PGB7, F8W8J3, O75454, O96021, P62508, Q68DA0, Q6P274, Q6PK28, Q6TS38, Q9R1F3, Q9UNJ4
    UniProtKB/TrEMBL
    C0SQ93, F1D8R5
    Related
    ENSP00000386171.3, ENST00000408911.8
    Conserved Domains (2) summary
    cd06946
    Location:237 → 456
    NR_LBD_ERR; The ligand binding domain of estrogen receptor-related nuclear receptors
    cd07170
    Location:122 → 218
    NR_DBD_ERR; DNA-binding domain of estrogen related receptors (ERR) is composed of two C4-type zinc fingers

  19. NM_206594.3 → NP_996317.1  estrogen-related receptor gamma isoform 2

    See identical proteins and their annotated locations for NP_996317.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks the 5' exon but has three alternate 5' exons and uses a downstream AUG start codon, compared to variant 1. The resulting isoform (2) is shorter at the N-terminus, compared to isoform 1. Variants 2-4, 9-15, and 17-21 encode the same isoform.
    Source sequence(s)
    AB020639, BU752915, CA397450
    Consensus CDS
    CCDS1517.1
    UniProtKB/TrEMBL
    C0SQ93, F1D8R6
    Related
    ENSP00000355225.3, ENST00000361525.7
    Conserved Domains (2) summary
    cd06946
    Location:214 → 433
    NR_LBD_ERR; The ligand binding domain of estrogen receptor-related nuclear receptors
    cd07170
    Location:99 → 195
    NR_DBD_ERR; DNA-binding domain of estrogen related receptors (ERR) is composed of two C4-type zinc fingers

  20. NM_206595.3 → NP_996318.1  estrogen-related receptor gamma isoform 2

    See identical proteins and their annotated locations for NP_996318.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks the 5' exon but has two alternate 5' exons and uses a downstream AUG start codon, compared to variant 1. The resulting isoform (2) is shorter at the N-terminus, compared to isoform 1. Variants 2-4, 9-15, and 17-21 encode the same isoform.
    Source sequence(s)
    AB020639, AK291028, BU752915
    Consensus CDS
    CCDS1517.1
    UniProtKB/TrEMBL
    C0SQ93, F1D8R6
    Related
    ENSP00000352077.2, ENST00000359162.6
    Conserved Domains (2) summary
    cd06946
    Location:214 → 433
    NR_LBD_ERR; The ligand binding domain of estrogen receptor-related nuclear receptors
    cd07170
    Location:99 → 195
    NR_DBD_ERR; DNA-binding domain of estrogen related receptors (ERR) is composed of two C4-type zinc fingers

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

    Range
    216503246..217137702 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017000625.2 → XP_016856114.1  estrogen-related receptor gamma isoform X1

    UniProtKB/TrEMBL
    C0SQ93
    Conserved Domains (2) summary
    cd06946
    Location:256 → 475
    NR_LBD_ERR; The ligand binding domain of estrogen receptor-related nuclear receptors
    cd07170
    Location:134 → 230
    NR_DBD_ERR; DNA-binding domain of estrogen related receptors (ERR) is composed of two C4-type zinc fingers

  2. XM_047449371.1 → XP_047305327.1  estrogen-related receptor gamma isoform X3

  3. XM_017000622.2 → XP_016856111.1  estrogen-related receptor gamma isoform X1

    UniProtKB/TrEMBL
    C0SQ93
    Conserved Domains (2) summary
    cd06946
    Location:256 → 475
    NR_LBD_ERR; The ligand binding domain of estrogen receptor-related nuclear receptors
    cd07170
    Location:134 → 230
    NR_DBD_ERR; DNA-binding domain of estrogen related receptors (ERR) is composed of two C4-type zinc fingers

  4. XM_047449402.1 → XP_047305358.1  estrogen-related receptor gamma isoform X8

    Related
    ENSP00000500992.1, ENST00000673908.1

  5. XM_017000637.2 → XP_016856126.1  estrogen-related receptor gamma isoform X8

    UniProtKB/TrEMBL
    C0SQ93
    Conserved Domains (2) summary
    cd06946
    Location:221 → 440
    NR_LBD_ERR; The ligand binding domain of estrogen receptor-related nuclear receptors
    cd07170
    Location:99 → 195
    NR_DBD_ERR; DNA-binding domain of estrogen related receptors (ERR) is composed of two C4-type zinc fingers

  6. XM_017000624.3 → XP_016856113.1  estrogen-related receptor gamma isoform X1

    UniProtKB/TrEMBL
    C0SQ93
    Conserved Domains (2) summary
    cd06946
    Location:256 → 475
    NR_LBD_ERR; The ligand binding domain of estrogen receptor-related nuclear receptors
    cd07170
    Location:134 → 230
    NR_DBD_ERR; DNA-binding domain of estrogen related receptors (ERR) is composed of two C4-type zinc fingers

  7. XM_011509265.4 → XP_011507567.1  estrogen-related receptor gamma isoform X1

    UniProtKB/TrEMBL
    C0SQ93
    Conserved Domains (2) summary
    cd06946
    Location:256 → 475
    NR_LBD_ERR; The ligand binding domain of estrogen receptor-related nuclear receptors
    cd07170
    Location:134 → 230
    NR_DBD_ERR; DNA-binding domain of estrogen related receptors (ERR) is composed of two C4-type zinc fingers

  8. XM_017000621.3 → XP_016856110.1  estrogen-related receptor gamma isoform X1

    UniProtKB/TrEMBL
    C0SQ93
    Conserved Domains (2) summary
    cd06946
    Location:256 → 475
    NR_LBD_ERR; The ligand binding domain of estrogen receptor-related nuclear receptors
    cd07170
    Location:134 → 230
    NR_DBD_ERR; DNA-binding domain of estrogen related receptors (ERR) is composed of two C4-type zinc fingers

  9. XM_047449398.1 → XP_047305354.1  estrogen-related receptor gamma isoform X8

  10. XM_047449392.1 → XP_047305348.1  estrogen-related receptor gamma isoform X7

  11. XM_047449368.1 → XP_047305324.1  estrogen-related receptor gamma isoform X3

  12. XM_047449351.1 → XP_047305307.1  estrogen-related receptor gamma isoform X3

  13. XM_017000634.3 → XP_016856123.1  estrogen-related receptor gamma isoform X8

    UniProtKB/TrEMBL
    C0SQ93
    Conserved Domains (2) summary
    cd06946
    Location:221 → 440
    NR_LBD_ERR; The ligand binding domain of estrogen receptor-related nuclear receptors
    cd07170
    Location:99 → 195
    NR_DBD_ERR; DNA-binding domain of estrogen related receptors (ERR) is composed of two C4-type zinc fingers

  14. XM_017000631.3 → XP_016856120.1  estrogen-related receptor gamma isoform X8

    UniProtKB/TrEMBL
    C0SQ93
    Conserved Domains (2) summary
    cd06946
    Location:221 → 440
    NR_LBD_ERR; The ligand binding domain of estrogen receptor-related nuclear receptors
    cd07170
    Location:99 → 195
    NR_DBD_ERR; DNA-binding domain of estrogen related receptors (ERR) is composed of two C4-type zinc fingers

  15. XM_047449391.1 → XP_047305347.1  estrogen-related receptor gamma isoform X7

  16. XM_047449362.1 → XP_047305318.1  estrogen-related receptor gamma isoform X3

  17. XM_047449396.1 → XP_047305352.1  estrogen-related receptor gamma isoform X8

  18. XM_047449395.1 → XP_047305351.1  estrogen-related receptor gamma isoform X8

  19. XM_047449389.1 → XP_047305345.1  estrogen-related receptor gamma isoform X5

  20. XM_047449344.1 → XP_047305300.1  estrogen-related receptor gamma isoform X3

  21. XM_047449397.1 → XP_047305353.1  estrogen-related receptor gamma isoform X8

  22. XM_017000632.3 → XP_016856121.1  estrogen-related receptor gamma isoform X8

    UniProtKB/TrEMBL
    C0SQ93
    Conserved Domains (2) summary
    cd06946
    Location:221 → 440
    NR_LBD_ERR; The ligand binding domain of estrogen receptor-related nuclear receptors
    cd07170
    Location:99 → 195
    NR_DBD_ERR; DNA-binding domain of estrogen related receptors (ERR) is composed of two C4-type zinc fingers

  23. XM_011509266.4 → XP_011507568.1  estrogen-related receptor gamma isoform X2

    UniProtKB/TrEMBL
    C0SQ93
    Conserved Domains (2) summary
    cd06946
    Location:249 → 468
    NR_LBD_ERR; The ligand binding domain of estrogen receptor-related nuclear receptors
    cd07170
    Location:134 → 230
    NR_DBD_ERR; DNA-binding domain of estrogen related receptors (ERR) is composed of two C4-type zinc fingers

  24. XM_047449307.1 → XP_047305263.1  estrogen-related receptor gamma isoform X1

  25. XM_017000636.3 → XP_016856125.1  estrogen-related receptor gamma isoform X8

    UniProtKB/TrEMBL
    C0SQ93
    Conserved Domains (2) summary
    cd06946
    Location:221 → 440
    NR_LBD_ERR; The ligand binding domain of estrogen receptor-related nuclear receptors
    cd07170
    Location:99 → 195
    NR_DBD_ERR; DNA-binding domain of estrogen related receptors (ERR) is composed of two C4-type zinc fingers

  26. XM_017000623.3 → XP_016856112.1  estrogen-related receptor gamma isoform X1

    UniProtKB/TrEMBL
    C0SQ93
    Conserved Domains (2) summary
    cd06946
    Location:256 → 475
    NR_LBD_ERR; The ligand binding domain of estrogen receptor-related nuclear receptors
    cd07170
    Location:134 → 230
    NR_DBD_ERR; DNA-binding domain of estrogen related receptors (ERR) is composed of two C4-type zinc fingers

  27. XM_047449403.1 → XP_047305359.1  estrogen-related receptor gamma isoform X8

  28. XM_047449385.1 → XP_047305341.1  estrogen-related receptor gamma isoform X4

  29. XM_011509271.3 → XP_011507573.1  estrogen-related receptor gamma isoform X7

    See identical proteins and their annotated locations for XP_011507573.1

    UniProtKB/TrEMBL
    C0SQ93
    Conserved Domains (2) summary
    cd06946
    Location:226 → 445
    NR_LBD_ERR; The ligand binding domain of estrogen receptor-related nuclear receptors
    cd07170
    Location:104 → 200
    NR_DBD_ERR; DNA-binding domain of estrogen related receptors (ERR) is composed of two C4-type zinc fingers

  30. XM_047449390.1 → XP_047305346.1  estrogen-related receptor gamma isoform X6

  31. XM_011509269.3 → XP_011507571.1  estrogen-related receptor gamma isoform X3

    See identical proteins and their annotated locations for XP_011507571.1

    UniProtKB/TrEMBL
    C0SQ93
    Conserved Domains (2) summary
    cd06946
    Location:249 → 468
    NR_LBD_ERR; The ligand binding domain of estrogen receptor-related nuclear receptors
    cd07170
    Location:127 → 223
    NR_DBD_ERR; DNA-binding domain of estrogen related receptors (ERR) is composed of two C4-type zinc fingers

  32. XM_011509268.3 → XP_011507570.1  estrogen-related receptor gamma isoform X3

    See identical proteins and their annotated locations for XP_011507570.1

    UniProtKB/TrEMBL
    C0SQ93
    Conserved Domains (2) summary
    cd06946
    Location:249 → 468
    NR_LBD_ERR; The ligand binding domain of estrogen receptor-related nuclear receptors
    cd07170
    Location:127 → 223
    NR_DBD_ERR; DNA-binding domain of estrogen related receptors (ERR) is composed of two C4-type zinc fingers

  33. XM_011509267.1 → XP_011507569.1  estrogen-related receptor gamma isoform X3

    See identical proteins and their annotated locations for XP_011507569.1

    UniProtKB/TrEMBL
    C0SQ93
    Conserved Domains (2) summary
    cd06946
    Location:249 → 468
    NR_LBD_ERR; The ligand binding domain of estrogen receptor-related nuclear receptors
    cd07170
    Location:127 → 223
    NR_DBD_ERR; DNA-binding domain of estrogen related receptors (ERR) is composed of two C4-type zinc fingers

  34. XM_047449394.1 → XP_047305350.1  estrogen-related receptor gamma isoform X7

  35. XM_047449401.1 → XP_047305357.1  estrogen-related receptor gamma isoform X8

  36. XM_047449393.1 → XP_047305349.1  estrogen-related receptor gamma isoform X7

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060925.1 Alternate T2T-CHM13v2.0

    Range
    215743580..216378774 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054335068.1 → XP_054191043.1  estrogen-related receptor gamma isoform X1

  2. XM_054335071.1 → XP_054191046.1  estrogen-related receptor gamma isoform X3

  3. XM_054335065.1 → XP_054191040.1  estrogen-related receptor gamma isoform X1

  4. XM_054335064.1 → XP_054191039.1  estrogen-related receptor gamma isoform X1

  5. XM_054335063.1 → XP_054191038.1  estrogen-related receptor gamma isoform X1

  6. XM_054335091.1 → XP_054191066.1  estrogen-related receptor gamma isoform X8

  7. XM_054335088.1 → XP_054191063.1  estrogen-related receptor gamma isoform X8

  8. XM_054335067.1 → XP_054191042.1  estrogen-related receptor gamma isoform X1

  9. XM_054335085.1 → XP_054191060.1  estrogen-related receptor gamma isoform X8

  10. XM_054335086.1 → XP_054191061.1  estrogen-related receptor gamma isoform X8

  11. XM_054335080.1 → XP_054191055.1  estrogen-related receptor gamma isoform X8

  12. XM_054335083.1 → XP_054191058.1  estrogen-related receptor gamma isoform X8

  13. XM_054335084.1 → XP_054191059.1  estrogen-related receptor gamma isoform X8

  14. XM_054335069.1 → XP_054191044.1  estrogen-related receptor gamma isoform X2

  15. XM_054335087.1 → XP_054191062.1  estrogen-related receptor gamma isoform X8

  16. XM_054335066.1 → XP_054191041.1  estrogen-related receptor gamma isoform X1

  17. XM_054335089.1 → XP_054191064.1  estrogen-related receptor gamma isoform X8

  18. XM_054335092.1 → XP_054191067.1  estrogen-related receptor gamma isoform X8

  19. XM_054335074.1 → XP_054191049.1  estrogen-related receptor gamma isoform X4

  20. XM_054335078.1 → XP_054191053.1  estrogen-related receptor gamma isoform X7

  21. XM_054335076.1 → XP_054191051.1  estrogen-related receptor gamma isoform X6

  22. XM_054335073.1 → XP_054191048.1  estrogen-related receptor gamma isoform X3

  23. XM_054335072.1 → XP_054191047.1  estrogen-related receptor gamma isoform X3

  24. XM_054335070.1 → XP_054191045.1  estrogen-related receptor gamma isoform X3

  25. XM_054335082.1 → XP_054191057.1  estrogen-related receptor gamma isoform X8

  26. XM_054335081.1 → XP_054191056.1  estrogen-related receptor gamma isoform X8

  27. XM_054335075.1 → XP_054191050.1  estrogen-related receptor gamma isoform X5

  28. XM_054335079.1 → XP_054191054.1  estrogen-related receptor gamma isoform X7

  29. XM_054335090.1 → XP_054191065.1  estrogen-related receptor gamma isoform X8

  30. XM_054335077.1 → XP_054191052.1  estrogen-related receptor gamma isoform X7

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P62508.1 GenPept UniProtKB/Swiss-Prot:P62508

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous