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Thsd7b thrombospondin, type I, domain containing 7B [ Mus musculus (house mouse) ]

Gene ID: 210417, updated on 11-Apr-2024

Summary

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Official Symbol
Thsd7bprovided by MGI
Official Full Name
thrombospondin, type I, domain containing 7Bprovided by MGI
Primary source
MGI:MGI:2443925
See related
Ensembl:ENSMUSG00000042581 AllianceGenome:MGI:2443925
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
B930082A18; 1700074E13Rik; D130067I03Rik
Summary
Predicted to be involved in actin cytoskeleton reorganization. Predicted to be located in membrane. Predicted to be integral component of membrane. Predicted to be active in plasma membrane. Is expressed in embryo. Orthologous to human THSD7B (thrombospondin type 1 domain containing 7B). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Low expression observed in reference dataset See more
Orthologs
human all
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Genomic context

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Location:
1 E4; 1 56.55 cM
Exon count:
31
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (129201010..130147015)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (129273190..130219278)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene CapStarr-seq enhancer MGSCv37_chr1:130487786-130488065 Neighboring gene STARR-positive B cell enhancer ABC_E10032 Neighboring gene CapStarr-seq enhancer MGSCv37_chr1:130502453-130502636 Neighboring gene STARR-positive B cell enhancer ABC_E4345 Neighboring gene STARR-positive B cell enhancer ABC_E10033 Neighboring gene STARR-positive B cell enhancer ABC_E7744 Neighboring gene C-X-C motif chemokine receptor 4 Neighboring gene STARR-seq mESC enhancer starr_02173 Neighboring gene STARR-positive B cell enhancer ABC_E9477 Neighboring gene STARR-seq mESC enhancer starr_02174 Neighboring gene STARR-positive B cell enhancer ABC_E2007 Neighboring gene STARR-seq mESC enhancer starr_02175 Neighboring gene STARR-seq mESC enhancer starr_02176 Neighboring gene STARR-seq mESC enhancer starr_02178 Neighboring gene STARR-seq mESC enhancer starr_02179 Neighboring gene predicted gene, 23056 Neighboring gene STARR-seq mESC enhancer starr_02180 Neighboring gene STARR-seq mESC enhancer starr_02181 Neighboring gene STARR-seq mESC enhancer starr_02182 Neighboring gene STARR-seq mESC enhancer starr_02183 Neighboring gene STARR-seq mESC enhancer starr_02184 Neighboring gene STARR-seq mESC enhancer starr_02185 Neighboring gene STARR-seq mESC enhancer starr_02186 Neighboring gene predicted gene, 36347 Neighboring gene STARR-seq mESC enhancer starr_02187 Neighboring gene ribosomal protein L31, pseudogene 9 Neighboring gene nucleoporin 54 pseudogene Neighboring gene STARR-seq mESC enhancer starr_02188 Neighboring gene STARR-seq mESC enhancer starr_02189 Neighboring gene STARR-seq mESC enhancer starr_02190 Neighboring gene STARR-seq mESC enhancer starr_02191 Neighboring gene STARR-seq mESC enhancer starr_02192 Neighboring gene predicted gene 29428 Neighboring gene STARR-seq mESC enhancer starr_02193 Neighboring gene STARR-seq mESC enhancer starr_02194 Neighboring gene predicted gene, 41951 Neighboring gene CD55 molecule, opposite strand sequence Neighboring gene CD55 molecule, decay accelerating factor for complement B

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. O-fucosylation of thrombospondin type 1 repeats restricts epithelial to mesenchymal transition (EMT) and maintains epiblast pluripotency during mouse gastrulation. Du J, et al. Dev Biol, 2010 Oct 1. PMID 20637190, Free PMC Article
  2. Database resources of the National Center for Biotechnology Information. Wheeler DL, et al. Nucleic Acids Res, 2001 Jan 1. PMID 11125038, Free PMC Article
  3. Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. Hansen GM, et al. Genome Res, 2008 Oct. PMID 18799693, Free PMC Article
  4. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article
  5. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068, Free PMC Article

See all (15) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in actin cytoskeleton organization IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
thrombospondin type-1 domain-containing protein 7B

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_172485.3 → NP_766073.2  thrombospondin type-1 domain-containing protein 7B precursor

    See identical proteins and their annotated locations for NP_766073.2

    Status: VALIDATED

    Source sequence(s)
    AC110536, BB658510, BC063250
    Consensus CDS
    CCDS15255.1
    UniProtKB/Swiss-Prot
    Q6P4U0
    Related
    ENSMUSP00000073220.7, ENSMUST00000073527.13
    Conserved Domains (2) summary
    smart00209
    Location:1252 → 1302
    TSP1; Thrombospondin type 1 repeats
    cl15278
    Location:1132 → 1177
    TSP_1; Thrombospondin type 1 domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    129201010..130147015
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011247964.3 → XP_011246266.1  thrombospondin type-1 domain-containing protein 7B isoform X1

    See identical proteins and their annotated locations for XP_011246266.1

    Conserved Domains (2) summary
    pfam19028
    Location:337 → 398
    TSP1_spondin; Spondin-like TSP1 domain
    pfam19030
    Location:1065 → 1125
    TSP1_ADAMTS; Thrombospondin type 1 domain

  2. XM_011247966.4 → XP_011246268.1  thrombospondin type-1 domain-containing protein 7B isoform X2

    Conserved Domains (1) summary
    smart00209
    Location:340 → 399
    TSP1; Thrombospondin type 1 repeats

  3. XM_036163210.1 → XP_036019103.1  thrombospondin type-1 domain-containing protein 7B isoform X1

    Conserved Domains (2) summary
    pfam19028
    Location:337 → 398
    TSP1_spondin; Spondin-like TSP1 domain
    pfam19030
    Location:1065 → 1125
    TSP1_ADAMTS; Thrombospondin type 1 domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6P4U0.1 GenPept UniProtKB/Swiss-Prot:Q6P4U0

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