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Tbc1d31 TBC1 domain family, member 31 [ Mus musculus (house mouse) ]

Gene ID: 210544, updated on 23-Jun-2021

Summary

Official Symbol
Tbc1d31provided by MGI
Official Full Name
TBC1 domain family, member 31provided by MGI
Primary source
MGI:MGI:2684931
See related
Ensembl:ENSMUSG00000022364
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
4B3; Gm85; Wdr6; Wdr67; D330013L20Rik
Expression
Broad expression in testis adult (RPKM 7.4), CNS E11.5 (RPKM 4.6) and 25 other tissues See more
Orthologs
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Genomic context

See Tbc1d31 in Genome Data Viewer
Location:
15; 15 D1
Exon count:
25
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (57775081..57833464)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (57911685..57970068)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 15 NC_000081.5 (57743754..57801623)

Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene zinc fingers and homeoboxes 2 Neighboring gene Der1-like domain family, member 1 Neighboring gene uncharacterized LOC115488500 Neighboring gene nuclear encoded tRNA methionine 16 (anticodon CAT) Neighboring gene family with sequence similarity 83, member A

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Homology

Clone Names

  • MGC76603

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
 
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
 
Component Evidence Code Pubs
is_active_in centrosome IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in centrosome ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
TBC1 domain family member 31
Names
WD repeat domain 67
WD repeat-containing protein 67
protein 4-B-3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001081396.2NP_001074865.2  TBC1 domain family member 31 isoform 1

    See identical proteins and their annotated locations for NP_001074865.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the shorter transcript but encodes the longer isoform (1).
    Source sequence(s)
    AC154874, BC050039, BC066830
    Consensus CDS
    CCDS37077.2
    UniProtKB/Swiss-Prot
    Q6NXY1
    Related
    ENSMUSP00000022992.7, ENSMUST00000022992.13
    Conserved Domains (6) summary
    COG2319
    Location:34346
    WD40; WD40 repeat [General function prediction only]
    pfam15346
    Location:766895
    ARGLU; Arginine and glutamate-rich 1
    sd00039
    Location:4381
    7WD40; WD40 repeat [structural motif]
    cl02495
    Location:461619
    RabGAP-TBC; Rab-GTPase-TBC domain
    cl02567
    Location:39334
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    cl23750
    Location:713834
    vATP-synt_E; ATP synthase (E/31 kDa) subunit
  2. NM_001167679.1NP_001161151.1  TBC1 domain family member 31 isoform 2

    See identical proteins and their annotated locations for NP_001161151.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 3' coding region and 3' UTR, compared to variant 1. The encoded isoform (2) has a distinct and shorter C-terminus, compared to isoform 1.
    Source sequence(s)
    AC154874
    UniProtKB/Swiss-Prot
    Q6NXY1
    Related
    ENSMUST00000110175.9
    Conserved Domains (5) summary
    COG2319
    Location:34346
    WD40; WD40 repeat [General function prediction only]
    sd00039
    Location:4381
    7WD40; WD40 repeat [structural motif]
    cl02495
    Location:461619
    RabGAP-TBC; Rab-GTPase-TBC domain
    cl02567
    Location:39334
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    cl23750
    Location:713834
    vATP-synt_E; ATP synthase (E/31 kDa) subunit
  3. NM_001356310.1NP_001343239.1  TBC1 domain family member 31 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC154874
    Conserved Domains (4) summary
    sd00039
    Location:4580
    7WD40; WD40 repeat [structural motif]
    cl02495
    Location:343520
    RabGAP-TBC; Rab-GTPase-TBC domain
    cl25539
    Location:30249
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    cl25545
    Location:599821
    V-ATPase_G_2; Vacuolar (H+)-ATPase G subunit

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000081.7 Reference GRCm39 C57BL/6J

    Range
    57775081..57833464
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006520700.3XP_006520763.1  TBC1 domain family member 31 isoform X2

    See identical proteins and their annotated locations for XP_006520763.1

    Conserved Domains (4) summary
    sd00039
    Location:4580
    7WD40; WD40 repeat [structural motif]
    pfam17380
    Location:599921
    DUF5401; Family of unknown function (DUF5401)
    cl02495
    Location:343534
    RabGAP-TBC; Rab-GTPase-TBC domain
    cl29593
    Location:30249
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
  2. XM_006520698.3XP_006520761.1  TBC1 domain family member 31 isoform X1

    Conserved Domains (4) summary
    sd00039
    Location:4381
    7WD40; WD40 repeat [structural motif]
    pfam17380
    Location:6841006
    DUF5401; Family of unknown function (DUF5401)
    cl02495
    Location:428619
    RabGAP-TBC; Rab-GTPase-TBC domain
    cl29593
    Location:39334
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
  3. XM_006520699.3XP_006520762.1  TBC1 domain family member 31 isoform X2

    See identical proteins and their annotated locations for XP_006520762.1

    Conserved Domains (4) summary
    sd00039
    Location:4580
    7WD40; WD40 repeat [structural motif]
    pfam17380
    Location:599921
    DUF5401; Family of unknown function (DUF5401)
    cl02495
    Location:343534
    RabGAP-TBC; Rab-GTPase-TBC domain
    cl29593
    Location:30249
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
  4. XM_030248441.1XP_030104301.1  TBC1 domain family member 31 isoform X3

    Conserved Domains (4) summary
    sd00039
    Location:944
    7WD40; WD40 repeat [structural motif]
    pfam17380
    Location:563874
    DUF5401; Family of unknown function (DUF5401)
    cl02495
    Location:307498
    RabGAP-TBC; Rab-GTPase-TBC domain
    cl29593
    Location:1213
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
  5. XM_036159297.1XP_036015190.1  TBC1 domain family member 31 isoform X4

    Conserved Domains (4) summary
    sd00039
    Location:944
    7WD40; WD40 repeat [structural motif]
    pfam17380
    Location:563820
    DUF5401; Family of unknown function (DUF5401)
    cl02495
    Location:307498
    RabGAP-TBC; Rab-GTPase-TBC domain
    cl29593
    Location:1213
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
  6. XM_006520702.3XP_006520765.1  TBC1 domain family member 31 isoform X3

    See identical proteins and their annotated locations for XP_006520765.1

    Conserved Domains (4) summary
    sd00039
    Location:944
    7WD40; WD40 repeat [structural motif]
    pfam17380
    Location:563874
    DUF5401; Family of unknown function (DUF5401)
    cl02495
    Location:307498
    RabGAP-TBC; Rab-GTPase-TBC domain
    cl29593
    Location:1213
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
  7. XM_006520703.3XP_006520766.1  TBC1 domain family member 31 isoform X3

    See identical proteins and their annotated locations for XP_006520766.1

    Conserved Domains (4) summary
    sd00039
    Location:944
    7WD40; WD40 repeat [structural motif]
    pfam17380
    Location:563874
    DUF5401; Family of unknown function (DUF5401)
    cl02495
    Location:307498
    RabGAP-TBC; Rab-GTPase-TBC domain
    cl29593
    Location:1213
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_199300.1: Suppressed sequence

    Description
    NM_199300.1: This RefSeq was suppressed temporarily based on the calculation that the annotated protein was shorter than a protein or proteins from a putative ortholog.
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