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Prrt3 proline-rich transmembrane protein 3 [ Mus musculus (house mouse) ]

Gene ID: 210673, updated on 5-Mar-2024

Summary

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Official Symbol
Prrt3provided by MGI
Official Full Name
proline-rich transmembrane protein 3provided by MGI
Primary source
MGI:MGI:2444810
See related
Ensembl:ENSMUSG00000045009 AllianceGenome:MGI:2444810
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
6330505P20; B230206N24Rik
Summary
Predicted to be located in membrane. Predicted to be integral component of membrane. Orthologous to human PRRT3 (proline rich transmembrane protein 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in cortex adult (RPKM 8.5), cerebellum adult (RPKM 8.3) and 6 other tissues See more
Orthologs
human all
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Genomic context

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Location:
6 E3; 6 52.77 cM
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (113470599..113479071, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (113493638..113502082, complement)

Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene interleukin 17 receptor C Neighboring gene STARR-positive B cell enhancer ABC_E684 Neighboring gene STARR-seq mESC enhancer starr_17041 Neighboring gene cysteine-rich with EGF-like domains 1 Neighboring gene CapStarr-seq enhancer MGSCv37_chr6:113467707-113467969 Neighboring gene ER membrane protein complex subunit 3 Neighboring gene Fanconi anemia, complementation group D2 Neighboring gene predicted gene, 46971

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Pancreatic islet and progenitor cell surface markers with cell sorting potential. Hald J, et al. Diabetologia, 2012 Jan. PMID 21947380
  2. Rescue of neuropsychiatric phenotypes in a mouse model of 16p11.2 duplication syndrome by genetic correction of an epilepsy network hub. Forrest MP, et al. Nat Commun, 2023 Feb 17. PMID 36808153, Free PMC Article
  3. Comprehensive identification of phosphorylation sites in postsynaptic density preparations. Trinidad JC, et al. Mol Cell Proteomics, 2006 May. PMID 16452087
  4. Qualitative and quantitative analyses of protein phosphorylation in naive and stimulated mouse synaptosomal preparations. Munton RP, et al. Mol Cell Proteomics, 2007 Feb. PMID 17114649
  5. Database resources of the National Center for Biotechnology Information. Wheeler DL, et al. Nucleic Acids Res, 2001 Jan 1. PMID 11125038, Free PMC Article

See all (17) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
proline-rich transmembrane protein 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001289699.1 → NP_001276628.1  proline-rich transmembrane protein 3 isoform a precursor

    See identical proteins and their annotated locations for NP_001276628.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (a). Variants 1 and 2 encode the same isoform (a).
    Source sequence(s)
    AC153910, AK031947, AK136854
    Consensus CDS
    CCDS85122.1
    UniProtKB/TrEMBL
    A0A0N4SVB5
    Related
    ENSMUSP00000145443.2, ENSMUST00000204268.3
    Conserved Domains (1) summary
    PHA03247
    Location:64 → 464
    PHA03247; large tegument protein UL36; Provisional

  2. NM_001289700.1 → NP_001276629.1  proline-rich transmembrane protein 3 isoform a precursor

    See identical proteins and their annotated locations for NP_001276629.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate splice site in the 5' UTR, compared to variant 1. Variants 1 and 2 encode the same isoform (a).
    Source sequence(s)
    AC153910, AK031947, AK136854, BC058349
    Consensus CDS
    CCDS85122.1
    UniProtKB/TrEMBL
    A0A0N4SVB5
    Related
    ENSMUSP00000145031.2, ENSMUST00000204134.3
    Conserved Domains (1) summary
    PHA03247
    Location:64 → 464
    PHA03247; large tegument protein UL36; Provisional

  3. NM_172487.4 → NP_766075.2  proline-rich transmembrane protein 3 isoform b precursor

    See identical proteins and their annotated locations for NP_766075.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and uses an alternate in-frame splice site, compared to variant 1. The encoded isoform (b) is shorter than isoform 1.
    Source sequence(s)
    AC153910, AK136854, BC058349
    Consensus CDS
    CCDS20424.1
    UniProtKB/Swiss-Prot
    Q6PE13
    Related
    ENSMUSP00000098620.2, ENSMUST00000101059.4
    Conserved Domains (2) summary
    PHA03247
    Location:64 → 463
    PHA03247; large tegument protein UL36; Provisional
    PRK07764
    Location:273 → 447
    PRK07764; DNA polymerase III subunits gamma and tau; Validated

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000072.7 Reference GRCm39 C57BL/6J

    Range
    113470599..113479071 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030255299.2 → XP_030111159.1  proline-rich transmembrane protein 3 isoform X2

    UniProtKB/Swiss-Prot
    Q6PE13
    Conserved Domains (2) summary
    PHA03247
    Location:64 → 463
    PHA03247; large tegument protein UL36; Provisional
    PRK07764
    Location:273 → 447
    PRK07764; DNA polymerase III subunits gamma and tau; Validated

  2. XM_006505843.5 → XP_006505906.1  proline-rich transmembrane protein 3 isoform X2

    See identical proteins and their annotated locations for XP_006505906.1

    UniProtKB/Swiss-Prot
    Q6PE13
    Conserved Domains (2) summary
    PHA03247
    Location:64 → 463
    PHA03247; large tegument protein UL36; Provisional
    PRK07764
    Location:273 → 447
    PRK07764; DNA polymerase III subunits gamma and tau; Validated

  3. XM_011241275.2 → XP_011239577.1  proline-rich transmembrane protein 3 isoform X1

    See identical proteins and their annotated locations for XP_011239577.1

    UniProtKB/TrEMBL
    A0A0N4SVB5
    Conserved Domains (1) summary
    PHA03247
    Location:64 → 464
    PHA03247; large tegument protein UL36; Provisional
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6PE13.1 GenPept UniProtKB/Swiss-Prot:Q6PE13

Gene LinkOut

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