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Mtss1 MTSS I-BAR domain containing 1 [ Mus musculus (house mouse) ]

Gene ID: 211401, updated on 23-Jun-2021

Summary

Official Symbol
Mtss1provided by MGI
Official Full Name
MTSS I-BAR domain containing 1provided by MGI
Primary source
MGI:MGI:2384818
See related
Ensembl:ENSMUSG00000022353
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
MI; Mim; BC024131; mKIAA0429; 2310003N14Rik; D130001D01Rik
Expression
Ubiquitous expression in liver adult (RPKM 26.2), CNS E18 (RPKM 25.7) and 28 other tissues See more
Orthologs
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Genomic context

See Mtss1 in Genome Data Viewer
Location:
15; 15 D1
Exon count:
18
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (58813083..58955805, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (58941234..59083956, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 15 NC_000081.5 (58772789..58913581, complement)

Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene ring finger protein 139 Neighboring gene TatD DNase domain containing 1 Neighboring gene NADH:ubiquinone oxidoreductase subunit B9 Neighboring gene RIKEN cDNA 4930544F09 gene Neighboring gene ribosomal protein L7, pseudogene 8 Neighboring gene ribosomal protein L17 pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC37896

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables actin binding IDA
Inferred from Direct Assay
more info
PubMed 
enables actin filament binding IDA
Inferred from Direct Assay
more info
PubMed 
enables actin monomer binding ISO
Inferred from Sequence Orthology
more info
 
enables identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables signaling receptor binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in actin cytoskeleton organization IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within actin filament organization IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within actin filament polymerization IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within adherens junction maintenance IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within bone mineralization IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cellular response to fluid shear stress IDA
Inferred from Direct Assay
more info
PubMed 
involved_in epithelial cell proliferation involved in renal tubule morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in glomerulus morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within in utero embryonic development IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within magnesium ion homeostasis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within metanephric tubule development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in muscle organ development NAS
Non-traceable Author Statement
more info
PubMed 
involved_in negative regulation of epithelial cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in nephron tubule epithelial cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in nervous system development NAS
Non-traceable Author Statement
more info
PubMed 
involved_in plasma membrane organization IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within positive regulation of actin filament bundle assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in renal tubule morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
located_in actin cytoskeleton ISO
Inferred from Sequence Orthology
more info
 
located_in adherens junction IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
protein MTSS 1
Names
actin monomer-binding protein
metastasis suppressor 1
metastasis suppressor protein 1
missing in metastasis protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001146180.1NP_001139652.1  protein MTSS 1 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) has multiple differences in 3' coding region, compared to variant 1. These differences result in a shorter isoform (2), compared to isoform 1.
    Source sequence(s)
    AK129139, BY451400, CB518394
    UniProtKB/TrEMBL
    Q6ZQB7
    Conserved Domains (1) summary
    cd07643
    Location:7237
    I-BAR_IMD_MIM; Inverse (I)-BAR, also known as the IRSp53/MIM homology Domain (IMD), of Missing In Metastasis
  2. NM_144800.2NP_659049.2  protein MTSS 1 isoform 1

    See identical proteins and their annotated locations for NP_659049.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AK030533, AK129139, BY451400, CB518394
    Consensus CDS
    CCDS27496.1
    UniProtKB/Swiss-Prot
    Q8R1S4
    UniProtKB/TrEMBL
    G3X9H7, Q6ZQB7
    Related
    ENSMUSP00000079239.7, ENSMUST00000080371.8
    Conserved Domains (2) summary
    cd07643
    Location:7241
    I-BAR_IMD_MIM; Inverse (I)-BAR, also known as the IRSp53/MIM homology Domain (IMD), of Missing In Metastasis
    pfam02205
    Location:729754
    WH2; WH2 motif

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000081.7 Reference GRCm39 C57BL/6J

    Range
    58813083..58955805 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030248450.1XP_030104310.1  protein MTSS 1 isoform X27

    Conserved Domains (2) summary
    cd07643
    Location:7241
    I-BAR_IMD_MIM; Inverse (I)-BAR, also known as the IRSp53/MIM homology Domain (IMD), of Missing In Metastasis
    pfam03276
    Location:528656
    Gag_spuma; Spumavirus gag protein
  2. XM_030248449.1XP_030104309.1  protein MTSS 1 isoform X25

    Conserved Domains (2) summary
    cd07643
    Location:7241
    I-BAR_IMD_MIM; Inverse (I)-BAR, also known as the IRSp53/MIM homology Domain (IMD), of Missing In Metastasis
    PHA03247
    Location:330680
    PHA03247; large tegument protein UL36; Provisional
  3. XM_011245548.3XP_011243850.1  protein MTSS 1 isoform X23

    Conserved Domains (2) summary
    cd07643
    Location:7241
    I-BAR_IMD_MIM; Inverse (I)-BAR, also known as the IRSp53/MIM homology Domain (IMD), of Missing In Metastasis
    PHA03247
    Location:330728
    PHA03247; large tegument protein UL36; Provisional
  4. XM_036159298.1XP_036015191.1  protein MTSS 1 isoform X11

    Conserved Domains (3) summary
    cd07643
    Location:7241
    I-BAR_IMD_MIM; Inverse (I)-BAR, also known as the IRSp53/MIM homology Domain (IMD), of Missing In Metastasis
    PHA03247
    Location:330745
    PHA03247; large tegument protein UL36; Provisional
    cd22060
    Location:743773
    WH2_MTSS1; Wiskott Aldrich syndrome homology region 2 (WH2 motif) found in Metastasis suppressor protein 1 (MTSS-1)
  5. XM_011245543.3XP_011243845.1  protein MTSS 1 isoform X7

    Conserved Domains (3) summary
    cd07643
    Location:7241
    I-BAR_IMD_MIM; Inverse (I)-BAR, also known as the IRSp53/MIM homology Domain (IMD), of Missing In Metastasis
    PHA03247
    Location:339765
    PHA03247; large tegument protein UL36; Provisional
    pfam03276
    Location:628756
    Gag_spuma; Spumavirus gag protein
  6. XM_006520712.4XP_006520775.1  protein MTSS 1 isoform X19

    Conserved Domains (2) summary
    cd07643
    Location:7241
    I-BAR_IMD_MIM; Inverse (I)-BAR, also known as the IRSp53/MIM homology Domain (IMD), of Missing In Metastasis
    pfam03276
    Location:583711
    Gag_spuma; Spumavirus gag protein
  7. XM_011245545.3XP_011243847.1  protein MTSS 1 isoform X13

    Conserved Domains (3) summary
    cd07643
    Location:7241
    I-BAR_IMD_MIM; Inverse (I)-BAR, also known as the IRSp53/MIM homology Domain (IMD), of Missing In Metastasis
    PHA03247
    Location:499768
    PHA03247; large tegument protein UL36; Provisional
    pfam03276
    Location:603731
    Gag_spuma; Spumavirus gag protein
  8. XM_006520709.4XP_006520772.1  protein MTSS 1 isoform X5

    Conserved Domains (2) summary
    cd07643
    Location:7241
    I-BAR_IMD_MIM; Inverse (I)-BAR, also known as the IRSp53/MIM homology Domain (IMD), of Missing In Metastasis
    pfam03276
    Location:633761
    Gag_spuma; Spumavirus gag protein
  9. XM_011245542.3XP_011243844.1  protein MTSS 1 isoform X3

    Conserved Domains (2) summary
    cd07643
    Location:7241
    I-BAR_IMD_MIM; Inverse (I)-BAR, also known as the IRSp53/MIM homology Domain (IMD), of Missing In Metastasis
    pfam03276
    Location:653781
    Gag_spuma; Spumavirus gag protein
  10. XM_006520707.4XP_006520770.1  protein MTSS 1 isoform X4

    Conserved Domains (2) summary
    cd07643
    Location:7241
    I-BAR_IMD_MIM; Inverse (I)-BAR, also known as the IRSp53/MIM homology Domain (IMD), of Missing In Metastasis
    pfam03276
    Location:648776
    Gag_spuma; Spumavirus gag protein
  11. XM_011245540.3XP_011243842.1  protein MTSS 1 isoform X1

    Conserved Domains (3) summary
    cd07643
    Location:7241
    I-BAR_IMD_MIM; Inverse (I)-BAR, also known as the IRSp53/MIM homology Domain (IMD), of Missing In Metastasis
    PHA03247
    Location:564833
    PHA03247; large tegument protein UL36; Provisional
    pfam03276
    Location:668796
    Gag_spuma; Spumavirus gag protein
  12. XM_030248443.1XP_030104303.1  protein MTSS 1 isoform X8

    Conserved Domains (3) summary
    cd07643
    Location:7237
    I-BAR_IMD_MIM; Inverse (I)-BAR, also known as the IRSp53/MIM homology Domain (IMD), of Missing In Metastasis
    PHA03247
    Location:335761
    PHA03247; large tegument protein UL36; Provisional
    pfam03276
    Location:624752
    Gag_spuma; Spumavirus gag protein
  13. XM_011245541.3XP_011243843.1  protein MTSS 1 isoform X2

    Conserved Domains (3) summary
    cd07643
    Location:7237
    I-BAR_IMD_MIM; Inverse (I)-BAR, also known as the IRSp53/MIM homology Domain (IMD), of Missing In Metastasis
    PHA03247
    Location:560829
    PHA03247; large tegument protein UL36; Provisional
    pfam03276
    Location:664792
    Gag_spuma; Spumavirus gag protein
  14. XM_036159299.1XP_036015192.1  protein MTSS 1 isoform X26

    Conserved Domains (3) summary
    cd07643
    Location:7237
    I-BAR_IMD_MIM; Inverse (I)-BAR, also known as the IRSp53/MIM homology Domain (IMD), of Missing In Metastasis
    PHA03247
    Location:326676
    PHA03247; large tegument protein UL36; Provisional
    cd22060
    Location:674704
    WH2_MTSS1; Wiskott Aldrich syndrome homology region 2 (WH2 motif) found in Metastasis suppressor protein 1 (MTSS-1)
  15. XM_030248448.2XP_030104308.1  protein MTSS 1 isoform X24

    Conserved Domains (2) summary
    cd07643
    Location:7237
    I-BAR_IMD_MIM; Inverse (I)-BAR, also known as the IRSp53/MIM homology Domain (IMD), of Missing In Metastasis
    PHA03247
    Location:326724
    PHA03247; large tegument protein UL36; Provisional
  16. XM_017316531.3XP_017172020.1  protein MTSS 1 isoform X14

    Conserved Domains (3) summary
    cd07643
    Location:7237
    I-BAR_IMD_MIM; Inverse (I)-BAR, also known as the IRSp53/MIM homology Domain (IMD), of Missing In Metastasis
    PHA03247
    Location:495764
    PHA03247; large tegument protein UL36; Provisional
    pfam03276
    Location:599727
    Gag_spuma; Spumavirus gag protein
  17. XM_030248442.2XP_030104302.1  protein MTSS 1 isoform X6

    Conserved Domains (2) summary
    cd07643
    Location:7237
    I-BAR_IMD_MIM; Inverse (I)-BAR, also known as the IRSp53/MIM homology Domain (IMD), of Missing In Metastasis
    pfam03276
    Location:629757
    Gag_spuma; Spumavirus gag protein
  18. XM_011245546.2XP_011243848.1  protein MTSS 1 isoform X17

    Conserved Domains (3) summary
    PHA03247
    Location:483752
    PHA03247; large tegument protein UL36; Provisional
    pfam03276
    Location:587715
    Gag_spuma; Spumavirus gag protein
    cl12013
    Location:1160
    BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
  19. XM_011245547.2XP_011243849.1  protein MTSS 1 isoform X20

    Conserved Domains (3) summary
    PHA03247
    Location:479748
    PHA03247; large tegument protein UL36; Provisional
    pfam03276
    Location:583711
    Gag_spuma; Spumavirus gag protein
    cl12013
    Location:1156
    BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
  20. XM_011245544.1XP_011243846.1  protein MTSS 1 isoform X10

    Conserved Domains (3) summary
    PHA03247
    Location:505774
    PHA03247; large tegument protein UL36; Provisional
    pfam03276
    Location:609737
    Gag_spuma; Spumavirus gag protein
    cl12013
    Location:9182
    BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
  21. XM_017316532.2XP_017172021.1  protein MTSS 1 isoform X21

    Conserved Domains (2) summary
    cd07643
    Location:7241
    I-BAR_IMD_MIM; Inverse (I)-BAR, also known as the IRSp53/MIM homology Domain (IMD), of Missing In Metastasis
    pfam03276
    Location:568696
    Gag_spuma; Spumavirus gag protein
  22. XM_030248446.2XP_030104306.1  protein MTSS 1 isoform X16

    Conserved Domains (2) summary
    cd07643
    Location:7241
    I-BAR_IMD_MIM; Inverse (I)-BAR, also known as the IRSp53/MIM homology Domain (IMD), of Missing In Metastasis
    pfam03276
    Location:588716
    Gag_spuma; Spumavirus gag protein
  23. XM_006520711.5XP_006520774.1  protein MTSS 1 isoform X15

    Conserved Domains (3) summary
    cd07643
    Location:7237
    I-BAR_IMD_MIM; Inverse (I)-BAR, also known as the IRSp53/MIM homology Domain (IMD), of Missing In Metastasis
    PHA03247
    Location:326726
    PHA03247; large tegument protein UL36; Provisional
    pfam03276
    Location:589717
    Gag_spuma; Spumavirus gag protein
  24. XM_006520714.5XP_006520777.1  protein MTSS 1 isoform X22

    Conserved Domains (2) summary
    cd07643
    Location:7237
    I-BAR_IMD_MIM; Inverse (I)-BAR, also known as the IRSp53/MIM homology Domain (IMD), of Missing In Metastasis
    pfam03276
    Location:564692
    Gag_spuma; Spumavirus gag protein
  25. XM_030248447.2XP_030104307.1  protein MTSS 1 isoform X18

    Conserved Domains (2) summary
    cd07643
    Location:7237
    I-BAR_IMD_MIM; Inverse (I)-BAR, also known as the IRSp53/MIM homology Domain (IMD), of Missing In Metastasis
    pfam03276
    Location:584712
    Gag_spuma; Spumavirus gag protein
  26. XM_030248452.2XP_030104312.1  protein MTSS 1 isoform X30

    Conserved Domains (2) summary
    pfam03276
    Location:483611
    Gag_spuma; Spumavirus gag protein
    cl12013
    Location:1156
    BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
  27. XM_006520717.3XP_006520780.1  protein MTSS 1 isoform X29

    Conserved Domains (3) summary
    PHA03247
    Location:249649
    PHA03247; large tegument protein UL36; Provisional
    pfam03276
    Location:512640
    Gag_spuma; Spumavirus gag protein
    cl12013
    Location:1160
    BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
  28. XM_030248444.1XP_030104304.1  protein MTSS 1 isoform X9

    Conserved Domains (2) summary
    cd07643
    Location:7237
    I-BAR_IMD_MIM; Inverse (I)-BAR, also known as the IRSp53/MIM homology Domain (IMD), of Missing In Metastasis
    pfam03276
    Location:609737
    Gag_spuma; Spumavirus gag protein
  29. XM_030248445.2XP_030104305.1  protein MTSS 1 isoform X12

    Conserved Domains (2) summary
    cd07643
    Location:7237
    I-BAR_IMD_MIM; Inverse (I)-BAR, also known as the IRSp53/MIM homology Domain (IMD), of Missing In Metastasis
    PHA03247
    Location:326741
    PHA03247; large tegument protein UL36; Provisional
  30. XM_030248451.2XP_030104311.1  protein MTSS 1 isoform X28

    Conserved Domains (2) summary
    cd07643
    Location:7237
    I-BAR_IMD_MIM; Inverse (I)-BAR, also known as the IRSp53/MIM homology Domain (IMD), of Missing In Metastasis
    pfam03276
    Location:524652
    Gag_spuma; Spumavirus gag protein
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