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Mgst2 microsomal glutathione S-transferase 2 [ Mus musculus (house mouse) ]

Gene ID: 211666, updated on 11-Apr-2024

Summary

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Official Symbol
Mgst2provided by MGI
Official Full Name
microsomal glutathione S-transferase 2provided by MGI
Primary source
MGI:MGI:2448481
See related
Ensembl:ENSMUSG00000074604 AllianceGenome:MGI:2448481
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
GST2; MGST-II
Summary
Predicted to enable several functions, including glutathione binding activity; glutathione peroxidase activity; and glutathione transferase activity. Predicted to be involved in glutathione biosynthetic process; leukotriene biosynthetic process; and membrane lipid catabolic process. Predicted to be located in intracellular membrane-bounded organelle and plasma membrane. Predicted to be active in endoplasmic reticulum and nuclear envelope. Orthologous to human MGST2 (microsomal glutathione S-transferase 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in large intestine adult (RPKM 4.2), bladder adult (RPKM 2.7) and 15 other tissues See more
Orthologs
human all
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Genomic context

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Location:
3 C; 3 22.52 cM
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (51544179..51590096)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (51636912..51682675)

Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene CapStarr-seq enhancer MGSCv37_chr3:51314972-51315081 Neighboring gene STARR-seq mESC enhancer starr_07615 Neighboring gene RIKEN cDNA 5031434O11 gene Neighboring gene CapStarr-seq enhancer MGSCv37_chr3:51358072-51358308 Neighboring gene predicted gene, 36008 Neighboring gene STARR-positive B cell enhancer mm9_chr3:51363442-51363743 Neighboring gene SET domain containing (lysine methyltransferase) 7 Neighboring gene STARR-seq mESC enhancer starr_07617 Neighboring gene STARR-seq mESC enhancer starr_07618 Neighboring gene STARR-seq mESC enhancer starr_07619 Neighboring gene STARR-seq mESC enhancer starr_07620 Neighboring gene STARR-positive B cell enhancer ABC_E11183 Neighboring gene CapStarr-seq enhancer MGSCv37_chr3:51440808-51440917 Neighboring gene STARR-seq mESC enhancer starr_07621 Neighboring gene STARR-seq mESC enhancer starr_07622 Neighboring gene STARR-seq mESC enhancer starr_07623 Neighboring gene STARR-seq mESC enhancer starr_07624 Neighboring gene predicted gene, 38247 Neighboring gene VISTA enhancer mm1010 Neighboring gene CapStarr-seq enhancer MGSCv37_chr3:51549117-51549270 Neighboring gene mastermind like transcriptional coactivator 3 Neighboring gene predicted gene, 46803 Neighboring gene VISTA enhancer mm1452 Neighboring gene STARR-seq mESC enhancer starr_07625 Neighboring gene VISTA enhancer mm1388 Neighboring gene STARR-seq mESC enhancer starr_07626 Neighboring gene STARR-positive B cell enhancer ABC_E1019 Neighboring gene STARR-positive B cell enhancer ABC_E7911 Neighboring gene CapStarr-seq enhancer MGSCv37_chr3:51839623-51839732 Neighboring gene predicted gene, 30074

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Leukotriene C4 is the major trigger of stress-induced oxidative DNA damage. Dvash E, et al. Nat Commun, 2015 Dec 11. PMID 26656251, Free PMC Article
  2. Defective transcription initiation causes postnatal growth failure in a mouse model of nucleotide excision repair (NER) progeria. Kamileri I, et al. Proc Natl Acad Sci U S A, 2012 Feb 21. PMID 22323595, Free PMC Article
  3. GenePaint.org: an atlas of gene expression patterns in the mouse embryo. Visel A, et al. Nucleic Acids Res, 2004 Jan 1. PMID 14681479, Free PMC Article
  4. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073
  5. High-efficiency full-length cDNA cloning. Carninci P, et al. Methods Enzymol, 1999. PMID 10349636

See all (12) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1)  1 citation
  • Endonuclease-mediated (2) 

Pathways from PubChem

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General gene information

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Markers

Homology

Clone Names

  • MGC41409

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables enzyme activator activity IEA
Inferred from Electronic Annotation
more info
  
enables glutathione binding ISO
Inferred from Sequence Orthology
more info
  
enables glutathione peroxidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables glutathione peroxidase activity ISO
Inferred from Sequence Orthology
more info
  
enables glutathione transferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables glutathione transferase activity ISO
Inferred from Sequence Orthology
more info
  
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables leukotriene-C4 synthase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables leukotriene-C4 synthase activity ISO
Inferred from Sequence Orthology
more info
  
enables lyase activity IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in glutathione biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
involved_in leukotriene biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in leukotriene biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
involved_in leukotriene metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in lipid metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in membrane lipid catabolic process ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
  
located_in membrane ISO
Inferred from Sequence Orthology
more info
  
is_active_in nuclear envelope IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
microsomal glutathione S-transferase 2
Names
glutathione peroxidase MGST2
leukotriene C4 synthase MGST2
microsomal GST-2
microsomal GST-II
microsomal glutathione S-transferase II
NP_001297411.1
NP_778160.2
XP_006501311.1
XP_011238358.1
XP_011238359.1
XP_030108387.1
XP_030108388.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001310482.1 → NP_001297411.1  microsomal glutathione S-transferase 2 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate exon in the 3' coding region, resulting in a frameshift and an early stop codon compared to variant 1. The encoded isoform (2) has a shorter and distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AI005961, BC145529, EH107642
    Consensus CDS
    CCDS79903.1
    UniProtKB/TrEMBL
    A0A0A6YWX7
    Related
    ENSMUSP00000141745.2, ENSMUST00000159554.7
    Conserved Domains (1) summary
    pfam01124
    Location:8 → 72
    MAPEG; MAPEG family

  2. NM_174995.3 → NP_778160.2  microsomal glutathione S-transferase 2 isoform 1

    See identical proteins and their annotated locations for NP_778160.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AA794266, AI005961, AV064608, EH107642
    Consensus CDS
    CCDS38428.1
    UniProtKB/Swiss-Prot
    A2RST1
    Related
    ENSMUSP00000096705.4, ENSMUST00000099106.10
    Conserved Domains (1) summary
    pfam01124
    Location:8 → 124
    MAPEG; MAPEG family

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000069.7 Reference GRCm39 C57BL/6J

    Range
    51544179..51590096
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030252528.2 → XP_030108388.1  microsomal glutathione S-transferase 2 isoform X2

  2. XM_006501248.1 → XP_006501311.1  microsomal glutathione S-transferase 2 isoform X2

    See identical proteins and their annotated locations for XP_006501311.1

  3. XM_011240056.4 → XP_011238358.1  microsomal glutathione S-transferase 2 isoform X1

  4. XM_030252527.2 → XP_030108387.1  microsomal glutathione S-transferase 2 isoform X2

  5. XM_011240057.4 → XP_011238359.1  microsomal glutathione S-transferase 2 isoform X2

    See identical proteins and their annotated locations for XP_011238359.1

    Conserved Domains (1) summary
    pfam01124
    Location:1 → 58
    MAPEG; MAPEG family
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A2RST1.1 GenPept UniProtKB/Swiss-Prot:A2RST1

Gene LinkOut

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