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Ark2n arkadia (RNF111) N-terminal like PKA signaling regulator 2N [ Mus musculus (house mouse) ]

Gene ID: 212163, updated on 16-Apr-2024

Summary

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Official Symbol
Ark2nprovided by MGI
Official Full Name
arkadia (RNF111) N-terminal like PKA signaling regulator 2Nprovided by MGI
Primary source
MGI:MGI:2444951
See related
Ensembl:ENSMUSG00000047466 AllianceGenome:MGI:2444951
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Akd2; 8030462N17Rik
Summary
Predicted to enable ubiquitin protein ligase activity. Predicted to be involved in ubiquitin-dependent protein catabolic process. Orthologous to human C18orf25 (chromosome 18 open reading frame 25). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in cerebellum adult (RPKM 5.2), frontal lobe adult (RPKM 3.7) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
18 E3; 18 52.38 cM
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 18 NC_000084.7 (77719184..77802190, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 18 NC_000084.6 (77631488..77714490, complement)

Chromosome 18 - NC_000084.7Genomic Context describing neighboring genes Neighboring gene arkadia (RNF111) C-terminal like ring finger ubiquitin ligase 2C Neighboring gene STARR-seq mESC enhancer starr_45121 Neighboring gene predicted gene, 41784 Neighboring gene predicted gene, 26014 Neighboring gene RIKEN cDNA 4930465K10 gene Neighboring gene RIKEN cDNA A330094K24 gene Neighboring gene RIKEN cDNA 5730552O08 gene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Phosphoproteomics of three exercise modalities identifies canonical signaling and C18ORF25 as an AMPK substrate regulating skeletal muscle function. Blazev R, et al. Cell Metab, 2022 Oct 4. PMID 35882232
  2. Rnf165/Ark2C enhances BMP-Smad signaling to mediate motor axon extension. Kelly CE, et al. PLoS Biol, 2013. PMID 23610558, Free PMC Article
  3. A large-scale, gene-driven mutagenesis approach for the functional analysis of the mouse genome. Hansen J, et al. Proc Natl Acad Sci U S A, 2003 Aug 19. PMID 12904583, Free PMC Article
  4. BayGenomics: a resource of insertional mutations in mouse embryonic stem cells. Stryke D, et al. Nucleic Acids Res, 2003 Jan 1. PMID 12520002, Free PMC Article
  5. BraInMap Elucidates the Macromolecular Connectivity Landscape of Mammalian Brain. Pourhaghighi R, et al. Cell Syst, 2020 Apr 22. PMID 32325033, Free PMC Article

See all (17) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Affinity Purification-Mass Spectrometry and Single Fiber Physiology/Proteomics Reveals Mechanistic Insights of C18ORF25.
    Title: Affinity Purification-Mass Spectrometry and Single Fiber Physiology/Proteomics Reveals Mechanistic Insights of C18ORF25.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables transcription corepressor activity ISO
Inferred from Sequence Orthology
more info
  
enables ubiquitin protein ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in negative regulation of viral life cycle ISO
Inferred from Sequence Orthology
more info
  
involved_in ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
  
part_of chromatin ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
protein ARK2N
Names
arkadia 2
protein C18orf25 homolog
uncharacterized protein C18orf25 homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001368759.1 → NP_001355688.1  protein ARK2N isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC102195, AC162291
    Conserved Domains (1) summary
    pfam15303
    Location:67 → 213
    RNF111_N; E3 ubiquitin-protein ligase Arkadia N-terminus

  2. NM_178670.4 → NP_848785.2  protein ARK2N isoform 1

    See identical proteins and their annotated locations for NP_848785.2

    Status: VALIDATED

    Source sequence(s)
    AC102195, AC162291
    Consensus CDS
    CCDS29355.1
    UniProtKB/TrEMBL
    Q0VAW6
    Related
    ENSMUSP00000074225.5, ENSMUST00000074653.6
    Conserved Domains (1) summary
    pfam15303
    Location:67 → 213
    RNF111_N; E3 ubiquitin-protein ligase Arkadia N-terminus

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000084.7 Reference GRCm39 C57BL/6J

    Range
    77719184..77802190 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006526426.2 → XP_006526489.1  protein ARK2N isoform X1

    See identical proteins and their annotated locations for XP_006526489.1

    UniProtKB/TrEMBL
    Q0VAW6
    Related
    ENSMUSP00000158108.2, ENSMUST00000237203.2
    Conserved Domains (1) summary
    pfam15303
    Location:67 → 213
    RNF111_N; E3 ubiquitin-protein ligase Arkadia N-terminus

  2. XM_011247069.4 → XP_011245371.1  protein ARK2N isoform X3

    See identical proteins and their annotated locations for XP_011245371.1

    Conserved Domains (1) summary
    pfam15303
    Location:67 → 213
    RNF111_N; E3 ubiquitin-protein ligase Arkadia N-terminus

  3. XM_006526428.3 → XP_006526491.1  protein ARK2N isoform X5

  4. XM_011247067.4 → XP_011245369.1  protein ARK2N isoform X2

    See identical proteins and their annotated locations for XP_011245369.1

    Conserved Domains (1) summary
    pfam15303
    Location:67 → 213
    RNF111_N; E3 ubiquitin-protein ligase Arkadia N-terminus

  5. XM_011247070.4 → XP_011245372.1  protein ARK2N isoform X4

    Conserved Domains (1) summary
    pfam15303
    Location:67 → 213
    RNF111_N; E3 ubiquitin-protein ligase Arkadia N-terminus

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001039480.1: Suppressed sequence

    Description
    NM_001039480.1: This RefSeq record was removed by NCBI staff. Contact info@ncbi.nlm.nih.gov for further information.
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8BH50.1 GenPept UniProtKB/Swiss-Prot:Q8BH50

Gene LinkOut

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