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Gsap gamma-secretase activating protein [ Mus musculus (house mouse) ]

Gene ID: 212167, updated on 16-Oct-2021

Summary

Official Symbol
Gsapprovided by MGI
Official Full Name
gamma-secretase activating proteinprovided by MGI
Primary source
MGI:MGI:2442259
See related
Ensembl:ENSMUSG00000039934
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Pion; A530088I07Rik
Expression
Broad expression in lung adult (RPKM 7.7), liver adult (RPKM 3.7) and 22 other tissues See more
Orthologs
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Genomic context

See Gsap in Genome Data Viewer
Location:
5; 5 A3
Exon count:
39
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (21380767..21518423)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (21176019..21291737)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 5 NC_000071.5 (20692085..20797519)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene neuroepithelial cell transforming gene 1 pseudogene Neighboring gene predicted gene, 42222 Neighboring gene coiled-coil domain containing 146 Neighboring gene predicted gene, 50626 Neighboring gene VISTA enhancer mm186 Neighboring gene fibrinogen-like protein 2

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables amyloid-beta binding ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in Golgi apparatus IEA
Inferred from Electronic Annotation
more info
 
is_active_in trans-Golgi network IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in trans-Golgi network ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
gamma-secretase-activating protein
Names
pigeon homolog
protein pigeon homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001359876.1NP_001346805.1  gamma-secretase-activating protein isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1.
    Source sequence(s)
    AC113052
    Related
    ENSMUSP00000142986.2, ENSMUST00000198937.2
    Conserved Domains (1) summary
    pfam14959
    Location:615722
    GSAP-16; gamma-Secretase-activating protein C-term
  2. NM_001359877.1NP_001346806.1  gamma-secretase-activating protein isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 3' UTR and coding sequence compared to variant 1. The resulting isoform (3) has a shorter and distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AC113052, AK080244
    Related
    ENSMUST00000197522.5
  3. NM_175437.3NP_780646.2  gamma-secretase-activating protein isoform 1

    See identical proteins and their annotated locations for NP_780646.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AK033694, BC059054
    Consensus CDS
    CCDS39021.1
    UniProtKB/Swiss-Prot
    Q3TCV3
    Related
    ENSMUSP00000043679.9, ENSMUST00000036031.13
    Conserved Domains (1) summary
    pfam14959
    Location:646753
    GSAP-16; gamma-Secretase-activating protein C-term

RNA

  1. NR_153365.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC113052
    Related
    ENSMUST00000198014.5
  2. NR_153366.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC113052

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    21380767..21518423
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030254347.2XP_030110207.1  gamma-secretase-activating protein isoform X4

    Conserved Domains (1) summary
    pfam14959
    Location:404511
    GSAP-16; gamma-Secretase-activating protein C-term
  2. XM_011249760.4XP_011248062.1  gamma-secretase-activating protein isoform X2

    Conserved Domains (1) summary
    pfam14959
    Location:561668
    GSAP-16; gamma-Secretase-activating protein C-term
  3. XM_036164977.1XP_036020870.1  gamma-secretase-activating protein isoform X7

    Conserved Domains (1) summary
    pfam14959
    Location:341448
    GSAP-16; gamma-Secretase-activating protein C-term
  4. XM_036164974.1XP_036020867.1  gamma-secretase-activating protein isoform X1

    Conserved Domains (1) summary
    pfam14959
    Location:620727
    GSAP-16; gamma-Secretase-activating protein C-term
  5. XM_036164976.1XP_036020869.1  gamma-secretase-activating protein isoform X7

    Conserved Domains (1) summary
    pfam14959
    Location:341448
    GSAP-16; gamma-Secretase-activating protein C-term
  6. XM_030254346.1XP_030110206.1  gamma-secretase-activating protein isoform X4

    Conserved Domains (1) summary
    pfam14959
    Location:404511
    GSAP-16; gamma-Secretase-activating protein C-term
  7. XM_036164978.1XP_036020871.1  gamma-secretase-activating protein isoform X7

    Conserved Domains (1) summary
    pfam14959
    Location:341448
    GSAP-16; gamma-Secretase-activating protein C-term
  8. XM_006535669.4XP_006535732.1  gamma-secretase-activating protein isoform X6

    Conserved Domains (1) summary
    pfam14959
    Location:401508
    GSAP-16; gamma-Secretase-activating protein C-term
  9. XM_036164975.1XP_036020868.1  gamma-secretase-activating protein isoform X3

    Conserved Domains (1) summary
    pfam14959
    Location:646701
    GSAP-16; gamma-Secretase-activating protein C-term
  10. XM_006535668.4XP_006535731.1  gamma-secretase-activating protein isoform X5

RNA

  1. XR_004942490.1 RNA Sequence

  2. XR_004942489.1 RNA Sequence

  3. XR_001784656.3 RNA Sequence

  4. XR_001784657.3 RNA Sequence

  5. XR_001784658.3 RNA Sequence

  6. XR_004942491.1 RNA Sequence

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