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Mars2 methionine-tRNA synthetase 2 (mitochondrial) [ Mus musculus (house mouse) ]

Gene ID: 212679, updated on 5-Jan-2022

Summary

Official Symbol
Mars2provided by MGI
Official Full Name
methionine-tRNA synthetase 2 (mitochondrial)provided by MGI
Primary source
MGI:MGI:2444136
See related
Ensembl:ENSMUSG00000046994
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
MetRS; C730026E21Rik
Summary
Predicted to enable methionine-tRNA ligase activity. Predicted to be involved in methionyl-tRNA aminoacylation. Predicted to act upstream of or within translation. Located in mitochondrion. Is expressed in several structures, including alimentary system; brain; cardiovascular system; genitourinary system; and immune system. Human ortholog(s) of this gene implicated in combined oxidative phosphorylation deficiency 25 and spastic ataxia 3. Orthologous to human MARS2 (methionyl-tRNA synthetase 2, mitochondrial). [provided by Alliance of Genome Resources, Nov 2021]
Orthologs
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Genomic context

See Mars2 in Genome Data Viewer
Location:
1; 1 C1.2
Exon count:
1
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (55276336..55279217)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (55237177..55240058)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 1 NC_000067.5 (55294021..55296902)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene ATP synthase, H+ transporting, mitochondrial F0 complex, subunit g pseudogene Neighboring gene raftlin family member 2 Neighboring gene predicted gene 10561 Neighboring gene boule homolog, RNA binding protein Neighboring gene predicted gene 8292 Neighboring gene basic transcription factor 3, pseudogene 17

Genomic regions, transcripts, and products

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables aminoacyl-tRNA ligase activity IEA
Inferred from Electronic Annotation
more info
 
enables ligase activity IEA
Inferred from Electronic Annotation
more info
 
enables methionine-tRNA ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables methionine-tRNA ligase activity ISO
Inferred from Sequence Orthology
more info
 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in methionyl-tRNA aminoacylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in methionyl-tRNA aminoacylation ISO
Inferred from Sequence Orthology
more info
 
involved_in tRNA aminoacylation for protein translation IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within translation IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in mitochondrial matrix ISO
Inferred from Sequence Orthology
more info
 
located_in mitochondrion HDA PubMed 

General protein information

Preferred Names
methionine--tRNA ligase, mitochondrial
Names
methionine--tRNA ligase 2
methionyl-tRNA synthetase 2
methionyl-tRNA synthetase, mitochondrial
mitochondrial methionine--tRNA ligase
mitochondrial methionyl-tRNA synthetase
mtMetRS
NP_780648.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_175439.3NP_780648.1  methionine--tRNA ligase, mitochondrial precursor

    See identical proteins and their annotated locations for NP_780648.1

    Status: VALIDATED

    Source sequence(s)
    AC122223
    Consensus CDS
    CCDS14963.1
    UniProtKB/Swiss-Prot
    Q499X9
    UniProtKB/TrEMBL
    A2RT28
    Related
    ENSMUSP00000049770.9, ENSMUST00000061334.10
    Conserved Domains (3) summary
    cd07957
    Location:388532
    Anticodon_Ia_Met; Anticodon-binding domain of methionyl tRNA synthetases
    cd00814
    Location:37379
    MetRS_core; catalytic core domain of methioninyl-tRNA synthetases
    PRK11893
    Location:39574
    PRK11893; methionyl-tRNA synthetase; Reviewed

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    55276336..55279217
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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