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Fstl5 follistatin-like 5 [ Mus musculus (house mouse) ]

Gene ID: 213262, updated on 11-Apr-2024

Summary

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Official Symbol
Fstl5provided by MGI
Official Full Name
follistatin-like 5provided by MGI
Primary source
MGI:MGI:2442179
See related
Ensembl:ENSMUSG00000034098 AllianceGenome:MGI:2442179
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
9130207J01Rik
Summary
Predicted to enable calcium ion binding activity. Predicted to be involved in cell differentiation. Predicted to be located in extracellular region. Is expressed in several structures, including central nervous system; dorsal root ganglion; heart; limb; and retina. Orthologous to human FSTL5 (follistatin like 5). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in CNS E18 (RPKM 5.6), whole brain E14.5 (RPKM 4.6) and 5 other tissues See more
Orthologs
human all
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Genomic context

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Location:
3 E3; 3 34.04 cM
Exon count:
18
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (75981582..76617317)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (76074275..76710010)

Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E1260 Neighboring gene golgi integral membrane protein 4 Neighboring gene STARR-positive B cell enhancer mm9_chr3:75805184-75805484 Neighboring gene crumbs homolog 1 pseudogene Neighboring gene VISTA enhancer mm1370 Neighboring gene STARR-seq mESC enhancer starr_07975 Neighboring gene STARR-seq mESC enhancer starr_07976 Neighboring gene STARR-seq mESC enhancer starr_07977 Neighboring gene SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily e, member 1 pseudogene Neighboring gene STARR-seq mESC enhancer starr_07978 Neighboring gene predicted gene, 23644

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Follistatin-like 5 is expressed in restricted areas of the adult mouse brain: Implications for its function in the olfactory system. Masuda T, et al. Congenit Anom (Kyoto), 2014 Feb. PMID 24588779
  2. Genetic association and characterization of FSTL5 in isolated clubfoot. Khanshour AM, et al. Hum Mol Genet, 2021 Jan 21. PMID 33105483, Free PMC Article
  3. Autism risk gene POGZ promotes chromatin accessibility and expression of clustered synaptic genes. Markenscoff-Papadimitriou E, et al. Cell Rep, 2021 Dec 7. PMID 34879283, Free PMC Article
  4. Laser capture microdissection and cDNA array analysis for identification of mouse KIAA/FLJ genes differentially expressed in the embryonic dorsal spinal cord. Masuda T, et al. Brain Res, 2009 Jan 16. PMID 19026994
  5. A neurogenomics approach to gene expression analysis in the developing brain. Jensen P, et al. Brain Res Mol Brain Res, 2004 Dec 20. PMID 15582152

See all (21) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Restricted expression in the olfactory system suggests a possible role for Fstl5 in maintaining odor perception
    Title: Follistatin-like 5 is expressed in restricted areas of the adult mouse brain: Implications for its function in the olfactory system.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1) 
  • Endonuclease-mediated (2) 

General gene information

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Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in cell differentiation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in multicellular organism development IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of BMP signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in extracellular region IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
follistatin-related protein 5
Names
follistatin-like protein 5
m-D/Bsp120I 1-2
ollistatin-like 5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001253719.1 → NP_001240648.1  follistatin-related protein 5 precursor

    See identical proteins and their annotated locations for NP_001240648.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants encode the same protein.
    Source sequence(s)
    AK046070, BC075640
    Consensus CDS
    CCDS38455.1
    UniProtKB/Swiss-Prot
    Q80TG3, Q8BFR2, Q8C4T3
    UniProtKB/TrEMBL
    Q3UUI4
    Related
    ENSMUSP00000125393.2, ENSMUST00000160261.8
    Conserved Domains (4) summary
    cd05736
    Location:358 → 433
    Ig2_Follistatin_like; Second immunoglobulin (Ig)-like domain of a Follistatin-related protein 5 and similar proteins
    cd00104
    Location:93 → 133
    KAZAL_FS; Kazal type serine protease inhibitors and follistatin-like domains. Kazal inhibitors inhibit serine proteases, such as, trypsin, chyomotrypsin, avian ovomucoids, and elastases. The inhibitory domain has one reactive site peptide bond, which serves the ...
    cd00096
    Location:266 → 323
    Ig; Immunoglobulin domain
    pfam13499
    Location:182 → 243
    EF-hand_7; EF-hand domain pair

  2. NM_178673.4 → NP_848788.2  follistatin-related protein 5 precursor

    See identical proteins and their annotated locations for NP_848788.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Both variants encode the same protein.
    Source sequence(s)
    BB646895, BC075640
    Consensus CDS
    CCDS38455.1
    UniProtKB/Swiss-Prot
    Q80TG3, Q8BFR2, Q8C4T3
    UniProtKB/TrEMBL
    Q3UUI4
    Related
    ENSMUSP00000038506.9, ENSMUST00000038364.15
    Conserved Domains (4) summary
    cd05736
    Location:358 → 433
    Ig2_Follistatin_like; Second immunoglobulin (Ig)-like domain of a Follistatin-related protein 5 and similar proteins
    cd00104
    Location:93 → 133
    KAZAL_FS; Kazal type serine protease inhibitors and follistatin-like domains. Kazal inhibitors inhibit serine proteases, such as, trypsin, chyomotrypsin, avian ovomucoids, and elastases. The inhibitory domain has one reactive site peptide bond, which serves the ...
    cd00096
    Location:266 → 323
    Ig; Immunoglobulin domain
    pfam13499
    Location:182 → 243
    EF-hand_7; EF-hand domain pair

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000069.7 Reference GRCm39 C57BL/6J

    Range
    75981582..76617317
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006501262.1 → XP_006501325.1  follistatin-related protein 5 isoform X3

    UniProtKB/TrEMBL
    Q3UUI4
    Conserved Domains (4) summary
    cd05736
    Location:358 → 433
    Ig2_Follistatin_like; Second immunoglobulin (Ig)-like domain of a Follistatin-related protein 5 and similar proteins
    cd00104
    Location:93 → 133
    KAZAL_FS; Kazal type serine protease inhibitors and follistatin-like domains. Kazal inhibitors inhibit serine proteases, such as, trypsin, chyomotrypsin, avian ovomucoids, and elastases. The inhibitory domain has one reactive site peptide bond, which serves the ...
    cd00096
    Location:266 → 323
    Ig; Immunoglobulin domain
    pfam13499
    Location:182 → 243
    EF-hand_7; EF-hand domain pair

  2. XM_017319517.1 → XP_017175006.1  follistatin-related protein 5 isoform X2

    UniProtKB/TrEMBL
    Q3UUI4
    Conserved Domains (5) summary
    cd00104
    Location:92 → 132
    KAZAL_FS; Kazal type serine protease inhibitors and follistatin-like domains. Kazal inhibitors inhibit serine proteases, such as, trypsin, chyomotrypsin, avian ovomucoids, and elastases. The inhibitory domain has one reactive site peptide bond, which serves the ...
    pfam13499
    Location:181 → 242
    EF-hand_7; EF-hand domain pair
    pfam13927
    Location:255 → 322
    Ig_3; Immunoglobulin domain
    cd00096
    Location:265 → 269
    Ig; Ig strand B [structural motif]
    cd05736
    Location:340 → 432
    IgI_2_Follistatin_like; Second immunoglobulin (Ig)-like domain of a Follistatin-related protein 5, and similar domains; member of the I-set of Ig superfamily (IgSF) domains

  3. XM_006501263.1 → XP_006501326.1  follistatin-related protein 5 isoform X4

    UniProtKB/TrEMBL
    Q3UUI4
    Conserved Domains (4) summary
    cd05736
    Location:357 → 432
    Ig2_Follistatin_like; Second immunoglobulin (Ig)-like domain of a Follistatin-related protein 5 and similar proteins
    cd00104
    Location:92 → 132
    KAZAL_FS; Kazal type serine protease inhibitors and follistatin-like domains. Kazal inhibitors inhibit serine proteases, such as, trypsin, chyomotrypsin, avian ovomucoids, and elastases. The inhibitory domain has one reactive site peptide bond, which serves the ...
    cd00096
    Location:265 → 322
    Ig; Immunoglobulin domain
    pfam13499
    Location:181 → 242
    EF-hand_7; EF-hand domain pair

  4. XM_030252533.2 → XP_030108393.1  follistatin-related protein 5 isoform X1

    UniProtKB/Swiss-Prot
    Q80TG3, Q8BFR2, Q8C4T3
    UniProtKB/TrEMBL
    Q3UUI4
    Conserved Domains (4) summary
    cd05736
    Location:358 → 433
    Ig2_Follistatin_like; Second immunoglobulin (Ig)-like domain of a Follistatin-related protein 5 and similar proteins
    cd00104
    Location:93 → 133
    KAZAL_FS; Kazal type serine protease inhibitors and follistatin-like domains. Kazal inhibitors inhibit serine proteases, such as, trypsin, chyomotrypsin, avian ovomucoids, and elastases. The inhibitory domain has one reactive site peptide bond, which serves the ...
    cd00096
    Location:266 → 323
    Ig; Immunoglobulin domain
    pfam13499
    Location:182 → 243
    EF-hand_7; EF-hand domain pair

  5. XM_036162997.1 → XP_036018890.1  follistatin-related protein 5 isoform X2

    UniProtKB/TrEMBL
    Q3UUI4
    Conserved Domains (5) summary
    cd00104
    Location:92 → 132
    KAZAL_FS; Kazal type serine protease inhibitors and follistatin-like domains. Kazal inhibitors inhibit serine proteases, such as, trypsin, chyomotrypsin, avian ovomucoids, and elastases. The inhibitory domain has one reactive site peptide bond, which serves the ...
    pfam13499
    Location:181 → 242
    EF-hand_7; EF-hand domain pair
    pfam13927
    Location:255 → 322
    Ig_3; Immunoglobulin domain
    cd00096
    Location:265 → 269
    Ig; Ig strand B [structural motif]
    cd05736
    Location:340 → 432
    IgI_2_Follistatin_like; Second immunoglobulin (Ig)-like domain of a Follistatin-related protein 5, and similar domains; member of the I-set of Ig superfamily (IgSF) domains
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8BFR2.1 GenPept UniProtKB/Swiss-Prot:Q8BFR2

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