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Tank TRAF family member-associated Nf-kappa B activator [ Mus musculus (house mouse) ]

Gene ID: 21353, updated on 5-Mar-2024

Summary

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Official Symbol
Tankprovided by MGI
Official Full Name
TRAF family member-associated Nf-kappa B activatorprovided by MGI
Primary source
MGI:MGI:107676
See related
Ensembl:ENSMUSG00000064289 AllianceGenome:MGI:107676
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
I-TRAF; E430026L09Rik
Summary
Predicted to enable deubiquitinase activator activity and ubiquitin protein ligase binding activity. Predicted to contribute to thiol-dependent deubiquitinase. Acts upstream of or within I-kappaB kinase/NF-kappaB signaling. Predicted to be located in cytosol. Predicted to be part of protein-containing complex. Is expressed in several structures, including alimentary system; brain; genitourinary system; hemolymphoid system gland; and liver and biliary system. Orthologous to human TANK (TRAF family member associated NFKB activator). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in bladder adult (RPKM 6.0), frontal lobe adult (RPKM 5.6) and 26 other tissues See more
Orthologs
human all
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Genomic context

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Location:
2 C1.3; 2 35.56 cM
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (61408901..61484515)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (61578557..61654171)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E4455 Neighboring gene STARR-positive B cell enhancer ABC_E4456 Neighboring gene STARR-positive B cell enhancer mm9_chr2:61332470-61332771 Neighboring gene DEAD (Asp-Glu-Ala-Asp) box polypeptide 18 pseudogene Neighboring gene predicted gene, 33841 Neighboring gene STARR-seq mESC enhancer starr_04631 Neighboring gene STARR-positive B cell enhancer ABC_E808 Neighboring gene STARR-positive B cell enhancer ABC_E5924 Neighboring gene STARR-positive B cell enhancer ABC_E506 Neighboring gene STARR-positive B cell enhancer ABC_E7821 Neighboring gene STARR-positive B cell enhancer mm9_chr2:61481154-61481454 Neighboring gene STARR-seq mESC enhancer starr_04632 Neighboring gene STARR-positive B cell enhancer ABC_E4457 Neighboring gene proteasome (prosome, macropain) 26S subunit, non-ATPase, 14 Neighboring gene T-box brain transcription factor 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. TANK prevents IFN-dependent fatal diffuse alveolar hemorrhage by suppressing DNA-cGAS aggregation. Wakabayashi A, et al. Life Sci Alliance, 2022 Feb. PMID 34819357, Free PMC Article
  2. TRAF family member-associated NF-κB activator (TANK) induced by RANKL negatively regulates osteoclasts survival and function. Wu M, et al. Int J Biol Sci, 2012. PMID 23139637, Free PMC Article
  3. TRAF family member-associated NF-κB activator (TANK) is a negative regulator of osteoclastogenesis and bone formation. Maruyama K, et al. J Biol Chem, 2012 Aug 17. PMID 22773835, Free PMC Article
  4. TANK, a co-inducer with TRAF2 of TNF- and CD 40L-mediated NF-kappaB activation. Cheng G, et al. Genes Dev, 1996 Apr 15. PMID 8608943
  5. TANK Promotes Pressure Overload Induced Cardiac Hypertrophy via Activating AKT Signaling Pathway. Pang Y, et al. Front Cardiovasc Med, 2021. PMID 34540911, Free PMC Article

See all (40) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Findings suggest that the cortical neuroimmune regulator TANK is involved in cortical aversive emotion processing and related control of alcohol drinking behavior. A tank knock out mouse model suggests a role of TANK in alcohol drinking, anxiety-related behavior, as well as alcohol exposure induced activation of insular cortex NF-kappaB.
    Title: The Cortical Neuroimmune Regulator TANK Affects Emotional Processing and Enhances Alcohol Drinking: A Translational Study.
  2. TANK is expressed in DRG neurons. TANK is increased by peripheral nerve injury. the regulation of TANK expression is, at least in part, controlled by the injury-associated transcription factor Sox11.
    Title: TRAF family member-associated NF-kappa B activator (TANK) expression increases in injured sensory neurons and is transcriptionally regulated by Sox11.
  3. Tank, whose expression is increased during osteoclastogenesis, inhibits osteoclast formation, activity and survival, by regulating NF-kappaB activity and c-FLIP expression.
    Title: TRAF family member-associated NF-κB activator (TANK) induced by RANKL negatively regulates osteoclasts survival and function.
  4. TANK is critical for osteoclastogenesis by regulating NF-kappaB, and is also important for proper bone remodeling.
    Title: TRAF family member-associated NF-κB activator (TANK) is a negative regulator of osteoclastogenesis and bone formation.
  5. role for TANK in enabling the canonical IKKs and the IKK-related kinases to regulate each other, which is required to limit the strength of TLR signaling and ultimately, prevent autoimmunity
    Title: The TRAF-associated protein TANK facilitates cross-talk within the IkappaB kinase family during Toll-like receptor signaling.
  6. MARCH5 is an authentic E3 ubiquitin ligase and catalyzes K63-linked polyubiquitination of TANK. MARCH5 modulates TLR7 signaling via releasing the inhibitory action of TANK toward TRAF6.
    Title: Mitochondrial ubiquitin ligase MARCH5 promotes TLR7 signaling by attenuating TANK action.
  7. constitutive TLR signaling by intestinal commensal microflora is suppressed by TANK.
    Title: TANK is a negative regulator of Toll-like receptor signaling and is critical for the prevention of autoimmune nephritis.
  8. TANK may be a critical adaptor that regulates the assembly of the TANK-binding kinase 1-inducible IkappaB kinase complex with upstream signaling molecules in multiple antiviral pathways
    Title: Modulation of the interferon antiviral response by the TBK1/IKKi adaptor protein TANK.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
contributes_to cysteine-type deubiquitinase activity ISO
Inferred from Sequence Orthology
more info
  
enables deubiquitinase activator activity ISO
Inferred from Sequence Orthology
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables molecular adaptor activity ISO
Inferred from Sequence Orthology
more info
  
enables molecular function inhibitor activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables ubiquitin protein ligase binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in DNA damage response ISO
Inferred from Sequence Orthology
more info
  
involved_in canonical NF-kappaB signal transduction IEA
Inferred from Electronic Annotation
more info
  
involved_in cellular response to interleukin-1 ISO
Inferred from Sequence Orthology
more info
  
involved_in cellular response to ionizing radiation ISO
Inferred from Sequence Orthology
more info
  
involved_in cellular response to tumor necrosis factor ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of canonical NF-kappaB signal transduction ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of tumor necrosis factor-mediated signaling pathway IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of protein deubiquitination ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of type I interferon production ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of ubiquitin-specific protease activity ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
part_of protein-containing complex ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
TRAF family member-associated NF-kappa-B activator
Names
TRAF-interacting protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001164071.1 → NP_001157543.1  TRAF family member-associated NF-kappa-B activator isoform 1

    See identical proteins and their annotated locations for NP_001157543.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes isoform 1. Variants 1 and 4 both encode the same isoform (1).
    Source sequence(s)
    AK147727, AL845291, BB660164
    Consensus CDS
    CCDS50592.1
    UniProtKB/TrEMBL
    Q3UGW0
    Related
    ENSMUSP00000108120.3, ENSMUST00000112501.9
    Conserved Domains (1) summary
    pfam12845
    Location:134 → 185
    TBD; TBD domain

  2. NM_001164072.1 → NP_001157544.1  TRAF family member-associated NF-kappa-B activator isoform 2

    See identical proteins and their annotated locations for NP_001157544.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate exon in the 5' UTR and uses an alternate in-frame splice site in the central coding region, compared to variant 1. The resulting isoform (2) lacks one internal residue, compared to isoform 1.
    Source sequence(s)
    AK147727, AK165420, AL845291, BB660164
    Consensus CDS
    CCDS50593.1
    UniProtKB/TrEMBL
    Q3TNB4, Q8C2D3
    Related
    ENSMUSP00000108114.2, ENSMUST00000112495.8
    Conserved Domains (2) summary
    pfam05557
    Location:25 → 83
    MAD; Mitotic checkpoint protein
    pfam12845
    Location:131 → 184
    TBD; TBD domain

  3. NM_001355267.1 → NP_001342196.1  TRAF family member-associated NF-kappa-B activator isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 1. Variants 1 and 4 both encode the same isoform (1).
    Source sequence(s)
    AL845291, AL928859
    Consensus CDS
    CCDS50592.1
    UniProtKB/TrEMBL
    Q3UGW0
    Conserved Domains (1) summary
    pfam12845
    Location:134 → 185
    TBD; TBD domain

  4. NM_001355268.1 → NP_001342197.1  TRAF family member-associated NF-kappa-B activator isoform 4

    Status: VALIDATED

    Source sequence(s)
    AL845291, AL928859
    Related
    ENSMUST00000141544.8
    Conserved Domains (1) summary
    pfam12845
    Location:2 → 52
    TBD; TBD domain

  5. NM_001374667.1 → NP_001361596.1  TRAF family member-associated NF-kappa-B activator isoform 5

    Status: VALIDATED

    Source sequence(s)
    AL845291, AL928859
    Consensus CDS
    CCDS89491.1
    UniProtKB/TrEMBL
    A2AR76, Q3TNB4
    Related
    ENSMUSP00000108121.2, ENSMUST00000112502.8
    Conserved Domains (2) summary
    pfam05557
    Location:59 → 117
    MAD; Mitotic checkpoint protein
    pfam12845
    Location:165 → 218
    TBD; TBD domain

  6. NM_001378922.1 → NP_001365851.1  TRAF family member-associated NF-kappa-B activator isoform 6

    Status: VALIDATED

    Source sequence(s)
    AL845291, AL928859
    Conserved Domains (1) summary
    pfam12845
    Location:2 → 51
    TBD; TBD domain

  7. NM_011529.2 → NP_035659.1  TRAF family member-associated NF-kappa-B activator isoform 3

    See identical proteins and their annotated locations for NP_035659.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) represents use of an alternate promoter and 5' UTR and uses an upstream start codon, compared to variant 1. The resulting isoform (3) has a longer N-terminus, compared to isoform 1.
    Source sequence(s)
    AL845291, U59864
    Consensus CDS
    CCDS16061.1
    UniProtKB/Swiss-Prot
    P70347, Q61178
    UniProtKB/TrEMBL
    Q3UGW0
    Related
    ENSMUSP00000077219.3, ENSMUST00000078074.9
    Conserved Domains (1) summary
    pfam12845
    Location:166 → 218
    TBD; TBD domain

RNA

  1. NR_149323.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL845291, AL928859

  2. NR_149324.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL845291, AL928859

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    61408901..61484515
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036160230.1 → XP_036016123.1  TRAF family member-associated NF-kappa-B activator isoform X1

    UniProtKB/TrEMBL
    A2AR78
    Conserved Domains (1) summary
    pfam12845
    Location:166 → 218
    TBD; TBD domain

  2. XM_036160231.1 → XP_036016124.1  TRAF family member-associated NF-kappa-B activator isoform X3

    UniProtKB/TrEMBL
    A2AR78
    Conserved Domains (1) summary
    pfam12845
    Location:132 → 184
    TBD; TBD domain

  3. XM_036160232.1 → XP_036016125.1  TRAF family member-associated NF-kappa-B activator isoform X4

    UniProtKB/TrEMBL
    A2AR78
    Conserved Domains (1) summary
    pfam12845
    Location:131 → 183
    TBD; TBD domain

  4. XM_017316913.3 → XP_017172402.1  TRAF family member-associated NF-kappa-B activator isoform X2

    UniProtKB/TrEMBL
    Q3TNB4, Q8C2D3
    Conserved Domains (2) summary
    pfam05557
    Location:25 → 83
    MAD; Mitotic checkpoint protein
    pfam12845
    Location:131 → 184
    TBD; TBD domain

  5. XM_036160236.1 → XP_036016129.1  TRAF family member-associated NF-kappa-B activator isoform X5

    Conserved Domains (1) summary
    pfam12845
    Location:2 → 51
    TBD; TBD domain

  6. XM_036160233.1 → XP_036016126.1  TRAF family member-associated NF-kappa-B activator isoform X5

    Conserved Domains (1) summary
    pfam12845
    Location:2 → 51
    TBD; TBD domain

  7. XM_036160237.1 → XP_036016130.1  TRAF family member-associated NF-kappa-B activator isoform X5

    Conserved Domains (1) summary
    pfam12845
    Location:2 → 51
    TBD; TBD domain

  8. XM_036160235.1 → XP_036016128.1  TRAF family member-associated NF-kappa-B activator isoform X5

    Conserved Domains (1) summary
    pfam12845
    Location:2 → 51
    TBD; TBD domain

  9. XM_036160234.1 → XP_036016127.1  TRAF family member-associated NF-kappa-B activator isoform X5

    Conserved Domains (1) summary
    pfam12845
    Location:2 → 51
    TBD; TBD domain

RNA

  1. XR_866264.4 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P70347.1 GenPept UniProtKB/Swiss-Prot:P70347

Gene LinkOut

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