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Tap1 transporter 1, ATP-binding cassette, sub-family B (MDR/TAP) [ Mus musculus (house mouse) ]

Gene ID: 21354, updated on 5-Jul-2021

Summary

Official Symbol
Tap1provided by MGI
Official Full Name
transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)provided by MGI
Primary source
MGI:MGI:98483
See related
Ensembl:ENSMUSG00000037321
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
T; RI; Y3; Ham; MTP; PSF; TAP; APT1; Abcb; Ham-; Ham1; MTP1; PSF1; ABC17; Abcb2; Ham-1; RING4; Tap-1
Summary
The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. This protein forms a heterodimer with Tap2 that transports short peptides from the cytosol into the endoplasmic reticulum lumen. Mutations in the human gene may be associated with ankylosing spondylitis, insulin-dependent diabetes mellitus, and celiac disease. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2009]
Expression
Broad expression in spleen adult (RPKM 66.8), thymus adult (RPKM 59.4) and 17 other tissues See more
Orthologs
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Genomic context

See Tap1 in Genome Data Viewer
Location:
17 B1; 17 17.98 cM
Exon count:
12
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (34406530..34416199)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (34187556..34197225)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 17 NC_000083.5 (34324501..34334170)

Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene histocompatibility 2, class II, locus Mb1 Neighboring gene proteasome (prosome, macropain) subunit, beta type 9 (large multifunctional peptidase 2) Neighboring gene proteasome (prosome, macropain) subunit, beta type 8 (large multifunctional peptidase 7) Neighboring gene transporter 2, ATP-binding cassette, sub-family B (MDR/TAP)

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ABC-type peptide antigen transporter activity EXP
Inferred from Experiment
more info
PubMed 
enables ABC-type peptide antigen transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables ABC-type peptide antigen transporter activity ISO
Inferred from Sequence Orthology
more info
 
enables ABC-type peptide transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables ADP binding ISO
Inferred from Sequence Orthology
more info
 
enables ATP binding ISO
Inferred from Sequence Orthology
more info
 
enables ATP hydrolysis activity IEA
Inferred from Electronic Annotation
more info
 
enables ATPase-coupled transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables MHC class I protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables MHC class I protein binding ISO
Inferred from Sequence Orthology
more info
 
enables MHC class Ib protein binding ISO
Inferred from Sequence Orthology
more info
 
enables MHC protein binding IEA
Inferred from Electronic Annotation
more info
 
enables TAP1 binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables TAP1 binding ISO
Inferred from Sequence Orthology
more info
 
enables TAP2 binding ISO
Inferred from Sequence Orthology
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables nucleotide binding ISO
Inferred from Sequence Orthology
more info
 
contributes_to peptide antigen binding ISO
Inferred from Sequence Orthology
more info
 
enables peptide antigen binding ISO
Inferred from Sequence Orthology
more info
 
contributes_to peptide transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
 
enables peptide transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
 
enables protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
 
enables protein-containing complex binding ISO
Inferred from Sequence Orthology
more info
 
enables tapasin binding ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
part_of MHC class I peptide loading complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of MHC class I peptide loading complex ISO
Inferred from Sequence Orthology
more info
 
part_of TAP complex ISO
Inferred from Sequence Orthology
more info
 
located_in centriolar satellite ISO
Inferred from Sequence Orthology
more info
 
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
 
located_in integral component of endoplasmic reticulum membrane ISO
Inferred from Sequence Orthology
more info
 
is_active_in integral component of membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in integral component of membrane ISO
Inferred from Sequence Orthology
more info
 
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in mitochondrion HDA PubMed 
located_in phagocytic vesicle membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
antigen peptide transporter 1
Names
ABC transporter, MHC, 1
ATP dependent transport protein family member
ATP-binding cassette sub-family B member 2
ATP-binding cassette transporter, major histocompatibility complex, 1
ATP-binding cassette, sub-family B (MDR/TAP), member 2
histocompatibility antigen modifier 1
peptide supply factor 1
peptide transporter PSF1
peptide transporter TAP1
transporter 1 ATP-binding cassette sub-family B
transporter 1, ABC (ATP binding cassette)
transporter associated with antigen processing 1
transporter, ABC, MHC, 1
transporter, ATP-binding cassette, major histocompatibility complex, 1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001161730.1NP_001155202.1  antigen peptide transporter 1 isoform 2

    See identical proteins and their annotated locations for NP_001155202.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame segment compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1.
    Source sequence(s)
    AK152953, AK167485, AK171363
    Consensus CDS
    CCDS50072.1
    UniProtKB/TrEMBL
    Q3TBA3, Q3U6V4
    Related
    ENSMUSP00000039264.9, ENSMUST00000041633.15
    Conserved Domains (3) summary
    TIGR00958
    Location:21688
    3a01208; Conjugate Transporter-2 (CT2) Family protein
    pfam00664
    Location:176398
    ABC_membrane; ABC transporter transmembrane region
    cl21455
    Location:440668
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
  2. NM_013683.2NP_038711.2  antigen peptide transporter 1 isoform 1

    See identical proteins and their annotated locations for NP_038711.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AK152953, AK162731, AK167485
    Consensus CDS
    CCDS28643.1
    UniProtKB/Swiss-Prot
    P21958
    UniProtKB/TrEMBL
    Q3U6V4
    Related
    ENSMUSP00000128401.2, ENSMUST00000170086.8
    Conserved Domains (3) summary
    TIGR00958
    Location:21716
    3a01208; Conjugate Transporter-2 (CT2) Family protein
    pfam00664
    Location:176434
    ABC_membrane; ABC transporter transmembrane region
    cl21455
    Location:468696
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000083.7 Reference GRCm39 C57BL/6J

    Range
    34406530..34416199
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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