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Tap2 transporter 2, ATP-binding cassette, sub-family B (MDR/TAP) [ Mus musculus (house mouse) ]

Gene ID: 21355, updated on 23-Jun-2021

Summary

Official Symbol
Tap2provided by MGI
Official Full Name
transporter 2, ATP-binding cassette, sub-family B (MDR/TAP)provided by MGI
Primary source
MGI:MGI:98484
See related
Ensembl:ENSMUSG00000024339
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
PS; Y1; Ham; MTP; Tap; jas; APT2; Abcb; Ham-; Ham2; MTP2; PSF2; ABC18; Abcb3; Ham-2; Tap-2; RING11; AI462429
Summary
The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. The protein encoded by this gene is involved in antigen presentation. This protein forms a heterodimer with Tap1 in order to transport peptides from the cytoplasm to the endoplasmic reticulum. Mutations in the human gene may be associated with ankylosing spondylitis, insulin-dependent diabetes mellitus, and celiac disease. [provided by RefSeq, Jul 2008]
Expression
Broad expression in thymus adult (RPKM 79.3), spleen adult (RPKM 48.3) and 16 other tissues See more
Orthologs
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Genomic context

See Tap2 in Genome Data Viewer
Location:
17 B1; 17 17.98 cM
Exon count:
12
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (34423453..34435295)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (34204479..34216321)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 17 NC_000083.5 (34341424..34353266)

Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene transporter 1, ATP-binding cassette, sub-family B (MDR/TAP) Neighboring gene proteasome (prosome, macropain) subunit, beta type 8 (large multifunctional peptidase 7) Neighboring gene histocompatibility 2, O region beta locus Neighboring gene predicted gene 20506

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Chemically induced (ENU) (5) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ABC-type peptide antigen transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables ABC-type peptide antigen transporter activity ISO
Inferred from Sequence Orthology
more info
 
enables ABC-type peptide transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables ADP binding ISO
Inferred from Sequence Orthology
more info
 
enables ATP binding ISO
Inferred from Sequence Orthology
more info
 
enables ATP hydrolysis activity IEA
Inferred from Electronic Annotation
more info
 
enables ATPase-coupled transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
contributes_to MHC class I protein binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
contributes_to MHC class I protein binding ISO
Inferred from Sequence Orthology
more info
 
enables MHC class I protein binding ISO
Inferred from Sequence Orthology
more info
 
enables MHC class Ib protein binding ISO
Inferred from Sequence Orthology
more info
 
enables MHC protein binding IEA
Inferred from Electronic Annotation
more info
 
enables TAP1 binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables TAP1 binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables TAP1 binding ISO
Inferred from Sequence Orthology
more info
 
enables TAP2 binding ISO
Inferred from Sequence Orthology
more info
 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables nucleotide binding ISO
Inferred from Sequence Orthology
more info
 
contributes_to peptide antigen binding ISO
Inferred from Sequence Orthology
more info
 
enables peptide antigen binding ISO
Inferred from Sequence Orthology
more info
 
contributes_to peptide transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
 
enables protein-containing complex binding ISO
Inferred from Sequence Orthology
more info
 
enables tapasin binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within adaptive immune response IEA
Inferred from Electronic Annotation
more info
 
involved_in antigen processing and presentation of endogenous peptide antigen via MHC class I IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within antigen processing and presentation of endogenous peptide antigen via MHC class I ISO
Inferred from Sequence Orthology
more info
 
involved_in antigen processing and presentation of endogenous peptide antigen via MHC class I ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-dependent IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within antigen processing and presentation of endogenous peptide antigen via MHC class Ib via ER pathway, TAP-dependent IDA
Inferred from Direct Assay
more info
PubMed 
involved_in antigen processing and presentation of endogenous peptide antigen via MHC class Ib via ER pathway, TAP-dependent ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within antigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependent IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cytosol to endoplasmic reticulum transport ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within immune system process IEA
Inferred from Electronic Annotation
more info
 
involved_in peptide antigen transport ISO
Inferred from Sequence Orthology
more info
 
involved_in peptide transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in peptide transport ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of T cell mediated cytotoxicity IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within positive regulation of T cell mediated cytotoxicity IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within positive regulation of T cell mediated cytotoxicity ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of antigen processing and presentation of peptide antigen via MHC class I ISO
Inferred from Sequence Orthology
more info
 
involved_in protection from natural killer cell mediated cytotoxicity ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within protein transport IEA
Inferred from Electronic Annotation
more info
 
involved_in protein-containing complex assembly ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within response to molecule of bacterial origin IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
part_of MHC class I peptide loading complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of MHC class I peptide loading complex ISO
Inferred from Sequence Orthology
more info
 
part_of TAP complex ISO
Inferred from Sequence Orthology
more info
 
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
 
located_in integral component of endoplasmic reticulum membrane ISO
Inferred from Sequence Orthology
more info
 
is_active_in integral component of membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in integral component of membrane ISO
Inferred from Sequence Orthology
more info
 
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in nuclear speck ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
antigen peptide transporter 2
Names
ATP dependent transport protein family member
ATP-binding cassette sub-family B member 3
ATP-binding cassette, sub-family B (MDR/TAP), member 3
histocompatibility antigen modifier 2
transporter 2 ATP-binding cassette sub-family B
transporter 2, ABC (ATP binding cassette)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_011530.3NP_035660.3  antigen peptide transporter 2

    See identical proteins and their annotated locations for NP_035660.3

    Status: REVIEWED

    Source sequence(s)
    BE691532, CJ046345, M90459
    Consensus CDS
    CCDS28644.1
    UniProtKB/Swiss-Prot
    P36371
    UniProtKB/TrEMBL
    Q792S7
    Related
    ENSMUSP00000025197.6, ENSMUST00000025197.6
    Conserved Domains (3) summary
    TIGR00958
    Location:1696
    3a01208; Conjugate Transporter-2 (CT2) Family protein
    pfam00664
    Location:155415
    ABC_membrane; ABC transporter transmembrane region
    cl21455
    Location:456679
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000083.7 Reference GRCm39 C57BL/6J

    Range
    34423453..34435295
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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