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Tbrg4 transforming growth factor beta regulated gene 4 [ Mus musculus (house mouse) ]

Gene ID: 21379, updated on 5-Mar-2024

Summary

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Official Symbol
Tbrg4provided by MGI
Official Full Name
transforming growth factor beta regulated gene 4provided by MGI
Primary source
MGI:MGI:1100868
See related
Ensembl:ENSMUSG00000000384 AllianceGenome:MGI:1100868
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Cpr2; Tb-12; 2310042P22Rik
Summary
Predicted to enable RNA binding activity. Predicted to be involved in mitochondrial mRNA processing and regulation of mitochondrial mRNA stability. Located in mitochondrion. Is expressed in axial musculature and seminiferous cord. Orthologous to human TBRG4 (transforming growth factor beta regulator 4). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in colon adult (RPKM 29.8), large intestine adult (RPKM 26.5) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
11 A1; 11 4.6 cM
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (6565598..6576089, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (6615598..6626084, complement)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene cerebral cavernous malformation 2 Neighboring gene STARR-positive B cell enhancer mm9_chr11:6481502-6481803 Neighboring gene NAC alpha domain containing Neighboring gene predicted gene, 24313 Neighboring gene small nucleolar RNA, H/ACA box 5C Neighboring gene whey acidic protein Neighboring gene predicted gene 11978 Neighboring gene receptor (calcitonin) activity modifying protein 3

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Single-cell transcriptomics reveal temporal dynamics of critical regulators of germ cell fate during mouse sex determination. Mayère C, et al. FASEB J, 2021 Apr. PMID 33749946
  2. Epigenetic modifications and chromatin loop organization explain the different expression profiles of the Tbrg4, WAP and Ramp3 genes. Montazer-Torbati MB, et al. Exp Cell Res, 2008 Mar 10. PMID 18255060
  3. Modulation of gene expression in the preimplantation mouse embryo by TGF-alpha and TGF-beta. Babalola GO, et al. Mol Reprod Dev, 1995 Jun. PMID 7654366
  4. Fast kinase domain-containing protein 3 is a mitochondrial protein essential for cellular respiration. Simarro M, et al. Biochem Biophys Res Commun, 2010 Oct 22. PMID 20869947, Free PMC Article
  5. Expressed genes in interleukin-4 treated B cells identified by cDNA representational difference analysis. Chu CC, et al. Mol Immunol, 1998 Jun. PMID 9798653

See all (28) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. tight regulation of WAP gene expression parallels variations in the chromatin structure and DNA methylation profile throughout the Ramp3-WAP-Tbrg4 locus.
    Title: Epigenetic modifications and chromatin loop organization explain the different expression profiles of the Tbrg4, WAP and Ramp3 genes.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • mKIAA0948

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in mRNA metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in mitochondrial RNA processing IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mitochondrial mRNA processing ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of mitochondrial mRNA stability IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of mitochondrial mRNA stability ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in mitochondrial matrix IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrial matrix ISO
Inferred from Sequence Orthology
more info
  
located_in mitochondrion HDA PubMed 
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
  
is_active_in ribonucleoprotein granule IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
FAST kinase domain-containing protein 4
Names
cell cycle progression 2 protein
protein TBRG4
transforming growth factor beta regulator 4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001130457.2 → NP_001123929.1  FAST kinase domain-containing protein 4 isoform 1

    See identical proteins and their annotated locations for NP_001123929.1

    Status: VALIDATED

    Source sequence(s)
    BC031910, BY784127
    Consensus CDS
    CCDS24423.1
    UniProtKB/Swiss-Prot
    O89082, Q3TKZ4, Q6ZQ19, Q8C6D1, Q91YM4
    Related
    ENSMUSP00000140835.2, ENSMUST00000189268.7
    Conserved Domains (3) summary
    smart00952
    Location:562 → 619
    RAP; This domain is found in various eukaryotic species, particularly in apicomplexans
    pfam06743
    Location:368 → 437
    FAST_1; FAST kinase-like protein, subdomain 1
    pfam08368
    Location:453 → 534
    FAST_2; FAST kinase-like protein, subdomain 2

  2. NM_001362713.1 → NP_001349642.1  FAST kinase domain-containing protein 4 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AL603787
    Consensus CDS
    CCDS24423.1
    UniProtKB/Swiss-Prot
    O89082, Q3TKZ4, Q6ZQ19, Q8C6D1, Q91YM4
    Conserved Domains (3) summary
    smart00952
    Location:562 → 619
    RAP; This domain is found in various eukaryotic species, particularly in apicomplexans
    pfam06743
    Location:368 → 437
    FAST_1; FAST kinase-like protein, subdomain 1
    pfam08368
    Location:453 → 534
    FAST_2; FAST kinase-like protein, subdomain 2

  3. NM_001362714.1 → NP_001349643.1  FAST kinase domain-containing protein 4 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AL603787
    Consensus CDS
    CCDS24423.1
    UniProtKB/Swiss-Prot
    O89082, Q3TKZ4, Q6ZQ19, Q8C6D1, Q91YM4
    Conserved Domains (3) summary
    smart00952
    Location:562 → 619
    RAP; This domain is found in various eukaryotic species, particularly in apicomplexans
    pfam06743
    Location:368 → 437
    FAST_1; FAST kinase-like protein, subdomain 1
    pfam08368
    Location:453 → 534
    FAST_2; FAST kinase-like protein, subdomain 2

  4. NM_001362715.1 → NP_001349644.1  FAST kinase domain-containing protein 4 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AL603787
    Conserved Domains (3) summary
    smart00952
    Location:275 → 332
    RAP; This domain is found in various eukaryotic species, particularly in apicomplexans
    pfam06743
    Location:81 → 150
    FAST_1; FAST kinase-like protein, subdomain 1
    pfam08368
    Location:166 → 247
    FAST_2; FAST kinase-like protein, subdomain 2

  5. NM_001362716.1 → NP_001349645.1  FAST kinase domain-containing protein 4 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AL603787
    Conserved Domains (3) summary
    smart00952
    Location:275 → 332
    RAP; This domain is found in various eukaryotic species, particularly in apicomplexans
    pfam06743
    Location:81 → 150
    FAST_1; FAST kinase-like protein, subdomain 1
    pfam08368
    Location:166 → 247
    FAST_2; FAST kinase-like protein, subdomain 2

  6. NM_134011.3 → NP_598772.1  FAST kinase domain-containing protein 4 isoform 1

    See identical proteins and their annotated locations for NP_598772.1

    Status: VALIDATED

    Source sequence(s)
    AK144813, BB727683, BC031910, BY784127
    Consensus CDS
    CCDS24423.1
    UniProtKB/Swiss-Prot
    O89082, Q3TKZ4, Q6ZQ19, Q8C6D1, Q91YM4
    Related
    ENSMUSP00000000394.8, ENSMUST00000000394.14
    Conserved Domains (3) summary
    smart00952
    Location:562 → 619
    RAP; This domain is found in various eukaryotic species, particularly in apicomplexans
    pfam06743
    Location:368 → 437
    FAST_1; FAST kinase-like protein, subdomain 1
    pfam08368
    Location:453 → 534
    FAST_2; FAST kinase-like protein, subdomain 2

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    6565598..6576089 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006514607.5 → XP_006514670.1  FAST kinase domain-containing protein 4 isoform X1

    See identical proteins and their annotated locations for XP_006514670.1

    UniProtKB/Swiss-Prot
    O89082, Q3TKZ4, Q6ZQ19, Q8C6D1, Q91YM4
    Conserved Domains (3) summary
    smart00952
    Location:562 → 619
    RAP; This domain is found in various eukaryotic species, particularly in apicomplexans
    pfam06743
    Location:368 → 437
    FAST_1; FAST kinase-like protein, subdomain 1
    pfam08368
    Location:453 → 534
    FAST_2; FAST kinase-like protein, subdomain 2

  2. XM_011243672.3 → XP_011241974.1  FAST kinase domain-containing protein 4 isoform X2

    Conserved Domains (3) summary
    smart00952
    Location:275 → 332
    RAP; This domain is found in various eukaryotic species, particularly in apicomplexans
    pfam06743
    Location:81 → 150
    FAST_1; FAST kinase-like protein, subdomain 1
    pfam08368
    Location:166 → 247
    FAST_2; FAST kinase-like protein, subdomain 2

RNA

  1. XR_001779944.2 RNA Sequence

    Related
    ENSMUST00000150697.8
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q91YM4.1 GenPept UniProtKB/Swiss-Prot:Q91YM4

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