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Tbx3 T-box 3 [ Mus musculus (house mouse) ]

Gene ID: 21386, updated on 20-Jul-2021

Summary

Official Symbol
Tbx3provided by MGI
Official Full Name
T-box 3provided by MGI
Primary source
MGI:MGI:98495
See related
Ensembl:ENSMUSG00000018604
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
D5Ertd189; D5Ertd189e
Expression
Biased expression in adrenal adult (RPKM 118.3), small intestine adult (RPKM 47.5) and 8 other tissues See more
Orthologs
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Genomic context

See Tbx3 in Genome Data Viewer
Location:
5 F; 5 60.34 cM
Exon count:
9
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (119808600..119822789)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (119670534..119684724)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 5 NC_000071.5 (120120678..120134610)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene T-box 3, opposite strand 1 Neighboring gene predicted gene 16063 Neighboring gene enhancer eA upstream of Tbx3 Neighboring gene predicted gene 16064 Neighboring gene T-box 3, opposite strand 2 Neighboring gene predicted gene, 42017

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Process Evidence Code Pubs
acts_upstream_of_or_within animal organ morphogenesis ISO
Inferred from Sequence Orthology
more info
PubMed 
involved_in anterior/posterior axis specification, embryo ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within atrioventricular bundle cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in atrioventricular canal development IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in atrioventricular canal morphogenesis IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within blood vessel development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within branching involved in mammary gland duct morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cardiac chamber development IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in cardiac epithelial to mesenchymal transition ISO
Inferred from Sequence Orthology
more info
 
involved_in cardiac jelly development ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within cardiac muscle cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within cardiac muscle cell fate commitment IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within cell aging IDA
Inferred from Direct Assay
more info
PubMed 
involved_in cell aging ISO
Inferred from Sequence Orthology
more info
 
involved_in cell fate specification IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in cellular senescence ISO
Inferred from Sequence Orthology
more info
 
involved_in central nervous system development IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within embryonic digit morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in embryonic digit morphogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in embryonic forelimb morphogenesis ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within embryonic heart tube development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within embryonic hindlimb morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in endocardial cushion formation ISO
Inferred from Sequence Orthology
more info
 
involved_in female genitalia development ISO
Inferred from Sequence Orthology
more info
 
involved_in follicle-stimulating hormone secretion ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within forelimb morphogenesis ISO
Inferred from Sequence Orthology
more info
PubMed 
involved_in heart looping IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within heart looping IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within heart morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within in utero embryonic development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within limb morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within limbic system development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in luteinizing hormone secretion ISO
Inferred from Sequence Orthology
more info
 
involved_in male genitalia development ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within mammary gland development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in mammary gland development ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within mammary placode formation IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within mammary placode formation IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in mesoderm morphogenesis ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within multicellular organism development IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of cell proliferation involved in heart morphogenesis ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within negative regulation of epithelial cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of myoblast differentiation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within negative regulation of transcription, DNA-templated IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within negative regulation of transcription, DNA-templated IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of transcription, DNA-templated ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within outflow tract morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of cell cycle ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cell population proliferation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of cell population proliferation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of stem cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of transcription, DNA-templated IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within regulation of cell population proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in regulation of transcription, DNA-templated IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within roof of mouth development IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within sinoatrial node cell development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in sinoatrial node cell development ISO
Inferred from Sequence Orthology
more info
 
involved_in skeletal system development ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within smooth muscle cell differentiation IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within specification of animal organ position IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within stem cell population maintenance IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within ureteric peristalsis IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within ventricular septum morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 
part_of transcription regulator complex IPI
Inferred from Physical Interaction
more info
PubMed 

General protein information

Preferred Names
T-box transcription factor TBX3
Names
T-box protein 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_011535.3NP_035665.2  T-box transcription factor TBX3 isoform 1

    See identical proteins and their annotated locations for NP_035665.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AA543734, AK052453, AK145436, BB054411, BB694449, BB728182, CJ216213
    Consensus CDS
    CCDS19613.1
    UniProtKB/Swiss-Prot
    P70324
    UniProtKB/TrEMBL
    Q3ULL3
    Related
    ENSMUSP00000018748.9, ENSMUST00000018748.9
    Conserved Domains (2) summary
    pfam00907
    Location:105305
    T-box
    pfam12598
    Location:323402
    TBX; T-box transcription factor
  2. NM_198052.2NP_932169.1  T-box transcription factor TBX3 isoform 2

    See identical proteins and their annotated locations for NP_932169.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and lacks an alternate in-frame exon in the 5' coding region, compared to variant 1. It encodes isoform 2, which is shorter than isoform 1.
    Source sequence(s)
    AA543734, BB054411, BB694449, BB728182, BC096551, CJ216213
    Consensus CDS
    CCDS19614.1
    UniProtKB/TrEMBL
    Q4VA43
    Related
    ENSMUSP00000112519.2, ENSMUST00000121021.8
    Conserved Domains (2) summary
    pfam12598
    Location:303391
    TBX; T-box transcription factor
    cd00182
    Location:102287
    TBOX; T-box DNA binding domain of the T-box family of transcriptional regulators. The T-box family is an ancient group that appears to play a critical role in development in all animal species. These genes were uncovered on the basis of similarity to the DNA ...

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    119808600..119822789
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006530276.5XP_006530339.1  T-box transcription factor TBX3 isoform X1

    See identical proteins and their annotated locations for XP_006530339.1

    UniProtKB/Swiss-Prot
    P70324
    Conserved Domains (2) summary
    pfam00907
    Location:105305
    T-box
    pfam12598
    Location:323402
    TBX; T-box transcription factor
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