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Tbx4 T-box 4 [ Mus musculus (house mouse) ]

Gene ID: 21387, updated on 22-Aug-2021

Summary

Official Symbol
Tbx4provided by MGI
Official Full Name
T-box 4provided by MGI
Primary source
MGI:MGI:102556
See related
Ensembl:ENSMUSG00000000094
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
3930401C23
Expression
Biased expression in lung adult (RPKM 26.7), limb E14.5 (RPKM 11.0) and 1 other tissue See more
Orthologs
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Genomic context

See Tbx4 in Genome Data Viewer
Location:
11 C; 11 51.42 cM
Exon count:
10
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (85777193..85806923)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (85886367..85916097)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 11 NC_000077.5 (85703565..85729599)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene VISTA enhancer mm1583 Neighboring gene HLEA enhancer upstream of Tbx4 Neighboring gene Tbx4 lung enhancer Neighboring gene 60S ribosomal protein L21 pseudogene Neighboring gene HLEB enhancer downstream of Tbx4

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
 
enables DNA-binding transcription factor activity IEA
Inferred from Electronic Annotation
more info
 
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in angiogenesis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within angiogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cell fate specification IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in embryonic hindlimb morphogenesis ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within embryonic limb morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in embryonic lung development ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within limb morphogenesis IDA
Inferred from Direct Assay
more info
PubMed 
involved_in limb morphogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in limb morphogenesis ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
acts_upstream_of_or_within lung development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within morphogenesis of an epithelium IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within multicellular organism development IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in regulation of transcription, DNA-templated IEA
Inferred from Electronic Annotation
more info
 
involved_in skeletal system morphogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in skeletal system morphogenesis ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
Component Evidence Code Pubs
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
T-box transcription factor TBX4
Names
T-box protein 4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_011536.3NP_035666.2  T-box transcription factor TBX4 isoform a

    See identical proteins and their annotated locations for NP_035666.2

    Status: VALIDATED

    Source sequence(s)
    AL592465
    Consensus CDS
    CCDS25196.1
    UniProtKB/Swiss-Prot
    P70325
    UniProtKB/TrEMBL
    Q8BSY3
    Related
    ENSMUSP00000103682.2, ENSMUST00000108047.8
    Conserved Domains (1) summary
    cd00182
    Location:71260
    TBOX; T-box DNA binding domain of the T-box family of transcriptional regulators. The T-box family is an ancient group that appears to play a critical role in development in all animal species. These genes were uncovered on the basis of similarity to the DNA ...
  2. NM_172798.1NP_766386.1  T-box transcription factor TBX4 isoform b

    See identical proteins and their annotated locations for NP_766386.1

    Status: VALIDATED

    Source sequence(s)
    AK028407, BB755063, BQ560189
    Consensus CDS
    CCDS48874.1
    UniProtKB/TrEMBL
    Q8BSY3
    Related
    ENSMUSP00000103680.3, ENSMUST00000108045.3
    Conserved Domains (1) summary
    cd00182
    Location:1160
    TBOX; T-box DNA binding domain of the T-box family of transcriptional regulators. The T-box family is an ancient group that appears to play a critical role in development in all animal species. These genes were uncovered on the basis of similarity to the DNA ...

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    85777193..85806923
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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