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Tbx5 T-box 5 [ Mus musculus (house mouse) ]

Gene ID: 21388, updated on 20-Jul-2021

Summary

Official Symbol
Tbx5provided by MGI
Official Full Name
T-box 5provided by MGI
Primary source
MGI:MGI:102541
See related
Ensembl:ENSMUSG00000018263
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Expression
Biased expression in limb E14.5 (RPKM 8.8), lung adult (RPKM 8.1) and 4 other tissues See more
Orthologs
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Genomic context

See Tbx5 in Genome Data Viewer
Location:
5 F; 5 60.42 cM
Exon count:
15
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (119934581..120023285)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (119796514..119885220)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 5 NC_000071.5 (120284672..120335227)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene T-box 3, opposite strand 2 Neighboring gene predicted gene, 42017 Neighboring gene predicted gene 5563 Neighboring gene predicted gene, 31773 Neighboring gene predicted gene, 38554

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
enables DNA binding ISO
Inferred from Sequence Orthology
more info
 
enables DNA-binding transcription activator activity, RNA polymerase II-specific IDA
Inferred from Direct Assay
more info
PubMed 
enables DNA-binding transcription factor activity IDA
Inferred from Direct Assay
more info
PubMed 
enables DNA-binding transcription factor activity ISO
Inferred from Sequence Orthology
more info
 
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables DNA-binding transcription factor activity, RNA polymerase II-specific ISO
Inferred from Sequence Orthology
more info
 
enables DNA-binding transcription factor binding ISO
Inferred from Sequence Orthology
more info
 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
 
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within atrial septum development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within atrial septum morphogenesis IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in atrioventricular bundle cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in atrioventricular node cell development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in atrioventricular node cell fate commitment IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within atrioventricular valve morphogenesis IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within bundle of His cell to Purkinje myocyte communication by electrical coupling IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within bundle of His development IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in bundle of His development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cardiac left ventricle formation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in cardiac left ventricle formation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within cardiac muscle cell differentiation IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in cardiac muscle cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cell fate specification IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in cell-cell signaling ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within cell-cell signaling involved in cardiac conduction IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in embryonic forelimb morphogenesis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within embryonic forelimb morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in embryonic forelimb morphogenesis ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within embryonic limb morphogenesis IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within embryonic limb morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in embryonic limb morphogenesis ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within endocardial cushion development IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within forelimb morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within forelimb morphogenesis ISO
Inferred from Sequence Orthology
more info
PubMed 
acts_upstream_of_or_within heart development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within heart development ISO
Inferred from Sequence Orthology
more info
PubMed 
involved_in heart development ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within lung development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within morphogenesis of an epithelium IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within multicellular organism development IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of cardiac muscle cell proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of cell migration ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of cell population proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in pattern specification process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within pattern specification process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in pericardium development ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of positive regulation of cardiac conduction IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within positive regulation of cardiac muscle cell proliferation IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in positive regulation of cardioblast differentiation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of gap junction assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within positive regulation of secondary heart field cardioblast proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of transcription, DNA-templated IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of transcription, DNA-templated ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within regulation of atrial cardiac muscle cell membrane depolarization IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within regulation of transcription, DNA-templated IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in transdifferentiation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within ventricular cardiac muscle tissue development IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in ventricular septum development IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 
part_of protein-DNA complex ISO
Inferred from Sequence Orthology
more info
 
part_of protein-containing complex ISO
Inferred from Sequence Orthology
more info
 
part_of transcription regulator complex IPI
Inferred from Physical Interaction
more info
PubMed 

General protein information

Preferred Names
T-box transcription factor TBX5
Names
T-box protein 5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_011537.3NP_035667.1  T-box transcription factor TBX5

    See identical proteins and their annotated locations for NP_035667.1

    Status: VALIDATED

    Source sequence(s)
    AI413447, BC090639, BX529547
    Consensus CDS
    CCDS19615.1
    UniProtKB/Swiss-Prot
    P70326
    UniProtKB/TrEMBL
    Q5CZX7
    Related
    ENSMUSP00000018407.7, ENSMUST00000018407.10
    Conserved Domains (1) summary
    cd00182
    Location:53241
    TBOX; T-box DNA binding domain of the T-box family of transcriptional regulators. The T-box family is an ancient group that appears to play a critical role in development in all animal species. These genes were uncovered on the basis of similarity to the DNA ...

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    119934581..120023285
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006530283.3XP_006530346.1  T-box transcription factor TBX5 isoform X2

    See identical proteins and their annotated locations for XP_006530346.1

    UniProtKB/Swiss-Prot
    P70326
    UniProtKB/TrEMBL
    Q5CZX7
    Conserved Domains (1) summary
    cd00182
    Location:53241
    TBOX; T-box DNA binding domain of the T-box family of transcriptional regulators. The T-box family is an ancient group that appears to play a critical role in development in all animal species. These genes were uncovered on the basis of similarity to the DNA ...
  2. XM_006530282.5XP_006530345.1  T-box transcription factor TBX5 isoform X2

    See identical proteins and their annotated locations for XP_006530345.1

    UniProtKB/Swiss-Prot
    P70326
    UniProtKB/TrEMBL
    Q5CZX7
    Conserved Domains (1) summary
    cd00182
    Location:53241
    TBOX; T-box DNA binding domain of the T-box family of transcriptional regulators. The T-box family is an ancient group that appears to play a critical role in development in all animal species. These genes were uncovered on the basis of similarity to the DNA ...
  3. XM_006530281.3XP_006530344.1  T-box transcription factor TBX5 isoform X2

    See identical proteins and their annotated locations for XP_006530344.1

    UniProtKB/Swiss-Prot
    P70326
    UniProtKB/TrEMBL
    Q5CZX7
    Conserved Domains (1) summary
    cd00182
    Location:53241
    TBOX; T-box DNA binding domain of the T-box family of transcriptional regulators. The T-box family is an ancient group that appears to play a critical role in development in all animal species. These genes were uncovered on the basis of similarity to the DNA ...
  4. XM_006530280.1XP_006530343.1  T-box transcription factor TBX5 isoform X2

    See identical proteins and their annotated locations for XP_006530343.1

    UniProtKB/Swiss-Prot
    P70326
    UniProtKB/TrEMBL
    Q5CZX7
    Conserved Domains (1) summary
    cd00182
    Location:53241
    TBOX; T-box DNA binding domain of the T-box family of transcriptional regulators. The T-box family is an ancient group that appears to play a critical role in development in all animal species. These genes were uncovered on the basis of similarity to the DNA ...
  5. XM_006530279.5XP_006530342.1  T-box transcription factor TBX5 isoform X1

    Conserved Domains (1) summary
    cd00182
    Location:72260
    TBOX; T-box DNA binding domain of the T-box family of transcriptional regulators. The T-box family is an ancient group that appears to play a critical role in development in all animal species. These genes were uncovered on the basis of similarity to the DNA ...
  6. XM_011248191.4XP_011246493.1  T-box transcription factor TBX5 isoform X2

    See identical proteins and their annotated locations for XP_011246493.1

    UniProtKB/Swiss-Prot
    P70326
    UniProtKB/TrEMBL
    Q5CZX7
    Conserved Domains (1) summary
    cd00182
    Location:53241
    TBOX; T-box DNA binding domain of the T-box family of transcriptional regulators. The T-box family is an ancient group that appears to play a critical role in development in all animal species. These genes were uncovered on the basis of similarity to the DNA ...
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