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Tcea2 transcription elongation factor A (SII), 2 [ Mus musculus (house mouse) ]

Gene ID: 21400, updated on 11-Apr-2024

Summary

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Official Symbol
Tcea2provided by MGI
Official Full Name
transcription elongation factor A (SII), 2provided by MGI
Primary source
MGI:MGI:107368
See related
Ensembl:ENSMUSG00000059540 AllianceGenome:MGI:107368
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Tceat; SII-T1; S-II-T1
Summary
Predicted to enable DNA binding activity and zinc ion binding activity. Predicted to be involved in positive regulation of transcription by RNA polymerase II and transcription, DNA-templated. Predicted to be located in centrosome and nucleoplasm. Predicted to be active in nucleus. Is expressed in heart; inner ear; lung epithelium; testis; and urinary system. Orthologous to human TCEA2 (transcription elongation factor A2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in testis adult (RPKM 125.6), cortex adult (RPKM 23.3) and 8 other tissues See more
Orthologs
human all
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Genomic context

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Location:
2 H4; 2 103.72 cM
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (181322090..181329860)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (181680297..181688067)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene predicted gene, 25879 Neighboring gene SRY (sex determining region Y)-box 18 Neighboring gene regulator of G-protein signaling 19 Neighboring gene LKAAEAR motif containing 1 (IKAAEAR murine motif)

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Restricted expression of a member of the transcription elongation factor S-II family in testicular germ cells during and after meiosis. Umehara T, et al. J Biochem, 1997 Mar. PMID 9133631
  2. The RNA polymerase II general elongation factors. Reines D, et al. Trends Biochem Sci, 1996 Sep. PMID 8870500, Free PMC Article
  3. Spermatocyte-specific expression of the gene for mouse testis-specific transcription elongation factor S-II. Ito T, et al. FEBS Lett, 1996 Apr 29. PMID 8641458
  4. Transcription factor genes and the developing eye: a genetic perspective. Freund C, et al. Hum Mol Genet, 1996. PMID 8875254
  5. GRIP1tau, a novel PDZ domain-containing transcriptional activator, cooperates with the testis-specific transcription elongation factor SII-T1. Nakata A, et al. Genes Cells, 2004 Nov. PMID 15507123

See all (27) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. role in regulating GRIP1tau
    Title: GRIP1tau, a novel PDZ domain-containing transcriptional activator, cooperates with the testis-specific transcription elongation factor SII-T1.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables nucleic acid binding IEA
Inferred from Electronic Annotation
more info
  
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in DNA-templated transcription IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
involved_in transcription elongation by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in centrosome ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
transcription elongation factor A protein 2
Names
testis-specific S-II
transcription elongation factor S-II protein 2
transcription elongation factor TFIIS.l

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001356342.1 → NP_001343271.1  transcription elongation factor A protein 2 isoform b

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate splice junction in the 5' end compared to variant 1. The resulting isoform (b) is shorter at the N-terminus compared to isoform a. Variants 2 and 3 both encode the same isoform (b).
    Source sequence(s)
    AK137527, AL844529, BE990349
    UniProtKB/TrEMBL
    Q3UV78
    Related
    ENSMUSP00000119646.2, ENSMUST00000129745.8
    Conserved Domains (1) summary
    TIGR01385
    Location:1 → 273
    TFSII; transcription elongation factor S-II

  2. NM_001356343.1 → NP_001343272.1  transcription elongation factor A protein 2 isoform b

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) uses an alternate splice junction in the 5' end compared to variant 1. The resulting isoform (b) is shorter at the N-terminus compared to isoform a. Variants 2 and 3 both encode the same isoform (b).
    Source sequence(s)
    AL844529
    UniProtKB/TrEMBL
    Q3UV78
    Conserved Domains (1) summary
    TIGR01385
    Location:1 → 273
    TFSII; transcription elongation factor S-II

  3. NM_009326.3 → NP_033352.1  transcription elongation factor A protein 2 isoform a

    See identical proteins and their annotated locations for NP_033352.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (a).
    Source sequence(s)
    BC049617, BE990349, BY143976
    Consensus CDS
    CCDS17219.1
    UniProtKB/Swiss-Prot
    O08667, Q9QVN7
    UniProtKB/TrEMBL
    Q3UV78, Q6P072, Q810R3
    Related
    ENSMUSP00000099331.4, ENSMUST00000103042.10
    Conserved Domains (5) summary
    cd00183
    Location:4 → 80
    TFIIS_I; N-terminal domain (domain I) of transcription elongation factor S-II (TFIIS); similar to a domain found in elongin A and CRSP70; likely to be involved in transcription; domain I from TFIIS interacts with RNA polymerase II holoenzyme
    cd13749
    Location:252 → 298
    Zn-ribbon_TFIIS; domain III/zinc ribbon domain of Transcription Factor IIS
    TIGR01385
    Location:5 → 299
    TFSII; transcription elongation factor S-II
    pfam07500
    Location:136 → 243
    TFIIS_M; Transcription factor S-II (TFIIS), central domain
    pfam15223
    Location:87 → 148
    DUF4584; Domain of unknown function (DUF4584)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    181322090..181329860
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9QVN7.2 GenPept UniProtKB/Swiss-Prot:Q9QVN7

Gene LinkOut

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