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Tcf7l2 transcription factor 7 like 2, T cell specific, HMG box [ Mus musculus (house mouse) ]

Gene ID: 21416, updated on 25-Nov-2021

Summary

Official Symbol
Tcf7l2provided by MGI
Official Full Name
transcription factor 7 like 2, T cell specific, HMG boxprovided by MGI
Primary source
MGI:MGI:1202879
See related
Ensembl:ENSMUSG00000024985
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Tcf4; TCF4B; TCF4E; Tcf-4
Annotation information
Note: Tcf4 (GeneID: 21413) and Tcf7l2 (GeneID: 21416) loci share the Tcf4 symbol/alias in common. Tcf4 is a widely used alternative name for T-cell-specific transcription factor 4 (Tcf7l2) conflicting with the official symbol for transcription factor 4 (Tcf4). [26 Jun 2008]
Expression
Broad expression in whole brain E14.5 (RPKM 35.3), CNS E14 (RPKM 21.4) and 25 other tissues See more
Orthologs
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Genomic context

See Tcf7l2 in Genome Data Viewer
Location:
19 D2; 19 51.59 cM
Exon count:
18
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (55730226..55922091)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (55741797..55933659)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 19 NC_000085.5 (55816300..56008145)

Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene vesicle transport through interaction with t-SNAREs 1A Neighboring gene RIKEN cDNA 4930552P12 gene Neighboring gene predicted gene, 41871 Neighboring gene predicted gene, 31734 Neighboring gene predicted gene, 52391 Neighboring gene predicted gene 4470

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
 
enables DNA-binding transcription activator activity, RNA polymerase II-specific IDA
Inferred from Direct Assay
more info
PubMed 
enables DNA-binding transcription factor activity ISO
Inferred from Sequence Orthology
more info
 
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
 
enables RNA polymerase II-specific DNA-binding transcription factor binding ISO
Inferred from Sequence Orthology
more info
 
enables armadillo repeat domain binding ISO
Inferred from Sequence Orthology
more info
 
enables beta-catenin binding IDA
Inferred from Direct Assay
more info
PubMed 
enables beta-catenin binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables beta-catenin binding ISO
Inferred from Sequence Orthology
more info
 
enables chromatin binding IDA
Inferred from Direct Assay
more info
PubMed 
enables chromatin binding IGI
Inferred from Genetic Interaction
more info
PubMed 
enables gamma-catenin binding ISO
Inferred from Sequence Orthology
more info
 
enables nuclear receptor binding ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein kinase binding ISO
Inferred from Sequence Orthology
more info
 
enables sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
enables sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
 
enables transcription cis-regulatory region binding IDA
Inferred from Direct Assay
more info
PubMed 
enables transcription cis-regulatory region binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within Wnt signaling pathway IEA
Inferred from Electronic Annotation
more info
 
involved_in Wnt signaling pathway IEA
Inferred from Electronic Annotation
more info
 
involved_in blood vessel development ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within bone mineralization IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in canonical Wnt signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in canonical Wnt signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
involved_in canonical Wnt signaling pathway IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in canonical Wnt signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in canonical Wnt signaling pathway involved in positive regulation of epithelial to mesenchymal transition ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within cellular glucose homeostasis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within cellular response to starvation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within embryonic digestive tract morphogenesis IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within embryonic genitalia morphogenesis IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within embryonic hindgut morphogenesis IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within face morphogenesis IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in fat cell differentiation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within glucose homeostasis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in glucose homeostasis ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within glucose metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within glycogen metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within in utero embryonic development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within insulin metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in maintenance of DNA repeat elements ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within multicellular organism growth IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within myoblast fate commitment IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in myoblast fate commitment ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within negative regulation of BMP signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of DNA-binding transcription factor activity ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of canonical Wnt signaling pathway ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within negative regulation of fat cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within negative regulation of fibroblast growth factor receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within negative regulation of organ growth IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of transcription, DNA-templated ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within neural tube development IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within odontogenesis of dentin-containing tooth IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within oligodendrocyte development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within pituitary gland development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within positive regulation of apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within positive regulation of epithelial cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of epithelial cell proliferation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of gluconeogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of heparan sulfate proteoglycan biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of insulin secretion IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of insulin secretion ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of lipid biosynthetic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of protein binding ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of protein export from nucleus ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of protein kinase B signaling ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of transcription, DNA-templated IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within positive regulation of triglyceride biosynthetic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within post-embryonic development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within regulation of gluconeogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of hormone metabolic process ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within regulation of insulin secretion involved in cellular response to glucose stimulus IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within regulation of insulin secretion involved in cellular response to glucose stimulus ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within regulation of myelination IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within regulation of oligodendrocyte differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within regulation of skeletal muscle tissue development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of smooth muscle cell proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within regulation of transcription, DNA-templated IDA
Inferred from Direct Assay
more info
PubMed 
involved_in response to glucose IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within secretory granule localization IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within skin development IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within somatic stem cell population maintenance IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within somatic stem cell population maintenance IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
part_of beta-catenin-TCF complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of beta-catenin-TCF7L2 complex ISO
Inferred from Sequence Orthology
more info
 
part_of catenin-TCF7L2 complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of catenin-TCF7L2 complex IDA
Inferred from Direct Assay
more info
PubMed 
located_in chromatin ISO
Inferred from Sequence Orthology
more info
 
located_in cytosol IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 
part_of protein-DNA complex ISO
Inferred from Sequence Orthology
more info
 
part_of transcription regulator complex IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
transcription factor 7-like 2
Names
HMG box transcription factor 4
HMG box transcription factor TCF7L2
T-cell-specific transcription factor 4

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001142918.2NP_001136390.1  transcription factor 7-like 2 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC118695, AC137148, AC157916, AI451561, AJ223070
    Consensus CDS
    CCDS50471.1
    UniProtKB/Swiss-Prot
    Q924A0
    UniProtKB/TrEMBL
    E9QQ91
    Related
    ENSMUSP00000107283.2, ENSMUST00000111656.8
    Conserved Domains (2) summary
    cd01388
    Location:330397
    SOX-TCF_HMG-box; SOX-TCF_HMG-box, class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and ...
    pfam08347
    Location:1236
    CTNNB1_binding; N-terminal CTNNB1 binding
  2. NM_001142919.2NP_001136391.1  transcription factor 7-like 2 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC118695, AC157916, AI451561, AK038720
    Consensus CDS
    CCDS89418.1
    UniProtKB/TrEMBL
    Q8CAI6
    Related
    ENSMUSP00000123428.3, ENSMUST00000127233.9
    Conserved Domains (2) summary
    cd01388
    Location:330397
    SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...
    pfam08347
    Location:1236
    CTNNB1_binding; N-terminal CTNNB1 binding
  3. NM_001142920.2NP_001136392.1  transcription factor 7-like 2 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC118695, AC137148, AC157916, AI451561, AK035059
    Consensus CDS
    CCDS50469.1
    UniProtKB/TrEMBL
    E9Q990, Q8BS68
    Related
    ENSMUSP00000107286.4, ENSMUST00000111658.10
    Conserved Domains (2) summary
    cd01388
    Location:354421
    SOX-TCF_HMG-box; SOX-TCF_HMG-box, class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and ...
    pfam08347
    Location:17259
    CTNNB1_binding; N-terminal CTNNB1 binding
  4. NM_001142921.2NP_001136393.1  transcription factor 7-like 2 isoform 5

    See identical proteins and their annotated locations for NP_001136393.1

    Status: VALIDATED

    Source sequence(s)
    AC118695, AC137148, AC157916
    Consensus CDS
    CCDS50470.1
    UniProtKB/Swiss-Prot
    Q924A0
    UniProtKB/TrEMBL
    A0A0R4J1G0
    Related
    ENSMUSP00000107287.3, ENSMUST00000111659.9
    Conserved Domains (2) summary
    cd01388
    Location:335402
    SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...
    pfam08347
    Location:1236
    CTNNB1_binding; N-terminal CTNNB1 binding
  5. NM_001142922.2NP_001136394.1  transcription factor 7-like 2 isoform 6

    Status: VALIDATED

    Source sequence(s)
    AC118695, AC137148, AC157916
    Consensus CDS
    CCDS50472.1
    UniProtKB/TrEMBL
    E9QQ90
    Related
    ENSMUSP00000107284.4, ENSMUST00000111657.11
    Conserved Domains (2) summary
    cd01388
    Location:330397
    SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...
    pfam08347
    Location:1236
    CTNNB1_binding; N-terminal CTNNB1 binding
  6. NM_001142923.2NP_001136395.1  transcription factor 7-like 2 isoform 7

    Status: VALIDATED

    Source sequence(s)
    AC118695, AC137148, AC157916
    Consensus CDS
    CCDS50473.1
    UniProtKB/TrEMBL
    D3YWT3
    Related
    ENSMUSP00000042950.8, ENSMUST00000041717.14
    Conserved Domains (2) summary
    cd01388
    Location:330397
    SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...
    pfam08347
    Location:1236
    CTNNB1_binding; N-terminal CTNNB1 binding
  7. NM_001142924.2NP_001136396.1  transcription factor 7-like 2 isoform 8

    See identical proteins and their annotated locations for NP_001136396.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (8) uses an alternate 5' UTR and 5' coding region, compared to variant 1. The resulting isoform (8) has a substantially shorter and distinct N-terminus, compared to isoform 1.
    Source sequence(s)
    AC118695, AI451561, AK048536, CA750374
    Consensus CDS
    CCDS50474.1
    UniProtKB/Swiss-Prot
    Q924A0
    Related
    ENSMUSP00000107273.2, ENSMUST00000111646.8
    Conserved Domains (2) summary
    cd01388
    Location:170237
    SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...
    pfam08347
    Location:276
    CTNNB1_binding; N-terminal CTNNB1 binding
  8. NM_001331135.1NP_001318064.1  transcription factor 7-like 2 isoform 9

    Status: VALIDATED

    Source sequence(s)
    AC118695, AC137148, AC157916
    Conserved Domains (2) summary
    cd01388
    Location:349416
    SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...
    pfam08347
    Location:17259
    CTNNB1_binding; N-terminal CTNNB1 binding
  9. NM_001331136.1NP_001318065.1  transcription factor 7-like 2 isoform 10

    Status: VALIDATED

    Source sequence(s)
    AC118695, AC137148, AC157916
    Conserved Domains (2) summary
    cd01388
    Location:335402
    SOX-TCF_HMG-box; SOX-TCF_HMG-box, class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and ...
    pfam08347
    Location:1236
    CTNNB1_binding; N-terminal CTNNB1 binding
  10. NM_001331137.1NP_001318066.1  transcription factor 7-like 2 isoform 11

    Status: VALIDATED

    Source sequence(s)
    AC118695, AC137148, AC157916
  11. NM_001331138.1NP_001318067.1  transcription factor 7-like 2 isoform 12

    Status: VALIDATED

    Source sequence(s)
    AC118695, AC137148, AC157916
    Conserved Domains (2) summary
    cd01388
    Location:349416
    SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...
    pfam08347
    Location:17259
    CTNNB1_binding; N-terminal CTNNB1 binding
  12. NM_001331139.1NP_001318068.1  transcription factor 7-like 2 isoform 13

    Status: VALIDATED

    Source sequence(s)
    AC118695, AC137148, AC157916
    Related
    ENSMUSP00000107291.5, ENSMUST00000111662.11
    Conserved Domains (2) summary
    cd01388
    Location:330397
    SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...
    pfam08347
    Location:1236
    CTNNB1_binding; N-terminal CTNNB1 binding
  13. NM_001331140.1NP_001318069.1  transcription factor 7-like 2 isoform 14

    Status: VALIDATED

    Source sequence(s)
    AC118695, AC137148, AC157916
    Conserved Domains (2) summary
    cd01388
    Location:326393
    SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...
    pfam08347
    Location:1236
    CTNNB1_binding; N-terminal CTNNB1 binding
  14. NM_001331141.1NP_001318070.1  transcription factor 7-like 2 isoform 15

    Status: VALIDATED

    Source sequence(s)
    AC118695, AC137148, AC157916
    Conserved Domains (2) summary
    cd01388
    Location:326393
    SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...
    pfam08347
    Location:1236
    CTNNB1_binding; N-terminal CTNNB1 binding
  15. NM_001331142.1NP_001318071.1  transcription factor 7-like 2 isoform 16

    Status: VALIDATED

    Source sequence(s)
    AC118695, AC137148, AC157916
    Conserved Domains (2) summary
    cd01388
    Location:326393
    SOX-TCF_HMG-box; SOX-TCF_HMG-box, class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and ...
    pfam08347
    Location:1236
    CTNNB1_binding; N-terminal CTNNB1 binding
  16. NM_001331143.1NP_001318072.1  transcription factor 7-like 2 isoform 17

    Status: VALIDATED

    Source sequence(s)
    AC118695, AC137148, AC157916
    Conserved Domains (2) summary
    cd01388
    Location:326393
    SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...
    pfam08347
    Location:1236
    CTNNB1_binding; N-terminal CTNNB1 binding
  17. NM_001331144.1NP_001318073.1  transcription factor 7-like 2 isoform 18

    Status: VALIDATED

    Source sequence(s)
    AC118695, AC137148, AC157916
  18. NM_001331145.1NP_001318074.1  transcription factor 7-like 2 isoform 19

    Status: VALIDATED

    Source sequence(s)
    AC118695, AC137148, AC157916
    Conserved Domains (2) summary
    cd01388
    Location:326393
    SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...
    pfam08347
    Location:1236
    CTNNB1_binding; N-terminal CTNNB1 binding
  19. NM_001331146.1NP_001318075.1  transcription factor 7-like 2 isoform 20

    Status: VALIDATED

    Description
    Transcript Variant: This variant (21) encodes the longest protein (isoform 20).
    Source sequence(s)
    AC118695, AC137148, AC157916
    Conserved Domains (2) summary
    cd01388
    Location:353420
    SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...
    pfam08347
    Location:17259
    CTNNB1_binding; N-terminal CTNNB1 binding
  20. NM_001331147.1NP_001318076.1  transcription factor 7-like 2 isoform 21

    Status: VALIDATED

    Source sequence(s)
    AC118695, AC137148, AC157916
    Conserved Domains (2) summary
    cd01388
    Location:353420
    SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...
    pfam08347
    Location:17259
    CTNNB1_binding; N-terminal CTNNB1 binding
  21. NM_001331148.1NP_001318077.1  transcription factor 7-like 2 isoform 22

    Status: VALIDATED

    Source sequence(s)
    AC118695, AC137148, AC157916
    Conserved Domains (2) summary
    cd01388
    Location:353420
    SOX-TCF_HMG-box; SOX-TCF_HMG-box, class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and ...
    pfam08347
    Location:17259
    CTNNB1_binding; N-terminal CTNNB1 binding
  22. NM_001331149.1NP_001318078.1  transcription factor 7-like 2 isoform 23

    Status: VALIDATED

    Source sequence(s)
    AC118695, AC137148, AC157916
    Conserved Domains (2) summary
    cd01388
    Location:353420
    SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...
    pfam08347
    Location:17259
    CTNNB1_binding; N-terminal CTNNB1 binding
  23. NM_001331150.1NP_001318079.1  transcription factor 7-like 2 isoform 24

    Status: VALIDATED

    Source sequence(s)
    AC118695, AC137148, AC157916
    Conserved Domains (2) summary
    cd01388
    Location:353420
    SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...
    pfam08347
    Location:17259
    CTNNB1_binding; N-terminal CTNNB1 binding
  24. NM_009333.4NP_033359.2  transcription factor 7-like 2 isoform 3

    See identical proteins and their annotated locations for NP_033359.2

    Status: VALIDATED

    Source sequence(s)
    AC118695, AC137148, AC157916
    Consensus CDS
    CCDS29911.1
    UniProtKB/TrEMBL
    F6WBK9
    Related
    ENSMUSP00000050081.10, ENSMUST00000061496.17
    Conserved Domains (2) summary
    cd01388
    Location:330397
    SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...
    pfam08347
    Location:1236
    CTNNB1_binding; N-terminal CTNNB1 binding

RNA

  1. NR_138565.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC118695, AC137148, AC157916

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000085.7 Reference GRCm39 C57BL/6J

    Range
    55730226..55922091
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017318127.3XP_017173616.1  transcription factor 7-like 2 isoform X16

    Conserved Domains (2) summary
    cd01388
    Location:331398
    SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...
    pfam08347
    Location:1236
    CTNNB1_binding; N-terminal CTNNB1 binding
  2. XM_017318116.3XP_017173605.1  transcription factor 7-like 2 isoform X9

    Conserved Domains (2) summary
    cd01388
    Location:358425
    SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...
    pfam08347
    Location:17259
    CTNNB1_binding; N-terminal CTNNB1 binding
  3. XM_006526860.5XP_006526923.1  transcription factor 7-like 2 isoform X1

    Conserved Domains (2) summary
    cd01388
    Location:358425
    SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...
    pfam08347
    Location:17259
    CTNNB1_binding; N-terminal CTNNB1 binding
  4. XM_017318117.3XP_017173606.1  transcription factor 7-like 2 isoform X10

    Conserved Domains (2) summary
    cd01388
    Location:358425
    SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...
    pfam08347
    Location:17259
    CTNNB1_binding; N-terminal CTNNB1 binding
  5. XM_017318110.3XP_017173599.1  transcription factor 7-like 2 isoform X3

    Conserved Domains (2) summary
    cd01388
    Location:358425
    SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...
    pfam08347
    Location:17259
    CTNNB1_binding; N-terminal CTNNB1 binding
  6. XM_017318114.3XP_017173603.1  transcription factor 7-like 2 isoform X7

    Related
    ENSMUSP00000118661.3, ENSMUST00000153888.9
    Conserved Domains (2) summary
    cd01388
    Location:353420
    SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...
    pfam08347
    Location:17259
    CTNNB1_binding; N-terminal CTNNB1 binding
  7. XM_006526861.5XP_006526924.1  transcription factor 7-like 2 isoform X2

    Conserved Domains (2) summary
    cd01388
    Location:354421
    SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...
    pfam08347
    Location:17259
    CTNNB1_binding; N-terminal CTNNB1 binding
  8. XM_017318115.3XP_017173604.1  transcription factor 7-like 2 isoform X8

    Conserved Domains (2) summary
    cd01388
    Location:349416
    SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...
    pfam08347
    Location:17259
    CTNNB1_binding; N-terminal CTNNB1 binding
  9. XM_017318119.3XP_017173608.1  transcription factor 7-like 2 isoform X11

    Conserved Domains (2) summary
    cd01388
    Location:349416
    SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...
    pfam08347
    Location:17259
    CTNNB1_binding; N-terminal CTNNB1 binding
  10. XM_017318126.3XP_017173615.1  transcription factor 7-like 2 isoform X15

    Conserved Domains (2) summary
    cd01388
    Location:349416
    SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...
    pfam08347
    Location:17259
    CTNNB1_binding; N-terminal CTNNB1 binding
  11. XM_036161506.1XP_036017399.1  transcription factor 7-like 2 isoform X12

    Conserved Domains (2) summary
    cd01388
    Location:335402
    SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...
    pfam08347
    Location:17236
    CTNNB1_binding; N-terminal CTNNB1 binding
  12. XM_006526866.5XP_006526929.1  transcription factor 7-like 2 isoform X4

    Conserved Domains (2) summary
    cd01388
    Location:335402
    SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...
    pfam08347
    Location:1236
    CTNNB1_binding; N-terminal CTNNB1 binding
  13. XM_006526888.5XP_006526951.1  transcription factor 7-like 2 isoform X14

    Conserved Domains (2) summary
    cd01388
    Location:335402
    SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...
    pfam08347
    Location:1236
    CTNNB1_binding; N-terminal CTNNB1 binding
  14. XM_017318131.3XP_017173620.1  transcription factor 7-like 2 isoform X18

    Conserved Domains (2) summary
    cd01388
    Location:335402
    SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...
    pfam08347
    Location:1236
    CTNNB1_binding; N-terminal CTNNB1 binding
  15. XM_030250847.2XP_030106707.1  transcription factor 7-like 2 isoform X6

    Conserved Domains (2) summary
    cd01388
    Location:335402
    SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...
    pfam08347
    Location:1236
    CTNNB1_binding; N-terminal CTNNB1 binding
  16. XM_036161508.1XP_036017401.1  transcription factor 7-like 2 isoform X17

    Conserved Domains (2) summary
    cd01388
    Location:330397
    SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...
    pfam08347
    Location:17236
    CTNNB1_binding; N-terminal CTNNB1 binding
  17. XM_017318112.3XP_017173601.1  transcription factor 7-like 2 isoform X5

    Conserved Domains (2) summary
    cd01388
    Location:331398
    SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...
    pfam08347
    Location:1236
    CTNNB1_binding; N-terminal CTNNB1 binding
  18. XM_036161507.1XP_036017400.1  transcription factor 7-like 2 isoform X13

    Conserved Domains (2) summary
    cd01388
    Location:326393
    SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...
    pfam08347
    Location:17236
    CTNNB1_binding; N-terminal CTNNB1 binding
  19. XM_017318132.2XP_017173621.1  transcription factor 7-like 2 isoform X22

    Conserved Domains (2) summary
    cd01388
    Location:170237
    SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...
    pfam08347
    Location:276
    CTNNB1_binding; N-terminal CTNNB1 binding
  20. XM_030250860.1XP_030106720.1  transcription factor 7-like 2 isoform X28

    Conserved Domains (2) summary
    cd01388
    Location:170237
    SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...
    pfam08347
    Location:276
    CTNNB1_binding; N-terminal CTNNB1 binding
  21. XM_006526895.4XP_006526958.1  transcription factor 7-like 2 isoform X20

    See identical proteins and their annotated locations for XP_006526958.1

    Conserved Domains (2) summary
    cd01388
    Location:175242
    SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...
    pfam08347
    Location:276
    CTNNB1_binding; N-terminal CTNNB1 binding
  22. XM_030250859.1XP_030106719.1  transcription factor 7-like 2 isoform X27

    Conserved Domains (2) summary
    cd01388
    Location:170237
    SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...
    pfam08347
    Location:276
    CTNNB1_binding; N-terminal CTNNB1 binding
  23. XM_006526897.4XP_006526960.1  transcription factor 7-like 2 isoform X23

    Conserved Domains (2) summary
    cd01388
    Location:170237
    SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...
    pfam08347
    Location:276
    CTNNB1_binding; N-terminal CTNNB1 binding
  24. XM_030250854.1XP_030106714.1  transcription factor 7-like 2 isoform X25

    Conserved Domains (2) summary
    cd01388
    Location:166233
    SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...
    pfam08347
    Location:276
    CTNNB1_binding; N-terminal CTNNB1 binding
  25. XM_017318135.3XP_017173624.1  transcription factor 7-like 2 isoform X29

    Conserved Domains (2) summary
    cd01388
    Location:166233
    SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...
    pfam08347
    Location:276
    CTNNB1_binding; N-terminal CTNNB1 binding
  26. XM_006526894.5XP_006526957.1  transcription factor 7-like 2 isoform X19

    See identical proteins and their annotated locations for XP_006526957.1

    Conserved Domains (2) summary
    cd01388
    Location:175242
    SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...
    pfam08347
    Location:276
    CTNNB1_binding; N-terminal CTNNB1 binding
  27. XM_030250855.2XP_030106715.1  transcription factor 7-like 2 isoform X26

    Conserved Domains (2) summary
    cd01388
    Location:175242
    SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...
    pfam08347
    Location:276
    CTNNB1_binding; N-terminal CTNNB1 binding
  28. XM_030250851.2XP_030106711.1  transcription factor 7-like 2 isoform X21

    Conserved Domains (2) summary
    cd01388
    Location:171238
    SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...
    pfam08347
    Location:276
    CTNNB1_binding; N-terminal CTNNB1 binding
  29. XM_030250853.2XP_030106713.1  transcription factor 7-like 2 isoform X24

    Conserved Domains (2) summary
    cd01388
    Location:166233
    SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...
    pfam08347
    Location:276
    CTNNB1_binding; N-terminal CTNNB1 binding
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