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Zeb1 zinc finger E-box binding homeobox 1 [ Mus musculus (house mouse) ]

Gene ID: 21417, updated on 26-Jul-2021

Summary

Official Symbol
Zeb1provided by MGI
Official Full Name
zinc finger E-box binding homeobox 1provided by MGI
Primary source
MGI:MGI:1344313
See related
Ensembl:ENSMUSG00000024238
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
N; Tw; ARE; BZP; ZEB; MEB1; Nil2; Tcf8; Zfhe; Zfx1; AREB6; TCF-8; Tcf18; Zfhep; Zfhx1; Zfx1a; Zfhx1a; Zfx1ha; [delta]E; [delta]EF1; 3110032K11Rik
Expression
Ubiquitous expression in CNS E11.5 (RPKM 9.2), limb E14.5 (RPKM 8.6) and 26 other tissues See more
Orthologs
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Genomic context

See Zeb1 in Genome Data Viewer
Location:
18 4.42 cM; 18 A1
Exon count:
18
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 18 NC_000084.7 (5591330..5775468)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 18 NC_000084.6 (5591327..5775468)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 18 NC_000084.5 (5591889..5774909)

Chromosome 18 - NC_000084.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 34630 Neighboring gene predicted gene 10125 Neighboring gene predicted gene, 52340 Neighboring gene predicted gene, 34740 Neighboring gene predicted gene, 34804

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
 
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables DNA-binding transcription repressor activity, RNA polymerase II-specific IDA
Inferred from Direct Assay
more info
PubMed 
enables DNA-binding transcription repressor activity, RNA polymerase II-specific ISO
Inferred from Sequence Orthology
more info
 
enables E-box binding IDA
Inferred from Direct Assay
more info
PubMed 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables chromatin binding IDA
Inferred from Direct Assay
more info
PubMed 
enables chromatin binding ISO
Inferred from Sequence Orthology
more info
 
enables double-stranded DNA binding ISO
Inferred from Sequence Orthology
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in anatomical structure development IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within animal organ development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within cartilage development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within cell differentiation IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within cellular response to amino acid stimulus IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within central nervous system development IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within cochlea morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within embryonic camera-type eye morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within embryonic morphogenesis IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within embryonic skeletal system morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within negative regulation of cell population proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of endothelial cell differentiation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within negative regulation of epithelial cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of transcription, DNA-templated IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of transcription, DNA-templated ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within nervous system development IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within pattern specification process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of neuron differentiation IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within regulation of T cell differentiation in thymus IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within regulation of mesenchymal cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within regulation of smooth muscle cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within regulation of transforming growth factor beta receptor signaling pathway IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within semicircular canal morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
zinc finger E-box-binding homeobox 1
Names
transcription factor 8
twirler
zinc finger homeobox protein 1a

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001360981.1NP_001347910.1  zinc finger E-box-binding homeobox 1 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC127028, AC138619
    Conserved Domains (4) summary
    smart00389
    Location:554590
    HOX; Homeodomain
    sd00017
    Location:867887
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:203225
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:907932
    zf-H2C2_2; Zinc-finger double domain
  2. NM_001360982.1NP_001347911.1  zinc finger E-box-binding homeobox 1 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC127028, AC138619
    Conserved Domains (3) summary
    sd00017
    Location:828848
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:164186
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:868893
    zf-H2C2_2; Zinc-finger double domain
  3. NM_011546.3NP_035676.1  zinc finger E-box-binding homeobox 1 isoform 1

    See identical proteins and their annotated locations for NP_035676.1

    Status: VALIDATED

    Source sequence(s)
    AC127028, AK034821, BC139769, BE852657
    Consensus CDS
    CCDS29039.1
    UniProtKB/Swiss-Prot
    Q64318
    Related
    ENSMUSP00000025081.6, ENSMUST00000025081.13
    Conserved Domains (4) summary
    smart00389
    Location:571607
    HOX; Homeodomain
    sd00017
    Location:884904
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:220242
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:924949
    zf-H2C2_2; Zinc-finger double domain

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000084.7 Reference GRCm39 C57BL/6J

    Range
    5591330..5775468
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030250410.2XP_030106270.1  zinc finger E-box-binding homeobox 1 isoform X3

    Conserved Domains (3) summary
    sd00017
    Location:828848
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:164186
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:868893
    zf-H2C2_2; Zinc-finger double domain
  2. XM_030250409.2XP_030106269.1  zinc finger E-box-binding homeobox 1 isoform X3

    Conserved Domains (3) summary
    sd00017
    Location:828848
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:164186
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:868893
    zf-H2C2_2; Zinc-finger double domain
  3. XM_030250411.2XP_030106271.1  zinc finger E-box-binding homeobox 1 isoform X4

    Conserved Domains (4) summary
    smart00389
    Location:504540
    HOX; Homeodomain
    sd00017
    Location:817837
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:153175
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:857882
    zf-H2C2_2; Zinc-finger double domain
  4. XM_036161065.1XP_036016958.1  zinc finger E-box-binding homeobox 1 isoform X3

    Conserved Domains (3) summary
    sd00017
    Location:828848
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:164186
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:868893
    zf-H2C2_2; Zinc-finger double domain
  5. XM_030250401.1XP_030106261.1  zinc finger E-box-binding homeobox 1 isoform X1

    Conserved Domains (3) summary
    sd00017
    Location:877897
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:213235
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:917942
    zf-H2C2_2; Zinc-finger double domain
  6. XM_030250405.2XP_030106265.1  zinc finger E-box-binding homeobox 1 isoform X3

    Conserved Domains (3) summary
    sd00017
    Location:828848
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:164186
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:868893
    zf-H2C2_2; Zinc-finger double domain
  7. XM_030250400.2XP_030106260.1  zinc finger E-box-binding homeobox 1 isoform X1

    Conserved Domains (3) summary
    sd00017
    Location:877897
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:213235
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:917942
    zf-H2C2_2; Zinc-finger double domain
  8. XM_030250406.2XP_030106266.1  zinc finger E-box-binding homeobox 1 isoform X3

    Conserved Domains (3) summary
    sd00017
    Location:828848
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:164186
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:868893
    zf-H2C2_2; Zinc-finger double domain
  9. XM_036161061.1XP_036016954.1  zinc finger E-box-binding homeobox 1 isoform X1

    Conserved Domains (3) summary
    sd00017
    Location:877897
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:213235
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:917942
    zf-H2C2_2; Zinc-finger double domain
  10. XM_006525769.4XP_006525832.1  zinc finger E-box-binding homeobox 1 isoform X1

    See identical proteins and their annotated locations for XP_006525832.1

    Conserved Domains (3) summary
    sd00017
    Location:877897
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:213235
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:917942
    zf-H2C2_2; Zinc-finger double domain
  11. XM_036161062.1XP_036016955.1  zinc finger E-box-binding homeobox 1 isoform X3

    Conserved Domains (3) summary
    sd00017
    Location:828848
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:164186
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:868893
    zf-H2C2_2; Zinc-finger double domain
  12. XM_036161059.1XP_036016952.1  zinc finger E-box-binding homeobox 1 isoform X1

    Conserved Domains (3) summary
    sd00017
    Location:877897
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:213235
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:917942
    zf-H2C2_2; Zinc-finger double domain
  13. XM_030250407.2XP_030106267.1  zinc finger E-box-binding homeobox 1 isoform X3

    Conserved Domains (3) summary
    sd00017
    Location:828848
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:164186
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:868893
    zf-H2C2_2; Zinc-finger double domain
  14. XM_030250404.2XP_030106264.1  zinc finger E-box-binding homeobox 1 isoform X3

    Conserved Domains (3) summary
    sd00017
    Location:828848
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:164186
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:868893
    zf-H2C2_2; Zinc-finger double domain
  15. XM_036161068.1XP_036016961.1  zinc finger E-box-binding homeobox 1 isoform X3

    Conserved Domains (3) summary
    sd00017
    Location:828848
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:164186
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:868893
    zf-H2C2_2; Zinc-finger double domain
  16. XM_036161067.1XP_036016960.1  zinc finger E-box-binding homeobox 1 isoform X3

    Conserved Domains (3) summary
    sd00017
    Location:828848
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:164186
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:868893
    zf-H2C2_2; Zinc-finger double domain
  17. XM_030250402.2XP_030106262.1  zinc finger E-box-binding homeobox 1 isoform X2

    Conserved Domains (4) summary
    smart00389
    Location:557593
    HOX; Homeodomain
    sd00017
    Location:870890
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:206228
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:910935
    zf-H2C2_2; Zinc-finger double domain
  18. XM_030250399.2XP_030106259.1  zinc finger E-box-binding homeobox 1 isoform X1

    Conserved Domains (3) summary
    sd00017
    Location:877897
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:213235
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:917942
    zf-H2C2_2; Zinc-finger double domain
  19. XM_036161066.1XP_036016959.1  zinc finger E-box-binding homeobox 1 isoform X3

    Conserved Domains (3) summary
    sd00017
    Location:828848
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:164186
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:868893
    zf-H2C2_2; Zinc-finger double domain
  20. XM_036161069.1XP_036016962.1  zinc finger E-box-binding homeobox 1 isoform X3

    Conserved Domains (3) summary
    sd00017
    Location:828848
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:164186
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:868893
    zf-H2C2_2; Zinc-finger double domain
  21. XM_036161063.1XP_036016956.1  zinc finger E-box-binding homeobox 1 isoform X3

    Conserved Domains (3) summary
    sd00017
    Location:828848
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:164186
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:868893
    zf-H2C2_2; Zinc-finger double domain
  22. XM_036161064.1XP_036016957.1  zinc finger E-box-binding homeobox 1 isoform X3

    Conserved Domains (3) summary
    sd00017
    Location:828848
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:164186
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:868893
    zf-H2C2_2; Zinc-finger double domain
  23. XM_036161070.1XP_036016963.1  zinc finger E-box-binding homeobox 1 isoform X3

    Conserved Domains (3) summary
    sd00017
    Location:828848
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:164186
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:868893
    zf-H2C2_2; Zinc-finger double domain
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