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Tmprss13 transmembrane protease, serine 13 [ Mus musculus (house mouse) ]

Gene ID: 214531, updated on 23-Jun-2021

Summary

Official Symbol
Tmprss13provided by MGI
Official Full Name
transmembrane protease, serine 13provided by MGI
Primary source
MGI:MGI:2682935
See related
Ensembl:ENSMUSG00000037129
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
BC010843; Tpmrss13
Expression
Biased expression in bladder adult (RPKM 12.6), stomach adult (RPKM 7.6) and 6 other tissues See more
Orthologs
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Genomic context

See Tmprss13 in Genome Data Viewer
Location:
9; 9 A5.2
Exon count:
15
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (45230286..45258879)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (45318988..45347581)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 9 NC_000075.5 (45127183..45155664)

Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC118567698 Neighboring gene transmembrane protease, serine 4 Neighboring gene cDNA sequence BC049352 Neighboring gene interleukin 10 receptor, alpha Neighboring gene microRNA 7086 Neighboring gene brown adipose tissue enriched long noncoding RNA 3 Neighboring gene uncharacterized LOC118567699 Neighboring gene FXYD domain-containing ion transport regulator 6 Neighboring gene FXYD domain-containing ion transport regulator 2

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1) 

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC103261

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
enables peptidase activity IEA
Inferred from Electronic Annotation
more info
 
enables scavenger receptor activity IEA
Inferred from Electronic Annotation
more info
 
enables serine-type endopeptidase activity IEA
Inferred from Electronic Annotation
more info
 
enables serine-type peptidase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within establishment of skin barrier IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within proteolysis IEA
Inferred from Electronic Annotation
more info
 
involved_in proteolysis IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
transmembrane protease serine 13
Names
membrane-type mosaic serine protease

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001013373.2NP_001013391.2  transmembrane protease serine 13

    Status: VALIDATED

    Source sequence(s)
    AC162176, AC166051
    Consensus CDS
    CCDS23132.1
    UniProtKB/TrEMBL
    E9QPR6
    Related
    ENSMUSP00000034597.8, ENSMUST00000034597.8
    Conserved Domains (5) summary
    smart00020
    Location:306535
    Tryp_SPc; Trypsin-like serine protease
    cd00190
    Location:307535
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
    pfam00530
    Location:225297
    SRCR; Scavenger receptor cysteine-rich domain
    pfam15494
    Location:212301
    SRCR_2; Scavenger receptor cysteine-rich domain
    cl23807
    Location:662
    WWbp; WW-domain ligand protein

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000075.7 Reference GRCm39 C57BL/6J

    Range
    45230286..45258879
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006510132.4XP_006510195.1  transmembrane protease serine 13 isoform X1

    Conserved Domains (4) summary
    smart00020
    Location:319548
    Tryp_SPc; Trypsin-like serine protease
    PHA03378
    Location:6122
    PHA03378; EBNA-3B; Provisional
    cd00112
    Location:204220
    LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
    pfam15494
    Location:225314
    SRCR_2; Scavenger receptor cysteine-rich domain
  2. XM_011242445.3XP_011240747.1  transmembrane protease serine 13 isoform X2

    Conserved Domains (4) summary
    smart00020
    Location:319454
    Tryp_SPc; Trypsin-like serine protease
    PHA03378
    Location:6122
    PHA03378; EBNA-3B; Provisional
    cd00112
    Location:204220
    LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
    pfam15494
    Location:225314
    SRCR_2; Scavenger receptor cysteine-rich domain
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