U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Tmprss13 transmembrane protease, serine 13 [ Mus musculus (house mouse) ]

Gene ID: 214531, updated on 5-Mar-2024

Summary

Go to the top of the page Help
Official Symbol
Tmprss13provided by MGI
Official Full Name
transmembrane protease, serine 13provided by MGI
Primary source
MGI:MGI:2682935
See related
Ensembl:ENSMUSG00000037129 AllianceGenome:MGI:2682935
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Tpmrss13
Summary
Predicted to enable scavenger receptor activity and serine-type endopeptidase activity. Acts upstream of or within establishment of skin barrier. Predicted to be located in membrane. Predicted to be integral component of membrane. Is expressed in several structures, including alimentary system; eye; genitourinary system; heart; and immune system. Orthologous to human TMPRSS13 (transmembrane serine protease 13). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in bladder adult (RPKM 12.6), stomach adult (RPKM 7.6) and 6 other tissues See more
Orthologs
human all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Location:
9 A5.2; 9 24.84 cM
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (45230286..45258879)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (45318988..45347581)

Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene transmembrane protease, serine 4 Neighboring gene predicted gene, 57797 Neighboring gene small integral membrane protein 35 Neighboring gene STARR-positive B cell enhancer mm9_chr9:45029701-45030002 Neighboring gene STARR-positive B cell enhancer mm9_chr9:45054121-45054422 Neighboring gene interleukin 10 receptor, alpha Neighboring gene microRNA 7086 Neighboring gene CapStarr-seq enhancer MGSCv37_chr9:45108641-45108750 Neighboring gene brown adipose tissue enriched long noncoding RNA 3 Neighboring gene STARR-seq mESC enhancer starr_23995 Neighboring gene FXYD domain-containing ion transport regulator 6 Neighboring gene predicted gene, 57798 Neighboring gene FXYD domain-containing ion transport regulator 2

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. The cell-surface anchored serine protease TMPRSS13 promotes breast cancer progression and resistance to chemotherapy. Murray AS, et al. Oncogene, 2020 Oct. PMID 32868877, Free PMC Article
  2. TMPRSS13 deficiency impairs stratum corneum formation and epidermal barrier acquisition. Madsen DH, et al. Biochem J, 2014 Aug 1. PMID 24832573, Free PMC Article
  3. Phenotypic analysis of mice lacking the Tmprss2-encoded protease. Kim TS, et al. Mol Cell Biol, 2006 Feb. PMID 16428450, Free PMC Article
  4. Prospective isolation and global gene expression analysis of definitive and visceral endoderm. Sherwood RI, et al. Dev Biol, 2007 Apr 15. PMID 17328885
  5. BraInMap Elucidates the Macromolecular Connectivity Landscape of Mammalian Brain. Pourhaghighi R, et al. Cell Syst, 2020 Apr 22. PMID 32325033, Free PMC Article

See all (15) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

Go to the top of the page Help

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1) 
  • Endonuclease-mediated (1) 

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Homology

Clone Names

  • MGC103261

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables peptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables serine-type endopeptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables serine-type peptidase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within establishment of skin barrier IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within proteolysis IEA
Inferred from Electronic Annotation
more info
  
involved_in proteolysis IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

Go to the top of the page Help
Preferred Names
transmembrane protease serine 13
Names
membrane-type mosaic serine protease

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001013373.2 → NP_001013391.2  transmembrane protease serine 13

    Status: VALIDATED

    Source sequence(s)
    AC162176, AC166051
    Consensus CDS
    CCDS23132.1
    UniProtKB/TrEMBL
    E9QPR6
    Related
    ENSMUSP00000034597.8, ENSMUST00000034597.8
    Conserved Domains (5) summary
    smart00020
    Location:306 → 535
    Tryp_SPc; Trypsin-like serine protease
    cd00190
    Location:307 → 535
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
    pfam00530
    Location:225 → 297
    SRCR; Scavenger receptor cysteine-rich domain
    pfam15494
    Location:212 → 301
    SRCR_2; Scavenger receptor cysteine-rich domain
    cl23807
    Location:6 → 62
    WWbp; WW-domain ligand protein

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000075.7 Reference GRCm39 C57BL/6J

    Range
    45230286..45258879
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006510132.4 → XP_006510195.1  transmembrane protease serine 13 isoform X1

    Conserved Domains (4) summary
    smart00020
    Location:319 → 548
    Tryp_SPc; Trypsin-like serine protease
    PHA03378
    Location:6 → 122
    PHA03378; EBNA-3B; Provisional
    cd00112
    Location:204 → 220
    LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
    pfam15494
    Location:225 → 314
    SRCR_2; Scavenger receptor cysteine-rich domain

  2. XM_011242445.3 → XP_011240747.1  transmembrane protease serine 13 isoform X2

    Conserved Domains (4) summary
    smart00020
    Location:319 → 454
    Tryp_SPc; Trypsin-like serine protease
    PHA03378
    Location:6 → 122
    PHA03378; EBNA-3B; Provisional
    cd00112
    Location:204 → 220
    LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
    pfam15494
    Location:225 → 314
    SRCR_2; Scavenger receptor cysteine-rich domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q5U405.2 GenPept UniProtKB/Swiss-Prot:Q5U405

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous