Prmt7 protein arginine N-methyltransferase 7 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Prmt7provided by MGI
Official Full Name: protein arginine N-methyltransferase 7provided by MGI
Primary source: MGI:MGI:2384879
See related: Ensembl:ENSMUSG00000060098 AllianceGenome:MGI:2384879
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: 4933402B05Rik
Summary: Enables histone methyltransferase activity (H4-R3 specific) and protein-arginine omega-N symmetric methyltransferase activity. Involved in DNA methylation involved in gamete generation; histone arginine methylation; and regulation of gene expression by genetic imprinting. Predicted to be located in cytosol; fibrillar center; and nucleoplasm. Is expressed in several structures, including brain and retina nuclear layer. Orthologous to human PRMT7 (protein arginine methyltransferase 7). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in testis adult (RPKM 37.9), ovary adult (RPKM 19.4) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 8 D3; 8 53.11 cM

Exon count:: 19

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	8	NC_000074.7 (106937686..106978326)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	8	NC_000074.6 (106211054..106251694)

Chromosome 8 - NC_000074.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Prmt7 regulates the JAK/STAT/Socs3 signaling pathway in postmenopausal cardiomyopathy.
Title: Prmt7 regulates the JAK/STAT/Socs3 signaling pathway in postmenopausal cardiomyopathy.
PRMT7-Dependent Transcriptional Activation of Hmgb2 Aggravates Severe Acute Pancreatitis by Promoting Acsl1-Induced Ferroptosis.
Title: PRMT7-Dependent Transcriptional Activation of Hmgb2 Aggravates Severe Acute Pancreatitis by Promoting Acsl1-Induced Ferroptosis.
A role for protein arginine methyltransferase 7 in repetitive and mild traumatic brain injury.
Title: A role for protein arginine methyltransferase 7 in repetitive and mild traumatic brain injury.
Loss of PRMT7 reprograms glycine metabolism to selectively eradicate leukemia stem cells in CML.
Title: Loss of PRMT7 reprograms glycine metabolism to selectively eradicate leukemia stem cells in CML.
Protein arginine methyltransferase 7 modulates neuronal excitability by interacting with NaV1.9.
Title: Protein arginine methyltransferase 7 modulates neuronal excitability by interacting with NaV1.9.
The arginine methyltransferase PRMT7 promotes extravasation of monocytes resulting in tissue injury in COPD.
Title: The arginine methyltransferase PRMT7 promotes extravasation of monocytes resulting in tissue injury in COPD.
PRMT7 ablation in cardiomyocytes causes cardiac hypertrophy and fibrosis through beta-catenin dysregulation.
Title: PRMT7 ablation in cardiomyocytes causes cardiac hypertrophy and fibrosis through β-catenin dysregulation.
PRMT7 targets of Foxm1 controls alveolar myofibroblast proliferation and differentiation during alveologenesis.
Title: PRMT7 targets of Foxm1 controls alveolar myofibroblast proliferation and differentiation during alveologenesis.
The Effects of Flavonoid Apigenin on Male Reproductive Health: Inhibition of Spermatogonial Proliferation through Downregulation of Prmt7/Akt3 Pathway.
Title: The Effects of Flavonoid Apigenin on Male Reproductive Health: Inhibition of Spermatogonial Proliferation through Downregulation of Prmt7/Akt3 Pathway.
Arginine monomethylation by PRMT7 controls MAVS-mediated antiviral innate immunity.
Title: Arginine monomethylation by PRMT7 controls MAVS-mediated antiviral innate immunity.

Submit: New GeneRIF Correction See all GeneRIFs (25)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Gene trapped (1)
Targeted (6) 1 citation
Endonuclease-mediated (4)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

AI427456 (e-PCR)
- UniSTS:159805

NoName (e-PCR)
- UniSTS:224500

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables S-adenosylmethionine-dependent methyltransferase activity	ISO Inferred from Sequence Orthology more info
enables histone H4 methyltransferase activity	ISO Inferred from Sequence Orthology more info
enables histone H4R3 methyltransferase activity	IDA Inferred from Direct Assay more info	PubMed
enables histone binding	ISO Inferred from Sequence Orthology more info
enables histone methyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables methyltransferase activity	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein-arginine N-methyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein-arginine omega-N monomethyltransferase activity	ISO Inferred from Sequence Orthology more info
enables protein-arginine omega-N symmetric methyltransferase activity	IDA Inferred from Direct Assay more info	PubMed
enables protein-arginine omega-N symmetric methyltransferase activity	ISO Inferred from Sequence Orthology more info
enables ribonucleoprotein complex binding	ISO Inferred from Sequence Orthology more info
enables transferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within cell differentiation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within chromatin organization	IEA Inferred from Electronic Annotation more info
involved_in chromatin remodeling	IBA Inferred from Biological aspect of Ancestor more info
involved_in genomic imprinting	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within methylation	IEA Inferred from Electronic Annotation more info
involved_in peptidyl-arginine methylation	ISO Inferred from Sequence Orthology more info
involved_in peptidyl-arginine methylation, to asymmetrical-dimethyl arginine	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein methylation	IEA Inferred from Electronic Annotation more info
involved_in spliceosomal snRNP assembly	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in fibrillar center	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: protein arginine N-methyltransferase 7

Names: [Myelin basic protein]-arginine N-methyltransferase PRMT7; histone-arginine N-methyltransferase PRMT7

NP_663379.1

EC 2.1.1.321

XP_006530891.1

EC 2.1.1.321

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_145404.1 → NP_663379.1 protein arginine N-methyltransferase 7

See identical proteins and their annotated locations for NP_663379.1

Status: PROVISIONAL

Source sequence(s)

BC006705

Consensus CDS

CCDS22633.1

UniProtKB/Swiss-Prot

Q3TRZ6, Q69Z62, Q6B955, Q6PG80, Q922X9

Related

ENSMUSP00000071521.6, ENSMUST00000071592.12

Conserved Domains (1) summary

cl17173
Location:37 → 186

AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...