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Tcra T cell receptor alpha chain [ Mus musculus (house mouse) ]

Gene ID: 21473, updated on 7-Dec-2021

Summary

Official Symbol
Tcraprovided by MGI
Official Full Name
T cell receptor alpha chainprovided by MGI
Primary source
MGI:MGI:98553
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Tcralpha
Summary
T cell receptors recognize foreign antigens which have been processed as small peptides and bound to major histocompatibility complex (MHC) molecules at the surface of antigen presenting cells (APC). Each T cell receptor is a dimer consisting of one alpha and one beta chain or one delta and one gamma chain. In a single cell, the T cell receptor loci are rearranged and expressed in the order delta, gamma, beta, and alpha. If both delta and gamma rearrangements produce functional chains, the cell expresses delta and gamma. If not, the cell proceeds to rearrange the beta and alpha loci. This region represents the germline organization of the T cell receptor alpha and delta loci. Both the alpha and delta loci include V (variable), J (joining), and C (constant) segments and the delta locus also includes diversity (D) segments. The delta locus is situated within the alpha locus, between the alpha variable and joining genes. During T cell development, the delta chain is synthesized by a recombination event at the DNA level joining a D segment with a J segment; a V segment is then joined to the D-J gene. The alpha chain is synthesized by recombination joining a single V segment with a J segment. For both chains, the C segment is later joined by splicing at the RNA level. Recombination of many different V segments with several J segments provides a wide range of antigen recognition. Additional diversity is attained by junctional diversity, resulting from the random additional of nucleotides by terminal deoxynucleotidyltransferase. Ten variable segments can be used in either alpha or delta chains and are described by TRAV/DV symbols. Several V and J segments of the alpha locus are known to be incapable of encoding a protein and are considered pseudogenes. [provided by RefSeq, Jul 2008]
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Genomic context

See Tcra in Genome Data Viewer
Location:
14 C2; 14
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (52665424..54461655)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (52427967..54224198)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 14 NC_000080.5 (53047642..54843873)

Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene olfactory receptor 1511 Neighboring gene olfactory receptor 1510 Neighboring gene olfactory receptor enhancer H Neighboring gene olfactory receptor 1509 Neighboring gene olfactory receptor 1508 Neighboring gene olfactory receptor 1507 Neighboring gene T cell receptor alpha variable 1 Neighboring gene predicted gene, 36382 Neighboring gene enolase 1, alpha non-neuron pseudogene Neighboring gene predicted gene, 36448 Neighboring gene ATPase, H+ transporting, lysosomal accessory protein 2 pseudogene Neighboring gene T cell receptor alpha variable 3-1 Neighboring gene T cell receptor alpha variable 4-1 Neighboring gene T cell receptor alpha variable 2 Neighboring gene T cell receptor alpha variable 5-1 Neighboring gene T cell receptor alpha variable 15D-1-DV6D-1 Neighboring gene T cell receptor alpha variable 6-1 Neighboring gene T cell receptor alpha variable 7D-2 Neighboring gene T cell receptor alpha variable 7-1 Neighboring gene T cell receptor alpha variable 6-2 Neighboring gene T cell receptor alpha variable 4D-2 Neighboring gene T cell receptor alpha variable 6D-3 Neighboring gene T cell receptor alpha variable 7D-3 Neighboring gene T cell receptor alpha variable 15D-2-DV6D-2 Neighboring gene T cell receptor alpha variable 6D-4 Neighboring gene T cell receptor alpha variable 7D-4 Neighboring gene T cell receptor alpha variable 8D-1 Neighboring gene T cell receptor alpha variable 9D-1 Neighboring gene T cell receptor alpha variable 6D-5 Neighboring gene T cell receptor alpha variable 12D-1 Neighboring gene T cell receptor alpha variable 6D-6 Neighboring gene T cell receptor alpha variable 13D-1 Neighboring gene T-cell receptor alpha variable region 14D-1 Neighboring gene solute carrier family 45, member 4 pseudogene Neighboring gene T cell receptor alpha variable 10D Neighboring gene T cell receptor alpha variable 7D-5 Neighboring gene T cell receptor alpha variable 11D Neighboring gene ribosomal protein S19, pseudogene 2 Neighboring gene T cell receptor alpha variable 3D-2 Neighboring gene T cell receptor alpha variable 12D-2 Neighboring gene T cell receptor alpha variable 9D-2 Neighboring gene T cell receptor alpha variable 4D-3 Neighboring gene T cell receptor alpha variable 12D-3 Neighboring gene nuclear receptor binding factor 2 pseudogene Neighboring gene T cell receptor alpha variable 5D-2 Neighboring gene T cell receptor alpha variable 13D-2 Neighboring gene T cell receptor alpha variable 9D-3 Neighboring gene T cell receptor alpha variable 14D-2 Neighboring gene T cell receptor alpha variable 5D-3 Neighboring gene T cell receptor alpha variable 16D-DV11 Neighboring gene T cell receptor alpha variable 14D-3-DV8 Neighboring gene T cell receptor alpha variable 3D-3 Neighboring gene T cell receptor alpha variable 9D-4 Neighboring gene T cell receptor alpha variable 4D-4 Neighboring gene T cell receptor alpha variable 5D-4 Neighboring gene T cell receptor alpha variable 6D-7 Neighboring gene T cell receptor alpha variable 13D-3 Neighboring gene T cell receptor alpha variable 7D-6 Neighboring gene glutamate oxaloacetate transaminase 2, mitochondrial pseudogene Neighboring gene T cell receptor alpha variable 8D-2 Neighboring gene T cell receptor alpha variable 13D-4 Neighboring gene T cell receptor alpha variable 15D-3 Neighboring gene predicted gene, 30214 Neighboring gene T cell receptor alpha variable 7N-4 Neighboring gene T cell receptor alpha variable 9N-1 Neighboring gene T cell receptor alpha variable 6N-5 Neighboring gene T cell receptor alpha variable 12N-1 Neighboring gene T cell receptor alpha variable 6N-6 Neighboring gene T cell receptor alpha variable 13N-1 Neighboring gene T cell receptor alpha variable 14N-1 Neighboring gene T cell receptor alpha variable 10N Neighboring gene T cell receptor alpha variable 7N-5 Neighboring gene T cell receptor alpha variable 15N-1 Neighboring gene T cell receptor alpha variable 11N Neighboring gene ribosomal protein S19, pseudogene 1 Neighboring gene T cell receptor alpha variable 3N-2 Neighboring gene T cell receptor alpha variable 9N-2 Neighboring gene T cell receptor alpha variable 12N-2 Neighboring gene T cell receptor alpha variable 4N-3 Neighboring gene T cell receptor alpha variable 12N-3 Neighboring gene nuclear receptor binding factor 2 pseudogene Neighboring gene T cell receptor alpha variable 5N-2 Neighboring gene T cell receptor alpha variable 13N-2 Neighboring gene T cell receptor alpha variable 9N-3 Neighboring gene T cell receptor alpha variable 14N-2 Neighboring gene T cell receptor alpha variable 5N-3 Neighboring gene T cell receptor alpha variable 15N-2 Neighboring gene T cell receptor alpha variable 3N-3 Neighboring gene T cell receptor alpha variable 9N-4 Neighboring gene T cell receptor alpha variable 4N-4 Neighboring gene T cell receptor alpha variable 5N-4 Neighboring gene T cell receptor alpha variable 13N-3 Neighboring gene T cell receptor alpha variable 6N-7 Neighboring gene T cell receptor alpha variable 7N-6 Neighboring gene aspartate aminotransferase, mitochondrial, pseudogene Neighboring gene T cell receptor alpha variable 13N-4 Neighboring gene T cell receptor alpha variable 14N-3 Neighboring gene T cell receptor alpha variable 8n-2 Neighboring gene T cell receptor alpha variable 15N-3 Neighboring gene T cell receptor alpha variable 16n Neighboring gene T cell receptor alpha variable 15-1-DV6-1 Neighboring gene T cell receptor alpha variable 7-2 Neighboring gene T cell receptor alpha variable 4-2 Neighboring gene T cell receptor alpha variable 6-3 Neighboring gene T cell receptor alpha variable 7-3 Neighboring gene T cell receptor alpha variable 6-4 Neighboring gene T cell receptor alpha variable 7-4 Neighboring gene predicted gene, 18711 Neighboring gene T cell receptor alpha variable 8-1 Neighboring gene T cell receptor alpha variable 15-2-DV6-2 Neighboring gene T cell receptor alpha variable 9-1 Neighboring gene T cell receptor alpha variable 6-5 Neighboring gene T cell receptor alpha variable 12-1 Neighboring gene T cell receptor alpha variable 6-6 Neighboring gene T cell receptor alpha variable 13-1 Neighboring gene T cell receptor alpha variable 14-1 Neighboring gene T cell receptor alpha variable 7-5 Neighboring gene T cell receptor alpha variable 10 Neighboring gene T cell receptor alpha variable 11 Neighboring gene T cell receptor alpha variable 4-4-DV10 Neighboring gene T cell receptor alpha variable 3-2 Neighboring gene T cell receptor alpha variable 9-2 Neighboring gene T cell receptor alpha variable 12-2 Neighboring gene T cell receptor alpha variable 12-3 Neighboring gene T cell receptor alpha variable 4-3 Neighboring gene T cell receptor alpha variable 6-7-DV9 Neighboring gene T cell receptor alpha variable 13-2 Neighboring gene T cell receptor alpha variable 14-2 Neighboring gene T cell receptor alpha variable 5-2 Neighboring gene T cell receptor alpha variable 13-4-DV7 Neighboring gene glutamate oxaloacetate transaminase 2, mitochondrial pseudogene Neighboring gene T cell receptor alpha variable 3-3 Neighboring gene T cell receptor alpha variable 9-4 Neighboring gene T cell receptor alpha variable 5-4 Neighboring gene T cell receptor alpha variable 13-3 Neighboring gene T cell receptor alpha variable 7-6 Neighboring gene T cell receptor alpha variable 14-3 Neighboring gene T-cell receptor alpha variable 8-2 Neighboring gene T cell receptor alpha variable 15-3 Neighboring gene T cell receptor alpha variable 12-4 Neighboring gene T cell receptor alpha variable 16 Neighboring gene T cell receptor alpha variable 13-5 Neighboring gene T cell receptor alpha variable 21-DV12 Neighboring gene T cell receptor alpha variable 3-4 Neighboring gene T cell receptor alpha variable 17 Neighboring gene T cell receptor alpha variable 18 Neighboring gene T cell receptor alpha variable 19 Neighboring gene T cell receptor alpha variable 20 Neighboring gene predicted gene, 30392 Neighboring gene T cell receptor delta variable 1 Neighboring gene T cell receptor delta variable 2-1 Neighboring gene T cell receptor alpha variable 22 Neighboring gene T cell receptor delta variable 2-2 Neighboring gene T cell receptor alpha variable 23 Neighboring gene T cell receptor delta chain Neighboring gene T cell receptor delta variable 3 Neighboring gene predicted gene, 30275 Neighboring gene T cell receptor delta variable 4 Neighboring gene T cell receptor delta diversity 1 Neighboring gene T cell receptor delta diversity 2 Neighboring gene T cell receptor delta joining 1 Neighboring gene T cell receptor alpha joining 61 Neighboring gene T cell receptor alpha joining 60 Neighboring gene T cell receptor alpha joining 59 Neighboring gene T cell receptor alpha joining 58 Neighboring gene T cell receptor alpha joining 57 Neighboring gene T cell receptor alpha joining 56 Neighboring gene T cell receptor alpha joining 55 Neighboring gene T cell receptor alpha joining 51 Neighboring gene T cell receptor alpha joining 52 Neighboring gene T cell receptor alpha joining 53 Neighboring gene T cell receptor alpha joining 54 Neighboring gene T cell receptor delta joining 2 Neighboring gene T cell receptor alpha joining 50 Neighboring gene T cell receptor alpha joining 49 Neighboring gene T cell receptor alpha joining 48 Neighboring gene T cell receptor alpha joining 47 Neighboring gene T cell receptor delta variable 5 Neighboring gene T cell receptor alpha joining 46 Neighboring gene T cell receptor alpha joining 45 Neighboring gene T cell receptor alpha joining 44 Neighboring gene T cell receptor alpha joining 43 Neighboring gene T cell receptor alpha joining 42 Neighboring gene T cell receptor alpha joining 41 Neighboring gene T cell receptor alpha joining 39 Neighboring gene T cell receptor alpha joining 36 Neighboring gene T cell receptor alpha joining 37 Neighboring gene T cell receptor alpha joining 38 Neighboring gene T cell receptor alpha joining 40 Neighboring gene T cell receptor alpha joining 35 Neighboring gene T cell receptor alpha joining 34 Neighboring gene T cell receptor alpha joining 33 Neighboring gene T cell receptor alpha joining 32 Neighboring gene T cell receptor alpha joining 31 Neighboring gene T cell receptor alpha joining 30 Neighboring gene T cell receptor alpha joining 29 Neighboring gene T cell receptor alpha joining 28 Neighboring gene T cell receptor alpha joining 27 Neighboring gene T cell receptor alpha joining 26 Neighboring gene T cell receptor alpha joining 22 Neighboring gene T cell receptor alpha joining 23 Neighboring gene T cell receptor alpha joining 25 Neighboring gene T cell receptor delta, constant region Neighboring gene T cell receptor alpha joining 24 Neighboring gene T cell receptor alpha joining 21 Neighboring gene T cell receptor alpha joining 20 Neighboring gene T cell receptor alpha joining 19 Neighboring gene T cell receptor alpha joining 18 Neighboring gene T cell receptor alpha joining 17 Neighboring gene T cell receptor alpha joining 16 Neighboring gene T cell receptor alpha joining 11 Neighboring gene T cell receptor alpha joining 12 Neighboring gene T cell receptor alpha joining 13 Neighboring gene T cell receptor alpha joining 14 Neighboring gene T cell receptor alpha joining 15 Neighboring gene T cell receptor alpha joining 9 Neighboring gene T cell receptor alpha joining 8 Neighboring gene T cell receptor alpha joining 7 Neighboring gene T cell receptor alpha joining 6 Neighboring gene T cell receptor alpha joining 5 Neighboring gene T cell receptor alpha joining 4 Neighboring gene T cell receptor alpha joining 3 Neighboring gene T cell receptor alpha joining 2 Neighboring gene T cell receptor alpha joining 1 Neighboring gene abhydrolase domain containing 4 Neighboring gene T cell receptor alpha constant Neighboring gene defender against cell death 1

Genomic regions, transcripts, and products

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Other Names

  • Tcr alpha

Gene Ontology Provided by MGI

Process Evidence Code Pubs
involved_in response to bacterium IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Names
T cell receptor alpha chain
Tcr alpha

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_007044.1 

    Range
    501..1796732
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000080.7 Reference GRCm39 C57BL/6J

    Range
    52665424..54461655
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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